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Active substance(s): MEFENAMIC ACID

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3. How to take

Ponstan Capsules 250 mg
Mefenamic acid


Read all of this leaflet carefully before you start using this medicine.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as
If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:
1. What this medicine is and what it is used for
2. Before you take
3. How to take
4. Possible side effects
5. How to store
6. Further information

1. What this medicine is and what
it is used for
Ponstan capsules contain mefenamic acid which is a
non-steroidal anti-inflammatory drug (NSAID).
They can help to relieve:
symptoms of inflammation, such as redness and swelling
pain and discomfort caused by arthritis, muscular or
rheumatic disorders
headache, muscle ache or toothache
pain after operations, trauma
childbirth pain
fever in children
painful or heavy periods.

2. Before you take
Do NOT take Ponstan if you:
are allergic to mefenamic acid, to any other
anti-inflammatory medicines (such as aspirin, ibuprofen,
celecoxib), or to any of the other ingredients (see Section 6)
have, or have ever had, stomach or intestinal conditions such
as peptic ulcer, bleeding in the stomach or severe gastritis
have an inflammatory bowel disease (e.g. ulcerative colitis,
Crohn's disease)
have severe heart, liver or kidney problems
have just had heart bypass surgery
are more than 6 months pregnant.
If any of the above apply to you, speak to your doctor or
Take special care with Ponstan
Before taking the capsules, tell your doctor if you:
are taking any other NSAIDs (e.g. ibuprofen, diclofenac)
are taking any other anti-inflammatory medicines including
steroids (e.g. prednisolone)
are taking aspirin or medicines that thin the blood (e.g.
warfarin, clopidogrel)
are taking antidepressants called selective serotonin
re-uptake inhibitors (SSRIs) (e.g. paroxetine)
have kidney or liver problems. Your doctor may check your
kidney or liver function before and during treatment
are elderly (see Section 3)
are trying to become pregnant (see Section on Fertility)
have stomach or digestive tract problems or if you have ever
had an upset stomach after taking pain killers such as
aspirin. Bleeding in the stomach or gut can occur in patients
taking Ponstan
have a bleeding disorder or if you are going to have a major
operation. Ponstan can affect the clotting of your blood. It
can make you bleed more and for longer than usual
have asthma, or a history of asthma, as this medicine may
cause breathing difficulties
have a connective tissue disorder, e.g. Systemic Lupus
Erythematosus (SLE)
have epilepsy
are dehydrated (thirsty with dry skin, dark urine, dry mouth,
have heart problems, previous stroke or think that you might
be at risk of these conditions (e.g. if you have high blood
pressure, diabetes or high cholesterol or are a smoker).
Additional monitoring may be carried out by your doctor.
Medicines such as Ponstan may be associated with a small
increased risk of heart attack or stroke. Any risk is more
likely with high doses and prolonged treatment. Do not
exceed the recommended dose or duration of treatment.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription, and herbal preparations.
Some medicines may be affected by Ponstan or they may affect
how well Ponstan will work. Tell your doctor or pharmacist if you
are taking:
medicines that can increase the chance of getting ulcers or
a bleed in the stomach or gut, such as:
- corticosteroids used to treat arthritis and inflammation
- medicines such as anti-platelet agents, used to thin the
blood (e.g. warfarin, aspirin, clopidogrel)
- antidepressants called selective serotonin re-uptake
inhibitors (SSRIs) (e.g. paroxetine)
- any other anti-inflammatory medicines (e.g. diclofenac,
aspirin including low doses of aspirin used to prevent your
blood from clotting in certain heart conditions
medicines used for high blood pressure (e.g. atenolol,
ramipril, valsartan)
diuretics (water tablets) or heart medicines (e.g. digoxin,
sotalol, diltiazem)
some diabetic medicines such as (e.g. glipizide,
medicines which suppress the immune system (e.g.
ciclosporin, tacrolimus, methotrexate)
lithium, a medicine used to treat mood swings and some
types of depression
a medicine usually prescribed through hospitals, called
mifepristone (taken within the last 12 days)
quinolone antibiotics (antibiotics used to treat infections)
aminoglycoside antibiotics, used under medical supervision
in hospitals
zidovudine, a medicine used for HIV
probenecid, a medicine used in special cases, to protect the
medicines which bind to protein in the blood - (check with
your pharmacist).
Blood tests
Your doctor may test your blood during treatment.
Pregnancy and breast-feeding
Mefenamic acid will be passed to your unborn baby. It is not
known how much it will affect your unborn baby in the first
6 months of pregnancy.
DO NOT take the capsules in the last 3 months of pregnancy
as they may delay the onset of labour and prolong its duration.
They may also increase the likelihood of bleeding in the
mother and in the baby.
If you need to take these capsules, your doctor can help you
decide whether or not to take them during the first 6 months of
Mefenamic acid passes into breast milk and can affect the
baby. You should not take the capsules while breast-feeding
unless advised by your doctor.
DO NOT take the capsules if you are trying to become
pregnant, as they may make it more difficult to get pregnant.
You should inform your doctor if you are planning to become
pregnant or if you have problems becoming pregnant.
Ask your doctor for advice before taking any medicine.
Driving and using machines
Ponstan may cause drowsiness, dizziness, fatigue or affect your
vision. If any of these occur do not drive, use machinery, or
perform any tasks that may require you to be alert.
Important information about some of the ingredients of
Ponstan Capsules
If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before taking
this medicine.
Continued over page


Always take Ponstan capsules exactly as your doctor has told you
and always read the label. Your doctor will decide on the
appropriate dose to suit your condition. Ask your doctor or
pharmacist if you are not sure.
Take the capsules with or immediately after a meal.
Do NOT drink alcohol while taking Ponstan.
Alcohol and smoking can irritate the stomach and make some
of the side effects worse.
Adults and the elderly: the usual dose is 2 capsules three
times a day.
Elderly patients are at a higher risk of side effects and should
take the lowest effective dose for the shortest possible time,
with additional monitoring carried out by their doctor.
Children: this medicine is NOT suitable for children under 12
If you take more than you should
If you take more capsules than you should you may harm your
stomach, kidneys and you may get seizures (fits).
1. Tell your doctor, pharmacist or nearest hospital casualty
department immediately.
2. Take the container and any remaining capsules with you so
that people can see what you have taken.
3. Do this even if you feel well.
If you forget to take
If you forget to take a dose take it as soon as you remember, but
if it is almost time for your next dose, skip the missed dose and
continue as usual.
Do not use a double dose to make up for a missed dose.
If you have any further questions on the use of this product, ask
your doctor or pharmacist.

4. Possible side effects
Like all medicines, Ponstan capsules can cause side effects,
although not everybody gets them. Do not be alarmed by this
list of possible side effects. You may not experience any of them.

STOP taking the capsules and seek medical help immediately
if you have any of the following allergic reactions:
difficulty breathing or swallowing, swelling of the face, lips,
tongue or throat
severe itching of the skin, with a red rash or raised lumps
blistering of the mouth, eyes, and genital region, and patchy
areas of rash, peeling skin
or any of the following reactions
passing blood in your stools (faeces/motions)
passing black tarry stools
vomiting any blood or dark particles that look like coffee
Seek immediate medical attention if you have any of the
following symptoms:
indigestion or heartburn, abdominal pain (pain in your
stomach) or other abnormal stomach symptoms, nausea
(feeling sick), vomiting
any unusual bruising or bleeding, for example nose-bleeds,
pinpoint red spots on the skin, unusual purple bruise-like
rash on the skin or in the mouth
signs of anaemia such as feeling tired, breathless, and
looking pale
fever, sore throat, mouth ulcers, repeated infections or
infections that will not go away. This may be due to a low
level of white blood cells
seizures (fits)
signs of low sodium levels such as headache, nausea,
vomiting, tiredness, muscle cramps
sudden headache, stiff neck, fever, sensitivity to bright light,
drowsiness and muscle pain, with or without a rash
fever, rash, nausea, aches and pains, passing more or less
urine than usual, passing red urine or passing urine at night.
This may be due to changes in your kidneys
sudden loss or blurring of vision, loss of colour vision, eye
pain which worsens with eye movement
headache, in particular on waking in the morning. This may
be due to high blood pressure
pain behind the ribs radiating towards the back, often worse
when lying down, nausea, vomiting, fever. This may be due
to inflammation of your pancreas
yellowing of your skin or eyes, pale faeces and dark urine,
unexplained persistent nausea, stomach problems, loss of
appetite or unusual tiredness. This may be due to changes in
your liver.


Tell your doctor if you get any of the following side effects:
head-spins (vertigo)
fatty stools
inability to sleep
rapid heartbeat (palpitations)
mental confusion
ear pain
loss of appetite
constipation or bloating
blurred vision, eye irritation
feeling ill (malaise)
ringing or buzzing in the ears (tinnitus)
numbness or tingling in hands or feet
sudden poor blood sugar control if you have
diabetes. Your doctor or pharmacist can
measure your sugar levels
asthma or asthma that is worse than usual
swelling of your hands and feet (around the ankles)
sore mouth (pain or ulcers on the tongue, cheeks, lips, throat
or gums)
dizziness, drowsiness, feeling lethargic and tired
signs of low blood pressure such as light-headedness
reactions to the sun. Your skin may become red, painful and
swollen - do not sunbathe, use a sun bed, or expose your
skin to artificial UV light.
Medicines such as Ponstan may be associated with a small
increased risk of heart attack or stroke. (See Section 2 - end of
'Take special care').
Urine tests: Tell the doctor if you are having urine tests, as your
medicine may affect the results.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow Card
Scheme at:
By reporting side effects you can help provide more information
on the safety of this medicine.

5. How to store
Keep out of the reach and sight of children.
Do not take after the expiry date which is stated on the blister,
carton/bottle/container. The expiry date refers to the last day of
that month.
Do not store above 25ºC. Store in the original package.
Do not throw it away with your household waste or in water.
Return all the unwanted medicine to your pharmacist. This will
help to protect the environment.

6. Further information
What Ponstan Capsules contain
The active ingredient is mefenamic acid (250 mg).
The other ingredients are:
lactose monohydrate, sodium laurilsulfate, gelatin, water.
The capsule shell contains:
gelatin, erythrosine, quinoline yellow, titanium dioxide,
patent blue V.
The printing ink contains either shellac, black iron oxide
(E172), propylene glycol (E1520), ammonium hydroxide
(E527), or shellac, propylene glycol (E1520), strong
ammonia solution, potassium hydroxide (E525), black iron
oxide (E172).
(See end of Section 2 for further information on lactose).
What Ponstan Capsules look like and contents of the pack
Ponstan Capsules are ivory and blue hard gelatin capsules
marked 'Ponstan 250'.
They are available in blister packs containing 6, 10, 12, 20, 30,
50, 100, or 168 capsules and in containers of 100 or 500
Not all types and pack sizes may be marketed.
Marketing Authorisation Holder
Chemidex Pharma Ltd, Chemidex House, Egham Business
Village, Crabtree Road, Egham, Surrey, TW20 8RB.
Dales Pharmaceuticals Ltd, Snaygill Industrial Estate, Keighley
Road, Skipton BD23 2RW.
This leaflet was last revised in
April 2015
'Ponstan' and 'Chemidex' are trade marks.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.