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TETRACYCLINE 250MG TABLETS

Active substance(s): TETRACYCLINE HYDROCHLORIDE

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Sigma / SCD
Tetracycline Leaflet
156 x 315mm
Double Sided
8pt
24-02-16 (30-06-16)

Package leaflet: Information for the patient

Tetracycline 250 mg Tablets
Tetracycline Hydrochloride

Read all of this leaflet carefully before you start
taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor
or pharmacist
• This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them,
even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4
What is in this leaflet
1. What Tetracycline Tablet is and what it is used for
2. What you need to know before you take Tetracycline
Tablet
3. How to take Tetracycline Tablet
4. Possible side effects
5. How to store Tetracycline Tablet
6. Contents of the pack and other information
1. What Tetracycline Tablet is and what it
is used for
These tablets contain the active ingredient,
tetracycline hydrochloride. Tetracycline is a broad
spectrum antibiotic which means it is effective against
a variety of infections and organisms caused by
bacteria. Tetracycline Tablets are used to treat a wide
range of infections susceptible to tetracycline. These
include chronic bronchitis; pneumonia or whooping
cough, urinary tract infections (e.g cystitis) and
urethritis (inflammation of the tube which passes
urine from the body) both which result in pain and
difficulty urinating; severe acne; and venereal
diseases such as syphilis, chlamydia and gonorrhea;
infections of the eye such as conjunctivitis; rickettsial
infections such as Q fever or tick fever; other
infections including brucellosis, psittacosis, plague,
cholera; tetracycline may also be used to treat
leptospirosis, gasgangrene and tetanus.
2. What you need to know before you take
Tetracycline Tablet
Do not take Tetracycline Tablet:
• If you are allergic to Tetracycline Hydrochloride,
other similar antibiotics (e.g. minocycline or
doxycycline), or any of the other ingredients of this
medicine (Listed in Section 6)
• If you have had liver or kidney problems for a long
time or have severe kidney disease
• If you are pregnant or breastfeeding
• If you suffer from the condition systemic lupus
erythematosus (SLE). This is an allergic condition
which causes joint pain, rash (especially on the
face), hair loss, malaise and fever.
Tetracycline should not be taken by children under the
age of 12 years as it can cause permanent
discolouration of growing teeth or poor growth of tooth
enamel.
Warnings and precautions
Talk to your doctor or pharmacist before taking
Tetracycline Tablets.
• If you suffer from myasthenia gravis. This is a
condition which causes muscle weakness, difficulty
chewing and swallowing and slurred speech
• If you suffer from porphyria
• If you have kidney or liver disease
• If you are sensitive to sunlight
Other medicines and Tetracycline Tablet
Tell your doctor or pharmacist if you are taking , have
recently taken or might take any other medicines.
• Anti-coagulants to stop the blood clotting (e.g.
warfarin or phenindione)
• The contraceptive pill. If you vomit or get diarrhoea,
or if you lose blood when you are not expecting a
period, your pill may not work properly and you will
need to use other means of contraception e.g. a
condom
• Ulcer healing drugs (e.g. sucralfate and tripotassium
dicitratcbismuthate)
• Ergotamine or methysergide (to treat or prevent
migraine)
• Atovaquone (to treat pneumocystis pneumonia)
• Vitamin A
• Retinoids to treat acne and psoriasis (e.g. tretinoin,
isotretinoin and acitretin)

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• Antacids (indigestion remedies), any other
medicines containing iron, calcium, bismuth,
magnesium, aluminium or zinc salts (which may be
included in vitamin and mineral supplements). Do
not take at the same time as Tetracycline Tablet, as
absorption of tetracycline may be reduced and
tetracycline may reduce the absorption of zinc and
oral iron
• Medicines to treat diabetes e.g. insulin,
glibenclamide or gliclalide
• Diuretics (water tablets) e.g. furosemide
• Lithium to treat mental illness, bipolar disorder and
depression
• Digoxin to treat heart problems, an uneven
heartbeat (arrhythmia)
• Kaolin-pectin and bismuth subsalicylate (to treat
diarrhoea)
• Strontium ranelate (to treat postmenopausal
osteoporosis)
• Quinapril tablets which contain magnesium
carbonate (to treat high blood pressure and
congestive heart failure)
• Methotrexate (a cancer drug which can also be
used to treat psoriasis and rheumatoid arthritis)
• Penicillin antibiotics e.g. amoxicillin,
phenoxymethylpenicillin (to treat infections)
• Colestipol or colestyramine (taken to lower the
amount of fats in your blood)
• Oral typhoid vaccine as the vaccine may be
inactivated by tetracycline hydrochloride. The
vaccine and Tetracycline Tablet should not be taken
within 3 days of each other
• Methoxyflurane (an anaesthetic). If you need an
operation tell your doctor or dentist you are taking
Tetracycline Tablet
• You are taking drugs which you have been told can
cause liver or kidney problems.
Other special warnings
Avoid exposure to strong sunlight or UV light
(sunbeds), as you may experience photosensitivity
reactions (e.g. skin rash, skin discomfort or easier
burning). Consult your doctor if you notice any of
these reactions.
If you are taking this medicine for a long time your
doctor may want to carry out blood tests. This is
quite usual and nothing to worry about.
Tetracycline Tablet with food and drink
Do not take the tablets at the same time as milk or
food, as they can make the medicine less effective.
Pregnancy and breast feeding
If you are pregnant or breast-feeding, think you may
be pregnant or are planning to have a baby, ask your
doctor or pharmacist for advice before taking this
medicine as tetracycline hydrochloride could harm the
baby
Driving and using machines
Tetracycline Tablets should not affect your ability to
drive or operate machinery.
Tetracycline Tablet contains:
The tablet colouring contains Sunset Yellow (E110)
which may cause allergic reactions.
If you have been told by your doctor that you have
an intolerance to some sugars. contact your
doctor before taking the tablets as they contain
lactose and sucrose.
3. How to take Tetracycline Tablet
Always take this medicine exactly as your doctor or
pharmacist has told you. Check with your doctor or
pharmacist if you are not sure.
The tablets should be swallowed with a good drink
of water. Some foods, milk and other dairy products
can affect the absorption of this medicine. The tablets
should be taken preferably 1 hour before or 2 hours
after food. Swallow the tablets when standing or
sitting down, do not take them immediately before
going to bed.
The recommended dose is
For at least 10 days unless otherwise directed by your
doctor:
Adults, Elderly and Children 12 years or over:
General infections: 1 tablet (250mg) every 6 hours,
you may be given 2 tablets (500mg) initially. For
severe infections your doctor may increase your
dosage to 500mg (2 tablets) every 6 hours.
Specific infections:
Skin infections: 1-2 tablets (250-500mg) daily either
as a single dose or in divided doses for three months.

Brucellosis: 2 tablets (500mg) four times a day with
streptomycin.
Sexually transmitted diseases: 2 tablets (500mg) four
times a day for between 7 and 30 days depending on
your condition.
Children under 12 years old:
Tetracycline Tablets are not recommended for use in
children under 12 years of age as it can cause
permanent discolouration of tooth enamel and affect
bone development.
If you take more Tetracycline Tablet than you should
You should contact your doctor or pharmacist
straight away. Take your tablets or the pack with
you so that the doctor knows what you have taken.
If you forget to take Tetracycline Tablet
If you have missed a dose you should take it within
2 hours of your usual time. If it is more than 2
hours since your dose was due, skip the missed
dose and take your next one when it is due. Do not
take a double dose to make up for a forgotten dose.
If you stop taking Tetracycline Tablet
Do not stop treatment early as your infection may
return if you do not finish the course of tablets.
If you have any further questions on the use of this
medicine, ask your doctor or pharmacist.
4. Possible Side effects
Like all medicines, this medicine can cause side
effects, although not everybody gets them.

Not Know (frequency cannot be estimated from
the available data):
• Inflamation of the tongue or mouth, intestines or
pancreas (causing discomfort or pain in the
abdomen)
• Colitis (inflammation which causes abdominal pain,
fever or diarrhoea)
• Kidney problems, or worsening of symptoms in
patients who already have kidney problems
(symptoms may be an increase or decrease in the
amount of urine you produce or a change in
frequency of passing urine, swelling in the legs or
ankles), increased levels of urea in the blood
• Vaginal discharge, irritation or discomfort, thrush or
irritation around your bottom and genital area
• Increased muscle weakness if you suffer from
Myasthenia Gravis
• Feeling or being sick, diarrhoea, loss of appetite,
stomach discomfort, discolouration of tooth enamel
• Headache, dizziness
• Fatty liver (causes tiredness, discomfort in your
upper abdomen)
• Swollen tongue, sore or swollen mouth, sore throat
• Discoloured thyroid tissue (no changes in thyroid
function are known to occur)
• If you suffer from SLE (Systemic lupus
erythematosus) Tetracycline Tablets may make your
symptoms worse
• Redness or colour change of the skin, raised, itchy,
blistered or flaky skin, sensitivity to sunlight

Stop taking Tetracycline Tablet and tell your doctor
straightaway if you notice the following effects:
• Symptoms of an allergic reaction: skin rash which
may be itchy, swelling of your face, eyelids, lips or
tongue, sudden wheezing, chest pain or tightness,
breathing difficulties, collapse.
• Chest pain, breathing difficulties, collapse or a dry
cough since these may be symptoms of pericarditis
(inflammation of the sac surrounding the heart)
• Symptoms of raised pressure in the skull: severe or
persistent headaches, dizziness, ringing in the ears,
visual problems including blind spots, double vision
and blurred vision or in infants a bulging fontanelle
(soft spot on the head), because these may indicate
raised pressure inside the skull
• Worsening of the condition SLE (Systemic Lupus
Erythematosus)
• A skin reaction like sunburn caused by
photosensitivity (increased sensitivity to sunlight and
UV light)
• Symptoms of a severe skin rash: this may include
blisters or ulcers, swelling of skin, peeling, redness
or discolouration, or Stevens-Johnson syndrome
(symptoms are fever, blisters on the skin, eyes,
mouth and genitals)
• Severe or prolonged diarrhoea which may have
blood or mucus in it during or after treatment with
Tetracycline Tablet, as this may be a sign of serious
bowel inflammation
• A decrease in or loss of vision/eyesight.

Reporting of side effects:
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects not
listed in this leaflet. You can also report side effects
directly via www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more
information on the safety of this medicine.

Tell your doctor if any of the following side effects
occur:
Rare (affects fewer than 1 in 1,000 people)
• Inflammation of the liver (hepatitis) or liver failure or
jaundice (symptoms may include yellowing of the
skin or whites of the eyes, nausea, loss of appetite,
stomach discomfort, confusion, reduced
conciousness, pale stools or dark urine), transient
increases in liver function test values (detected in
blood tests)
• Swollen ankles or high blood pressure (caused by
inflammation of the kidney (nephritis), sudden
kidney failure (symptoms may include decrease or
total loss in the amount of urine you produce)
• Increased levels of urea, phosphates or acid in the
blood or changes in the numbers and types of your
blood cells. If you notice increased bruising,
nosebleeds, sore throats, infections, excessive
tiredness, breathlessness on exertion or abnormal
paleness of the skin, you should tell your doctor who
may want you to have a blood test
• Blood disorders including increased number of
eosinophils (detected in blood tests), and severe
reduction in the number of white or red blood cells
which may cause fever or chills, severe fatigue,
weakness, painful ulceration in the mouth, vagina or
rectum, stomach ache, pale skin
• Swelling or ulceration of the oesophagus (gullet),
particularly if the tablets are taken with insufficient
water or at bedtime, difficulty swallowing
• Hearing disturbances.

What Tetracycline Tablet contains:
Each coated tablet contains 250 mg of tetracycline
hydrochloride as the active ingredient.
The tablets also contain lactose, alginic acid,
pregelatinised maize starch, sodium laurilsulfate, talc,
magnesium stearate, sodium starch glycollate,
sucrose, titanium dioxide (E171) and dispersed yellow
Containing sunset yellow (E110).

5. How to store Tetracycline Tablet
Keep this medicine out of the sight and reach of
children.
Do not store above 25°C. Store in the original package
or container and keep tightly closed to protect the
tablets from moisture.
Do not use this medicine after the expiry date which is
stated on the carton or label. The expiry date refers to
the last day of that month.
Do not use this medicine if you notice any visible signs
of deterioration.
If your doctor tells you to stop taking the tablets,
please take any unused medicine back to your
pharmacist to be destroyed.
Do not throw away any medicines via wastewater or
household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures
will help protect the environment.
6. Contents of the pack and other
information

What Tetracycline Tablet looks like and contents of
the pack
The tablets are round and have an orange sugar coat.
They are supplied to your pharmacist in packs
containing 28, 100 or 1000 tablets. Not all pack sizes
may be available.
Marketing Authorisation Holder
The product licence holder is Special Concept
Development (UK) Limited, Units 1-7 Colonial Way,
Watford, Hertfordshire, WD24 AYR.
Manufacturer: Surepharm Services Ltd.
Bretby, Burton upon Trent, Staffs, DE15 OYZ. UK.
Product licence number
PL 36722/0018
This leaflet was last revised in June 2016
If you would like this leaflet in a different format,
please contact the licence holder at the above
address.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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