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This page contains information on Aquacillin for veterinary use.
The information provided typically includes the following:
  • Aquacillin Indications
  • Warnings and cautions for Aquacillin
  • Direction and dosage information for Aquacillin


This treatment applies to the following species:
Manufacturer: Vedco

Penicillin G Procaine in Aqueous Suspension

NADA 65-110, Approved by FDA

For Use In Cattle, Sheep, Swine and Horses


For Intramuscular Use Only

Each mL of AQUACILLIN® contains 300,000 units of procaine penicillin G and approximately: 0.8% sodium citrate; 0.15% sodium carboxymethylcellulose; 25% sorbitol solution U.S.P.; 0.06% povidone; 0.6% lecithin; 0.1% methylparaben; 0.01% propylparaben; 0.25% phenol.

General Information

Procaine penicillin G is a potent antibacterial agent which is effective against a variety of pathogenic organisms, chiefly in the gram-positive category. AQUACILLIN® is a free-flowing product prepared by combining penicillin G and procaine, molecule for molecule, with dispersing agents.


Milk that has been taken from animals during treatment and for 48 hours (4 milkings) after the latest treatment must not be used for food. A withdrawal period has not been established in pre-ruminating calves. Do not use in veal calves.

Discontinue use of this drug for the following time periods before treated animals are slaughtered for food: Cattle - 10 days; Sheep - 9 days; Swine - 7 days.

Not for use in horses intended for food.


Exceeding the highest recommended daily dosage of 3,000 units per pound of body weight, administering at the recommended levels for more than 4 consecutive days, and/or exceeding 10 mL intramuscularly per injection site, may result in antibiotic residues beyond the withdrawal time.

Aquacillin® Should Be Injected Deep Within The Fleshy Muscles Of The Hip, Rump, Round, Or Thigh. Do Not Inject This Material Subcutaneously (under The Skin), Into A Blood Vessel, Or Near A Major Nerve.

procaine Penicillin G Is A Substance Of Low Toxicity. However, Side Effects, Or So-called Allergic Or Anaphylactic Reactions - Sometimes Fatal, Have Been Known To Occur In Animals Hypersensitive To Penicillin And Procaine. Such Reactions Can Occur Unpredictably With Varying Intensity. Animals Administered aquacillin® Should Be Kept Under Close Observation For At Least One-half Hour. Should Allergic Or Anaphylactic Reactions Occur, Discontinue Use Of The Product And Immediately Administer Epinephrine Following Manufacturer’s Recommendations; Call A Veterinarian.

as With All Antibiotic Preparations, Use Of This Drug May Result In The Overgrowth Of Non-susceptible Organisms, Including Fungi. A Lack Of Response By The Treated Animal, Or The Development Of New Signs Or Symptoms Suggest That An Overgrowth Of Non-susceptible Organisms Has Occurred. In Such Instances, Consult Your Veterinarian.

since Bactericidal Drugs May Interfere With The Bacteriostatic Action Of Tetracyclines, It Is Advisable To Avoid Giving Penicillin In Conjunction With Tetracyclines.

aquacillin® Should Be Stored Between 2-8°c (36-46°f). Warm To Room Temperature And Shake Before Using.

indications: Aquacillin® Is Recommended For Treatment Of Bacterial Pneumonia (shipping Fever) Caused By pasteurella Multocida In Cattle And Sheep, Erysipelas Caused By erysipelothrix rhusiopathiae In Swine, And Strangles Caused By streptococcus equi In Horses.

dosage Levels

The recommended daily dosage of penicillin is 3,000 units per pound of body weight (one mL per 100 lb body weight).

Continue daily treatment until recovery is apparent and for at least 1 day after symptoms disappear, usually in 2 or 3 days. Treatment should not exceed 4 consecutive days.

Directions For Use

AQUACILLIN® should be administered by the intramuscular route.

A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized by boiling in water for 15 minutes). Before withdrawing the solution from the bottle, disinfect the rubber cap on the bottle with a suitable disinfectant such as 70 percent alcohol. The injection site should be similarly cleaned with the disinfectant. Needles of 16 to 18 gauge and 1 to 1 1/2 inches long are adequate for intramuscular injections.

Intramuscular Injection

In livestock, intramuscular injection should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle such as the rump, hip, or thigh region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site. No more than 10 mL should be injected at any one site in adult livestock; rotate injection sites for each succeeding treatment.

Care Of Sick Animals

The use of antibiotics in the management of disease is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by penicillin-susceptible organisms, most animals treated with AQUACILLIN® show a noticeable improvement within 24 to 48 hours. If improvement does not occur within this period of time, the diagnosis and course of treatment should be re-evaluated. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian. Since many diseases look alike but require different types of treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs, and needless losses. Good housing, sanitation, and nutrition are important in the maintenance of healthy animals and are essential in the treatment of disease.

PACKAGE INFORMATION: AQUACILLIN® is available in vials of 100 mL, 250 mL, and 500 mL with each mL containing 300,000 units procaine penicillin G. The 500 mL vial is intended for use with automatic syringes.


Restricted Drug(s) (california)

Not For Human Use.

Use Only As Directed.

Store Between 2°-8°c (36°-46°f)

Shake Well Before Using



Manufactured for VEDCO, Inc., St. Joseph, MO 64507

Nac No.


Telephone:   816-238-8840
Toll-Free:   888-708-3326 (888-70VEDCO)
Fax:   816-238-1837
Every effort has been made to ensure the accuracy of the Aquacillin information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-03-29