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TRANSIDERM-NITRO 10 MILLIGRAMS/24 HOURS TRANSDERMAL PATCH

Active substance(s): GLYCERYL TRINITRATE

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Transiderm-Nitro® 5 milligrams/24 hours
Transdermal Patch
Transiderm-Nitro® 10 milligrams/24 hours
Transdermal Patch
(glyceryl trinitrate)
Patient Information Leaflet
The name of this product is Transiderm-Nitro 5 milligrams/
24 hours Transdermal Patch or Transiderm-Nitro 10 milligrams/
24 hours Transdermal Patch but will be referred to as TransidermNitro 5 and 10 throughout this leaflet.

You should also ask yourself these questions before using
the patch:
• Have you recently had a heart attack or do you have heart
failure or other heart problems?
Transiderm‑Nitro is a patch which you stick on your skin. The
patch contains a supply of glyceryl trinitrate which is released from • Do you suffer from anaemia or lung disease?
the patch and absorbed through the skin and into the blood
• Are you pregnant or trying to become pregnant?
vessels. This is called a transdermal patch. See diagram of patch • Are you breast feeding?
below.
If the answer to any of these questions is YES, tell your doctor or
pharmacist because Transiderm-Nitro might not be the right
medicine for you.

1. What Transiderm-Nitro patches are and what they
are used for

What you need to know about Transiderm‑Nitro® 5 and 10
Your doctor has decided that you need this medicine to help treat
your condition.
Please read this leaflet carefully before you start to use the
patches. It contains important information. Keep the leaflet in
a safe place because you may want to read it again.
If you have any other questions, or if there is something you don’t
understand, please ask your doctor or pharmacist.
This medicine has been prescribed for you. Never give it to
someone else. It may not be the right medicine for them even if
their symptoms seem to be the same as yours.
If any of the side effects gets serious, or if you notice any side
effects not listed in this leaflet, please tell your doctor or
pharmacist.
In this leaflet:
1. What Transiderm-Nitro patches are and what they are used for
2. Things to consider before you start to use Transiderm-Nitro
patches
3. How to use Transiderm-Nitro
4. Possible side effects
5. How to store Transiderm-Nitro
6. Further information

Glyceryl trinitrate, the active ingredient in the patches is one of a
group of medicines called vasodilators. These cause blood
vessels to relax, increasing the supply of blood and oxygen to the
heart and reducing the amount of work the heart has to do.
Transiderm‑Nitro 5 and 10 are used
• to prevent angina attacks. Angina means a painful tightness in
the chest. This is a good description of a typical attack,
although the pain may also be felt in the arm or neck. The
pain really comes from the heart muscle and is a sign that part
of the muscle is not getting enough blood supply for the
amount of work it has to do.
Transiderm‑Nitro 5 is also used in patients who are receiving food
or drugs directly into a vein (intravenously)

to prevent irritation and the intravenous fluid leaking into the
surrounding tissues.

2. Things to consider before you start to use
Transiderm-Nitro patches
Some people MUST NOT use Transiderm-Nitro patches.
Talk to your doctor if:
• you think you may be allergic to glyceryl trinitrate or other
nitrates or to any of the other ingredients of the patch. (These
are listed at the end of the leaflet.)
• you have very low blood pressure.
• you have headaches, vomiting or seizures as a result of
raised pressure inside the skull.
• you have any problems with your heart because of faulty
valves or inflammation.
• you are taking any medicines for erectile dysfunction (male
impotence).
If you are hospitalised due to severe dehydration or loss of blood
tell the doctor you are using a Transiderm-Nitro patch.

Are you taking other medicines?
Transiderm-Nitro interacts with a large number of other medicines.
Tell your doctor or pharmacist if you are taking any of the
following:
• Medicines for depression
• Ergotamine products which are usually given for migraine
• Medicines for erectile dysfunction (male impotence)
• Medicines for high blood pressure or heart problems
• Aspirin or other painkillers called NSAIDs (non-steroidal antiinflammatory drugs)
• Diuretics ("water tablets")
• Tranquillisers (e.g. chlorpromazine, flupenthixol, haloperidol,
clozapine).
Always tell the doctor or pharmacist about all of the
medicines you are taking. This means medicines you have
bought yourself, as well as medicines on prescription from
the doctor.
Will there be any problems with driving or using machinery?
Some people have reported feeling faint or dizzy when they have
started to use the patches. You should not drive or operate
machinery if you are affected.
Other special warnings
Be careful when drinking alcohol as the patch may affect you
more than usual and you might feel faint or dizzy.
You might find that your GTN (glyceryl trinitrate) tablets or spray
aren’t working as well as they used to. Discuss this with your
doctor.
You must tell the doctor or nurse if you are wearing a patch before
an MRI scan (Magnetic Resonance Imaging scan to visualise
internal organs and tissues of the body) or diathermy treatment
(treatment using hot wires) and before electrical treatment on the
heart.

3.

How to use Transiderm-Nitro patches

It is important to follow what your doctor says about how and
when to use your patches. The dose will be on the pharmacist’s
label. Check the label carefully. If you are not sure, ask your
doctor or pharmacist.
The doctor will tell you how often to change the patch. Discard the
old patch carefully because it will still contain a little of the active
ingredient.

The side of the chest is a suitable place to apply the patch.
Choose a different area of skin each time you apply a new patch.
Leave several days before you use the same patch of skin again.
1. Decide where you
will put the patch.
It is important that
you put it on a
hairless area to
ensure that it
sticks well. The
side of the chest
is recommended.
2. Wash the skin
and dry it
thoroughly to
make sure the
patch sticks well.
Wait a minute
until the skin feels
quite dry.
Do not use
powder.
3. Remove one
sachet from the
box and tear open
the sachet at the
notch. Use your
fingers as cutting
with scissors
might damage the
patch inside.
Remove the
patch from the
sachet.
4. Peel off the white
plastic backing
and discard it. Do
not touch the
sticky surface of
the patch
5. Place the sticky
side of the patch
on the clean skin,
press firmly while
you count slowly
up to five.

4. Possible side effects

6. Further information

Transiderm‑Nitro patches are suitable for most people. However,
like all medicines they can sometimes cause side effects.

The patches come in two sizes. Each Transiderm‑Nitro 5 patch
contains 25 mg glyceryl trinitrate; your body will absorb
approximately 5 mg over 24 hours. Each Transiderm‑Nitro
10 patch contains 50 mg glyceryl trinitrate; your body will absorb
approximately 10 mg over 24 hours. The patches also contain the
inactive ingredients lactose monohydrate, dimeticone, colloidal
anhydrous silica, ethylene-vinyl acetate copolymer, medical
adhesive CH15, polyethylene terephthalate and aluminium and
printing ink SICURA Typo UV.

The side effects listed below have been reported:
More than 10% of people have experienced
• Nausea (feeling sick) or vomiting (being sick).
Up to 1 in 10 people have experienced:
• Headaches. These will probably wear off after a few days.
If necessary you can take mild painkillers e.g. paracetamol.
6/7 Run your finger around the edge of the patch to make sure no
air or water can get in. If you have applied the patch correctly
you can bathe, shower or swim with little risk of the patch
coming off.

Up to 1 in 100 people have experienced:
• Reddening, itching or burning of the skin at the site of the
patch. Be sure to put your patch in a different place each day.
• Allergic skin reactions such as reddening or itching anywhere
on the body.

To prevent angina
Up to 1 in 1,000 people have experienced:
The usual dosage for adults and the elderly is one or two patches
applied daily. The doctor will have decided which strength of patch • Increased heart rate or palpitations.
• Feeling faint or light-headed on standing, or feeling dizzy.
you need.
• Flushing of the face.
You may be told to wear a patch all of the time or for only part of
Reporting of side effects
the day.
If you get any side effects, talk to your doctor, pharmacist or
Don’t forget to follow the doctor’s instructions exactly.
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Do not stop using the patches suddenly without consulting your
Card Scheme at www.mhra.gov.uk/yellowcard.
doctor first.
By reporting side effects, you can help provide more information
Sometimes patches are not enough to prevent all of your angina
on the safety of this medicine.
attacks and you may be given tablets as well. Make sure you
know when you need to take the tablets.
5. How to store Transiderm-Nitro patches
To prevent skin irritation when you are receiving drugs
intravenously (into a vein)
One Transiderm-Nitro 5 patch will be applied when the treatment
is started and the patch changed every 3-4 days until the
treatment is stopped.
Transiderm-Nitro is not suitable for children.
What if you forget to change your patch?
If you forget to change your patch, do not worry. Put on a new one
as soon as you remember. Then go on as before.
What if you accidentally use too many patches?
If you accidentally apply too many Transiderm‑Nitro patches, tell
your doctor or nearest hospital casualty department immediately.
Take your medicine pack with you.

Keep your patches below 25°C. Do not open the sealed satchet
until you are going to use the patch.
Keep all medicines out of the reach and sight of children.
Do not use the patches after the expiry date which is printed on
the outside of the pack.
If your doctor tells you to stop using Transiderm-Nitro patches,
please take any which are left back to your pharmacist to be
destroyed.
Only keep them if the doctor tells you to. Do not throw them away
with your normal household water or waste. This will help to
protect the environment.

Transiderm‑Nitro 5 and 10 come in packs containing 28 patches.
What Transiderm-Nitro patches look like:
Transiderm-Nitro 5 patch is flat, foil like patch sealed at the edges
with white paste like filling, one side with a greyish orange backing
film with the imprint 'CG DOD', the other side with an off-white
protective liner
Transiderm-Nitro 10 patch is flat, foil like patch sealed at the
edges with white paste like filling, one side with a greyish orange
backing film with the imprint 'CG DPD', the other side with an offwhite protective liner
Manufacturer:
Novartis Pharmaceuticals UK Limited, Frimley Business Park,
Frimley, Camberley, Surrey, GU16 7SR, UK
Procured from within the EU by PilsCo Ltd, 10-16 Colvilles Place,
East Kilbride, G75 0SN.
PL 39467/0101 Transiderm-Nitro 5 milligrams/24 hours
Transdermal Patch
PL 39467/0102 Transiderm-Nitro 10 milligrams/24 hours
Transdermal Patch
This leaflet was revised in 18/02/2016
Transiderm-Nitro® is a registered trade mark
Copyright Novartis Pharmaceuticals UK Limited

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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