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Patient Information Leaflet
Suxamethonium Chloride Injection BP
100mg in 2mI
This leaflet will provide you with important information about your medicine. Please read it
carefully before your medicine is administered.
Each glass ampoule contains 2ml of clear, colourless, sterile solution and each 2ml of this solution
contains 100mg of Suxamethonium Chloride. There are 10x2ml ampoules in each carton.
Inactive ingredients: sodium acetate and water for injections
Holder of Product Licence:
MercuryPharm Ltd, 4045, Kingswood Road, City West Business Park, Co Dublin, Ireland.
Manufacturer: Antigen Pharmaceuticals Limited, Roscrea, Co. Tipperary, Ireland.
Suxamethonium Chloride Injection BP belongs to a group of medicines called depolarising
neuromuscular blocking agents. It produces relaxation of the body muscles that are under voluntary
control, i.e. skeletal muscles. Because neuromuscular blocking drugs affect muscles involved in
breathing as well as other skeletal muscles, your breathing will need to be controlled by the
anaesthetist until the effects of suxamethonium have worn off, fully.
Suxamethonium is used as an aid to general anaesthesia to facilitate the insertion of a tube
into the windpipe and to relax skeletal muscles during surgery. It is also used to reduce the intensity of
muscle contractions associated with drug-induced convulsions or with electroconvulsive therapy
Before receiving this injection, make sure to tell your doctor if
• you are allergic to any of the ingredients
• you ever had an allergic reaction to any muscle relaxing drug
• you are suffering from glaucoma, a detached retina or an eye injury
• you or a member of your family has a history of malignant hyperthermia
• you have a deficiency in pseudocholinesterase, the enzyme that breaks down suxamethonium in the
• you have too much potassium in your blood or you are suffering from kidney disease, a major
injury, severe burns, nerve or muscle damage such as injury to the spinal cord, a stroke, cerebral
palsy, myotonic dystrophy or Eaton-Lambert (myasthenic) syndrome
• you are suffering from myasthenia gravis
• you are suffering from a liver disease or from cancer
• you have been vomiting or had diarrhoea recently, or you have not been drinking normal
amounts of fluid
• you are pregnant or if you gave birth within the previous six weeks
• you are receiving any other medicines. These include medicines that may prolong the action
of suxamethonium, such as ecothiopate (eye drops for glaucoma), tetrahydroaminoacridine
(also called tacrine and used for Alzheimer's disease), hexaflurenium (sometimes used to

prolong the muscle relaxing effects of suxamethonium), acetylcholine inhibitors including
trimetaphan (to lower blood pressure) and some drugs used to relax muscles, propanidid
(an anaesthetic drug) digoxin, procaine, procainamide or quinidine (for an irregular heart
beat), lignocaine (a local anaesthetic drug), oxytocin (to contract the womb), some nonpenicillin
antibiotics (for infection), beta-blockers or verapamil (for example for angina, high blood pressure or
irregular heart beat), aprotinin (to reduce bleeding), magnesium salts (such as some laxatives or
antiacids), the anti-malarial drugs quinine (which is sometimes used for night cramps) or chloroquine,
morphine or pethidine (to relieve pain) or drugs to reverse their effects (called morphine antagonists),
the psychiatric drugs pheneIzine, lithium,chlorpromazine or promazine, anti-cancer drugs,
azathioprine (to suppress the immune response), oestrogens (e.g. for hormone replacement), oral
contraceptives, steroids, anticholinesterase drugs such as neostigmine, pyridostigmine, physostigmine
and edrophonium (e.g. for glaucoma or myasthenia gravis), or the antihistamine drugs
diphenhydramine or promethazine.

Suxamethonium Chloride Injection BP is usually given by injection into a vein.
It may also be administered into a vein through a drip. If necessary, it may be given by injection
into a muscle.
You must be fully asleep under a general anaesthetic before the injection may be given
Dosage in adults:
The dosage may vary but the usual single dose for an adult is in the range of 20 to 100mg by injection
into a vein. For administration as a continuous drip into a vein, a 0.1 to 0.2% solution (containing 1mg
to 2mg per ml of suxamethonium chloride) may be used and the usual dosage range is 2 to 5mg per
minute. If necessary, a dose of up to 2.5mg per kilogram of body weight may be given by injection
into a muscle, to a maximum total of 150mg.
Dosage in children:
The dosage may vary but the usual single dose for a child is in the range of 1 to 2mg per
kilogram of body weight by injection into a vein. If necessary, a dose of up to 2.5mg per kilogram
of body weight may be given by injection into a muscle, to a maximum total of 150mg.
Suxamethonium may sometimes cause unwanted effects in some patients. These include:
• muscle pain or muscle twitching
• tummy cramps or discomfort
• loose or frequent bowel motions
• too much saliva or coughing up a lot of mucus
• a very slow or rapid heart beat or irregular heart beats
• high or low blood pressure
• heart attack
• headache, dizziness or faintness
• difficulty in breathing
• feeling too hot
• blurred vision or problems with your eyes
• presence in the blood of myoglobin (a protein normally found in muscle)
• any signs of an allergic reaction such as a skin rash or breathlessness
If you notice any unwanted effects including ones that are not mentioned here, tell your doctor
Do not use after the expiry date shown on the ampoule and carton.
Keep the container in the outer carton in order to protect from light.
Store at 2-8ºC. Do not freeze.

MercuryPharm Ltd
4045, Kingswood Road,
City West Business Park,
Co Dublin, Ireland.
Date of revision: March, 2012.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.