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Active substance(s): GLYCERYL TRINITRATE

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Percutol Ointment

Read all of this leaflet carefully before you start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them,
even if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
In this leaflet:
1. What Percutol Ointment is and what it is used for
2. Before you use Percutol Ointment
3. How you use Percutol Ointment
4. Possible side effects
5. How to store Percutol Ointment
6. Further information

1 What Percutol Ointment is and
what it is used for

Percutol Ointment contains the active ingredient
glyceryl trinitrate 2%. Glyceryl trinitrate belongs to the
group of medicines known as vasodilators (widens
blood vessels). When Percutol Ointment is applied to
the skin, glyceryl trinitrate is slowly absorbed. When in
the bloodstream, glyceryl trinitrate widens blood
vessels in the body, which allows blood to flow more
easily. The heart gets more blood and also does not
need to work so hard to keep the blood flowing.
Percutol Ointment is used to prevent angina pectoris
(the chest pain caused by not enough blood getting to
the heart).

2 Before you use Percutol Ointment

Do not use Percutol Ointment if you
• are allergic (hypersensitive) to glyceryl trinitrate,
other nitrates (similar drugs) or any of the other
ingredients of Percutol Ointment (see list of
ingredients in Section 6). An allergic reaction may
include rash, itching, difficulty breathing or swelling
of the face, lips, throat or tongue.
• are taking medicines for failure to achieve an
erection such as Viagra (sildenafil), Levitra
(vardenafil), Cialis (tadalafil) or Caverject (alprostadil)

• have severe anaemia (a low red blood cell count)
• have ever had a serious head injury or have raised
intra cranial pressure (an increased pressure in
the skull)
• if you have cerebrovascular disease (previous stroke
or transient ischaemic attack - TIA)
• if you have toxic pulmonary oedema (increased
pressure in blood vessels supplying blood to the
• have problems with any of your heart valves
• suffer from inflammation of the heart lining
• suffer from increased fluid around the heart
• suffer from a heart condition called hypertrophic
obstructive cardiomyopathy
• have low blood pressure or low blood volume
• have an acute angina attack.
Take special care with Percutol Ointment
• if you have Glaucoma, check with your doctor that
it is safe to use
• if you have recently had alcohol (effect of Percutol
Ointment may be increased)
• when standing up suddenly, as you may get dizzy
(especially if you are elderly)
• if you suffer from hypoxaemia (insufficient oxygen in
your blood)
• if you have an underactive thyroid gland
• if you suffer from malnutrition
• if you have hypothermia (a very low body
• if you have any diseases of the lungs, liver
or kidneys
• if you have recently had a heart attack or you suffer
from heart failure.

Please tell your doctor if any of the above applies
to you.
Taking other medicines
Please tell your doctor or pharmacist if you are taking,
or have recently taken, any other medicines, including
medicines obtained without a prescription. This is
especially important of the following medicine (see
‘Do not use’ above):
• medicines used to treat erectile problems such as
Viagra (sildenafil), Levitra (vardenafil), Cialis
(tadalafil) or Caverject (alprostadil).
• medicines used to treat angina, heart failure or an
irregular heart beat
• alpha blockers (a type of medicine used to treat high
blood pressure and also to relieve the symptoms of
an enlarged prostate)
• other medicines used to treat high blood pressure
such as beta blockers, ACE inhibitors, calcium
channel blockers, angiotensin 2 receptor
antagonists, clonidine, or other vasodilators
(medicines that relax the blood vessels, e.g.
hydralazine, moxonidine, sodium nitroprusside,
• muscle relaxants (baclofen, tizanidine)
• medicines used for diseases affecting the brain
and central nervous system including anxiety
and depression, migraine, epilepsy and
Parkinson’s disease
• aldesleukin (a medicine used for certain cancers)
• moxisylyte (a medicine used for Reynaud’s disease)
• diuretics (water tablets)
• medicines used to treat pain and inflammation (e.g.
aspirin, non-steroidal anti-inflammatory drugs,
• certain hormones used in hormone replacement
therapy and for contraception (‘The Pill’).
Pregnancy and breast-feeding
Do not use Percutol Ointment while pregnant or while
breast-feeding unless your doctor tells you to.
Ask your doctor or pharmacist for advice before taking
any medicine.

Driving and using machines
Percutol Ointment may cause dizziness. If this
happens you should not drive or use machines.
You should wait until the effects of the treatment are
known before driving or using any machines.
Important information about some of the
ingredients of Percutol Ointment
Percutol Ointment contains lanolin. Lanolin may cause
local skin reactions (e.g. contact dermatitis).

3 How you use Percutol Ointment

Always take Percutol Ointment exactly as your doctor
has told you. You should check with your doctor or
pharmacist if you are not sure.
Adults and the elderly
The usual dose is 1 to 2 inches squeezed from the
tube. This dose may be repeated every 3 to 4 hours
as needed.
Half an inch of ointment should be applied on the first
day, increasing by half an inch per day until headache
occurs. This dose is then reduced by half an inch. If
several applications per day are needed, the dose may
be reduced.
Percutol is not recommended for children.
Method of administration
The ointment may be measured and applied using
the paper ‘Applirules’ enclosed in the carton.
After squeezing the required length of ointment onto
the ‘Applirule’ it should be pressed on to the chest,
thigh, or arm until the ointment is spread in a thin
layer under the paper. The ointment should not be
rubbed in. The ‘Applirule’ may be kept in place with
surgical tape.
If you use more Percutol Ointment than
you should
Wash the ointment off the skin then contact your
doctor or go to your nearest hospital immediately.
The symptoms of overdose include headache,
dizziness, and collapse.

If you forget to use Percutol Ointment
If you miss an application, use the application as soon
as possible. However, if it is nearly time for your next
application, skip the missed application and carry on
as before. Do not use a double application to make up
for a forgotten application.
If you stop using Percutol Ointment
You should not stop treatment suddenly. If your
doctor tells you to stop treatment, you will be told to
reduce the dose and number of doses gradually over
4-6 weeks.
If you have any further questions on the use of this
product, ask your doctor or pharmacist.

4 Possible side effects

Like all medicines, Percutol Ointment can cause side
effects, although not everybody gets them.
All medicines can cause allergic reactions, although
serious allergic reactions are very rare. Tell your
doctor straight away if you get any sudden
wheeziness, difficulty in breathing, swelling of
the eyelids, face or lips, rash or itching (especially
affecting your whole body).
The following side effects have been reported:
Very Common (affects more than 1 user in 10):
Common (affects 1 to 10 users in 100):
Feeling sick (Nausea), Vomiting
Uncommon (affects 1 to 10 users in 1,000):
Fainting (Syncope)
Burning sensation
Low blood pressure (Hypotension)
Circulatory Collapse
Allergic skin disorders including eczema, inflammation
of the skin, itching, hives and non specific rashes
Rare (affects 1 to 10 users in 10,000):
Increased heart rate (Tachycardia)
Decreased heart rate (Bradycardia) in the presence
of fainting
Very Rare (affects less than 1 user in 10,000):

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible side
effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card Scheme
By reporting side effects you can help provide more
information on the safety of this medicine.

5 How to store Percutol Ointment

Percutol Ointment should be kept out of reach and
sight of children.
Store below 25°C.
Do not use Percutol Ointment after the expiry date
which is stated on the carton. The expiry date refers to
the last day of that month.
Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose
of medicines no longer required. These measures will
help to protect the environment.

6 Further information

What Percutol Ointment contains
The active substance is glyceryl trinitrate 2%.
The other ingredients are: lanolin, purified water,
white petroleum and lactose.
What Percutol Ointment looks like and
contents of the pack
Percutol Ointment is a light yellow coloured ointment
and is in an aluminium tube containing 60g.
Marketing Authorisation Holder and Manufacturer
Aspire Pharma Ltd
Bellamy House, Winton Road, Petersfield,
Hampshire, GU32 3HA, United Kingdom
This leaflet was last revised in


Artwork for:
Product name:

Aspire Pharma Limited
Percutol Ointment

PL/PA no:
PL 35533/0020
Type: Leaflet
Artwork dimensions: 148mm x 210mm
Profile supplied: Yes
Date of first artwork: 12 May 2010
Reason for request: Text edits
Version no: 9.1
Date of revision:
16 January 2015
As swatch(es)
Text 8.25 FF Milo Headings 9.5pt FF Milo
Artwork software:
InDesign CS6
BAC ref:
S709 (formerly R650)


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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.