RANSOMS GLYCERIN LEMON HONEY & IPECACUANHA LINCTUS
Active substance(s): CITRIC ACID MONOHYDRATE / GLYCEROL / HONEY / IPECACUANHA LIQUID EXTRACT / LEMON OIL-TERPENELESS / SYRUP
NAME OF THE MEDICINAL PRODUCT
Ransom’s Glycerin, Lemon, Honey & Ipecacuanha Linctus
QUALITATIVE AND QUANTITATIVE COMPOSITION
Glycerol BP 0.25 ml/5 ml
Honey 0.5 g/5 ml
Citric Acid Monohydrate BP 25 mg/5 ml
Lemon Oil BP Terpeneless 0.0005 ml/5 ml
Syrup BP 3.75ml/5 ml
Ipecacuanha Liquid Extract 0.025 ml/5 ml
For the symptomatic relief of coughs and sore throats.
Posology and method of administration
Adults, the elderly and children over 12 years of age
Two 5 ml spoonfuls to be taken 3 or 4 times daily.
Children aged 3 to 12 years
One 5 ml spoonful to be taken 3 or 4 times daily.
Children under 3 years
This product is not recommended for use in diabetes mellitus because of the sugar
Special warnings and precautions for use
This product contains a small amount of ipecacuanha, which is potentially
cardiotoxic, and should not be used in patients on antiarrhythmic therapy.
Interaction with other medicinal products and other forms of interaction
Pregnancy and lactation
As with many other medicines, this product should be avoided in the first three
months of pregnancy and during lactation unless the benefits outweigh any risks. No
significant problems have been reported in breast-fed infants from mothers taking the
Effects on ability to drive and use machines
Occasionally gastric irritation, nausea and vomiting may occur.
Overdosage is unlikely (due to the ipecacuanha) as large doses are emetic but if it
does occur there have been cases of cardiotoxicity.
Other symptoms may include dryness of the mouth, thirst, nausea, headache and
If ingestion is recent then gastric lavage and the use of activated charcoal may be
employed. Treatment consists of correction of fluids and electrolytes, ECG
monitoring and general supportive therapy.
At the levels at which it is present in the product each dose of 2 x 5 ml is equivalent
to 0.950 - 1.050 mg of ipecacuanha alkaloids; At such a level these alkaloids offer an
expectorant action which is probably due to a reflex action from irritation of the nasal
The glycerol, honey and syrup act as demulcents and provide a soothing medium for
an irritated throat.
The citric acid Monohydrate and the lemon oil, Terpeneless both add to the sharpness
of the product and enhance the flavour.
It is readily absorbed from the intestine and metabolised to carbon
dioxide and glycogen.
Honey, Citric Acid Monohydrate BP and Lemon Oil, Terpeneless BP
Little is reported in the literature on the Pharmacokinetic of these
Syrup BP is a 66.7% w/v solution of sucrose in water; Sucrose is
hydrolysed by enzymes in the mouth and in the gastrointestinal tract to
glucose and fructose.
Ipecacuanha Liquid Extract BP
The principal alkaloids in Ipecacuanha Tincture BP are emetine and
cephaeline; little data are given in the literature about the
Pharmacokinetic of the expectorant action of ipecacuanha or its related
alkaloids but it is thought to cause a reflex action by irritation of the
nasal mucous membrane.
Preclinical safety data
No relevant data.
List of excipients
No major incompatibilities have been reported.
Special precautions for storage
The product should be protected from light; the product is supplied in amber glass
bottles. Store below 25oC.
Nature and contents of container
Amber glass bottle with a plastic “J” cap or
Amber glass bottle with a roll-on aluminium cap with an expanded polythene liner.
Pack size: 100 ml and 200 ml.
Special precautions for disposal
MARKETING AUTHORISATION HOLDER
Wise Pharmaceuticals Ltd
Hani Wells Business Park, Unit 7,
MARKETING AUTHORISATION NUMBER(S)
DATE OF FIRST AUTHORISATION/RENEWAL OF THE
22/01/2004 / 14/07/2006
DATE OF REVISION OF THE TEXT
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.