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ZOFRAN SUPPOSITORIES 16MG
Active substance(s): ONDANSETRON
5. How to store Zofran suppositories
• Keep this medicine out of the sight and reach of children.
• Do not use Zofran suppositories after the expiry date
which is stated on the pack after ‘Exp’. The expiry date
refers to the last day of that month.
• Store Zofran suppositories below 30°C.
• Zofran suppositories should only be taken out of the
blister immediately before use.
• Do not throw away any medicines via wastewater or
household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures will
help protect the environment.
6. Contents of the pack and other information
What Zofran suppositories contain
• The active ingredient is ondansetron. Each Zofran
suppository contains ondansetron 16 mg.
• The other ingredient is Witespol S58
What Zofran suppositories look like and contents of the pack
Zofran suppository is white and torpedo shaped. Each
suppository is in an individually sealed cavity enclosed in a
perforated cardboard mount and packed into a carton.
Marketing Authorisation Holder and Manufacturer
Novartis Pharmaceuticals UK Ltd, Frimley Business Park,
Frimley, Camberley, Surrey, GU16 7SR, United Kingdom
This leaflet was last revised in February 2016.
Package Leaflet: Information for the User
Zofran® suppositories 16 mg
Read all of this leaflet carefully before you start using this
medicine because it contains important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions about your illness or
your medicine, ask your doctor, nurse or pharmacist.
• This medicine has been prescribed for you only. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
• If any of the side effects get serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor, nurse or pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
What is in this leaflet:
1 What Zofran suppositories are and what they are used for
2 What you need to know before you use Zofran
3 How to use Zofran suppositories
4 Possible side effects
5 How to store Zofran suppositories
6 Contents of the pack and other information
1. What Zofran suppositories are and what they are used for
Zofran suppositories contain a medicine called ondansetron.
This belongs to a group of medicines called anti-emetics.
Zofran suppositories are for use in your back passage only
(rectal use). They should not be swallowed.
Zofran suppositories are used for:
• preventing nausea and vomiting caused by chemotherapy
or radiotherapy for cancer
Ask your doctor, nurse or pharmacist if you would like any
further explanation about these uses.
2. What you need to know before you use Zofran
Do not use Zofran suppositories if:
• you are taking apomorphine (used to treat Parkinson’s
• you are allergic (hypersensitive) to ondansetron or
Witespol S58 in Zofran suppositories.
If you are not sure, talk to your doctor, nurse or pharmacist
before using Zofran suppositories.
Warnings and precautions
Check with your doctor, nurse or pharmacist before using
Zofran suppositories if:
• you have ever had heart problems (e.g. congestive heart
failure which causes shortness of breath and swollen
• you have an uneven heart beat (arrhythmias)
• you are allergic to medicines similar to ondansetron, such
as granisetron or palonosetron
• you have liver problems
• you have a blockage in your gut
• you have problems with the levels of salts in your blood,
such as potassium, sodium and magnesium.
If you are not sure if any of the above apply to you, talk
to your doctor, nurse or pharmacist before using Zofran
Other medicines and Zofran
Please tell your doctor, nurse or pharmacist if you are taking
or have recently taken or might take other medicines.
This includes medicines that you buy without
a prescription and herbal medicines.
This is because Zofran can affect the way some medicines
work. Also some other medicines can affect the way Zofran
In particular, tell your doctor, nurse or pharmacist if you are
taking any of the following medicines:
• carbamazepine or phenytoin used to treat epilepsy
• rifampicin used to treat infections such as tuberculosis (TB)
• antibiotics such as erythromycin or ketoconazole
• anti-arrhythmic medicines used to treat an uneven heart
• beta-blocker medicines used to treat certain heart or eye
problems, anxiety or prevent migraines
• tramadol, a pain killer
• medicines that affect the heart (such as haloperidol or
• cancer medicines (especially anthracyclines and
• SSRIs (selective serotonin reuptake inhibitors) used to treat
depression and/or anxiety including fluoxetine, paroxetine,
sertraline, fluvoxamine, citalopram, escitalopram
• SNRIs (serotonin noradrenaline reuptake inhibitors) used
to treat depression and/or anxiety including venlafaxine,
If you keep feeling or being sick
Zofran suppositories should start to work within one or two
hours of using a dose.
If you continue to feel sick or are sick then tell your doctor or
nurse. Do not use the suppositories more often than the
If you use more Zofran suppositories than you should
If you or your child use more Zofran suppositories than you
should, or accidentally swallow one, talk to a doctor or go to
a hospital straight away. Take the medicine pack with you.
If you forget to use Zofran suppositories
If you miss a dose and feel sick or vomit:
• use a Zofran suppository as soon as possible, then
• use your next suppository at the usual time (as shown on
• do not use a double dose to make up for a forgotten
If you miss a dose but do not feel sick
• use the next dose as shown on the label
• do not use a double dose to make up for a forgotten
4. Possible side effects
If you are not sure if any of the above applies to you, talk to
your doctor, nurse or pharmacist before using Zofran
Like all medicines, Zofran suppositories can cause side
effects, although not everybody gets them.
Pregnancy and breast-feeding
It is not known if Zofran is safe during pregnancy. If you are
pregnant, think you are pregnant or are planning to have a
baby, ask your doctor or pharmacist for advice before using
Do not breast-feed if you are using Zofran. This is because
small amounts pass into the mother’s milk. Ask your doctor
or midwife for advice.
If you have an allergic reaction, stop using it and see a
doctor straight away. The signs may include:
• sudden wheezing and chest pain or chest tightness
• swelling of your eyelids, face, lips, mouth or tongue
• skin rash - red spots or lumps under your skin (hives)
anywhere on your body
3. How to use Zofran suppositories
Always use Zofran suppositories exactly as your doctor has
told you. You should check with your doctor, nurse or
pharmacist if you are not sure.
On the day of chemotherapy or radiotherapy:
• the usual dose is one suppository (16 mg) to be
inserted 1 to 2 hours before treatment.
On the following days:
• the usual dose is one suppository (16 mg) each day
• this may be repeated for up to 5 days.
Zofran suppositories are not recommended for children.
Patients with moderate or severe liver problems
You should use Zofran as injection or tablets because the
total daily dose should not be more than 8 mg.
Using Zofran suppositories
1. Empty your bowels if you need to. Wash your hands.
emove the suppository from its packaging by tearing
the foil (see illustration on pack)
ou may find that inserting the suppository is easier if
you squat or bend forward
ently push the pointed end of the suppository into the
back passage (rectum)
ush the suppository in as far as possible and remain still
for a little while. This allows the suppository to melt so
the medicine will work
6. Wash your hands
ry not to empty your bowels within 1 hour of inserting
8. If your suppository comes out of your back passage, push
it back in as far as possible and remain still for a while.
Wash your hands again.
Other side effects include:
Very common (may affect more than 1 in 10 people)
Common (may affect up to 1 in 10 people)
• a feeling of warmth or flushing
• changes to liver function test results (if you use Zofran
suppositories with a medicine called cisplatin, otherwise
this side effect is uncommon).
Uncommon (may affect up to 1 in 100 people)
• low blood pressure, which can make you feel faint or
• uneven heart beat
• chest pain
• unusual body movements or shaking.
Rare (may affect up to 1 in 1,000 people)
• feeling dizzy or light headed
• blurred vision
• disturbance in heart rhythm (sometimes causing a sudden
loss of consciousness)
Very rare (may affect up to 1 in 10,000 people)
• poor vision or temporary loss of eyesight, which usually
comes back within 20 minutes.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more
information on the safety of this medicine.