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TENORETIC 100MG/25MG FILM-COATED TABLETS

Active substance(s): ATENOLOL / CHLORTHALIDONE

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P040995

Package leaflet: Information for the patient

Tenoretic 100 mg/25 mg film coated tablets
atenolol 100 mg, chlortalidone 25 mg

Read all of this leaflet carefully
before you start taking this
medicine because it contains
important information for you.
• Keep this leaflet. You may need to
read it again.
• If you have any further questions,
ask your doctor or pharmacist.
• This medicine has been prescribed
for you only. Do not pass it on to
others. It may harm them, even if
their signs of illness are the same
as yours.
• If you get any side effects, talk
to your doctor or pharmacist.
This includes any possible side
effects not listed in this leaflet.
See section 4.
What is in this leaflet:
1. What Tenoretic is and what it is
used for
2. What you need to know before
you take Tenoretic
3. How to take Tenoretic
4. Possible side effects
5. How to store Tenoretic
6. Contents of pack and other
information
1. What Tenoretic is and what it is
used for
Tenoretic is used to treat high blood
pressure (hypertension). It contains
two different medicines: atenolol and
chlortalidone. These medicines work
together to lower your blood pressure.
• Atenolol belongs to a group of
medicines called beta‑blockers. It
works by making your heart beat
more slowly and with less force.
• Chlortalidone belongs to a group of
medicines called diuretics. It works
by increasing the amount of urine
produced by your kidneys.
2. What you need to know before
you take Tenoretic
Do not take Tenoretic:
• If you are allergic to Tenoretic,
Tenoret, Tenormin, atenolol,
chlortalidone or any of the other
ingredients of this medicine (listed
in section 6).
• If you have ever had any of the
following heart problems:
- heart failure which is not under
control (this usually makes you
breathless and causes your
ankles to swell)
- second- or third-degree heart
block (a condition which may be
treated by a pacemaker)
- very slow or very uneven heart
beats, very low blood pressure
or very poor circulation.
• If you have problems with your
kidneys.
• If you have a tumour called
phaeochromocytoma that is not
being treated. This is usually near
your kidney and can cause high
blood pressure.
• If you have been told that you have
higher than normal levels of acid in
your blood (metabolic acidosis).
• If you are pregnant, are trying
to become pregnant or are
breast-feeding.
Do not take Tenoretic if any of the
above apply to you. If you are not
sure, talk to your doctor or pharmacist
before taking Tenoretic.
Warning and precautions
Talk to your doctor or pharmacist
before taking Tenoretic:
• If you have asthma, wheezing
or any other similar breathing
problems, or you get allergic
reactions, for example to insect
stings. If you have ever had
asthma or wheezing, do not
take this medicine without first
checking with your doctor.
• If you have a type of chest pain
(angina) called Prinzmetal's angina.
• If you have poor blood circulation or
controlled heart failure.
• If you have first-degree heart block.

• If you have diabetes. Your medicine
may change how you respond to
having low blood sugar. You may
feel your heart beating faster.
• If you have thyrotoxicosis
(a condition caused by an
overactive thyroid gland). Your
medicine may hide the symptoms
of thyrotoxicosis.
• If you have problems with your
adrenal glands.
• If you have liver problems.
If you are not sure if any of the above
apply to you, talk to your doctor or
pharmacist before taking Tenoretic.
Children
This medicine is not for use in children.
Other medicines and Tenoretic
Tell your doctor or pharmacist if you
are taking, have recently taken or
might take any other medicines. This
includes medicines that you buy
without a prescription and herbal
medicines. This is because Tenoretic
can affect the way some other
medicines work and some medicines
can have an effect on Tenoretic.
In particular, tell your doctor if you are
taking any of the following medicines:
• Clonidine (for high blood pressure
or migraine). If you are taking
clonidine and Tenoretic together,
do not stop taking clonidine unless
your doctor tells you to do so. If
you have to stop taking clonidine,
your doctor will give you careful
instructions about how to do it.
• Verapamil, diltiazem and nifedipine
(for high blood pressure or chest
pain).
• Disopyramide or amiodarone
(for an uneven heart beat).
• Digoxin (for heart problems).
• Adrenaline, also known as
epinephrine (a medicine that
stimulates the heart).
• Baclofen (a medicine used for
muscle relaxation).
• Ibuprofen or indometacin (for pain
and inflammation).
• Insulin or medicines that you take
by mouth for diabetes.
• Lithium (for certain mental
illnesses).
• Medicines to treat nose or sinus
congestion or other cold remedies
(including those you can buy in the
pharmacy).
• Betaxolol, carteolol, levobunolol and
timolol (eye drops for glaucoma).
Operations
If you go into hospital to have an
operation, tell the anaesthetist or
medical staff that you are taking
Tenoretic. This is because you can
get low blood pressure (hypotension)
if you are given certain anaesthetics
while you are taking Tenoretic.
Pregnancy and breast-feeding
• Do not take Tenoretic if you are
pregnant or trying to get pregnant,
ask your doctor for advice before
using this medicine.
• Do not take Tenoretic if you are
breast-feeding, ask your doctor for
advice before using this medicine.
Driving and using machines
• Your medicine is not likely to affect
you being able to drive or use
any tools or machines. However,
it is best to wait to see how your
medicine affects you before trying
these activities.
• If you feel dizzy or tired when
taking this medicine, ask your
doctor for advice.
3. How to take Tenoretic
Always take this medicine exactly
as your doctor or pharmacist has
told you. Check with your doctor or
pharmacist if you are not sure.
• Your doctor will tell you how many
tablets to take each day and when
to take them. Read the label on
the carton to remind you what the
doctor said.
• Swallow your Tenoretic tablet with
a drink of water.

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P040995
630170L4
Pack Line Code Data:

1317
Tenoretic Leaflet

Technical
Info

Adults
The recommended dose for an adult
is one tablet each day.
Children
Your medicine must not be given to
children.
If you take more Tenoretic than
you should
If you take more Tenoretic than
prescribed by your doctor, talk to
a doctor or go to a hospital straight
away. Take the medicine pack with you
so that the tablets can be identified.
If you forget to take Tenoretic
If you forget to take a dose, take it as
soon as you remember. However, if it
is almost time for the next dose, skip
the missed dose. Do not take a double
dose to make up for a forgotten dose.
If you stop taking Tenoretic
Do not stop taking Tenoretic without
talking to your doctor. In some cases,
you may need to stop taking it gradually.
If you have any further questions on
the use of this medicine, ask your
doctor or pharmacist.
4. Possible side effects
Like all medicines, Tenoretic can
cause side effects, although not
everybody gets them.
Allergic reactions:
If you have an allergic reaction, see
a doctor straight away. The signs may
include raised lumps on your skin
(weals) or swelling of your face, lips,
mouth, tongue or throat.
Other possible side effects:
Common (may affect up to 1 in
10 people)
• Cold hands and feet.
• You may notice that your pulse
rate becomes slower while you
are taking the tablets. This
is normal, but if you are concerned
please tell your doctor about it.
• Diarrhoea.
• Feeling sick (nausea).
• Feeling tired.
• Changes in the amount of certain
substances in your blood.
It can cause:
- higher levels of sugar (glucose)
than normal,
- low levels of sodium, which may
cause weakness, being sick
(vomiting) and cramps,
- low levels of potassium,
- an increase in the amount of
uric acid.
Your doctor may take blood
samples every so often to check
on these levels.
Uncommon (may affect up to 1 in
100 people)
• Disturbed sleep.
Rare (may affect up to 1 in
1,000 people)
• Heart block (which can cause an
abnormal heart beat, dizziness,
tiredness or fainting).
• Numbness and spasm in your
fingers which is followed by
warmth and pain (Raynaud’s
 disease).
• Dizziness (particularly when
standing up).
• Headache.
• Feeling confused.
• Changes in personality (psychoses)
or hallucinations.
• Mood changes.
• Nightmares.
• Dry mouth.
• Thinning of your hair.
• Dry  eyes.
• Skin  rash.
• Tingling of your hands.
• Disturbances of vision.
• Bruising more easily or purplish
marks on your skin.
• Being unable to get an erection
(impotence).
• Jaundice (causing yellowing of your
skin or the whites of your eyes).
• Pancreatitis (inflammation of a large
gland behind the stomach).
• A reduced number of white
blood cells.
Very rare (may affect up to 1 in
10,000 people)
• Changes to some of the cells or
other parts of your blood. Your doctor
may take blood samples every so
often to check whether Tenoretic has
had any effect on your blood.

Not known (frequency cannot be
estimated from the available data)
• Constipation.
• Lupus-like syndrome (a disease
where the immune system
produces antibodies that attacks
mainly skin and joints).
Conditions that may get worse
If you have any of the following
conditions, they may get worse when
you start to take your medicine.
This happens rarely affecting less
than 1 in 1,000 people:
• Psoriasis (a skin condition).
• Being short of breath or having
swollen ankles (if you have heart
failure).
• Asthma or breathing problems.
• Poor circulation.
Reporting of side effects
If you get any side effects, talk to
your doctor or pharmacist. This
includes any possible side effects
not listed in this leaflet. You can
also report side effects directly via
the Yellow Card Scheme Website:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can
help provide more information on
the safety of this medicine.
5. How to store Tenoretic
• Keep this medicine out of the
sight and reach of children. Your
medicine could harm them.
Do not use your tablets after the expiry
• 
date which is stated on the blister strip
and carton. The expiry date refers to
the last day of that month.
• Do not store above 25°C.
Store your tablets in the original
package. Keep the blister strip in
the carton. This will protect your
medicine from light and moisture.
Do not throw any medicine via
wastewater or household waste.
Ask your pharmacist how to throw
away medicines you no longer use.
These measures will help protect the
environment.
6. Contents of the pack and other
information
What Tenoretic contains
The active substances are atenolol
and chlortalidone. Each tablet
contains 100 mg (milligrams) of
atenolol and 25 mg of chlortalidone.
The other ingredients are gelatin,
iron oxide, macrogol, magnesium
carbonate, magnesium stearate,
methylhydroxypropylcellulose, sodium
laurilsulfate and maize starch.
What Tenoretic looks like and
contents of the pack
Tenoretic tablets are brown.
They come in a pack (blister strip)
containing 28 tablets.
Marketing Authorisation Holder
and Manufacturer
The Marketing Authorisation
for Tenoretic tablets is held
by AstraZeneca UK Limited,
600 Capability Green, Luton,
LU1 3LU, UK.
Tenoretic tablets are manufactured
by AstraZeneca UK Limited, Silk
Road Business Park, Macclesfield,
Cheshire, SK10 2NA, UK.

To listen to or request a
copy of this leaflet in Braille,
large print or audio please
call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the
following information:
Product name
Tenoretic 100 mg/25 mg
film coated tablets
Reference number
17901/0049
This is a service provided by
the Royal National Institute
of Blind People.
This leaflet was last revised
in July 2015
© AstraZeneca 2015.
Tenoretic is a trade mark of the
AstraZeneca group of companies.
CV 15 0062

P040995

Font family: Nimbus Sans

12 pt
N
260205

ET

UK
01
06 August 2015

10:18

Black

Profile

P040995
630170L4
Pack Line Code Data:

1317
Tenoretic Leaflet

Technical
Info

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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