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TRANSIDERM NITRO 5 PATCHES

Active substance(s): GLYCERYL TRINITRATE

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PACKAGE LEAFLET: INFORMATION FOR THE USER
TRANSIDERM-NITRO® 5 PATCHES
(glyceryl trinitrate)
What you need to know about Transiderm-Nitro® 5
Your doctor has decided that you need this medicine to help treat your
condition.
Please read this leaflet carefully before you start to use the
patches. It contains important information. Keep the leaflet in a
safe place because you may want to read it again.
If you have any other questions, or if there is something you don’t
understand, please ask your doctor or pharmacist.
This medicine has been prescribed for you. Never give it to someone
else. It may not be the right medicine for them even if their symptoms
seem to be the same as yours.
If any of the side effects gets serious, or if you notice any side effects
not listed in this leaflet, please tell your doctor or pharmacist.
This product will be referred to as Transiderm-Nitro in this leaflet.
In this leaflet:
1. What Transiderm-Nitro patches are and what they are used for
2. Things to consider before you start to use Transiderm-Nitro
patches
3. How to use Transiderm-Nitro
4. Possible side effects
5. How to store Transiderm-Nitro
6. Further information
1. What Transiderm-Nitro patches are and what they are used
for
Transiderm-Nitro is a patch which you stick on your skin. The patch
contains a supply of glyceryl trinitrate which is released from the patch
and absorbed through the skin and into the blood vessels.
This is called a transdermal patch. See diagram of patch below.



Transiderm-Nitro is used
 to prevent angina attacks. Angina means a painful tightness in the
chest. This is a good description of a typical attack, although the
pain may also be felt in the arm or neck. The pain really comes
from the heart muscle and is a sign that part of the muscle is not
getting enough blood supply for the amount of work it has to do.

Remove one sachet from the box and tear
open the sachet at the notch. Use your
fingers as cutting with scissors might damage
the patch inside. Remove the patch from the
sachet.

4

5

Peel off the white plastic backing and discard
it. Do not touch the sticky surface of the
patch.

Place the sticky side of the patch on the
clean skin, press firmly while you count slowly
up to five.

Are you taking other medicines?
Transiderm-Nitro interacts with a large number of other medicines.
Tell your doctor or pharmacist if you are taking any of the following:
 Medicines for depression
 Ergotamine products which are usually given for migraine
 Medicines for erectile dysfunction (male impotence)
 Medicines for high blood pressure or heart problems
 Aspirin or other painkillers called NSAIDs (non-steroidal antiinflammatory drugs)
 Diuretics ("water tablets")
 Tranquillisers (e.g. chlorpromazine, flupenthixol, haloperidol,
clozapine).

If any of the symptoms become troublesome, or if you notice
anything else not mentioned here, please go and see your doctor.
He/she may want to reduce the dose or give you a different
medicine.

Do not use the patches after the date printed on the carton.
KEEP OUT OF SIGHT AND REACH OF CHILDREN.
Store below 25°C. Do not refrigerate.
If your doctor tells you to stop using the patches, please take the
patches back to the pharmacist for safe disposal.
Run your finger around the edge of the patch to make sure no
air or water can get in. If you have applied the patch correctly
you can bathe, shower or swim with little risk of the patch
coming off.

Other special warnings
Be careful when drinking alcohol as the patch may affect you more
than usual and you might feel faint or dizzy.

To prevent angina
The usual dosage for adults and the elderly is one or two patches
applied daily. The doctor will have decided which strength of patch you
need.

You might find that your GTN (glyceryl trinitrate) tablets or spray aren’t
working as well as they used to. Discuss this with your doctor.

You may be told to wear a patch all of the time or for only part of the
day. Don’t forget to follow the doctor’s instructions exactly.

You must tell the doctor or nurse if you are wearing a patch before an
MRI scan (Magnetic Resonance Imaging scan to visualise internal
organs and tissues of the body) or diathermy treatment (treatment
using hot wires) and before electrical treatment on the heart.

Do not stop using the patches suddenly without consulting your doctor
first.

The doctor will tell you how often to change the patch. Discard the old
patch carefully because it will still contain a little of the active
ingredient.

Up to 1 in 1,000 people have experienced:
 Increased heart rate or palpitations.
 Feeling faint or light-headed on standing, or feeling dizzy.
 Flushing of the face.

5. How to store Transiderm-Nitro patches

6 / 7.

It is important to follow what your doctor says about how and when to
use your patches. The dose will be on the pharmacist’s label. Check
the label carefully. If you are not sure, ask your doctor or pharmacist.

Up to 1 in 100 people have experienced:
Reddening, itching or burning of the skin at the site of the patch.
Be sure to put your patch in a different place each day.
 Allergic skin reactions such as reddening or itching anywhere on
the body.

Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. You
can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard. By reporting side effects you can
provide more information on the safety of this medicine.

Always tell the doctor or pharmacist about all of the medicines
you are taking. This means medicines you have bought yourself,
as well as medicines on prescription from the doctor.
Will there be any problems with driving or using machinery?
Some people have reported feeling faint or dizzy when they have
started to use the patches. You should not drive or operate machinery
if you are affected.

Up to 1 in 10 people have experienced:
 Headaches. These will probably wear off after a few days.
If necessary you can take mild painkillers e.g. paracetamol.


You should also ask yourself these questions before using the
patch:
 Have you recently had a heart attack or do you have heart failure
or other heart problems?
 Do you suffer from anaemia or lung disease?
 Are you pregnant or trying to become pregnant?
 Are you breast feeding?
If the answer to any of these questions is YES, tell your doctor or
pharmacist because Transiderm-Nitro might not be the right medicine
for you.

3. How to use Transiderm-Nitro patches
Glyceryl trinitrate, the active ingredient in the patches is one of a group
of medicines called vasodilators. These cause blood vessels to relax,
increasing the supply of blood and oxygen to the heart and reducing
the amount of work the heart has to do.

3

you have any problems with your heart because of faulty valves or
inflammation.
 you are taking any medicines for erectile dysfunction (male
impotence).
If you are hospitalised due to severe dehydration or loss of blood tell
the doctor you are using a Transiderm-Nitro patch.

Sometimes patches are not enough to prevent all of your angina
attacks and you may be given tablets as well. Make sure you know
when you need to take the tablets.
To prevent skin irritation when you are receiving drugs intravenously
(into a vein)
One Transiderm-Nitro 5 patch will be applied when the treatment is
started and the patch changed every 3-4 days until the treatment is
stopped.

If the patches become discoloured or show any signs of deterioration,
you should seek the advice of your pharmacist who will tell you what to
do.
6. Further information
Each patch contains 25mg of the active ingredient glyceryl trinitrate.
Your body will absorb approximately 5mg over 24 hours.
Transiderm-Nitro Patches also contain the following inactive
ingredients: silicone oil, silica dioxide, lactose, ethylene-vinylacetate
copolymer and silicone based adhesive.
The patches are flesh-coloured, oval shaped, self-adhesive patches.
They are marked with the letters ‘CG DOD’ and are packed in
cartons containing 30 patches.
Manufacturer
This product is manufactured by:
Novartis Pharma B.V. Raapopseweg 1, 6824 DP ARNHEM.

It is procured from within the EU and repackaged by the Parallel
Import Product Licence holder: G Pharma Ltd. Dakota Avenue,
Salford M50 2PU.
P

Transiderm-Nitro is not suitable for children.
PL NO 16369/0337

The side of the chest is a suitable place to apply the patch.
Choose a different area of skin each time you apply a new patch.
Leave several days before you use the same patch of skin again.

What if you forget to change your patch?
If you forget to change your patch, do not worry. Put on a new one as
soon as you remember. Then go on as before.

How to apply the patch

What if you accidentally use too many patches?
If you accidentally apply too many Transiderm-Nitro patches, tell your
doctor or nearest hospital casualty department immediately.
Take your medicine pack with you.

Transiderm-Nitro 5 Patches

01/09/2015

Transiderm-Nitro is a registered trademark of Novartis
Transiderm-Nitro is also used in patients who are receiving food or
drugs directly into a vein (intravenously)
 to prevent irritation and the intravenous fluid leaking into the
surrounding tissues.

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2. Things to consider before you start to use Transiderm-Nitro
patches
Some people MUST NOT use Transiderm-Nitro patches.
Talk to your doctor if:
 you think you may be allergic to glyceryl trinitrate or other nitrates
or to any of the other ingredients of the patch. (These are listed at
the end of the leaflet.)
 you have very low blood pressure.
 you have headaches, vomiting or seizures as a result of raised
pressure inside the skull.

Decide where you will put the patch. It is
important that you put it on a hairless area to
ensure that it sticks well.
The side of the chest is recommended.

4. Possible side effects
Transiderm-Nitro patches are suitable for most people. However, like
all medicines they can sometimes cause side effects.

2

Wash the skin and dry it thoroughly to make
sure the patch sticks well. Wait a minute until
the skin feels quite dry.
Do not use powder.

The side effects listed below have been reported:
More than 10% of people have experienced
 Nausea (feeling sick) or vomiting (being sick).

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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