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PURINETHOL 50MG TABLETS

Active substance(s): MERCAPTOPURINE

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Ref: 1378/140218/1/F

®

Puri-Nethol 50mg Tablets
(mercaptopurine)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor, pharmacist or nurse.
* This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
yours.
- If you get any side effects talk to your doctor, pharmacist or nurse. This
includes any
possible side effects not listed in the leaflet. See section 4.
Your medicine is called Puri-Nethol 50mg Tablets but will be referred to as
Puri-nethol throughout this leaflet.
What is in this leaflet:
1

What Puri-nethol is and what it is used for

2

What you need to know before you take Puri-nethol

3

How to take Puri-nethol

4

Possible side effects

5

How to store Puri-nethol

6

Contents of the pack and other information

1

What Puri-nethol is and what it is used for

Puri-nethol tablets contain the active substance called 6-puri-nethol.
6-puri-nethol belongs to a group of medicines called cytotoxics (also called
chemotherapy) and works by reducing the number of new blood cells your
body makes. Puri-nethol is used to treat cancer of the blood (leukaemia) in
adults, adolescents and children.

2

What you need to know before you take
Puri-nethol

Do not take Puri-nethol:
If you are allergic to 6-mercaptopurine or any of the other ingredients of this
medicine (listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Puri-nethol:
* If you have recently received, or are due to receive, a vaccination
(vaccine). If you take Puri-nethol, you should not have a live organism
vaccine (for example; flu vaccine, measles vaccine, BCG vaccine, etc.)
until advised it is safe to do so by your doctor. This is because some
vaccines may give you an infection if you receive them while you are
taking Puri-nethol
* If you have reduced liver function or liver damage
* If you have a genetic condition called TPMT (thiopurine methyltransferase)
deficiency
* If you have an inherited mutation in the NUDT15-gene (a gene which is
involved in the break-down of Puri-nethol in the body), you have a
higher risk of infections and hair loss and your doctor may in this case give
you a lower dose.
* If you have an allergy to a medicine called azathioprine (also used to treat
cancer)
* If you have a kidney problem.
* Tell your doctor whether you have, or have not, had chicken pox, shingles
or hepatitis B (a liver disease caused by a virus).
* If you have a genetic condition called Lesch-Nyhan Syndrome
If you are receiving immunosuppressive therapy, taking Puri-nethol
could put you at greater risk of:
* tumours, including skin cancer. Therefore, when taking Puri-nethol,
avoid excessive exposure to sunlight, wear protective clothing and use
protective sunscreen with a high protection factor.
* lymphoproliferative disorders:
- treatment with Puri-nethol increases your risk of getting a type of
cancer called lymphoproliferative disorder. With treatment regimen
containing multiple immunosuppressants (including thiopurines), this may
lead to death.
- a combination of multiple immunosuppressants, given concomitantly
increases the risk of disorders of the lymph system due to a viral
infection (Epstein-Barr virus (EBV) - associated lymphoproliferative
disorders).
Taking Puri-nethol could put you at greater risk of:
* developing a serious condition called Macrophage Activation Syndrome
(excessive activation of white blood cells associated with inflammation),
which usually occurs in people who have certain types of arthritis.

Infections
When you are treated with Puri-nethol the risk of viral, fungal and
bacterial infections is increased and the infections may be more serious. See
also section 4. Tell your doctor before starting treatment whether or not you
have had chickenpox, shingles or hepatitis B (a liver disease caused by a
virus).
Blood tests
* Treatment with Puri-nethol may affect your bone marrow. This means
you may have a reduced number of white blood cells, platelets and (less
commonly) red blood cells in your blood. Your doctor will carry out blood
tests daily when you are at the beginning of your treatment (induction) and
at least weekly when you are further along into your treatment
(maintenance). This is in order to monitor the levels of these cells in your
blood. If you stop treatment early enough, your blood cells will return to
normal.
Other laboratory tests
* Additional laboratory tests (urine, blood, etc.) may also be carried out as
directed by your doctor.
Liver function
* Puri-nethol is toxic to your liver. Therefore, your doctor will carry out
weekly liver function tests when you are taking Puri-nethol. If you
already have liver disease, or if you are taking other medications which
may affect your liver, your doctor will carry out more frequent tests. If you
notice the whites of your eyes or your skin turn yellow (jaundice) tell your
doctor immediately as you may need to stop your treatment
immediately.
Children and adolescents
Low blood sugar levels (sweating more than usual, nausea, dizziness,
confusion, etc.) have been reported in some children receiving Puri-nethol;
however, most of the children were under the age of six years old and had a
low body weight. If you are not sure if any of the above applies to you, talk
to your doctor or pharmacist before taking Puri-nethol.
Other medicines and Puri-nethol
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines.
In particular, tell your doctor or pharmacist if you are taking any of the
following:
* Ribavirin (used to treat viruses)
* Other cytotoxic medicines (chemotherapy - used to treat cancer)
* Allopurinol, thiopurinol, oxipurinol or febuxostat (used to treat gout)
* Olsalazine (used to treat a bowel problem called ulcerative colitis)
* Mesalazine (used to treat Crohn’s Disease and ulcerative colitis)
* Sulfasalazine (used to treat rheumatoid arthritis or ulcerative colitis)
* Methotrexate (used to treat rheumatoid arthritis or severe psoriasis)
* Infliximab (used to treat Crohn’s Disease and ulcerative colitis, rheumatoid
arthritis, ankylosing spondylitis or severe psoriasis)
* Warfarin or acenocoumarol (used to ‘thin’ the blood)
Having vaccines while you are taking Puri-nethol
If you are going to have a vaccination speak to your doctor or nurse before
you have it. If you take Puri-nethol, you should not have a live vaccine (for
example; flu vaccine, measles vaccine, BCG vaccine, etc.) until advised it is
safe to do so by your doctor. This is because some vaccines may give you
an infection if you have them whilst you are taking Puri-nethol.
Puri-nethol with food and drink
You can take Puri-nethol with food or on an empty stomach but the choice of
method should be consistent from day to day. You should take your medicine
at least 1 hour before or 2 hours after having milk or dairy products.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are
planning to have a baby, ask your doctor for advice before taking this
medicine.
Pregnancy
Treatment with Puri-nethol is not recommended during pregnancy,
particularly in the first trimester (three months) because it may cause
damage to the foetus. If you are pregnant your doctor will consider the risks
and benefits to you and your baby before prescribing Puri-nethol for you. If
you or your partner are taking Mercaptopurine, you must use a reliable form
of contraception to avoid pregnancy for the whole course of Puri-nethol
treatment and for at least 3 months after receiving the last dose of
Puri-nethol. This applies to both men and women.
Breast-feeding
It is recommended that you do not breast-feed when you are taking
Puri-nethol.
Driving and using machines
It is not expected that Puri-nethol will affect your ability to drive or use
machines, but no studies have been done to confirm this.

Ref: 1378/140218/1/F

®

Puri-Nethol 50mg Tablets
(mercaptopurine)
Patient Information Leaflet (continued)
Puri-nethol tablets contain lactose
If you have been told by your doctor that you have an intolerance to some
sugars, contact your doctor before you take Puri-nethol tablets.

How to take Puri-nethol

3

Puri-nethol should only be prescribed to you by a specialist doctor who is
experienced in treating cancers of the blood.

*
*

*

When you take Puri-nethol, your doctor will take regular blood tests.
This is to check the number and type of cells in your blood, and to ensure
your liver is working correctly
Your doctor may also ask for other blood and urine tests to monitor how
your kidneys are working and to measure uric acid levels. Uric acid is a
natural substance made in your body and levels of uric acid can rise while
you are taking Puri-nethol. High levels of uric acid may damage your
kidneys
Your doctor may sometimes change your dose of Puri-nethol as a
result of these tests.

Always take Puri-nethol exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure. It is important to
take your medicine at the right times. The label on your pack will tell you
how many tablets to take and how often to take them. If the label does not
say or if you are not sure, ask your doctor, nurse or pharmacist.
The usual dose for adults and children is 2.5 mg per kilogram of your body
weight each day (or alternatively 50 to 75 mg per m2 of your body surface
area each day). Your doctor will calculate and adjust your dose based on
your body weight, results of your blood tests, whether or not you are taking
other chemotherapy medicines and your kidney and liver function.
Swallow your tablets whole. Do not chew the tablets. The tablets should
not be broken or crushed. If you or your caregiver does handle broken
tablets, wash the hands immediately.

*

You can take your medicine with food or on an empty stomach but the
choice of method should be consistent from day to day. You should take
your medicine at least 1 hour before or 2 hours after having milk or dairy
products.
If you take more Puri-nethol than you should
If you take more Puri-nethol than you should, tell your doctor
immediately or go to a hospital straight away. Take the medicine pack with
you.

Rare (may affect up to 1 in 1,000 people)
* Mouth ulcers
* Inflammation of the pancreas (pancreatitis); symptoms may include
abdominal pain or feeling or being sick
* Damage to your liver (hepatic necrosis)
* Hair loss
* Various types of cancers including blood, lymph and skin cancers
Very rare (may affect up to 1 in 10,000 people)
* Blood cancer
* Cancer of the spleen and liver (in patients with a condition called
Inflammatory Bowel Disease)
* Ulcers in the intestines; symptoms may include abdominal pain and
bleeding
* Low sperm count in men
Not known (frequency cannot be estimated from the available data)
* Increased sensitivity to sunlight and UV light
Additional side effects in children
Low blood sugar levels (sweating more than usual, nausea, dizziness,
confusion, etc.) have been reported in some children receiving
Mercaptopurine; however, most of the children were under the age of six
years old and had a low body weight.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed on this leaflet. You can also report side
effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects, you can help provide more information on the
safety of this medicine.
5

How to store Puri-nethol

Keep out of the sight and reach of children.
Do not store above 25°C. Keep the container tightly closed.
Store in a dry place. Protect from light.
Do not take this medicine after the expiry date shown on the carton or bottle
label. If your doctor tells you to stop taking the medicine, take any
remaining medicine back to the pharmacist for safe disposal. Only keep this
medicine if your doctor tells you to.
If your medicine becomes discoloured or shows any signs of deterioration,
ask your pharmacist who will advise you what to do.
Medicines should not be disposed of via waterwaste or household waste.
Ask your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

If you forget to take Puri-nethol
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
If you stop taking Puri-nethol
If you stop taking Puri-nethol, tell your doctor immediately.
If you have any further questions on the use of this medicine, ask your
doctor, nurse or pharmacist.

4

Possible side effects

Like all medicines, this medicine can cause side effects, although not
everybody gets them.
If you get any of the following side effects, talk to your specialist doctor or go
to hospital immediately:
allergic reaction with swelling of the face and sometimes mouth and
* An
throat (this is a very rare side effect).
allergic reaction with joint pain, skin rashes, high temperature (fever)
* An
(this is a rare side effect).
of the skin and whites of the eyes. If you get such symptoms,
* Yellowing
you should stop taking Puri-Nethol.
signs of fever or infection (sore throat, sore mouth or urinary
* Any
problems) or any unexplained bruising or bleeding. Treatment with
Puri-Nethol affects your bone marrow and will cause a reduction in
your white blood cells and platelets (this is a very common side effect).
Talk to your doctor if you have any of the following side effects, which may
also happen with this medicine:
Common (may affect up to 1 in 10 people)
Nausea (you feel sick) or vomiting (being sick)
* Low
red blood cell count (anaemia)
*
Uncommon (may affect up to 1 in 100 people)
Loss of appetite

*

6

Contents of the pack and other information

What Puri-nethol contains
The active ingredient is Puri-nethol. Each tablet contains 50 mg of
Puri-nethol.
The other ingredients are lactose, maize starch, hydrolysed starch, stearic
acid and magnesium stearate.
What Puri-nethol looks like and contents of the pack
Puri-nethol tablets are pale yellow, round, biconvex, scored on one side,
engraved GX above the score and EX2 below the score and plain on the
other side. Mercaptopurine tablets are in bottles of 25 tablets.
Manufacturer and Licence Holder
This medicine is manufactured by Excella GmbH, Nurnberger Strasse 12,
Feucht, Germany and is procured from within the EU and repackaged by the
Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road,
East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1378 Puri-nethol 50mg Tablets

Revision date: 14/02/18

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 to obtain the leaflet
in a format suitable for you

Ref: 1378/140218/2/F

Mercaptopurine 50mg Tablets
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor, pharmacist or nurse.
* This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
yours.
* If you get any side effects talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in the leaflet. See section 4.
Your medicine is called Mercaptopurine 50mg Tablets but will be referred to
as Mercaptopurine throughout this leaflet.
What is in this leaflet:
1

What Mercaptopurine is and what it is used for

2

What you need to know before you take Mercaptopurine

3

How to take Mercaptopurine

4

Possible side effects

5

How to store Mercaptopurine

6

Contents of the pack and other information

1

What Mercaptopurine is and what it is used for

Mercaptopurine tablets contain the active substance called
6-mercaptopurine. 6-mercaptopurine belongs to a group of medicines called
cytotoxics (also called chemotherapy) and works by reducing the number of
new blood cells your body makes. Mercaptopurine is used to treat cancer of
the blood (leukaemia) in adults, adolescents and children.

2

What you need to know before you take
Mercaptopurine

Do not take Mercaptopurine:
If you are allergic to 6-mercaptopurine or any of the other ingredients of this
medicine (listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Mercaptopurine:
* If you have recently received, or are due to receive, a vaccination
(vaccine). If you take Mercaptopurine, you should not have a live organism
vaccine (for example; flu vaccine, measles vaccine, BCG vaccine, etc.)
until advised it is safe to do so by your doctor. This is because some
vaccines may give you an infection if you receive them while you are
taking Mercaptopurine
* If you have reduced liver function or liver damage
* If you have a genetic condition called TPMT (thiopurine methyltransferase)
deficiency
* If you have an inherited mutation in the NUDT15-gene (a gene which is
involved in the break-down of Mercaptopurine in the body), you have a
higher risk of infections and hair loss and your doctor may in this case give
you a lower dose.
* If you have an allergy to a medicine called azathioprine (also used to treat
cancer)
* If you have a kidney problem.
* Tell your doctor whether you have, or have not, had chicken pox, shingles
or hepatitis B (a liver disease caused by a virus).
* If you have a genetic condition called Lesch-Nyhan Syndrome
If you are receiving immunosuppressive therapy, taking Mercaptopurine
could put you at greater risk of:
* tumours, including skin cancer. Therefore, when taking Mercaptopurine,
avoid excessive exposure to sunlight, wear protective clothing and use
protective sunscreen with a high protection factor.
* lymphoproliferative disorders:
- treatment with Mercaptopurine increases your risk of getting a type of
cancer called lymphoproliferative disorder. With treatment regimen
containing multiple immunosuppressants (including thiopurines), this may
lead to death.
- a combination of multiple immunosuppressants, given concomitantly
increases the risk of disorders of the lymph system due to a viral
infection (Epstein-Barr virus (EBV) - associated lymphoproliferative
disorders).
Taking Mercaptopurine could put you at greater risk of:
* developing a serious condition called Macrophage Activation Syndrome
(excessive activation of white blood cells associated with inflammation),
which usually occurs in people who have certain types of arthritis.
Infections
When you are treated with Mercaptopurine the risk of viral, fungal and
bacterial infections is increased and the infections may be more serious. See
also section 4. Tell your doctor before starting treatment whether or not you
have had chickenpox, shingles or hepatitis B (a liver disease caused by a
virus).

Blood tests
* Treatment with Mercaptopurine may affect your bone marrow. This means
you may have a reduced number of white blood cells, platelets and (less
commonly) red blood cells in your blood. Your doctor will carry out blood
tests daily when you are at the beginning of your treatment (induction) and
at least weekly when you are further along into your treatment
(maintenance). This is in order to monitor the levels of these cells in your
blood. If you stop treatment early enough, your blood cells will return to
normal.
Other laboratory tests
* Additional laboratory tests (urine, blood, etc.) may also be carried out as
directed by your doctor.
Liver function
* Mercaptopurine is toxic to your liver. Therefore, your doctor will carry out
weekly liver function tests when you are taking Mercaptopurine. If you
already have liver disease, or if you are taking other medications which
may affect your liver, your doctor will carry out more frequent tests. If you
notice the whites of your eyes or your skin turn yellow (jaundice) tell your
doctor immediately as you may need to stop your treatment immediately.
Children and adolescents
Low blood sugar levels (sweating more than usual, nausea, dizziness,
confusion, etc.) have been reported in some children receiving
Mercaptopurine; however, most of the children were under the age of six
years old and had a low body weight. If you are not sure if any of the above
applies to you, talk to your doctor or pharmacist before taking
Mercaptopurine.
Other medicines and Mercaptopurine
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines.
In particular, tell your doctor or pharmacist if you are taking any of the
following:
* Ribavirin (used to treat viruses)
* Other cytotoxic medicines (chemotherapy - used to treat cancer)
* Allopurinol, thiopurinol, oxipurinol or febuxostat (used to treat gout)
* Olsalazine (used to treat a bowel problem called ulcerative colitis)
* Mesalazine (used to treat Crohn’s Disease and ulcerative colitis)
* Sulfasalazine (used to treat rheumatoid arthritis or ulcerative colitis)
* Methotrexate (used to treat rheumatoid arthritis or severe psoriasis)
* Infliximab (used to treat Crohn’s Disease and ulcerative colitis, rheumatoid
arthritis, ankylosing spondylitis or severe psoriasis)
* Warfarin or acenocoumarol (used to ‘thin’ the blood)
Having vaccines while you are taking Mercaptopurine
If you are going to have a vaccination speak to your doctor or nurse before
you have it. If you take Mercaptopurine, you should not have a live vaccine
(for example; flu vaccine, measles vaccine, BCG vaccine, etc.) until advised
it is safe to do so by your doctor. This is because some vaccines may give
you an infection if you have them whilst you are taking Mercaptopurine.
Mercaptopurine with food and drink
You can take Mercaptopurine with food or on an empty stomach but the
choice of method should be consistent from day to day. You should take
your medicine at least 1 hour before or 2 hours after having milk or dairy
products.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are
planning to have a baby, ask your doctor for advice before taking this#
medicine.
Pregnancy
Treatment with Mercaptopurine is not recommended during pregnancy,
particularly in the first trimester (three months) because it may cause
damage to the foetus. If you are pregnant your doctor will consider the risks
and benefits to you and your baby before prescribing Mercaptopurine for
you. If you or your partner are taking Mercaptopurine, you must use a reliable form of contraception to avoid pregnancy for the whole course of
Mercaptopurine treatment and for at least 3 months after receiving the last
dose of Mercaptopurine. This applies to both men and women.
Breast-feeding
It is recommended that you do not breast-feed when you are taking
Mercaptopurine.
Driving and using machines
It is not expected that Mercaptopurine will affect your ability to drive or use
machines, but no studies have been done to confirm this.
Mercaptopurine tablets contain lactose
If you have been told by your doctor that you have an intolerance to some
sugars, contact your doctor before you take Mercaptopurine tablets.

Ref: 1378/140218/2/F

Mercaptopurine 50mg Tablets
Patient Information Leaflet (continued)
3

How to take Mercaptopurine

Mercaptopurine should only be prescribed to you by a specialist doctor who
is experienced in treating cancers of the blood.

* When you take Mercaptopurine, your doctor will take regular blood tests.

This is to check the number and type of cells in your blood, and to ensure
your liver is working correctly
* Your doctor may also ask for other blood and urine tests to monitor how
your kidneys are working and to measure uric acid levels. Uric acid is a
natural substance made in your body and levels of uric acid can rise while
you are taking Mercaptopurine. High levels of uric acid may damage your
kidneys
* Your doctor may sometimes change your dose of Mercaptopurine as a
result of these tests.
Always take Mercaptopurine exactly as your doctor or pharmacist has told
you. Check with your doctor or pharmacist if you are not sure. It is important
to take your medicine at the right times. The label on your pack will tell you
how many tablets to take and how often to take them. If the label does not
say or if you are not sure, ask your doctor, nurse or pharmacist.
The usual dose for adults and children is 2.5 mg per kilogram of your body
weight each day (or alternatively 50 to 75 mg per m2 of your body surface
area each day). Your doctor will calculate and adjust your dose based on
your body weight, results of your blood tests, whether or not you are taking
other chemotherapy medicines and your kidney and
liver function.

* Swallow your tablets whole. Do not chew the tablets. The tablets should
not be broken or crushed. If you or your caregiver does handle broken
tablets, wash the hands immediately.

You can take your medicine with food or on an empty stomach but the
choice of method should be consistent from day to day. You should take
your medicine at least 1 hour before or 2 hours after having milk or dairy
products.
If you take more Mercaptopurine than you should
If you take more Mercaptopurine than you should, tell your doctor
immediately or go to a hospital straight away. Take the medicine pack with
you.
If you forget to take Mercaptopurine
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
If you stop taking Mercaptopurine
If you stop taking Mercaptopurine, tell your doctor immediately.
If you have any further questions on the use of this medicine, ask your
doctor, nurse or pharmacist.

4

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you get any of the following side effects, talk to your specialist doctor or go
to hospital immediately:
* An allergic reaction with swelling of the face and sometimes mouth and
throat (this is a very rare side effect).
* An allergic reaction with joint pain, skin rashes, high temperature (fever)
(this is a rare side effect).
* Yellowing of the skin and whites of the eyes. If you get such symptoms,
you should stop taking Mercaptopurine.
* Any signs of fever or infection (sore throat, sore mouth or urinary
problems) or any unexplained bruising or bleeding. Treatment with
Mercaptopurine affects your bone marrow and will cause a reduction in
your white blood cells and platelets (this is a very common side effect).
Talk to your doctor if you have any of the following side effects, which may
also happen with this medicine:
Common (may affect up to 1 in 10 people)
* Nausea (you feel sick) or vomiting (being sick)
* Low red blood cell count (anaemia)
Uncommon (may affect up to 1 in 100 people)
* Loss of appetite
Rare (may affect up to 1 in 1,000 people)
* Mouth ulcers
* Inflammation of the pancreas (pancreatitis); symptoms may include
abdominal pain or feeling or being sick
* Damage to your liver (hepatic necrosis)
* Hair loss
* Various types of cancers including blood, lymph and skin cancers

Very rare (may affect up to 1 in 10,000 people)
* Blood cancer
* Cancer of the spleen and liver (in patients with a condition called
Inflammatory Bowel Disease)
* Ulcers in the intestines; symptoms may include abdominal pain and
bleeding
* Low sperm count in men
Not known (frequency cannot be estimated from the available data)
* Increased sensitivity to sunlight and UV light
Additional side effects in children
Low blood sugar levels (sweating more than usual, nausea, dizziness, confusion, etc.) have been reported in some children receiving Mercaptopurine;
however, most of the children were under the age of six years old and had a
low body weight.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed on this leaflet. You can also report side
effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects, you can help provide more information on the
safety of this medicine.

5

How to store Mercaptopurine

Keep out of the sight and reach of children.
Do not store above 25°C. Keep the container tightly closed.
Store in a dry place. Protect from light.
Do not take this medicine after the expiry date shown on the carton or bottle
label. If your doctor tells you to stop taking the medicine, take any
remaining medicine back to the pharmacist for safe disposal. Only keep this
medicine if your doctor tells you to.
If your medicine becomes discoloured or shows any signs of deterioration,
ask your pharmacist who will advise you what to do.
Medicines should not be disposed of via waterwaste or household waste.
Ask your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

6

Contents of the pack and other information

What Mercaptopurine contains
The active ingredient is Mercaptopurine. Each tablet contains 50 mg of
Mercaptopurine.
The other ingredients are lactose, maize starch, hydrolysed starch, stearic
acid and magnesium stearate.
What Mercaptopurine looks like and contents of the pack
Mercaptopurine tablets are pale yellow, round, biconvex, scored on one side,
engraved GX above the score and EX2 below the score and plain on the
other side. Mercaptopurine tablets are in bottles of 25 tablets.
Manufacturer and Licence Holder
This medicine is manufactured by Excella GmbH, Nurnberger Strasse 12,
Feucht, Germany and is procured from within the EU and repackaged by the
Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road,
East Moons Moat, Redditch, Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1378 Mercaptopurine 50mg Tablets

Revision date: 14/02/18

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