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QUININE SULFATE TABLETS BP 300MG

Active substance(s): QUININE SULFATE

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Quinine Sulfate 300mg tablets
Read all of this leaflet carefully before
you start taking this medicine.
•  Keep this leaflet. You may need to read it
again.
•  If you have any further questions, ask
your doctor or pharmacist.
•  This medicine has been prescribed for
you. Do not pass it on to others. It may
harm them, even if their symptoms are
the same as yours.

Index
Quinine sulfate tablets are
1 What

and what they are used for
2 Before you take
3 How to take
4 Possible side effects
5 How to store
6 Further information

1 What Quinine sulfate tablets are and
what they are used for

Quinine sulfate belongs to a group of medicines called
anti-protozoal agents and they are used to treat:
• malaria
• and prevent night cramps in adults and the elderly
when sleep is regularly disrupted

2 Before you take

Do not take Quinine sulfate tablets and tell your
doctor if you have:

• an allergy (hypersensitivity) to quinine (including that
in tonic waters or other beverages), quinoline or any of
the other ingredients (see section 6)
• blood in your urine
• ringing in your ears
• suffer from muscle weakness (myasthenia gravis)
• problems with your eyes or difficulty seeing

You should not take more than the prescribed dose as
a condition called ‘cinchonism’ may occur even with
normal doses. Please see section 4 ‘Possible side effects’
for symptoms of cinchonism and tell your doctor if you
experience any of them.

Taking other medicines

Please tell your doctor or pharmacist if you are taking
or have recently taken any other medicines, including
medicines obtained without a prescription. Especially:
• anticoagulants (to stop your blood from clotting)
• cardiac glycosides (for your heart such as digoxin)
• chloroquine, mefloquine, artemether with lumefantrine
or primaquine (also to treat malaria)
• cimetidine (to treat stomach ulcers or acid reflux and
indigestion)
• amantadine (to treat Parkinsons Disease or some viral
infections)
• ciclosporin (to prevent transplant rejection)
• flecainide, quinidine or amiodarone (to treat irregular
heart beats)
• terfenadine (for allergic reactions)
• pimozide or thioridazine (to treat some mental
disorders)
• moxifloxacin, rifampicin or antifungals (to treat
infections)
• medicines to treat diabetes
• suxamethonium (muscle relaxant)
• HIV medicines
• barbiturates, carbamazepine or phenytoin (used in
epilepsy)

Pregnancy and breast-feeding

You should not take Quinine sulfate tablets if you are
pregnant, planning to become pregnant or breastfeeding unless advised to by your doctor. Quinine
sulfate tablets should not be used for night cramps
during pregnancy.

Driving and using machines

Quinine sulfate tablets may affect your vision. Make
sure you are not affected before you drive or operate
machinery.

Check with your doctor or pharmacist before
taking Quinine sulfate tablets if you:

• have irregular heart beats or other heart disease
• have had malaria for a long time
• suffer from severe glucose-6-phosphate
dehydrogenase deficiency (G6PD), this can cause
episodes of anaemia after eating certain foods such as
fava beans (favism) or certain drugs including drugs to
prevent malaria and dapsone
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3 How to take

Always take Quinine sulfate tablets exactly as your doctor
has told you. If you are not sure, check with your doctor or
pharmacist.
Swallow the tablets with water.
Doses:
• Malaria (you may be given another medicine for malaria
with or after this course of quinine):
Adults (including elderly) and children over 12 years 600mg every eight hours for 5-7 days
Children under 12 years - 10mg per kg of body weight
every eight hours for 7 days
If you have kidney or liver disease you may be given a
different dose.
• Night cramps:
Adults (including elderly) - 300mg at bedtime. It may
take up to 4 weeks before you notice any reduction in the
frequency of leg cramps.

If you take more than you should

If you (or someone else) swallow a lot of tablets at the same
time, or you think a child may have swallowed any, contact
your nearest hospital casualty department or tell your doctor
immediately. Symptoms include loss of consciousness,
difficulty breathing, changes in heart beat, fits, ‘ringing’ in
the ears, loss of hearing, headache, feeling or being sick and
changes in vision.

If you forget to take the tablets

Do not take a double dose to make up for a forgotten dose. If
you forget to take a dose take it as soon as you remember it
and then take the next dose at the right time.

4 Possible side effects

Like all medicines, Quinine sulfate tablets can cause side
effects, although not everybody gets them.
Contact your doctor at once if the following effects occur:
• allergic reactions –itchy skin rash, swelling of the lips, face,
throat or tongue, flushing, fever, asthma or sensitivity to
light
• cinchonism –abdominal pain, diarrhoea, disturbed vision
(blurred vision, changes in colour perception or field of
vision, total blindness), headache, feeling or being sick,
ringing in the ears or impaired hearing, rashes, loss of
consciousness, fits, shock due to heart problems, irregular
heart beats, death. If these occur while taking Quinine
sulfate tablets for leg cramps, treatment should be stopped
and a doctor contacted straight away.
• changes to blood cells, if you notice that you are bruising
or bleeding easily, have frequent nose bleeds, or you have
more sore throats and infections than usual tell your doctor
who may want to give you a blood test.

Tell your doctor if you notice any of the following side
effects or notice any other effects not listed:
• diarrhoea, feeling or being sick, abdominal pain, low blood
sugar.
• muscle weakness, excitement, agitation, ‘spinning’
sensation’, confusion, loss of consciousness, coma, death.
• headache, changes in vision, ‘ringing’ in the ears, loss of
hearing.
• swollen, itchy, flaky, red or raised patches of skin, rashes,
sensitivity to light.
• aggrevation of Myasthenia gravis.
• kidney damage, water retention, slowed heart rate, changes
in heart rhythm and the way the heart beats, eczema,
miscarriages (at very high concentrations), difficulty
breathing.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more
information on the safety of this medicine.

5 How to store

Keep out of the reach and sight of children.
Store below 25°C in a dry place
Do not use Quinine sulfate tablets after the expiry date stated
on the label/carton/bottle. The expiry date refers to the last
day of that month.
Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.

6 Further information

What Quinine sulfate tablets contain

• The active substance (the ingredient that makes the tablet
work) is 300mg quinine sulfate.
• The other ingredients are sodium lauryl sulfate,
povidone, microcrystalline cellulose (E460),
croscarmellose sodium, magnesium stearate,
hydrogenated vegetable oil.
• The coating contains hydroxypropylmethyl
cellulose, hydroxypropyl cellulose, medium chain
triglycerides, macrogol 3350, titanium dioxide
(E171).

What Quinine sulfate tablets look like and
contents of the pack
Quinine sulfate tablets are white, circular,
film-coated tablets.
Pack sizes are 28 tablets
Marketing Authorisation Holder and
Manufacturer
Actavis, Barnstaple, EX32 8NS, UK
Date of last revision: October 2015

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Actavis, Barnstaple, EX32 8NS, UK

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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