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SUXAMETHONIUM CHLORIDE INJECTION BP 100MG/2ML

Active substance(s): SUXAMETHONIUM CHLORIDE / SUXAMETHONIUM CHLORIDE / SUXAMETHONIUM CHLORIDE

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Package Leaflet: Information for the patient
Suxamethonium Chloride 100mg/2ml Solution for Injection
Suxamethonium Chloride
Read all of this leaflet carefully before you are given this medicine because it contains important
information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or nurse.
- If you get any side effects, talk to your doctor or nurse. This includes any possible side effects not listed
in this leaflet. See section 4.
The name of your medicine is Suxamethonium Chloride 100mg/2ml Solution for Injection. It will be
referred to as Suxamethonium Chloride for ease hereafter.
What is in this leaflet
1. What Suxamethonium Chloride is and what it is used for
2. What you need to know before you are given Suxamethonium Chloride
3. How Suxamethonium Chloride will be given to you
4. Possible side effects
5. How to store Suxamethonium Chloride
6. Contents of the pack and other information
1. What Suxamethonium Chloride is and what it is used for
Suxamethonium Chloride belongs to a group of medicines called muscle relaxants. Their effect is to block
the connection between the nerves and certain muscles, which relaxes these muscles by temporarily
paralysing them. This effect helps surgeons when performing operations.
This medicine can also be used when a patient is put on a ventilator to control breathing. During this
procedure, it is necessary for the muscles used for breathing to be paralysed. Suxamethonium Chloride
can also reduce the intensity of muscle contractions associated with drug-induced convulsions or with
electroconvulsive therapy (ECT).
2. What you need to know before you are given Suxamethonium Chloride
Do not use Suxamethonium Chloride
• if you are allergic to Suxamethonium Chloride, any other muscle relaxants or any of the other
ingredients of this medicine (listed in section 6)
• if you or your family have reacted badly to an anaesthetic before such as a very high body temperature
(malignant hyperthermia)
• if you have a deficiency of an enzyme, pseudocholinesterase which breaks down suxamethonium in the
body
• if you have had a major accident, operation or severe burns within the last three months
• if you have not been able to move for a long time such as to allow a broken bone to mend or a long
period of bed rest
• if you have high levels of potassium in your blood (hyperkalaemia)
• if you have recently had an eye injury
• if you suffer from a problem caused by too much pressure in your eye called ‘glaucoma’

• if you or any of your family have a disease of the muscles or nerves, such as a muscle wasting disease,
paralysis, motor neurone disease, muscular dystrophy or cerebral palsy.
If any of the above apply to you or if you are not sure, talk to your doctor, nurse or member of the
operating theatre staff before you are given Suxamethonium Chloride.
Warnings and precautions
Talk to your doctor, nurse or member of the operating theatre staff before you are given Suxamethonium
Chloride:
• if you are pregnant or have given birth in the last six weeks
• if you have tetanus, an infection which occurs through wound contamination
• if you have tuberculosis or other severe or long standing infection
• if you have had any long standing illness which has left you weak
• if you suffer from cancer
• if you have anaemia
• if you are undernourished
• if you have liver or kidney problems
• if you have auto-immune diseases, for example, multiple sclerosis
• if you have an underactive thyroid gland, a condition known as myxoedema
• if you have muscle disease, for example, myasthenia gravis
• if you have recently had a blood transfusion or a heart-lung by pass
• if you have been in contact with insecticides
• if you have ever had an allergic reaction to any muscle relaxant which was given as part of an operation.
Children
Care should be taken before administering Suxamethonium Chloride to children.
Other medicines and Suxamethonium Chloride
Tell your doctor, nurse or other relevant hospital staff member if you are taking, have recently taken or
might take any other medicines. This includes any herbal products or medicines bought without a
prescription. This is because these medicines can affect how well Suxamethonium Chloride works or can
cause side effects.
In particular tell your doctor, nurse or member of the operating theatre staff if you are taking any of the
following:
• anaesthetics such as propofol, ketamine, propanidid, lignocaine and procaine or other medicines used
during surgery such as pain killers (morphine, pethidine and pancuronium) or drugs to reverse their
effects (called morphine antagonists)
• medicines used to treat Alzheimer's disease, such as donepezil, galantamine and
tetrahydroaminoacridine (Tacrine hydrochloride)
• medicines for raised pressure in the eye (glaucoma) such as ecothiophate eye drops
• medicines for coughs, cold, sleeping or tablets for allergies
• medicines used to treat malaria, containing chloroquine or quinine. Quinine is sometimes used for night
cramps
• oral contraceptives
• medicines for treating asthma and other breathing conditions e.g. terbutaline, bambuterol
• medicines containing metoclopramide (used to treat and prevent feeling or being sick)
• medicines for treating cancer (cytotoxic drugs) such as cyclophosphamide, chlorethamine, tretamine
and thiotepa

• medicines for mental problems including phenelzine, lithium, chlorpromazine or promazine
• medicines containing magnesium (such as some laxatives or antacids)
• medicines containing oestrogens
• medicines containing steroids (used for inflammatory conditions e.g. rheumatism etc)
• oxytocin (to contract the womb)
• some non-penicillin antibiotics (for infection) e.g. clindamycin, polymyxins, and aminoglycosides,
vancomycin, piperacillin
• medicines used to treat disturbances in heartbeat rhythm (antiarrhythmic drugs), angina or high blood
pressure such as beta-blockers, verapamil, digoxin, procainamide or quinidine
• aprotinin (to reduce bleeding)
• medicines used to treat myasthenia gravis such as neostigmine, pyridostigmine, physostigmine and
edrophonium (known as acetylcholinesterase inhibitors)
• medicines used to control your blood pressure during surgery such as trimetaphan
• medicines that can affect the way your body fights disease (immunosuppressants) such as azathioprine.
These can be used to stop your body rejecting a transplanted organ or for ‘auto-immune’ diseases such as
rheumatoid arthritis
• medicines used to treat depression and/or anxiety SSRIs (selective serotonin reuptake inhibitors)
including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram.
Pregnancy and breast feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your
doctor for advice before you are given this medicine.
Suxamethonium Chloride should only be used during pregnancy when your doctor decides the benefits to
you are greater than any possible risk to the unborn baby.
There is insufficient information to say whether this medicine passes in to breast milk. It is
recommended not to breast feed for at least 24 hours following administration of Suxamethonium
Chloride.
Driving and using machines
It can be dangerous to drive or operate machinery too soon after having had an operation. Your
doctor will tell you how long to wait before you can drive or use machinery.
3
OW CHLORIDE GIVEN TO Y
3. How Suxamethonium Chloride will be given to you
You will never be expected to give yourself this medicine. It will always be given to you by a person who
is qualified to do so.
Suxamethonium Chloride can be given:
• as a single injection into your vein (intravenous bolus injection)
• as a continuous infusion into your vein. This is where the drug is slowly given to you over a long period
of time.
Your doctor will decide the way you are given the drug and the dose you will receive. It will depend on:
• your age
• your body weight
• the amount of muscle relaxation you require
• your expected response to the medicine.

It may be administered as an injection. The anaesthetist will make sure that you are asleep before this
muscle relaxant is administered.
If you receive more Suxamethonium Chloride than you should
Suxamethonium Chloride will always be given under carefully controlled conditions. However, if you
think that you have been given more than you should tell your doctor or nurse immediately.
If you have any further questions on the use of this medicine, ask your doctor or nurse.
POSSIBLE SIDE EFFECTS
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you get any side effects, talk to your doctor, nurse or other relevant hospital staff member.
This includes any possible side effects not listed in this leaflet.
All medicines can cause allergic reactions although serious allergic reactions are very rare. Any
sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching
(especially affecting your whole body) should be reported to a doctor immediately.
The following side effects have also been reported:
Very common (may affect more than 1 in 10 people)
• abdominal cramps or pain and a feeling of nausea or “fullness”
• visible twitching of muscle under the skin
• excessive production of saliva
• muscle pain after the operation - your doctor will monitor you for this.
Common (may affect up to 1 in 10 people)
• raised pressure of fluid in the eye which may cause headache or blurred vision
• speeding up or slowing down of your heart rate
• skin flushing
• skin rash
• laboratory tests revealing high level of potassium in your blood
• high/low blood pressure
• laboratory tests revealing protein in the blood or urine due to muscle damage
• muscle damage which may make your muscles ache or feel tender, stiff and weak.
Your urine may also look dark or be red or cola coloured.
Rare (may affect up to 1 in 1,000 people)
• abnormal heart rhythm
• heart problems including changes in the way in which your heart beats or your heart stops
beating
• difficulty in breathing or temporary loss of breath
• difficulty in opening your mouth.
Very rare (may affect up to 1 in 10,000 people)
• high body temperature.
5. HOW TO STORE
Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not
listed in this leaflet. You can also report side effects directly via www.mhra.gov.uk/yellowcard. By
reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Suxamethonium Chloride
• Keep this medicine out of the sight and reach of children.
• The expiry date (EXP) is printed on the label and the carton. The first 2 digits indicate the month and the
remaining digits indicate the year of expiry. Do not use this medicine after the expiry date which is stated
on the carton and label. The expiry date refers to the last day of that month.
• Your doctor or nurse will know how to store this medicine properly.
• Keep the ampoule in the outer carton in order to protect from light.
• The ampoules containing the injection solution are stored in refrigerator in their original packaging at a
temperature between 2° and 8°C. Do not freeze. Once opened, any unused liquid should be discarded.
Do not use if the ampoule is damaged or if the contents are discoloured or deteriorated.
The solution should not be mixed with any other drugs.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Suxamethonium Chloride contains
The active substance is Suxamethonium Chloride. There is 100mg of Suxamethonium Chloride in 2ml of
the injection.
The other ingredients of the solution are sodium acetate and water for injections.
What Suxamethonium Chloride looks like and contents of the pack
Suxamethonium Chloride is a clear, colourless sterile solution. The solution is supplied in glass ampoule
(small bottle). These ampoules are then packed into cardboard boxes. Each box contains 10 x 2ml
ampoules.
Marketing Authorisation Holder
MercuryPharm Ltd,
4045, Kingswood Road,
City West Business Park,
Co Dublin,
Ireland.
PL15372/0007.
Manufacturer
Antigen Pharmaceuticals Limited,
Roscrea,
Co. Tipperary,

Ireland.
For any information about this medicine, please contact the local representative of the Marketing
Authorisation Holder
MercuryPharm Ltd,
4045, Kingswood Road,
City West Business Park,
Co Dublin,
Ireland.
This leaflet was last revised in May 2017.

Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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