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PURINETHOL 50 MG TABLETS

Active substance(s): MERCAPTOPURINE / MERCAPTOPURINE / MERCAPTOPURINE

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Very rare (may affect up to 1 in 10,000 people)
• Blood cancer
• Cancer of the spleen and liver (in patients with a condition called Inflammatory
Bowel Disease)
• Ulcers in the intestines; symptoms may include abdominal pain and bleeding
• Low sperm count in men
Not known (frequency cannot be estimated from the available data)
• Increased sensitivity to sunlight and UV light
Additional side effects in children
Low blood sugar levels (sweating more than usual, nausea, dizziness, confusion,
etc.) have been reported in some children receiving Mercaptopurine; however, most
of the children were under the age of six years old and had a low body weight.
Reporting of side effects
If you get any side effects, talk to your doctor, nurse or pharmacist. This includes
any possible side effects not listed in this leaflet. You can also report side effects
directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the safety of this
medicine.
5 How to store Mercaptopurine
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the pack after
‘Exp’.
• Do not store above 25°C. Keep the container tightly closed.
• Store in a dry place. Protect from light.
• If your doctor tells you to stop taking the tablets, it is important to return any which
are left over to your pharmacist, who will destroy them according to disposal of
dangerous substance guidelines. Only keep the tablets if your doctor tells you to.
6 Contents of the pack and other information
What Mercaptopurine contains
The active substance is mercaptopurine. Each tablet contains 50 mg of
mercaptopurine.
The other ingredients are lactose, maize starch, hydrolysed starch, stearic acid,
magnesium stearate and purified water.
What Mercaptopurine looks like and contents of the pack
Mercaptopurine tablets are a pale yellow colour, are marked with ‘GX’ and ‘EX2’ on
either side of a scoreline and plain on the reverse.
Mercaptopurine tablets come in amber bottles of 25 tablets.
Manufacturer:
Manufactured by EXCELLA GmbH, Nurnberger Strasse 12, 90537 Feucht,
Germany.
Procured from within the EU by the Product Licence Holder:
Expono Ltd, Units 8-12 Cornwall Road Industrial Estate, Cornwall Road,
Smethwick,
West Midlands, B66 2JT, UK.
Repackaged by N.G.Ltd, West Midlands, B66 2JT, UK.

To request a copy of this leaflet in large print,
audio CD or Braille please call 0121 565 3101
POM

PL Number: 22961/0123

Leaflet Revision Date: 11.05.2017

Mercaptopurine 50 mg Tablets
Ref 857/Z

Package Leaflet: Information for the User

Mercaptopurine 50mg tablets
Your medicine is known as Mercaptopurine 50 mg Tablets but will be referred
to as Mercaptopurine throughout the following leaflet.
Read all of this leaflet carefully before you start taking this medicine because
it contains important information for you.
– Keep this leaflet. You may need to read it again.
– If you have any further questions, ask your doctor, pharmacist or nurse.
– This medicine has been prescribed for you only. Do not pass it on to others. It
may harm them, even if their signs of illness are the same as yours.
– If you get any side effects talk to your doctor, pharmacist or nurse. This includes
any possible side effects not listed in the leaflet. See section 4.
What is in this leaflet:
1 What Mercaptopurine is and what it is used for
2 What you need to know before you take Mercaptopurine
3 How to take Mercaptopurine
4 Possible side effects
5 How to store Mercaptopurine
6 Contents of the pack and other information
1 What Mercaptopurine is and what it is used for
Mercaptopurine tablets contain the active substance mercaptopurine.
Mercaptopurine belongs to a group of medicines called cytotoxics (also called
chemotherapy) and works by reducing the number of new blood cells your body
makes.
Mercaptopurine is used to treat cancer of the blood (leukaemia) in adults,
adolescents and children.
2 What you need to know before you take Mercaptopurine
Do not take Mercaptopurine:
If you are allergic to mercaptopurine or any of the other ingredients of this medicine
(listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Mercaptopurine:
• If you have recently received, or are due to receive, a vaccination (vaccine). If you
take Mercaptopurine, you should not have a live organism vaccine (for example;
flu vaccine, measles vaccine, BCG vaccine, etc.) until advised it is safe to do so
by your doctor. This is because some vaccines may give you an infection if you
receive them while you are taking Mercaptopurine
• If you have reduced liver function or liver damage
• If you have a genetic condition called TPMT (thiopurine methyltransferase)
deficiency
• If you have an allergy to a medicine called azathioprine (also used to treat cancer)
• If you have a kidney problem.
• Tell your doctor whether you have, or have not, had chicken pox, shingles or
hepatitis B (a liver disease caused by a virus).
• If you have a genetic condition called Lesch-Nyhan Syndrome
If you are receiving immunosuppressive therapy, taking Mercaptopurine could put
you at greater risk of:
• tumours, including skin cancer. Therefore, when taking Mercaptopurine, avoid
excessive exposure to sunlight, wear protective clothing and use protective
sunscreen with a high protection factor.
• lymphoproliferative disorders:
– treatment with Mercaptopurine increases your risk of getting a type of cancer
called lymphoproliferative disorder. With treatment regimen containing multiple
immunosuppressants (including thiopurines), this may lead to death.
– a combination of multiple immunosuppressants, given concomitantly increases
the risk of disorders of the lymph system due to a viral infection (Epstein-Barr
virus (EBV) - associated lymphoproliferative disorders).
Taking Mercaptopurine could put you at greater risk of:
• developing a serious condition called Macrophage Activation Syndrome
(excessive activation of white blood cells associated with inflammation), which
usually occurs in people who have certain types of arthritis.
Blood tests
• Treatment with Mercaptopurine may affect your bone marrow. This means you
may have a reduced number of white blood cells, platelets and (less commonly)
red blood cells in your blood. Your doctor will carry out blood tests daily when you
are at the beginning of your treatment (induction) and at least weekly when you
are further along into your treatment (maintenance). This is in order to monitor the
levels of these cells in your blood. If you stop treatment early enough, your blood
cells will return to normal.

Other laboratory tests
• Additional laboratory tests (urine, blood, etc.) may also be carried out as directed
by your doctor.
Liver function
• Mercaptopurine is toxic to your liver. Therefore, your doctor will carry out weekly
liver function tests when you are taking Mercaptopurine. If you already have liver
disease, or if you are taking other medications which may affect your liver, your
doctor will carry out more frequent tests. If you notice the whites of your eyes or
your skin turn yellow (jaundice) tell your doctor immediately as you may need to
stop your treatment immediately.
Infections
• When you are taking Mercaptopurine you may be more likely to get infections
caused by viruses, bacteria and fungus and your reaction to these infections may
be more severe than people who are not being taking Mercaptopurine. If you
think you have an infection, talk to your doctor immediately.
Children and adolescents
Low blood sugar levels (sweating more than usual, nausea, dizziness, confusion,
etc.) have been reported in some children receiving Mercaptopurine; however, most
of the children were under the age of six years old and had a low body weight.

3 How to take Mercaptopurine
Mercaptopurine should only be prescribed to you by a specialist doctor who is
experienced in treating cancers of the blood.
• When you take Mercaptopurine, your doctor will take regular blood tests. This is to
check the number and type of cells in your blood, and to ensure your liver is
working correctly
• Your doctor may also ask for other blood and urine tests to monitor how your
kidneys are working and to measure uric acid levels. Uric acid is a natural
substance made in your body and levels of uric acid can rise while you are taking
Mercaptopurine. High levels of uric acid may damage your kidneys
• Your doctor may sometimes change your dose of Mercaptopurine as a result of
these tests.
Always take Mercaptopurine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure. It is important to take your
medicine at the right times. The label on your pack will tell you how many tablets to
take and how often to take them. If the label does not say or if you are not sure, ask
your doctor, nurse or pharmacist.

If you are not sure if any of the above applies to you, talk to your doctor or
pharmacist before taking Mercaptopurine.

The usual dose for adults and children is 2.5 mg per kilogram of your body weight
each day (or alternatively 50 to 75 mg per m2 of your body surface area each day).
Your doctor will calculate and adjust your dose based on your body weight, results
of your blood tests, whether or not you are taking other chemotherapy medicines
and your kidney and liver function.

Other medicines and Mercaptopurine
Tell your doctor or pharmacist if you are taking, have recently taken or might take
any other medicines.

• Swallow your tablets whole. Do not chew the tablets. The tablets should not be
broken or crushed. If you or your caregiver does handle broken tablets, wash the
hands immediately.

In particular, tell your doctor or pharmacist if you are taking any of the following:
• Ribavirin (used to treat viruses)
• Other cytotoxic medicines (chemotherapy – used to treat cancer)
• Allopurinol, thiopurinol, oxipurinol or febuxostat (used to treat gout)
• Olsalazine (used to treat a bowel problem called ulcerative colitis)
• Mesalazine (used to treat Crohn’s Disease and ulcerative colitis)
• Sulfasalazine (used to treat rheumatoid arthritis or ulcerative colitis)
• Methotrexate (used to treat rheumatoid arthritis or severe psoriasis)
• Infliximab (used to treat Crohn’s Disease and ulcerative colitis, rheumatoid
arthritis, ankylosing spondylitis or severe psoriasis)
• Warfarin or acenocoumarol (used to ‘thin’ the blood)

You can take your medicine with food or on an empty stomach but the choice of
method should be consistent from day to day. You should take your medicine at
least 1 hour before or 2 hours after having milk or dairy products.

Having vaccines while you are taking Mercaptopurine
If you are going to have a vaccination speak to your doctor or nurse before you have
it. If you take Mercaptopurine, you should not have a live vaccine (for example; flu
vaccine, measles vaccine, BCG vaccine, etc.) until advised it is safe to do so by
your doctor. This is because some vaccines may give you an infection if you have
them whilst you are taking Mercaptopurine.

If you have any further questions on the use of this medicine, ask your doctor, nurse
or pharmacist.

Mercaptopurine with food and drink
You can take Mercaptopurine with food or on an empty stomach but the choice of
method should be consistent from day to day. You should take your medicine at
least 1 hour before or 2 hours after having milk or dairy products.

If you get any of the following, talk to your specialist doctor straight away or seek
urgent medical advice:
• An allergic reaction with swelling of the face and sometimes mouth and throat
(this is a very rare side effect).
• An allergic reaction with joint pain, skin rashes, high temperature (fever) (this is a
rare side effect).
• Yellowing of the skin and whites of the eyes. If you get such symptoms, you
should stop taking Mercaptopurine.
• Any signs of a high temperature or infection (feeling very tired or unwell, sore
throat, sore mouth or urinary problems) or any unexplained bruising or bleeding.
Treatment with Mercaptopurine affects your bone marrow and will cause a
reduction in your white blood cells and platelets (this is a very common side
effect).

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to
have a baby, ask your doctor for advice before taking this medicine.
Pregnancy
Treatment with Mercaptopurine is not recommended during pregnancy, particularly
in the first trimester (three months) because it may cause damage to the foetus. If
you are pregnant your doctor will consider the risks and benefits to you and your
baby before prescribing Mercaptopurine for you.
If you or your partner are taking Mercaptopurine, you must use a reliable form of
contraception to avoid pregnancy for the whole course of Mercaptopurine treatment
and for at least 3 months after receiving the last dose of Mercaptopurine. This
applies to both men and women.
Breast-feeding
Is it recommended that you do not breast-feed when you are taking Mercaptopurine.
Driving and using machines
It is not expected that Mercaptopurine will affect your ability to drive or use
machines, but no studies have been done to confirm this.
Mercaptopurine tablets contain lactose
If you have been told by your doctor that you have an intolerance to some sugars,
contact your doctor before you take Mercaptopurine tablets.

If you take more Mercaptopurine than you should
If you take more Mercaptopurine than you should, tell your doctor immediately or go
to ahospital straight away. Take the medicine pack with you.
If you forget to take Mercaptopurine
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
If you stop taking Mercaptopurine
If you stop taking Mercaptopurine, tell your doctor immediately.

4 Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody
gets them.

Talk to your doctor if you have any of the following side effects, which may also
happen with this medicine:
Common (may affect up to 1 in 10 people)
• Nausea (you feel sick) or vomiting (being sick)
• Low red blood cell count (anaemia)
Uncommon (may affect up to 1 in 100 people)
• Loss of appetite
Rare (may affect up to 1 in 1,000 people)
• Mouth ulcers
• Inflammation of the pancreas (pancreatitis); symptoms may include abdominal
pain or feeling or being sick
• Damage to your liver (hepatic necrosis)
• Hair loss
• Various types of cancers including blood, lymph and skin cancers

Very rare (may affect up to 1 in 10,000 people)
• Blood cancer
• Cancer of the spleen and liver (in patients with a condition called Inflammatory
Bowel Disease)
• Ulcers in the intestines; symptoms may include abdominal pain and bleeding
• Low sperm count in men

Package Leaflet: Information for the User

Not known (frequency cannot be estimated from the available data)
• Increased sensitivity to sunlight and UV light

Read all of this leaflet carefully before you start taking this medicine because
it contains important information for you.
– Keep this leaflet. You may need to read it again.
– If you have any further questions, ask your doctor, pharmacist or nurse.
– This medicine has been prescribed for you only. Do not pass it on to others. It
may harm them, even if their signs of illness are the same as yours.
– If you get any side effects talk to your doctor, pharmacist or nurse. This includes
any possible side effects not listed in the leaflet. See section 4.

Additional side effects in children
Low blood sugar levels (sweating more than usual, nausea, dizziness, confusion,
etc.) have been reported in some children receiving Purinethol; however, most of the
children were under the age of six years old and had a low body weight.
Reporting of side effects
If you get any side effects, talk to your doctor, nurse or pharmacist. This includes
any possible side effects not listed in this leaflet. You can also report side effects
directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the safety of this
medicine.
5 How to store Purinethol
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the pack after
‘Exp’.
• Do not store above 25°C. Keep the container tightly closed.
• Store in a dry place. Protect from light.
• If your doctor tells you to stop taking the tablets, it is important to return any which
are left over to your pharmacist, who will destroy them according to disposal of
dangerous substance guidelines. Only keep the tablets if your doctor tells you to.
6 Contents of the pack and other information
What Purinethol contains
The active substance is mercaptopurine. Each tablet contains 50 mg of
mercaptopurine.
The other ingredients are lactose, maize starch, hydrolysed starch, stearic acid,
magnesium stearate and purified water.
What Purinethol looks like and contents of the pack
Purinethol tablets are a pale yellow colour, are marked with ‘GX’ and ‘EX2’ on either
side of a scoreline and plain on the reverse.
Purinethol tablets come in amber bottles of 25 tablets.
Manufacturer:
Manufactured by EXCELLA GmbH, Nurnberger Strasse 12, 90537 Feucht,
Germany.
Procured from within the EU by the Product Licence Holder:
Expono Ltd, Units 8-12 Cornwall Road Industrial Estate, Cornwall Road,
Smethwick,
West Midlands, B66 2JT, UK.
Repackaged by N.G.Ltd, West Midlands, B66 2JT, UK.

To request a copy of this leaflet in large print,
audio CD or Braille please call 0121 565 3101
POM

PL Number: 22961/0123

Leaflet Revision Date: 11.05.2017

Purinethol 50 mg Tablets
Ref 856/Z

Purinethol® is a registered trademark of the GlaxoSmithKline Group of Companies.

Purinethol® 50 mg tablets
(mercaptopurine)

Your medicine is known as Purinethol 50 mg Tablets but will be referred to
as Purinethol throughout the following leaflet.

What is in this leaflet:
1 What Purinethol is and what it is used for
2 What you need to know before you take Purinethol
3 How to take Purinethol
4 Possible side effects
5 How to store Purinethol
6 Contents of the pack and other information
1 What Purinethol is and what it is used for
Purinethol tablets contain the active substance mercaptopurine. Purinethol belongs
to a group of medicines called cytotoxics (also called chemotherapy) and works by
reducing the number of new blood cells your body makes.
Purinethol is used to treat cancer of the blood (leukaemia) in adults, adolescents
and children.
2 What you need to know before you take Purinethol
Do not take Purinethol:
If you are allergic to mercaptopurine or any of the other ingredients of this medicine
(listed in section 6).
Warnings and precautions
Talk to your doctor or pharmacist before taking Purinethol:
• If you have recently received, or are due to receive, a vaccination (vaccine). If you
take Purinethol, you should not have a live organism vaccine (for example; flu
vaccine, measles vaccine, BCG vaccine, etc.) until advised it is safe to do so by
your doctor. This is because some vaccines may give you an infection if you
receive them while you are taking Purinethol
• If you have reduced liver function or liver damage
• If you have a genetic condition called TPMT (thiopurine methyltransferase)
deficiency
• If you have an allergy to a medicine called azathioprine (also used to treat cancer)
• If you have a kidney problem.
• Tell your doctor whether you have, or have not, had chicken pox, shingles or
hepatitis B (a liver disease caused by a virus).
• If you have a genetic condition called Lesch-Nyhan Syndrome
If you are receiving immunosuppressive therapy, taking Purinethol could put you at
greater risk of:
• tumours, including skin cancer. Therefore, when taking Purinethol, avoid
excessive exposure to sunlight, wear protective clothing and use protective
sunscreen with a high protection factor.
• lymphoproliferative disorders:
– treatment with Purinethol increases your risk of getting a type of cancer called
lymphoproliferative disorder. With treatment regimen containing multiple
immunosuppressants (including thiopurines), this may lead to death.
– a combination of multiple immunosuppressants, given concomitantly increases
the risk of disorders of the lymph system due to a viral infection (Epstein-Barr
virus (EBV) - associated lymphoproliferative disorders).
Taking Purinethol could put you at greater risk of:
• developing a serious condition called Macrophage Activation Syndrome
(excessive activation of white blood cells associated with inflammation), which
usually occurs in people who have certain types of arthritis.
Blood tests
• Treatment with Purinethol may affect your bone marrow. This means you may
have a reduced number of white blood cells, platelets and (less commonly) red
blood cells in your blood. Your doctor will carry out blood tests daily when you are
at the beginning of your treatment (induction) and at least weekly when you are
further along into your treatment (maintenance). This is in order to monitor the
levels of these cells in your blood. If you stop treatment early enough, your blood
cells will return to normal.

Other laboratory tests
• Additional laboratory tests (urine, blood, etc.) may also be carried out as directed
by your doctor.
Liver function
• Purinethol is toxic to your liver. Therefore, your doctor will carry out weekly liver
function tests when you are taking Purinethol. If you already have liver disease, or
if you are taking other medications which may affect your liver, your doctor will
carry out more frequent tests. If you notice the whites of your eyes or your skin
turn yellow (jaundice) tell your doctor immediately as you may need to stop your
treatment immediately.
Infections
• When you are taking Purinethol you may be more likely to get infections caused
by viruses, bacteria and fungus and your reaction to these infections may be more
severe than people who are not being taking Purinethol. If you think you have an
infection, talk to your doctor immediately.
Children and adolescents
Low blood sugar levels (sweating more than usual, nausea, dizziness, confusion,
etc.) have been reported in some children receiving Purinethol; however, most of the
children were under the age of six years old and had a low body weight.

3 How to take Purinethol
Purinethol should only be prescribed to you by a specialist doctor who is
experienced in treating cancers of the blood.
• When you take Purinethol, your doctor will take regular blood tests. This is to
check the number and type of cells in your blood, and to ensure your liver is
working correctly
• Your doctor may also ask for other blood and urine tests to monitor how your
kidneys are working and to measure uric acid levels. Uric acid is a natural
substance made in your body and levels of uric acid can rise while you are taking
Purinethol. High levels of uric acid may damage your kidneys
• Your doctor may sometimes change your dose of Purinethol as a result of these
tests.
Always take Purinethol exactly as your doctor or pharmacist has told you. Check
with your doctor or pharmacist if you are not sure. It is important to take your
medicine at the right times. The label on your pack will tell you how many tablets to
take and how often to take them. If the label does not say or if you are not sure, ask
your doctor, nurse or pharmacist.

If you are not sure if any of the above applies to you, talk to your doctor or
pharmacist before taking Purinethol.

The usual dose for adults and children is 2.5 mg per kilogram of your body weight
each day (or alternatively 50 to 75 mg per m2 of your body surface area each day).
Your doctor will calculate and adjust your dose based on your body weight, results
of your blood tests, whether or not you are taking other chemotherapy medicines
and your kidney and liver function.

Other medicines and Purinethol
Tell your doctor or pharmacist if you are taking, have recently taken or might take
any other medicines.

• Swallow your tablets whole. Do not chew the tablets. The tablets should not be
broken or crushed. If you or your caregiver does handle broken tablets, wash the
hands immediately.

In particular, tell your doctor or pharmacist if you are taking any of the following:
• Ribavirin (used to treat viruses)
• Other cytotoxic medicines (chemotherapy – used to treat cancer)
• Allopurinol, thiopurinol, oxipurinol or febuxostat (used to treat gout)
• Olsalazine (used to treat a bowel problem called ulcerative colitis)
• Mesalazine (used to treat Crohn’s Disease and ulcerative colitis)
• Sulfasalazine (used to treat rheumatoid arthritis or ulcerative colitis)
• Methotrexate (used to treat rheumatoid arthritis or severe psoriasis)
• Infliximab (used to treat Crohn’s Disease and ulcerative colitis, rheumatoid
arthritis, ankylosing spondylitis or severe psoriasis)
• Warfarin or acenocoumarol (used to ‘thin’ the blood)

You can take your medicine with food or on an empty stomach but the choice of
method should be consistent from day to day. You should take your medicine at
least 1 hour before or 2 hours after having milk or dairy products.

Having vaccines while you are taking Purinethol
If you are going to have a vaccination speak to your doctor or nurse before you have
it. If you take Purinethol, you should not have a live vaccine (for example; flu
vaccine, measles vaccine, BCG vaccine, etc.) until advised it is safe to do so by
your doctor. This is because some vaccines may give you an infection if you have
them whilst you are taking Purinethol.

If you have any further questions on the use of this medicine, ask your doctor, nurse
or pharmacist.

Purinethol with food and drink
You can take Purinethol with food or on an empty stomach but the choice of method
should be consistent from day to day. You should take your medicine at least 1 hour
before or 2 hours after having milk or dairy products.

If you get any of the following, talk to your specialist doctor straight away or seek
urgent medical advice:
• An allergic reaction with swelling of the face and sometimes mouth and throat
(this is a very rare side effect).
• An allergic reaction with joint pain, skin rashes, high temperature (fever) (this is a
rare side effect).
• Yellowing of the skin and whites of the eyes. If you get such symptoms, you
should stop taking Purinethol.
• Any signs of a high temperature or infection (feeling very tired or unwell, sore
throat, sore mouth or urinary problems) or any unexplained bruising or bleeding.
Treatment with Purinethol affects your bone marrow and will cause a reduction in
your white blood cells and platelets (this is a very common side effect).

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to
have a baby, ask your doctor for advice before taking this medicine.
Pregnancy
Treatment with Purinethol is not recommended during pregnancy, particularly in the
first trimester (three months) because it may cause damage to the foetus. If you are
pregnant your doctor will consider the risks and benefits to you and your baby
before prescribing Purinethol for you.
If you or your partner are taking Purinethol, you must use a reliable form of
contraception to avoid pregnancy for the whole course of Purinethol treatment and
for at least 3 months after receiving the last dose of Purinethol. This applies to
both men and women.
Breast-feeding
Is it recommended that you do not breast-feed when you are taking Purinethol.
Driving and using machines
It is not expected that Purinethol will affect your ability to drive or use machines, but
no studies have been done to confirm this.
Purinethol tablets contain lactose
If you have been told by your doctor that you have an intolerance to some sugars,
contact your doctor before you take Purinethol tablets.

If you take more Purinethol than you should
If you take more Purinethol than you should, tell your doctor immediately or go to
ahospital straight away. Take the medicine pack with you.
If you forget to take Purinethol
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
If you stop taking Purinethol
If you stop taking Purinethol, tell your doctor immediately.

4 Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody
gets them.

Talk to your doctor if you have any of the following side effects, which may also
happen with this medicine:
Common (may affect up to 1 in 10 people)
• Nausea (you feel sick) or vomiting (being sick)
• Low red blood cell count (anaemia)
Uncommon (may affect up to 1 in 100 people)
• Loss of appetite
Rare (may affect up to 1 in 1,000 people)
• Mouth ulcers
• Inflammation of the pancreas (pancreatitis); symptoms may include abdominal
pain or feeling or being sick
• Damage to your liver (hepatic necrosis)
• Hair loss
• Various types of cancers including blood, lymph and skin cancers

Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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