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Active substance(s): CAFFEINE / PARACETAMOL

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2. Check before you take Panadol Extra Advance Tablets
Do not take Panadol Extra Advance Tablets:
• if you have ever had an allergic reaction to paracetamol, caffeine or to any
of the other ingredients (listed in Section 6)
• if you are taking other medicines containing paracetamol.


500 mg/65 mg Tablets
Please read right through this leaflet before you start using this medicine.
This medicine is available without prescription, but you still need to use
Panadol Extra Advance Tablets carefully to get the best results from them.
•• Keep this leaflet, you may need to read it again.
•• If you have any questions, or if there is anything you do not understand, ask
your pharmacist.

In this leaflet:

1. What Panadol Extra Advance Tablets do
2. Check before you take Panadol Extra Advance Tablets
3. How to take Panadol Extra Advance Tablets
4. Possible side effects
5. How to store Panadol Extra Advance Tablets
6. Further information

1. What Panadol Extra Advance Tablets do

Panadol Extra Advance Tablets are faster absorbed than standard paracetamol
and caffeine tablets. They are suitable for the relief of headache, migraine,
backache, rheumatic pain, toothache and period pain. They also relieve the
fever, aches and pains of colds and flu.

Ask your doctor before you take this medicine:
• if you have liver or kidney disease, including alcoholic liver disease.

If you are taking other medicines
Talk to your doctor or pharmacist before taking these tablets if you are taking
any prescribed medicines; particularly metoclopramide or domperidone (for
nausea [feeling sick] or vomiting [being sick]) or colestyramine (to lower blood
cholesterol). If you take blood thinning drugs (anticoagulants e.g. warfarin)
and you need to take a pain reliever on a daily basis, talk to your doctor
because of the risk of bleeding. But you can still take occasional doses of
Panadol Extra Advance Tablets at the same time as anticoagulants.

Pregnancy and breast feeding
Due to the caffeine content of this product it should not be used if you are
pregnant or breast feeding.

The tablets contain two active ingredients. Paracetamol is a painkiller and
reduces your temperature when you have a fever. Caffeine acts to further
help the effectiveness of paracetamol.

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3. How to take Panadol Extra Advance Tablets
Adults and children aged 12 years and over:
Swallow 2 tablets every 4 hours as needed.
• Do not take more frequently than every 4 hours.
• Do not take more than 8 tablets in 24 hours.
• Do not take more than the recommended dose.
• Do not give to children under 12 years.
• Avoid too much caffeine in drinks like coffee and tea.
High caffeine intake can cause difficulty sleeping, shaking and an

uncomfortable feeling in the chest.

If you take too many tablets

Immediate medical advice should be sought in the event of an overdose, even
if you feel well, because of the risk of delayed, serious liver damage.
If your symptoms continue or your headache becomes persistent, see your

4. Possible side effects

Like all medicines, Panadol Extra Advance Tablets can have side effects but not
everybody gets them. A small number of people have had side effects.

6. Further information

Active ingredients: Each tablet contains Paracetamol 500 mg and Caffeine 65 mg.
Other ingredients: Starch pregelatinised, povidone k-25, calcium carbonate,
crospovidone, alginic acid, magnesium stearate and sodium methyl (E 219),
sodium ethyl (E 215) and sodium propyl (E 217) parahydroxybenzoates.
The tablet coating contains titanium dioxide (E 171), hypromellose, macrogol,
polysorbate 80 and carnauba wax.
The parahydroxybenzoates may cause allergic reactions (possibly delayed).
Packs of Panadol Extra Advance Tablets contain 8, 14, or 32 tablets.
The marketing authorisation holder is GlaxoSmithKline Consumer Healthcare (UK)
Trading Limited, Brentford, TW8 9GS, U.K. and all enquiries should be sent to this
The manufacturer is GlaxoSmithKline Dungarvan Ltd., Co. Waterford, Ireland or
Omega Pharma Manufacturing GmbH & Co. KG, Benzstraße 25, 71083,
Herrenberg, Germany.

This leaflet was last revised in January 2016.
Panadol is a registered trademark owned by or licensed to the GSK group
Stop taking the medicine and tell your doctor immediately if you experience:
of companies.
• Allergic reactions which may be severe such as skin rash and itching
sometimes with swelling of the mouth or face or shortness of breath
• Skin rash or peeling, or mouth ulcers
• Breathing problems. These are more likely if you have experienced them
before when taking other painkillers such as ibuprofen and aspirin
• Unexplained bruising or bleeding
• Nausea, sudden weight loss, loss of appetite and yellowing of the eyes and skin.
If you do get any side effects, even those not mentioned in this leaflet, tell your
doctor or pharmacist.

5. How to store Panadol Extra Advance Tablets
Keep out of the reach and sight of children.
Do not use this medicine after the ‘EXP’ date shown on the pack.
Store below 25°C.


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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.