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Otrivine-Antistin® Eye Drops,
Xylometazoline 0.05%w/v & Antazoline 0.5%w/v
Patient Information Leaflet
Please read this leaflet carefully before you start to use the eye drops.
It contains important information. Keep the leaflet in a safe place because
you may want to read it again.
Do not share these eye drops with anyone else just in case you have an eye
infection which you could pass on.
If you have any other questions, or if there is something you don’t
understand, please ask your pharmacist.
If any of the side effects gets serious, or if you notice any side effects not
listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:

1. What Otrivine Antistin Eye Drops are and what they are used for
2. Things to consider before you start to use Otrivine Antistin
3. How to use Otrivine Antistin
4. Possible side effects
5. How to store Otrivine Antistin
6. Further information

1. What Otrivine Antistin Eye Drops are and what they are used for
Otrivine Antistin Eye Drops contain two active ingredients.
Xylometazoline hydrochloride is a decongestant and antazoline sulphate is an
anti-allergic agent.
Otrivine Antistin Eye Drops helps to make your eyes feel more comfortable
by relieving the redness and itching caused by allergies such as hay fever, or
house dust allergy.

2. Things to consider before you start to use Otrivine Antistin
DO NOT use Otrivine Antistin if:

• you think you may be allergic to any of the ingredients of the eye drops
(These are listed at the end of the leaflet.)
• you have a condition called narrow angle glaucoma
• you wear contact lenses of any type
• you are taking, or in the last 14 days have taken, one of a group of
anti- depressant drugs called monoamineoxidase inhibitors.
You should also ask yourself these questions before starting to use
Otrivine Antistin:

• Do you have high blood pressure, a heart condition, a thyroid problem or
• Are you pregnant or breast-feeding?
• Do you suffer from dry eyes?
• Do you have difficulty in urinating (passing water)?
• Do you have an adrenal tumour (phaeochromocytoma)?
If the answer to any of these questions is YES, talk to the pharmacist because
Otrivine Antistin might not be suitable for you.
Are you taking other medicines?

Some medicines can interfere with your treatment. This means medicines
you have bought yourself as well as medicines on prescription from
your doctor.
Tell your doctor if you are taking any of the following:

• Any drugs which may cause drowsiness including some painkillers,
sedatives, alcohol and antipsychotics
• Atropine and some antidepressants.
• Digoxin and some other drugs used for high blood pressure or anxiety such
as atenolol and propranolol.
• If you are going to have an anaesthetic you should tell your doctor you are
using Otrivine-Antistin.
Your doctor will know which medicines should be avoided whilst using
Otrivin- Antistin
Will there be any problems with driving or using machinery?

Some people may experience blurred vision after using Otrivine Antistin.
If you are affected, you should not drive or use machinery.
Other special warnings

The eye drops contain benzalkonium chloride as a preservative. This can
sometimes irritate the eyes.

3. How to use Otrivine Antistin
The usual dosage is:
Adults: One or two drops in each eye, two or three times each day.
Elderly and children 12 years and over: One drop in each eye, two or
three times each day.
These drops should not be used in children under 12.
Do not exceed stated dosage
If your symptoms have not improved after 2 days you must go and see your
doctor because Otrivine Antistin might not be the right medicine for you.
You may have an infection and need an antibiotic.
1. Wash your hands
2. Remove the cap and hold the bottle between your thumb and
3. Tilt your head backwards
4. Rest one hand on your cheek and gently pull down your lower eyelid
5. Look upward


How to use your eye drops

6. Squeeze the bottle to release one or two drops into the eye
7. Close your eye for a short time
8. Repeat for the other eye
Note: Do not touch your eye or the surrounding area with the tip of the dropper.
Follow the instructions carefully. If there is anything you do not understand,
ask your pharmacist.
If you need to use more than one kind of eye drops wait 5 minutes
between treatments.
Otrivine-Antistin should not be used for more than 7 consecutive days without
talking to your doctor or pharmacist.
What if you use too much?

If you use Otrivine Antistin for more than 7 days you may find that the
itching, redness and/or swelling of the eyes or eyelids returns. Using too
much Otrivine Antistin, or using it for too long, or too often, can cause serious
side effects, especially in children.
If you accidentally swallow the eye drops consult a doctor.

4. Possible side effects
Otrivine Antistin is suitable for most people, but, like all medicines, it can
sometimes cause side effects.
Sometimes people notice that the drops make their eyes sting.
Very occasionally people have noticed that their red eyes get worse, or that
they have blurred vision, headache, drowsiness or enlarged pupils.
Allergic reactions have been reported causing rash, swelling and itching of the
eye area and eye irritation.
Certain sensitive people have experienced changes in heart beat rhythm,
raised blood pressure, sleeplessness, nausea, pallor and sweating.
Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via:

The Yellow Card Scheme.

HPRA Pharmacovigilance
Earlsfort Terrace
IRL - Dublin 2
Tel: +353 1 6764971
Fax: +353 1 6762517
By reporting side effects you can help provide more information on the safety
of this medicine.

5. How to store Otrivine Antistin
Keep all medicines out of the reach and sight of children.
Do not store the drops above 25°C.
The drops are sterile until the seal on the bottle is broken. Do not use if the
seal is broken when you receive the bottle. Take it back to the pharmacist.
Do not use the drops for longer than 28 days after first opening the bottle.
Do not use the drops after the expiry date which is printed on the outside of
the pack.
Do not throw them away with your normal household water or waste. This will
help to protect the environment.

6. Further information
These eye drops contain 0.05% w/v xylometazoline hydrochloride and
0.5% w/v antazoline sulphate. They also contain the inactive ingredients
benzalkonium chloride, boric acid, disodium edetate, sodium tetraborate and
water for injections. Each bottle contains 10 ml of eye drops.
The product licence/authorisation holder is
Laboratoires THEA
12, rue Louis Blériot
63017 Clermont-Ferrand Cedex 2
Otrivine Antistin Eye Drops are made by
Rue de la Lombardière
07100 Annonay
This leaflet was revised in 02/2017.

If you would like any more information, or would like the leaflet in a different
format, please contact Medical Information at Spectrum THEA Pharmaceuticals
Ltd, telephone number 0845 521 1290.


Otrivine Antistin is a registered trade mark.


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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.