Skip to Content

UK Edition. Click here for US version.

PARNATE 10 MG TABLETS

Active substance(s): TRANYLCYPROMINE

View full screen / Print PDF » Download PDF ⇩
Transcript
500000/PL1a

Parnate® 10 mg Tablets
(tranylcypromine)

Patient Information Leaflet
The name of your medicine is Parnate 10 mg Tablets.
Throughout this leaflet it will be referred to as Parnate
Tablets.
Read all of this leaflet carefully before you start
taking this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or
pharmacist.
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
- If any of the side effects become serious, or if you
notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.
In this leaflet:
1. What Parnate Tablets are and what they are used for
2. Before you take Parnate Tablets
3. How to take Parnate Tablets
4. Possible side effects
5. How to store Parnate Tablets
6. Further information
1.WHAT PARNATE TABLETS ARE AND WHAT THEY ARE
USED FOR
Parnate Tablets contain the active substance tranylcypromine
which belongs to a group of antidepressant medicines known
as monoamine oxidase inhibitors (MAOIs). It works by
stopping the breakdown of two substances in the brain called
serotonin and noradrenaline. Your medicine should help bring
these substances back to normal levels.
Parnate Tablets are used to treat moderate to severe
depression. They can also help feelings of fear (phobia) which
sometimes occurs in depression. This medicine is often used
when other types of antidepressant medicines have not
worked.
2. BEFORE YOU TAKE PARNATE TABLETS
DO NOT take Parnate Tablets if:
• You know that you are allergic to tranylcypromine or
any of the other ingredients of Parnate Tablets (see
section 6 of this leaflet)
• You are taking clomipramine, imipramine and
venlafaxine
• You suffer from porphyria which is an inherited disease
affecting the nervous system and skin
• You have severe heart disease or any disease of the
blood vessels of the brain
• You have pheochromocytoma which is a tumour of the
adrenal glands (glands near the kidneys) causing high
blood pressure
• You have known liver damage or a disorder affecting
the blood cells (your doctor will know)
• You are pregnant, trying to become pregnant or
breast-feeding
• You are in a manic phase
• You are taking any of the medicines listed under “Do
not take” in the Taking Other Medicines section of this
leaflet.
Please tell your doctor if any of the above applies to you.
Take special care with Parnate Tablets and talk to your
doctor if you:
• are elderly
• have a mild heart problem which restricts your activity
• suffer from seizures/fits (epilepsy)
• suffer from diabetes mellitus (sugar diabetes)
• suffer from blood disorders
• taking diuretics (water tablets)
• are due to have surgery in the next few weeks
• have depression or suicidal thoughts
• suffer from low blood pressure or high blood pressure
• suffer from schizophrenia
• have a history of dependence on drugs or alcohol.
Even though some of the above may be obvious, it is
important that your doctor is aware if any of them apply to
you.
Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription.

Parnate Tablets MUST NOT be taken with the following
medicines:
• Medicines called sympathomimetic agents - these
include ephedrine, pseudoephedrine, adrenaline and
noradrenaline (these may be found in medicines used
to treat heart problems and asthma as well as some
decongestants and cough/cold remedies e.g.
dextromethorphan bought without a prescription)
• Bupropion, a medicine to help you stop smoking
• Medicines for migraine e.g. 5HT1 agonists
• Strong pain killers e.g. pethidine, morphine, codeine
and nefopam
• It should not be administered at the same time as, or
within 14 days of treatment with other MAOIs such as
isocarboxid, buspirone, or dibenzazepine derivative
drugs (including tricyclic antidepressant agents,
perphenazine or carbamazepine)
• Medicines used to treat depression (e.g. clomipramine,
imipramine, venlafaxine)
• Tranylcypromine should not be administered together
with clomipramine and imipramine. In the cases of
clomipramine and imipramine, 3 weeks should be left
before starting tranylcypromine therapy.
• Tranylcypromine should not be administered in
combination with selective serotonin reuptake
inhibitors
(SSRIs)
e.g.,
fluoxetine
or
serotonin/noradrenaline reuptake inhibitors (SNRIs)
e.g. venlafaxine. Therefore SSRIs and SNRIs should
not be used in combination with an MAOI, or within 14
days of discontinuing therapy with an MAOI.
• Buspirone, used to treat anxiety
• Medicines to treat seizures/fits, e.g. carbamazepine
• Perphenazine used to treat schizophrenia
• Guanethidine used to treat high blood pressure
• SSRIs such as fluoxetine, paroxetine or sertaline (for
depression)
• Medicines like altretamine used for the treatment of
cancer
• Doxapram used to increase the rate of breathing,
especially during surgery
• Medicines like oxypertin, clozapine used for the
treatment of mental disorders like schizophrenia
• Tetrabenazine used for the treatment of excessive
restlessness.
Parnate Tablets must be taken with caution if you are
taking the following medicines:
• Barbiturates used to treat severe sleeping problems,
e.g. amylobarbitone
• Medicines used to treat depression (e.g. amitriptyline,
imipramine, tryptophan, amfebutamone)
• Phenylpropanolamine used to treat nasal congestion
associate with allergies
• Medicines for high blood pressure (e.g. reserpine,
methyldopa)
• Medicines to control appetite, e.g. amphetamine and
fenfluramine
• Antimuscarinics for motion sickness, muscle cramps in
the gut or bladder
• Medicines that treat Parkinson’s disease, e.g.
levodopa
• Dopamine, a medicine used to treat certain heart
conditions
• Local anaesthetics e.g. lidocaine
• Medicines to treat diabetes (e.g. insulin, metformin).
At least 5 weeks should be allowed after stopping fluoxetine
before starting Parnate Tablets.
At least 2 weeks should be allowed after stopping paroxetine
before starting Parnate Tablets.
Taking Parnate Tablets with food and drink:
You should NOT take alcohol (especially red wine) whilst you
are taking Parnate Tablets. This includes non-alcoholic beer
or lager.
Parnate Tablets stops the breakdown of a substance called
tyramine which is found in large amounts of certain foods. If
this substance is not broken down, it can cause very high
blood pressure. So, whilst you are taking
Parnate Tablets, you should avoid the following foods:
• Matured cheeses – cooked or plain (e.g. cheddar or
processed cheese made from mature cheese)
• Yeast extracts (e.g. Bovril, Oxo, brewer’s yeast or
Marmite)
• Meat, fish or poultry which is not fresh or has been
pickled or aged e.g. hung game, pickled herrings
• Broad bean pods
• Flavoured textured vegetable protein
• Protein foods that are not fresh and whose preparation
involved hydrolysis, fermentation, pickling, hanging,
smoking or bacterial contamination e.g. dry sausage
(salami, pepperoni etc.), fermented soya bean extract,
liver, yoghurt
• Excessive amounts of chocolate
• Excessive amounts of tea or coffee.

Continued overleaf

Pregnancy and breast feeding:
Please let the doctor know if you are pregnant, think you
might be pregnant, are planning to become pregnant or are
breast-feeding. Parnate Tablets should NOT be used during
pregnancy or breast feeding unless your doctor thinks it is
essential. This medicine may pass into breast milk.
Ask your doctor or pharmacist for advice before taking any
medicine.
Driving and using machines:
Parnate Tablets may make you feel drowsy or dizzy or affect
your concentration. You should not drive or use machines
when you first start to take this medicine until you are certain
that you are not getting these side effects. If in any doubt,
speak to your doctor before you drive or use machines.
Important information about some of the ingredients of
Parnate Tablets:
This medicine also contains carmoisine (E122) and
Ponceau 4R (E124) which may cause allergic reactions.
This medicine also contains sucrose (a sugar). If you have
been told by your doctor that you have an intolerance to some
sugars, contact your doctor before taking this medicine.
If you have an operation or you need to go to the Dentist:
Parnate Tablets are not normally taken for two weeks before
an operation or major dentistry. Check with your doctor or
dentist and alert them to your medication.
3. HOW TO TAKE PARNATE TABLETS
Always take Parnate Tablets exactly as your doctor has told
you. Do NOT take more than your doctor tells you to. You
should check with your doctor or pharmacist if you are not
sure.
Swallow the tablets whole with a glass of water.
USUAL DOSE (Adults only)
• One tablet in the morning and one tablet in the
afternoon each day
• Try to take the last dose before 3 o’clock in the
afternoon
• This dose may be increased by your doctor to three
tablets a day. Take the extra tablet at midday
• If you are elderly your doctor will usually prescribe you
a lower dose.
When you start to feel better, your doctor may change your
dose to one tablet a day.
Do NOT take more than three tablets each day unless your
doctor tells you.
Children: Parnate Tablets are not recommended for children
under 18 years old.
If you take more Parnate Tablets than you should:
If you think that you, or any other person, have taken too
many tablets, contact your doctor or hospital casualty
department immediately. Take any remaining tablets and this
leaflet with you so that the medical staff know exactly what
you have taken.
If you forget to take your Parnate Tablets:
If you miss a dose, wait until your next dose. Do not take the
dose you have missed. You can then carry on as before.
Do not take more than one dose at a time.
If you stop taking Parnate Tablets:
Continue to take Parnate Tablets even if you no longer feel ill.
DO NOT STOP taking this medicine without talking with your
doctor first, especially if you have taken large doses for a long
time. When the time comes to stop your doctor will probably
decrease your dose gradually as stopping the tablets
suddenly may cause ill-effects such as nausea (feeling sick),
vomiting (being sick), sweating, vivid nightmares, fits,
worsening of symptoms and difficulty in sleeping.
If you have any further questions on the use of this medicine,
ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Parnate Tablets can sometimes cause
side effects, although not everybody gets them. If you eat
foods or take medicines which interact with the active
ingredient, tranylcypromine, you may get very high blood
pressure (a hypertensive crisis).
If you notice any of the following symptoms please see your
doctor immediately.
• frequent
headaches,
shakiness,
nervousness,
excessive happiness or excitement (euphoria), painful
or stiff neck, changes in heart rate, pain in the middle
of the chest, feeling sick or being sick, sweating,
paleness, or flushing of the skin and enlarged pupils
which may make bright sunlight uncomfortable, muscle
twitching, muscle jerks, increased reflexes, feeling
nervous or uneasy. Although very rare, muscle rigidity,
fever and irregular body movements (i.e. neuroleptic
malignant syndrome), severe problems with the heart
and breathing, changes in the metabolism may occur,
feeling of a lump in the throat, increased muscular
movements, coma
• thought of suicide and suicidal behaviour early on in
treatment or shortly after stopping treatment.

If this occurs contact your doctor or go to a hospital
straight away.
Very rarely, liver problems (symptoms include yellowing of the
skin and the whites of the eyes), bruising and changes in
blood have been reported. Therefore, if you get a bad sore
throat or high fever or become very tired and pale or notice
bruises and nose bleeds, tell your doctor. Sometimes patients
feel anxious whilst taking this medicine and rarely some
patients will become very agitated or irritable. Your doctor
may reduce your dose if this happens.
Other side effects which may occur include:
• difficulty in sleeping, mild headache, sleepiness,
weakness, dizziness, fast or irregular heart beat
(palpitations), restlessness, dry mouth, inability to
normally open mouth, blurred vision, feeling sick, water
retention or swelling, difficulty in passing stools, other
tummy problems, swelling, increase in the level of liver
enzymes on examination, squint in the eyes, decrease
in the blood cell count in the body, sexual problems,
confusion, reduced or increased levels of salt in the
body, repetition or echoing of one's own spoken words,
fits, glaucoma (increased pressure in the eyes) itching,
tingling or pricking of skin, altered driving abilities,
weight gain, increased appetite, rash, being sick,
diarrhoea, fatigue, hallucinations and difficulty in
passing water.
Some patients get low blood pressure and may feel dizzy on
standing up. If this continues for a long time, your doctor may
stop your medicine.
Rarely some patients experience soreness in the hands and
feet which may be a sign of inflamed nerves, spasm of the
axial muscles.
If any of the side effects become serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
You may find it helpful to tell a relative or close friend that
you are depressed or have anxiety disorder, and to ask
them to read this leaflet. You might ask them to tell you if
they think your depression or anxiety is becoming worse or if
they are worried about changes in your behaviour.
Also you can help to make sure that medicines remain as safe
as possible by reporting any unwanted side effects via the
internet at www.mhra.gov.uk/yellowcard. Alternatively you can
call Freephone 0808 100 3352 (available from 10 a.m. to
2 p.m. Mondays to Fridays) or fill in a paper form available
from your local pharmacy.
5. HOW TO STORE PARNATE TABLETS
• Keep this medicine out of the sight and reach of
children.
• Do not use Parnate Tablets after the expiry date which
is stated on the box. The expiry date refers to the last
day of that month. If your tablets are out of date, take
them to your pharmacist who will get rid of them
safely.
• Do not store above 25°C. Store in the original
container to protect from light and tightly closed to
protect from moisture.
• If you notice any sign of deterioration or discolouration
of your medicine, please tell your pharmacist
immediately.
6. FURTHER INFORMATION
Each coated tablet contains tranylcypromine sulphate
equivalent to 10 mg tranylcypromine.
Parnate Tablets also contains sucrose, maize starch, calcium
sulphate dihydrate (E516), carmellose sodium, magnesium
stearate (E470b). The coating contains gelatine, sucrose,
docusate sodium, purified talc (E553b), light kaolin (E559),
calcium carbonate (E170), ethylcellulose, acacia (E414),
carmoisine (E122), ponceau 4R (E124), maize starch,
titanium dioxide (E171), carnauba wax (E903) and edible ink
(shellac (E904), soya lecithin (E322), iron oxide black (E172)
and trace amounts of dimethyl siloxane).
What Parnate Tablets look like and contents of the pack
Parnate 10 mg tablets are geranium-red coloured, bi-convex,
sugar-coated tablets marked 'FW 251' on one face only. They
are packed in plastic containers with 28 tablets. Each
container has a desiccant cartridge.
Product Licence Holder
Procured from within the EU. Product Licence Holder Ginova
Ltd, repackager Ginova UK Ltd, both of St James' House,
8 Overcliffe, Gravesend, Kent, DA11 0HJ.
Manufacturer
Dales Pharmaceuticals Ltd., Snaygill Industrial Estate, Keighly
Road, Skipton, North Yorkshire, BD23 2RW, UK.
Parnate 10 mg Tablets
PL No: 18067/0457

POM

®

Parnate is a registered trademark of Mercury Pharma Group
Ltd.
th

This leaflet was last revised on 12 February 2014.
To request a copy of this leaflet in Braille, large print or audio
please call 01622 690172.

500000/PL1a

Tranylcypromine 10 mg Tablets

Patient Information Leaflet
The name of your medicine is Tranylcypromine 10 mg
Tablets. Throughout this leaflet it will be referred to as
Tranylcypromine Tablets.
Read all of this leaflet carefully before you start
taking this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or
pharmacist.
- This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.
- If any of the side effects become serious, or if you
notice any side effects not listed in this leaflet, please
tell your doctor or pharmacist.
In this leaflet:
1. What Tranylcypromine Tablets are and what they are
used for
2. Before you take Tranylcypromine Tablets
3. How to take Tranylcypromine Tablets
4. Possible side effects
5. How to store Tranylcypromine Tablets
6. Further information
1.WHAT TRANYLCYPROMINE TABLETS ARE AND WHAT
THEY ARE USED FOR
Tranylcypromine Tablets contain the active substance
tranylcypromine which belongs to a group of antidepressant
medicines known as monoamine oxidase inhibitors (MAOIs).
It works by stopping the breakdown of two substances in the
brain called serotonin and noradrenaline. Your medicine
should help bring these substances back to normal levels.
Tranylcypromine Tablets are used to treat moderate to severe
depression. They can also help feelings of fear (phobia) which
sometimes occurs in depression. This medicine is often used
when other types of antidepressant medicines have not
worked.
2. BEFORE YOU TAKE TRANYLCYPROMINE TABLETS
DO NOT take Tranylcypromine Tablets if:
• You know that you are allergic to tranylcypromine or
any of the other ingredients of Tranylcypromine
Tablets (see section 6 of this leaflet)
• You are taking clomipramine, imipramine and
venlafaxine
• You suffer from porphyria which is an inherited disease
affecting the nervous system and skin
• You have severe heart disease or any disease of the
blood vessels of the brain
• You have pheochromocytoma which is a tumour of the
adrenal glands (glands near the kidneys) causing high
blood pressure
• You have known liver damage or a disorder affecting
the blood cells (your doctor will know)
• You are pregnant, trying to become pregnant or
breast-feeding
• You are in a manic phase
• You are taking any of the medicines listed under “Do
not take” in the Taking Other Medicines section of this
leaflet.
Please tell your doctor if any of the above applies to you.
Take special care with Tranylcypromine Tablets and talk
to your doctor if you:
• are elderly
• have a mild heart problem which restricts your activity
• suffer from seizures/fits (epilepsy)
• suffer from diabetes mellitus (sugar diabetes)
• suffer from blood disorders
• taking diuretics (water tablets)
• are due to have surgery in the next few weeks
• have depression or suicidal thoughts
• suffer from low blood pressure or high blood pressure
• suffer from schizophrenia
• have a history of dependence on drugs or alcohol.
Even though some of the above may be obvious, it is
important that your doctor is aware if any of them apply to
you.
Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines
obtained without a prescription.

Tranylcypromine Tablets MUST NOT be taken with the
following medicines:
• Medicines called sympathomimetic agents - these
include ephedrine, pseudoephedrine, adrenaline and
noradrenaline (these may be found in medicines used
to treat heart problems and asthma as well as some
decongestants and cough/cold remedies e.g.
dextromethorphan bought without a prescription)
• Bupropion, a medicine to help you stop smoking
• Medicines for migraine e.g. 5HT1 agonists
• Strong pain killers e.g. pethidine, morphine, codeine
and nefopam
• It should not be administered at the same time as, or
within 14 days of treatment with other MAOIs such as
isocarboxid, buspirone, or dibenzazepine derivative
drugs (including tricyclic antidepressant agents,
perphenazine or carbamazepine)
• Medicines used to treat depression (e.g. clomipramine,
imipramine, venlafaxine)
• Tranylcypromine should not be administered together
with clomipramine and imipramine. In the cases of
clomipramine and imipramine, 3 weeks should be left
before starting tranylcypromine therapy.
• Tranylcypromine should not be administered in
combination with selective serotonin reuptake
inhibitors
(SSRIs)
e.g.,
fluoxetine
or
serotonin/noradrenaline reuptake inhibitors (SNRIs)
e.g. venlafaxine. Therefore SSRIs and SNRIs should
not be used in combination with an MAOI, or within 14
days of discontinuing therapy with an MAOI.
• Buspirone, used to treat anxiety
• Medicines to treat seizures/fits, e.g. carbamazepine
• Perphenazine used to treat schizophrenia
• Guanethidine used to treat high blood pressure
• SSRIs such as fluoxetine, paroxetine or sertaline (for
depression)
• Medicines like altretamine used for the treatment of
cancer
• Doxapram used to increase the rate of breathing,
especially during surgery
• Medicines like oxypertin, clozapine used for the
treatment of mental disorders like schizophrenia
• Tetrabenazine used for the treatment of excessive
restlessness.
Tranylcypromine Tablets must be taken with caution if
you are taking the following medicines:
• Barbiturates used to treat severe sleeping problems,
e.g. amylobarbitone
• Medicines used to treat depression (e.g. amitriptyline,
imipramine, tryptophan, amfebutamone)
• Phenylpropanolamine used to treat nasal congestion
associate with allergies
• Medicines for high blood pressure (e.g. reserpine,
methyldopa)
• Medicines to control appetite, e.g. amphetamine and
fenfluramine
• Antimuscarinics for motion sickness, muscle cramps in
the gut or bladder
• Medicines that treat Parkinson’s disease, e.g.
levodopa
• Dopamine, a medicine used to treat certain heart
conditions
• Local anaesthetics e.g. lidocaine
• Medicines to treat diabetes (e.g. insulin, metformin).
At least 5 weeks should be allowed after stopping fluoxetine
before starting Tranylcypromine Tablets.
At least 2 weeks should be allowed after stopping paroxetine
before starting Tranylcypromine Tablets.
Taking Tranylcypromine Tablets with food and drink:
You should NOT take alcohol (especially red wine) whilst you
are taking Tranylcypromine Tablets. This includes nonalcoholic beer or lager.
Tranylcypromine Tablets stops the breakdown of a substance
called tyramine which is found in large amounts of certain
foods. If this substance is not broken down, it can cause very
high blood pressure. So, whilst you are taking
Tranylcypromine Tablets, you should avoid the following
foods:
• Matured cheeses – cooked or plain (e.g. cheddar or
processed cheese made from mature cheese)
• Yeast extracts (e.g. Bovril, Oxo, brewer’s yeast or
Marmite)
• Meat, fish or poultry which is not fresh or has been
pickled or aged e.g. hung game, pickled herrings
• Broad bean pods
• Flavoured textured vegetable protein
• Protein foods that are not fresh and whose preparation
involved hydrolysis, fermentation, pickling, hanging,
smoking or bacterial contamination e.g. dry sausage
(salami, pepperoni etc.), fermented soya bean extract,
liver, yoghurt
• Excessive amounts of chocolate
• Excessive amounts of tea or coffee.

Continued overleaf

Pregnancy and breast feeding:
Please let the doctor know if you are pregnant, think you
might be pregnant, are planning to become pregnant or are
breast-feeding. Tranylcypromine Tablets should NOT be used
during pregnancy or breast feeding unless your doctor thinks
it is essential. This medicine may pass into breast milk.
Ask your doctor or pharmacist for advice before taking any
medicine.
Driving and using machines:
Tranylcypromine Tablets may make you feel drowsy or dizzy
or affect your concentration. You should not drive or use
machines when you first start to take this medicine until you
are certain that you are not getting these side effects. If in any
doubt, speak to your doctor before you drive or use machines.
Important information about some of the ingredients of
Tranylcypromine Tablets:
This medicine also contains carmoisine (E122) and
Ponceau 4R (E124) which may cause allergic reactions.
This medicine also contains sucrose (a sugar). If you have
been told by your doctor that you have an intolerance to some
sugars, contact your doctor before taking this medicine.
If you have an operation or you need to go to the Dentist:
Tranylcypromine Tablets are not normally taken for two weeks
before an operation or major dentistry. Check with your doctor
or dentist and alert them to your medication.
3. HOW TO TAKE TRANYLCYPROMINE TABLETS
Always take Tranylcypromine Tablets exactly as your doctor
has told you. Do NOT take more than your doctor tells you to.
You should check with your doctor or pharmacist if you are
not sure.
Swallow the tablets whole with a glass of water.
USUAL DOSE (Adults only)
• One tablet in the morning and one tablet in the
afternoon each day
• Try to take the last dose before 3 o’clock in the
afternoon
• This dose may be increased by your doctor to three
tablets a day. Take the extra tablet at midday
• If you are elderly your doctor will usually prescribe you
a lower dose.
When you start to feel better, your doctor may change your
dose to one tablet a day.
Do NOT take more than three tablets each day unless your
doctor tells you.
Children: Tranylcypromine Tablets are not recommended for
children under 18 years old.
If you take more Tranylcypromine Tablets than you
should:
If you think that you, or any other person, have taken too
many tablets, contact your doctor or hospital casualty
department immediately. Take any remaining tablets and this
leaflet with you so that the medical staff know exactly what
you have taken.
If you forget to take your Tranylcypromine Tablets:
If you miss a dose, wait until your next dose. Do not take the
dose you have missed. You can then carry on as before.
Do not take more than one dose at a time.
If you stop taking Tranylcypromine Tablets:
Continue to take Tranylcypromine Tablets even if you no
longer feel ill. DO NOT STOP taking this medicine without
talking with your doctor first, especially if you have taken large
doses for a long time. When the time comes to stop your
doctor will probably decrease your dose gradually as stopping
the tablets suddenly may cause ill-effects such as nausea
(feeling sick), vomiting (being sick), sweating, vivid
nightmares, fits, worsening of symptoms and difficulty in
sleeping.
If you have any further questions on the use of this medicine,
ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Tranylcypromine Tablets can sometimes
cause side effects, although not everybody gets them. If you
eat foods or take medicines which interact with the active
ingredient, tranylcypromine, you may get very high blood
pressure (a hypertensive crisis).
If you notice any of the following symptoms please see your
doctor immediately.
• frequent
headaches,
shakiness,
nervousness,
excessive happiness or excitement (euphoria), painful
or stiff neck, changes in heart rate, pain in the middle
of the chest, feeling sick or being sick, sweating,
paleness, or flushing of the skin and enlarged pupils
which may make bright sunlight uncomfortable, muscle
twitching, muscle jerks, increased reflexes, feeling
nervous or uneasy. Although very rare, muscle rigidity,
fever and irregular body movements (i.e. neuroleptic
malignant syndrome), severe problems with the heart
and breathing, changes in the metabolism may occur,
feeling of a lump in the throat, increased muscular
movements, coma
• thought of suicide and suicidal behaviour early on in
treatment or shortly after stopping treatment.

If this occurs contact your doctor or go to a hospital
straight away.
Very rarely, liver problems (symptoms include yellowing of the
skin and the whites of the eyes), bruising and changes in
blood have been reported. Therefore, if you get a bad sore
throat or high fever or become very tired and pale or notice
bruises and nose bleeds, tell your doctor. Sometimes patients
feel anxious whilst taking this medicine and rarely some
patients will become very agitated or irritable. Your doctor
may reduce your dose if this happens.
Other side effects which may occur include:
• difficulty in sleeping, mild headache, sleepiness,
weakness, dizziness, fast or irregular heart beat
(palpitations), restlessness, dry mouth, inability to
normally open mouth, blurred vision, feeling sick, water
retention or swelling, difficulty in passing stools, other
tummy problems, swelling, increase in the level of liver
enzymes on examination, squint in the eyes, decrease
in the blood cell count in the body, sexual problems,
confusion, reduced or increased levels of salt in the
body, repetition or echoing of one's own spoken words,
fits, glaucoma (increased pressure in the eyes) itching,
tingling or pricking of skin, altered driving abilities,
weight gain, increased appetite, rash, being sick,
diarrhoea, fatigue, hallucinations and difficulty in
passing water.
Some patients get low blood pressure and may feel dizzy on
standing up. If this continues for a long time, your doctor may
stop your medicine.
Rarely some patients experience soreness in the hands and
feet which may be a sign of inflamed nerves, spasm of the
axial muscles.
If any of the side effects become serious, or if you notice
any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
You may find it helpful to tell a relative or close friend that
you are depressed or have anxiety disorder, and to ask
them to read this leaflet. You might ask them to tell you if
they think your depression or anxiety is becoming worse or if
they are worried about changes in your behaviour.
Also you can help to make sure that medicines remain as safe
as possible by reporting any unwanted side effects via the
internet at www.mhra.gov.uk/yellowcard. Alternatively you can
call Freephone 0808 100 3352 (available from 10 a.m. to
2 p.m. Mondays to Fridays) or fill in a paper form available
from your local pharmacy.
5. HOW TO STORE PARNATE TABLETS
• Keep this medicine out of the sight and reach of
children.
• Do not use Tranylcypromine Tablets after the expiry
date which is stated on the box. The expiry date refers
to the last day of that month. If your tablets are out of
date, take them to your pharmacist who will get rid of
them safely.
• Do not store above 25°C. Store in the original
container to protect from light and tightly closed to
protect from moisture.
• If you notice any sign of deterioration or discolouration
of your medicine, please tell your pharmacist
immediately.
6. FURTHER INFORMATION
Each coated tablet contains tranylcypromine sulphate
equivalent to 10 mg tranylcypromine.
Tranylcypromine Tablets also contains sucrose, maize starch,
calcium sulphate dihydrate (E516), carmellose sodium,
magnesium stearate (E470b). The coating contains gelatine,
sucrose, docusate sodium, purified talc (E553b), light kaolin
(E559), calcium carbonate (E170), ethylcellulose, acacia
(E414), carmoisine (E122), ponceau 4R (E124), maize starch,
titanium dioxide (E171), carnauba wax (E903) and edible ink
(shellac (E904), soya lecithin (E322), iron oxide black (E172)
and trace amounts of dimethyl siloxane).
What Tranylcypromine Tablets look like and contents of
the pack
Tranylcypromine 10 mg tablets are geranium-red coloured,
bi-convex, sugar-coated tablets marked 'FW 251' on one face
only. They are packed in plastic containers with 28 tablets.
Each container has a desiccant cartridge.
Product Licence Holder
Procured from within the EU. Product Licence Holder Ginova
Ltd, repackager Ginova UK Ltd, both of St James' House,
8 Overcliffe, Gravesend, Kent, DA11 0HJ.
Manufacturer
Dales Pharmaceuticals Ltd., Snaygill Industrial Estate, Keighly
Road, Skipton, North Yorkshire, BD23 2RW, UK.
Tranylcypromine 10 mg Tablets
PL No: 18067/0457

POM
th

This leaflet was last revised on 12 February 2014.
To request a copy of this leaflet in Braille, large print or audio
please call 01622 690172.

500000/PL1a

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Hide