Skip to Content

UK Edition. Click here for US version.


Active substance(s): DIPYRIDAMOLE

View full screen / Print PDF » Download PDF ⇩


Persantin Retard 200 mg Modified Release,
Hard Capsules
Patient Information Leaflet
This medicine is available using the above name but will be
referred to as Persantin Retard throughout this leaflet.
Read all of this leaflet carefully before you start
taking this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
- If any of the side effects gets troublesome or serious,
or if you notice any side effects not listed in this
leaflet, please tell your doctor or pharmacist.
In this leaflet:
1) What Persantin Retard is and what it is used for
2) Before you take Persantin Retard
3) How to take Persantin Retard
4) Possible side effects
5) How to store Persantin Retard
6) Further information

The name of your medicine is Persantin Retard. It contains a
medicine called Dipyridamole. This belongs to a group of
medicines called ‘anti-thrombotic agents’, which are used to
help stop blood clots forming.

Persantin Retard is used:
• To help stop blood clots which may occur if you have
had your heart valves replaced.
• In people who have had a stroke caused by a blood
clot in the brain. This medicine reduces the risk of
having another stroke.

Do not take Persantin Retard if you are allergic
(hypersensitive) to:
• Dipyridamole
• Any of the other ingredients of Persantin Retard (see
section 6: Further Information)

Take special care with Persantin Retard
Check with your doctor or pharmacist before taking your
medicine if:
• You have angina or other heart problems (including
heart valve or circulation problems) or have had a
recent heart attack
• You have myasthenia gravis (a rare muscle problem)
• You have any bleeding problems
• You are pregnant or planning to become pregnant or
are breast-feeding
If you are not sure if any of the above apply to you, talk to
your doctor or pharmacist before taking Persantin Retard.

In particular, tell your doctor or pharmacist if you are taking
any of the following medicines:
• Medicines for high blood pressure
• Medicines for muscle weakness such as something
called a ‘cholinesterase inhibitor’
• Aspirin (or planning to take aspirin for any condition)
• Adenosine injection - used for heart problems or tests
on the heart
• Warfarin or other medicines to stop blood clots
forming. If so, tell them at your next visit to the
anticoagulant clinic that you are now taking Persantin
If you are having heart tests
Persantin Retard contains dipyridamole. Dipyridamole is also
sometimes given as an injection during tests to see if the
heart is working properly (also called ‘myocardial imaging’).
This means that the test and your medicine may contain the
same substance. If you are going to have an injection of
dipyridamole, tell the doctor that you are taking Persantin
Pregnancy and breast-feeding
• Tell your doctor if you are pregnant or planning to get
• Tell your doctor if you are breast-feeding as Persantin
Retard should only be used during breast-feeding if
your doctor considers it essential.
Driving and using machines
You may feel dizzy while taking Persantin Retard. If this
happens do not drive or use any tools or machines.

Always take this medicine exactly as your doctor has told you.
You should check with your doctor or pharmacist if you are
not sure.
The usual dose is:
• One capsule twice a day
• Usually one in the morning and one in the evening
• It is best to take it with food
• Swallow the capsule whole
• Do not crush or chew it
Do not give to children.

If you take more Persantin Retard than you should
If you take more of this medicine than you should, talk to a
doctor or go to a hospital straight away. Take the medicine
pack with you, even if there are no capsules left.

If you forget to take Persantin Retard
• If you forget a dose, take it as soon as you remember
• However, if it is time for the next dose, skip the missed
• Do not take a double dose to make up for the forgotten
If you have any further questions on the use of this product,
ask your doctor or pharmacist.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription. This includes herbal
medicines. This is because Persantin Retard can affect the
way some other medicines work. Also some other medicines
can affect the way Persantin Retard works.

Continued overleaf

Like all medicines Persantin Retard can cause side effects,
although not everybody gets them.
Allergic reactions
If you have an allergic reaction, stop taking your medicine and
see a doctor straight away. The signs may include feeling
breathless, runny nose, severe rash with itching, swelling and
swelling around the eyes.

Other side effects that have been reported for Persantin
Retard are described below. They are listed as either very
common, common, or not known.
Very common (affects more than 1 in 10 people)
• Headache
• Feeling dizzy
• Feeling sick (nausea)
• Diarrhoea

Common (affects less than 1 in 10 people but more than 1 in
100 people)
• Muscle pain
• Being sick (vomiting)
• Worsening of the symptoms of heart disease such as
chest pain and shortness of breath.


What Persantin Retard looks like and contents of the
Hard gelatine capsules consisting of a red cap and an orange
Persantin Retard is available in packs of 60 capsules.
Product Licence Holder
Procured from within the EU. Product Licence Holder Ginova
Ltd, repackager Ginova UK Ltd, both of St James' House, 8
Overcliffe, Gravesend, Kent, DA11 0HJ.
Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer
Strasse 65, Biberach D-88397, Germany

Persantin Retard 200 mg Modified Release, Hard
PL No: 18067/0429

Persantin is a registered trademark Boehringer Ingelheim
Pharma GmbH & Co. KG.

This leaflet was last approved on 11 June 2015.
To request a copy of this leaflet in Braille, large print or audio
please call 01622 690172.

Not Known
• Hot flushes
• Lowering of blood pressure or increased heart rate
• A blood problem called ‘thrombocytopenia’ which can
cause bruising and prolonged bleeding from wounds,
including during or after surgery
In people who have gallstones, the dipyridamole in this
medicine can be absorbed into the gallstones.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme at:
By reporting side effects, you can help provide more
information on the safety of this medicine.

• Keep out of the sight and reach of children.
• Do not store above 30°C.
• Keep the bottle tightly closed.
• Store in the original package.
• Protect from moisture.
• Do not use Persantin Retard after the expiry date
which is stated on the carton and container label after
EXP. The expiry date refers to the last day of that
• Do not open the container until you are ready to start
taking the capsules. If you have any capsules left after
six weeks, these should not be taken.
• Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose
of medicines no longer required. These measures will
help protect the environment.
What Persantin Retard contains
The active substance is dipyridamole.
Each modified release capsule contains 200 mg dipyridamole.
Persantin Retard is a modified release capsule which
releases the active substance slowly in your body over a
number of hours.

The other ingredients in Persantin Retard are: hypromellose,
tartaric acid, arabic gum, povidone, Eudragit, hypromellose
phthalate, dimethicone, triacetin, talc and stearic/palmitic acid.
The capsule shells contain gelatin, titanium dioxide (E171),
red iron oxide (E172) and yellow iron oxide (E172).


Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.