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Rare (affects less than 1 person in 1,000):

Package leaflet: Information for the user

Feeling dizzy
Being unable to sleep or finding sleep difficult
A reduction in the amount of potassium in your blood (you may get an
uneven heartbeat, muscle weakness, cramp).

Very rare (affects less than 1 person in 10,000):

Breathing difficulties or wheezing that gets worse straight after taking
Serevent Evohaler. If this happens stop using your Serevent Evohaler.
Use your fast-acting ‘reliever’ inhaler to help your breathing and tell your
doctor straight away.
Uneven heartbeat or your heart gives an extra beat (arrhythmias). If this
happens do not stop using Serevent Evohaler but tell your doctor.
Increases in the amount of sugar (glucose) in your blood (hyperglycaemia). If
you have diabetes, more frequent blood sugar monitoring and possibly
adjustment of your usual diabetic treatment may be required.
Sore mouth or throat
Feeling sick (nausea)
Aching, swollen joints or chest pain.

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes
any possible side effects not listed in this leaflet. You can also report side effects
directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the safety of
this medicine.

5 How to store Serevent Evohaler
• Keep out of the sight and reach of children.
• Straight after use, replace the mouthpiece cover firmly and click it into
position. Do not use excessive force.
• Do not store above 30°C. Protect from heat and direct sunlight. Do not
expose to temperatures higher than 50°C. Do not pierce the canister.
• The metal canister contains a pressurised liquid. Do not puncture, break or
burn it even if you think it is empty.
• Do not use Serevent Evohaler after the expiry date which is stated on the
label and carton. The expiry date refers to the last day of the month.
Medicines should not be disposed of via wastewater or household waste. Ask
your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

6 Contents of the pack and other information

(salmeterol xinafoate)
This medicine is known by the above names but will be referred to as Serevent
Evohaler throughout this leaflet.

Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.

Each puff provides 25 micrograms of the active ingredient salmeterol.
There are 120 puffs in each canister.
The other ingredient is norflurane (HFA 134a).

What Serevent Evohaler looks like and contents of the pack

Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others.
It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.

In this leaflet:


What Serevent Evohaler is and what it is used for
What you need to know before you use Serevent Evohaler
How to use Serevent Evohaler
Possible side effects
How to store Serevent Evohaler
Contents of the pack and other information

1 What Serevent Evohaler is and what it is used for

What Serevent Evohaler contains

Serevent™ 25 Evohaler™ /
Salmeterol 25 micrograms Evohaler™

Serevent Evohaler contains the medicine salmeterol. It is a ‘long-acting
bronchodilator’. It helps the airways in the lungs to stay open. This makes it
easier for air to get in and out. The effects are usually felt within 10 to 20
minutes and last for 12 hours or more.
The doctor has prescribed it to help prevent breathing problems. These could
be caused by asthma. Taking Serevent Evohaler regularly will help prevent
asthma attacks. This also includes asthma brought on by exercise or at night.
Taking Serevent Evohaler regularly will also help prevent breathing
problems caused by other chest illnesses such as Chronic Obstructive
Pulmonary Disease (COPD).
Serevent Evohaler helps to stop breathlessness and wheezing coming on. It
does not work once you are breathless or wheezy. If that happens, you need
to use a fast-acting ‘reliever’ medicine, such as salbutamol.
Serevent Evohaler is supplied to you in an inhaler. You breathe the medicine
directly into your lungs.
Serevent Evohaler contains norflurane. This is less harmful to the
environment than older inhalers. Older inhalers may taste differently to
Serevent Evohaler. This will make no difference to how your medicine works.

If you are being treated for asthma, you should always be given both a
Serevent Evohaler and a steroid inhaler to use together.

Pressurised metered dose inhaler comprising a green plastic body with a light
green removable cap and a metal canister. The canister provides 120 metered
actuations of a white to off-white suspension.

2 What you need to know before you use Serevent

Who makes Serevent Evohaler?

Do not take Serevent Evohaler if:

Serevent Evohaler is made by Glaxo Wellcome Production, Zone Industrielle 2,
23 Rue Lavoisier, 27000 Evreux, France and is procured from within the EU by
the Product Licence holder: Caseview (PL) Limited, 3rd Floor, Page House, 40
East Street, Epsom KT17 1BH and repackaged by OPD Laboratories Ltd, Unit 6
Colonial Way, Watford, Herts WD24 4PR.
PL 13826/1612

you are allergic (hypersensitive) to salmeterol or to the other ingredient
norflurane (HFA 134a).

Take special care with Serevent Evohaler


Serevent™ 25 Evohaler™ / Salmeterol 25 micrograms Evohaler™
Leaflet revision and issue date (ref) 13.03.14
Serevent and Evohaler are registered trademarks of the GlaxoSmithKline Group
of Companies.

To request a copy of this leaflet in Braille, large print or audio please call 01923
332 796.

If your asthma or breathing gets worse tell your doctor straight away.
You may find that you feel more wheezy, your chest feels tight more often or
you may need to use more of your fast-acting ‘reliever’ medicine. If any of
these happen, do not increase your number of puffs of Serevent Evohaler.
Your chest condition may be getting worse and you could become seriously
ill. See your doctor as you may need a change in asthma treatment.
Once your asthma is well controlled your doctor may consider it appropriate
to gradually reduce the dose of Serevent Evohaler.
If you have been prescribed Serevent Evohaler for your asthma, continue to
use any other asthma medication you are already taking. These could
include a steroid inhaler or steroid tablets.
Continue taking the same doses as before, unless your doctor tells you
otherwise. Do this even if you feel much better. Do not stop taking your steroid
inhaler (or any steroid tablets) when you start using Serevent Evohaler.
Your doctor may want to check your health regularly if you have an
overactive thyroid gland, diabetes mellitus (Serevent Evohaler may increase
your blood sugar) or heart disease, including an irregular or fast heartbeat.

Other medicines and Serevent Evohaler

Tell your doctor if you are taking or have recently taken any other medicines.
This includes those for asthma or any other medicines obtained without a
prescription. This is because Serevent Evohaler may not be suitable to be
taken with other medicines.
Inform your doctor before using Serevent Evohaler if you are currently being
treated for any fungal infections with medicines containing ketoconazole or
itraconazole, or if you are being treated for HIV with ritonavir. These medicines
may increase the risk of you experiencing side effects with Serevent Evohaler,
including irregular heartbeats, or may make side effects worse.
Beta-blockers should be avoided when taking Serevent Evohaler, unless
your doctor tells you to take them. Beta-blockers, including atenolol,
propranolol and sotalol, are mostly used for high blood pressure or other
heart conditions. Tell your doctor if you are taking beta-blockers or have
recently been prescribed beta-blockers as they may reduce or abolish the
effects of salmeterol.

Serevent Evohaler can reduce the amount of potassium in your blood. If this
happens you may notice an uneven heartbeat, muscle weakness or cramp.
This is more likely to happen if you take Serevent Evohaler with some
medicines used to treat high blood pressure (diuretics) and other medicines
used to treat breathing problems such as theophylline or steroids. Your doctor
may ask for you to have blood tests to check the amount of potassium in your
blood. If you have any concerns discuss them with your doctor.

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to
have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

The possible side effects associated with Serevent Evohaler are unlikely to
affect your ability to drive or use machines.

3 How to use Serevent Evohaler

Breathe in through your mouth. Just after
5 Place the mouthpiece in 6
starting to breathe in, press down on the top
your mouth between your
teeth. Close your lips
around it. Do not bite.

Always use this medicine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure.
• If you are being treated for asthma, you should always be given both a
Serevent Evohaler and a steroid inhaler to use together.
• Use Serevent Evohaler every day, until your doctor advises you to stop.
• You will start to feel your medicine working within the first day of use.


Wait about half a minute between taking
each puff of medicine and then repeat steps 3
to 7.

9 After use always replace the mouthpiece

Serevent Evohaler is for inhalation by mouth only.

Adults and adolescents aged 12 years and older with Asthma

The usual starting dose is 2 puffs twice a day.
For people with more severe asthma, your doctor may increase your dose to
4 puffs twice a day.

7 Hold your breath, take

Children with Asthma

the inhaler from your mouth
and your finger from the top
of the inhaler. Continue
holding your breath for a
few seconds, or as long as
is comfortable.

In children aged 4 to 12 the usual dose is 2 puffs twice a day.
Serevent Evohaler is not recommended for use in children below 4 years of age.

Adults with Chronic Obstructive Pulmonary Disease (COPD)
including bronchitis and emphysema

The usual starting dose is 2 puffs twice a day.
Not applicable for children and adolescents.

Instructions for use

Your doctor, nurse or pharmacist should show you how to use your inhaler. They should
check how you use it from time to time. Not using the inhaler properly or as prescribed,
may mean that the medicine will not help your asthma or COPD as it should.
The medicine is contained in a pressurised canister in a plastic casing with a

Testing your inhaler

1 When using your inhaler for the

first time, test that it is working.
Remove the mouthpiece cover by
gently squeezing the sides with your
thumb and forefinger and pull apart.

2 To make sure that it works, shake
it well, point the mouthpiece away from
you and press the canister to release a
puff into the air. If you have not used
the inhaler for a week or more, release
one puff of medicine into the air.

Using your inhaler

It is important to start to breathe in as slowly as possible just before using
your inhaler.

1 Stand or sit upright when using your inhaler.
2 Remove the mouthpiece cover (as shown in the first picture). Check
inside and outside to make sure that the mouthpiece is clean and free of

of the canister to release a puff of medicine.
Do this while still breathing in steadily and

cover immediately to keep out dust. Replace
the cover by firmly pushing and snapping the
cap into position.
Practice in front of a mirror for the first few
If you see a ‘mist’ coming from the top of your
inhaler or the sides of your mouth you should
start again
If you or your child find it difficult to use
Serevent Evohaler, it may be used with other
devices to make its use easier e.g. a
HaleraidTM or VolumaticTM spacer device.
Serevent Evohaler is also available in an
alternative device. Talk to your doctor, nurse
or pharmacist for further advice.

Cleaning your inhaler

To stop your inhaler blocking up, it is important to clean it at least once a week.
To clean your inhaler:
• Remove the mouthpiece cover.
• Do not remove the metal canister from the plastic casing at any time.
• Wipe the inside and outside of the mouthpiece and the plastic casing with a
dry cloth or tissue.
• Replace the mouthpiece cover.
Do not put the metal canister in water.

If you use more Serevent Evohaler than you should
It is important to use the inhaler as instructed. If you accidentally take a larger
dose than recommended, talk to your doctor or pharmacist. You may notice your
heart beating faster than usual and that you feel shaky and/or dizzy. You may
also have a headache, muscle weakness and aching joints.

If you forget to use Serevent Evohaler

Do not take a double dose to make up for a missed dose. Just take your next
dose at the usual time.
If you have any further questions on the use of this medicine, ask your doctor or

4 Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody
gets them. To reduce the chances of side effects, your doctor will prescribe the
lowest dose of Serevent Evohaler to control your asthma or COPD. These are
the side effects reported by people taking Serevent Evohaler.
Allergic reactions: you may notice your breathing suddenly gets worse
after using Serevent Evohaler. You may be very wheezy and cough. You may
also notice itching and swelling (usually of the face, lips, tongue or throat). If you
get these effects or they happen suddenly after using Serevent Evohaler, tell
your doctor straight away. Allergic reactions to Serevent Evohaler are very
rare (they affect less than 1 person in 10,000).
Other side effects are listed below:

Common (affects less than 1 person in 10):

3 Shake the inhaler 4 or 5 4 Hold the inhaler upright with your thumb
times to ensure that any
loose objects are removed
and that the contents of the
inhaler are evenly mixed.

on the base, below the mouthpiece. Breathe
out as far as is comfortable.

Muscle cramps
Feeling shaky; fast or uneven heartbeat (palpitations), headache, shaking
hands (tremor). Tremors are more likely if you are taking more than two puffs
twice daily. These side effects do not last long and happen less as treatment
with Serevent Evohaler continues.

Uncommon (affects less than 1 person in 100):

Very fast heart rate (tachycardia). This is more likely to happen if you are
taking more than two puffs twice daily.
Feeling nervous.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.