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Persantin® Retard 200mg Capsules

Your medicine is known by the above name, but will be referred to as
Persantin Retard throughout this:
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to
others. It may harm them, even if their symptoms are the same as
• If any of the side effects gets troublesome or serious, or if you
notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
In this leaflet:
1) What Persantin Retard is and what it is used for
2) Before you take Persantin Retard
3) How to take Persantin Retard
4) Possible side effects
5) How to store Persantin Retard
6) Further information

1) What Persantin Retard is and what it is used for
The name of your medicine is Persantin Retard. It contains a medicine
called Dipyridamole. This belongs to a group of medicines called ‘antithrombotic agents’, which are used to help stop blood clots forming.
Persantin Retard is used:
• To help stop blood clots which may occur if you have had your heart
valves replaced.
• In people who have had a stroke caused by a blood clot in the brain.
This medicine reduces the risk of having another stroke.

2) Before you take Persantin Retard
Do not take Persantin Retard if you are allergic (hypersensitive) to:
• Dipyridamole
• Any of the other ingredients of Persantin Retard (see section 6: Further
Take special care with Persantin Retard
Check with your doctor or pharmacist before taking your medicine if:
• You have angina or other heart problems (including heart valve or
circulation problems) or have had a recent heart attack
• You have myasthenia gravis (a rare muscle problem)
• You have any bleeding problems
• You are pregnant or planning to become pregnant or are breastfeeding
If you are not sure if any of the above apply to you, talk to your doctor or
pharmacist before taking Persantin Retard.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently
taken any other medicines, including medicines obtained without a
prescription. This includes herbal medicines. This is because Persantin
Retard can affect the way some other medicines work. Also some other
medicines can affect the way Persantin Retard works.
In particular, tell your doctor or pharmacist if you are taking any of the
following medicines:
• Medicines for high blood pressure
• Medicines for muscle weakness such as something called a
‘cholinesterase inhibitor’
• Aspirin (or planning to take aspirin for any condition)
• Adenosine injection - used for heart problems or tests on the heart
• Warfarin or other medicines to stop blood clots forming. If so, tell them
at your next visit to the anticoagulant clinic that you are now taking
Persantin Retard
If you are having heart tests
Persantin Retard contains dipyridamole. Dipyridamole is also sometimes
given as an injection during tests to see if the heart is working properly
(also called ‘myocardial imaging’). This means that the test and your
medicine may contain the same substance. If you are going to have an
injection of dipyridamole, tell the doctor that you are taking Persantin
Pregnancy and breast-feeding
• Tell your doctor if you are pregnant or planning to get pregnant.
• Tell your doctor if you are breast-feeding as Persantin Retard should
only be used during breast-feeding if your doctor considers it essential.
Driving and using machines
You may feel dizzy while taking Persantin Retard. If this happens do not
drive or use any tools or machines.

3) How to take Persantin Retard
Always take this medicine exactly as your doctor has told you. You should
check with your doctor or pharmacist if you are not sure.
The usual dose is:
• One capsule twice a day
• Usually one in the morning and one in the evening
• It is best to take it with food
• Swallow the capsule whole
• Do not crush or chew it
Do not give to children.
If you take more Persantin Retard than you should
If you take more of this medicine than you should, talk to a doctor or go to
a hospital straight away. Take the medicine pack with you, even if there
are no capsules left.

If you forget to take Persantin Retard
• If you forget a dose, take it as soon as you remember it
• However, if it is time for the next dose, skip the missed dose
• Do not take a double dose to make up for the forgotten dose
If you have any further questions on the use of this product, ask your
doctor or pharmacist.

4) Possible side effects
Like all medicines Persantin Retard can cause side effects, although not
everybody gets them.
Allergic reactions
If you have an allergic reaction, stop taking your medicine and see a doctor
straight away. The signs may include feeling breathless, runny nose,
severe rash with itching, swelling and swelling around the eyes.
Other side effects that have been reported for Persantin Retard are
described below. They are listed as either very common, common, or not
Very common (affects more than 1 in 10 people)
• Headache
• Feeling dizzy
• Feeling sick (nausea)
• Diarrhoea
Common (affects less than 1 in 10 people but more than 1 in 100 people)
• Muscle pain
• Being sick (vomiting)
• Worsening of the symptoms of heart disease such as chest pain and
shortness of breath
Not Known
• Hot flushes
• Lowering of blood pressure or increased heart rate
• A blood problem called ‘thrombocytopenia’ which can cause bruising
and prolonged bleeding from wounds, including during or after surgery
In people who have gallstones, the dipyridamole in this medicine can be
absorbed into the gallstones.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at: By reporting side effects you can help
provide more information on the safety of this medicine.

5) How to store Persantin Retard

Keep all medicines out of the sight and reach of children.
Do not use after the expiry date printed on the carton label or container
label. The expiry date refers to the last day of that month.

Persantin Retard 200mg Capsules should be stored below 25°C. Any
capsules unused after 6 weeks should either be discarded safely or
returned to your pharmacist.
If the capsules become discoloured or show any other signs of
deterioration, you should seek the advice of your pharmacist who will
tell you what to do.
Medicines should not be disposed of via wastewater or household
waste. Ask your pharmacist how to dispose of medicines no longer
required. These measures will help to protect the environment.

6) Further information
What Persantin Retard contains
Each capsule contains 200mg of the active ingredient, dipyridamole in a
modified release formulation.
The capsules also contain the following ingredients:
Tartaric acid, povidone, methacrylic acid-methyl methacrylate co-polymer,
hypromellose phthalate, acacia, triacetin, talc, stearic acid, dimethicone
300, hypromellose, gelatin, erythrosine (E127), red and yellow iron oxide
(E172), and titanium dioxide (E171).
What Persantin Retard looks like and contents of the pack
Each hard gelatin capsule has a red cap and an orange body and is
Persantin Retard 200mg Capsules are available as packs of 30 or 60
PL 10383/0854


Who makes and repackages your medicine?
Your medicine is manufactured by Boehringer Ingelheim Pharma KG,
Birkendorfer Strasse 65, 88397 Biberach an der Riss, Germany. Procured
from within the EU and repackaged by Product Licence Holder:
Primecrown Ltd., 4/5 Northolt Trading Estate, Northolt, Middlesex UB5
Leaflet date: 03.04.2017
Persantin® is a trademark of Boehringer Ingelheim Pharma GmbH & Co.
KG, Germany.

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Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.