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This page contains information on Acarexx for veterinary use.
The information provided typically includes the following:
  • Acarexx Indications
  • Warnings and cautions for Acarexx
  • Direction and dosage information for Acarexx


This treatment applies to the following species:
Manufacturer: Idexx Pharm.

(0.01% Ivermectin)

otic Suspension

Acarexx Caution

U.S. federal law restricts this drug to use by or on the order of a licensed veterinarian.


Chemical Name: Ivermectin is a mixture of 5-0-demethyl-22, 23-dihydroavermectin A1a (component B1a) and 5-0-demethyl-25-de (1-methylpropyl)-22, 23-dihydro-25-(1-methylethyl)avermectin A1b (component B1b). Empirical formula: B1a = C48H74O14, B1b = C47H72O14. Molecular weight: B1a = 875.10, B1b = 861.07

Acarexx Indications

Acarexx® (0.01% ivermectin) Otic Suspension is indicated for the treatment of adult ear mite (Otodectes cynotis) infestations in cats and kittens four weeks of age or older. Effectiveness against eggs and immature stages has not been proven.

Human Warnings: Not For Human Use. Keep Out Of Reach Of Children.


The safe use of Acarexx in cats used for breeding purposes, during pregnancy, or in lactating queens, has not been evaluated.

Adverse Reactions

In approximately 1% of 80 cats and kittens, pain associated with the pinna and vomiting were observed following treatment with Acarexx.


Acarexx is administered topically in the ear canal at an ivermectin concentration of 0.01%. One dose of 0.5 mL is applied in each ear. Repeat treatment one time if necessary, based upon the ear mite life cycle and the response to treatment.


Tear foil pouch at the notch to remove the two plastic ampules. Use one ampule per ear. Shake well before use. Snap off the cap of the ampule and place the tip into the external ear canal. Squeeze the entire contents of one ampule into the ear and massage the base of the ear to distribute the medication. Repeat the procedure in the other ear using the second ampule. In clinical field trials, ears were not cleaned and many animals still had debris in their ears at the end of the study. Cleaning the ears prior to administration of Acarexx is not necessary to provide effectiveness.


One treatment with Acarexx was 92% effective in treating adult ear mite (Otodectes cynotis) infestations after seven days in a dose titration/confirmation study. In a well-controlled clinical field trial, one treatment of Acarexx was 94% effective in clearing cats and kittens of adult ear mite infestations within 7 to 10 days.

SAFETY: In two Target Animal Safety studies, Acarexx was proven to be safe in kittens four weeks of age or older. Four-week-old kittens were administered Acarexx at dose rates of 1X, 3X, and 5X the recommended dose for three or six consecutive days and no adverse reactions were observed except one kitten treated at 1X the dose had histologic evidence of minimal, chronic dermal inflammation of the ear. In a well-controlled clinical field trial, Acarexx was used safely in cats and kittens receiving other frequently used veterinary products such as flea control products, vaccines, anthelmintics, antibiotics, and steroids.

Storage Conditions

Acarexx should be stored at temperatures below 86ºF (30ºC). Protect from freezing.

How Supplied

Acarexx is packaged in two polypropylene ampules per foil pouch, which are packaged 12 foil pouches per display carton. Each ampule is filled to deliver 0.5 mL of 0.01% ivermectin otic suspension per ear.

For technical assistance or to report adverse drug reactions, please call 1-800-374-8006.

For more information, visit

Manufactured for IDEXX Pharmaceuticals, Inc., Greensboro, NC 27410 USA

A subsidiary of IDEXX Laboratories, Inc.

Acarexx is a registered trademark of IDEXX Laboratories, Inc.

© 2006 IDEXX Pharmaceuticals, Inc.

NADA 141-174, Approved by FDA

IPI/ILS/IN/6 3/06


Nac No.

A Subsidiary of Idexx Laboratories, Inc.

Telephone:   336-834-6500
Order Desk:   800-374-8006
Fax:   336-834-6502
Every effort has been made to ensure the accuracy of the Acarexx information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Acarexx product label or package insert.

Copyright © 2018 North American Compendiums. Updated: 2018-03-29