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OCTREOTIDE 500 MICROGRAMS/ML SOLUTION FOR INJECTION OR CONCENTRATE FOR SOLUTION FOR INFUSION

Active substance(s): OCTREOTIDE ACETATE

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TEVA UK Ref:

Version:

231-30-61204-C LEA OCTREOTIDE A/S SOLN TEVAH
3

05 February 2015

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The following information is intended for healthcare
professionals only:
s )NTRAVENOUS INFUSION FOR HEALTH CARE PROFESSIONALS 

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REG0083958

4HE TOTAL TIME BETWEEN RECONSTITUTION DILUTION WITH
INFUSION MEDIA STORAGE IN A REFRIGERATOR AND END OF
ADMINISTRATION MUST NOT BE LONGER THAN  HOURS
7HEN /CTREOTIDE IS TO BE ADMINISTERED AS INTRAVENOUS
/CTREOTIDE OCTREOTIDE ACETATE IS PHYSICALLY AND
INFUSION THE CONTENTS OF ONE  MG VIAL SHOULD
CHEMICALLY STABLE FOR  HOURS IN STERILE PHYSIOLOGICAL
NORMALLY BE DISSOLVED IN  M, PHYSIOLOGICAL SALINE AND
SALINE SOLUTIONS OR STERILE SOLUTIONS OF DEXTROSE GLUCOSE
THE RESULTING SOLUTION SHOULD BE INFUSED BY MEANS OF AN
 IN WATER (OWEVER BECAUSE /CTREOTIDE CAN AFFECT
INFUSION PUMP 4HIS SHOULD BE REPEATED AS OFTEN AS
GLUCOSE HOMEOSTASIS IT IS RECOMMENDED THAT
NECESSARY UNTIL THE PRESCRIBED DURATION OF TREATMENT IS
PHYSIOLOGICAL SALINE SOLUTIONS BE USED RATHER THAN
REACHED
DEXTROSE 4HE DILUTED SOLUTIONS ARE PHYSICALLY AND
CHEMICALLY STABLE FOR AT LEAST  HOURS BELOW  # &ROM "EFORE USING AN /CTREOTIDE VIAL CHECK THE SOLUTION FOR
A MICROBIOLOGICAL POINT OF VIEW THE DILUTED SOLUTION
PARTICLES OR A CHANGE OF COLOUR $O NOT USE IT IF YOU SEE
SHOULD PREFERABLY BE USED IMMEDIATELY )F THE SOLUTION IS ANYTHING UNUSUAL
NOT USED IMMEDIATELY STORAGE PRIOR TO USE IS THE
How much Octreotide to use
RESPONSIBILITY OF THE USER AND SHOULD BE AT  TO  #
"EFORE ADMINISTRATION THE SOLUTION HAS TO BE BROUGHT TO 4HE DOSE OF /CTREOTIDE DEPENDS ON THE CONDITION BEING
TREATED
ROOM TEMPERATURE AGAIN

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Warnings and precautions
4ALK TO YOUR DOCTOR BEFORE USING /CTREOTIDE
s IF YOU KNOW THAT YOU HAVE GALLSTONES NOW OR HAVE
HAD THEM IN THE PAST TELL YOUR DOCTOR AS PROLONGED
PACKAGE LEAFLET:
USE OF /CTREOTIDE MAY RESULT IN GALLSTONE FORMATION
INFORMATION FOR THE PATIENT
9OUR DOCTOR MAY WISH TO CHECK YOUR GALLBLADDER
PERIODICALLY
Octreotide 50 micrograms/ml
s IF YOU HAVE PROBLEMS WITH YOUR BLOOD SUGAR LEVELS
solution for injection or concentrate
EITHER TOO HIGH DIABETES OR TOO LOW HYPOGLYCAEMIA 
for solution for infusion,
7HEN /CTREOTIDE IS USED TO TREAT BLEEDING FROM
GASTRO OESOPHAGEAL VARICES MONITORING OF BLOOD
Octreotide 100 micrograms/ml
SUGAR LEVEL IS MANDATORY
solution for injection or concentrate
s IF YOU HAVE A HISTORY OF VITAMIN " DEPRIVATION YOUR
for solution for infusion
DOCTOR MAY WISH TO CHECK YOUR VITAMIN " LEVEL
Octreotide 500 micrograms/ml
PERIODICALLY
solution for injection or concentrate
Test and checks
)F
YOU
RECEIVE TREATMENT WITH /CTREOTIDE OVER A LONG
for solution for infusion
PERIOD OF TIME YOUR DOCTOR MAY WISH TO CHECK YOUR
Octreotide
THYROID
FUNCTION PERIODICALLY
Read all of this leaflet carefully before you start using
9OUR DOCTOR WILL CHECK YOUR LIVER FUNCTION
this medicine because it contains important
information for you.
Children
s +EEP THIS LEAFLET 9OU MAY NEED TO READ IT AGAIN
4HERE IS LITTLE EXPERIENCE WITH THE USE OF /CTREOTIDE IN
s )F YOU HAVE ANY FURTHER QUESTIONS ASK YOUR DOCTOR
CHILDREN
PHARMACIST OR NURSE
Other medicines and Octreotide
s 4HIS MEDICINE HAS BEEN PRESCRIBED FOR YOU ONLY $O
4ELL YOUR DOCTOR OR PHARMACIST IF YOU ARE TAKING HAVE
NOT PASS IT ON TO OTHERS )T MAY HARM THEM EVEN IF
RECENTLY TAKEN OR MIGHT TAKE ANY OTHER MEDICINES
THEIR SIGNS OF ILLNESS ARE THE SAME AS YOURS
9OU CAN GENERALLY CONTINUE TAKING OTHER MEDICINES WHILE
s )F YOU GET ANY SIDE EFFECTS TALK TO YOUR DOCTOR
ON /CTREOTIDE (OWEVER CERTAIN MEDICINES SUCH AS
PHARMACIST OR NURSE 4HIS INCLUDES ANY POSSIBLE SIDE
CIMETIDINE CICLOSPORIN BROMOCRIPTINE QUINIDINE AND
EFFECTS NOT LISTED IN THIS LEAFLET 3EE SECTION 
TERFENADINE HAVE BEEN REPORTED TO BE AFFECTED BY
WHAT IS IN THIS LEAFLET:
/CTREOTIDE
1. What Octreotide is and what it is used for
)F YOU ARE TAKING A MEDICINE TO CONTROL YOUR BLOOD
2. What you need to know before you use Octreotide
PRESSURE EG A BETA BLOCKER OR A CALCIUM CHANNEL
3. How to use Octreotide
BLOCKER OR AN AGENT TO CONTROL YOUR FLUID AND ELECTROLYTE
4. Possible side effects
BALANCE YOUR DOCTOR MAY NEED TO ADJUST THE DOSAGE
5. How to store Octreotide
)F YOU ARE DIABETIC YOUR DOCTOR MAY NEED TO ADJUST YOUR
6. Contents of the pack and other information
INSULIN DOSAGE
Pregnancy and breast-feeding
What Octreotide is and what it is used for
)F YOU ARE PREGNANT OR BREAST FEEDING THINK YOU MAY BE
/CTREOTIDE IS A SYNTHETIC COMPOUND DERIVED FROM
PREGNANT OR ARE PLANNING TO HAVE A BABY ASK YOUR
SOMATOSTATIN A SUBSTANCE NORMALLY FOUND IN THE HUMAN DOCTOR FOR ADVICE BEFORE TAKING THIS MEDICINE
BODY WHICH INHIBITS THE EFFECTS OF CERTAIN HORMONES SUCH /CTREOTIDE 4EVA SHOULD ONLY BE USED DURING PREGNANCY
AS GROWTH HORMONE 4HE ADVANTAGES OF /CTREOTIDE OVER IF CLEARLY NEEDED
SOMATOSTATIN ARE THAT IT IS STRONGER AND ITS EFFECTS LAST
7OMEN OF CHILD BEARING AGE SHOULD USE AN EFFECTIVE
LONGER
CONTRACEPTIVE METHOD DURING TREATMENT
/CTREOTIDE IS USED
$O NOT BREAST FEED WHILE USING /CTREOTIDE )T IS NOT
s IN acromegaly A CONDITION WHERE THE BODY PRODUCES KNOWN WHETHER /CTREOTIDE PASSES INTO BREAST MILK
TOO MUCH GROWTH HORMONE .ORMALLY GROWTH
Driving and using machines
HORMONE CONTROLS GROWTH OF TISSUES ORGANS AND
/CTREOTIDE HAS NO OR NEGLIGIBLE EFFECTS ON THE ABILITY TO
BONES 4OO MUCH GROWTH HORMONE LEADS TO AN
INCREASE IN THE SIZE OF BONES AND TISSUES ESPECIALLY IN DRIVE AND USE MACHINES (OWEVER SOME OF THE SIDE
THE HANDS AND FEET /CTREOTIDE MARKEDLY REDUCES THE EFFECTS YOU MAY EXPERIENCE WHILE USING /CTREOTIDE SUCH
AS HEADACHE AND TIREDNESS MAY REDUCE YOUR ABILITY TO
SYMPTOMS OF ACROMEGALY WHICH INCLUDE HEADACHE
DRIVE AND USE MACHINES SAFELY
EXCESSIVE PERSPIRATION NUMBNESS OF THE HANDS AND
FEET TIREDNESS AND JOINT PAIN
How to use Octreotide
s TO RELIEVE SYMPTOMS ASSOCIATED WITH SOME tumours of
the gastrointestinal tract EG CARCINOID TUMOURS
!LWAYS USE THIS MEDICINE EXACTLY AS YOUR DOCTOR HAS TOLD
6)0OMAS GLUCAGONOMAS GASTRINOMAS INSULINOMAS 
YOU #HECK WITH YOUR DOCTOR OR PHARMACIST IF YOU ARE
)N THESE CONDITIONS THERE IS OVERPRODUCTION OF SOME
NOT SURE
SPECIFIC HORMONES AND OTHER RELATED SUBSTANCES BY THE $EPENDING ON THE CONDITION BEING TREATED /CTREOTIDE IS
STOMACH BOWELS OR PANCREAS 4HIS OVERPRODUCTION
GIVEN BY
UPSETS THE NATURAL HORMONAL BALANCE OF THE BODY AND s SUBCUTANEOUS UNDER THE SKIN INJECTION OR
RESULTS IN A VARIETY OF SYMPTOMS SUCH AS FLUSHING
s INTRAVENOUS INTO A VEIN INFUSION
DIARRHOEA LOW BLOOD PRESSURE RASH AND WEIGHT LOSS
)F YOU HAVE LIVER CIRRHOSIS CHRONIC LIVER DISEASE YOUR
4REATMENT WITH /CTREOTIDE HELPS TO CONTROL THESE
DOCTOR MAY NEED TO ADJUST YOUR MAINTENANCE DOSE
SYMPTOMS
9OUR DOCTOR OR NURSE WILL EXPLAIN TO YOU HOW TO INJECT
s TO PREVENT complications following surgery of the
/CTREOTIDE UNDER THE SKIN BUT INFUSION INTO A VEIN MUST
pancreas gland 4REATMENT WITH /CTREOTIDE HELPS TO
ALWAYS BE PERFORMED BY A HEALTH CARE PROFESSIONAL
LOWER THE RISK OF COMPLICATIONS EG ABSCESS IN THE
s 3UBCUTANEOUS INJECTION
ABDOMEN INFLAMMATION OF THE PANCREAS GLAND AFTER
THE SURGERY
4HE UPPER ARMS THIGHS AND ABDOMEN ARE GOOD AREAS
s TO STOP BLEEDING AND TO PROTECT FROM re-bleeding from FOR SUBCUTANEOUS INJECTION
ruptured gastro-oesophageal varices IN PATIENTS
#HOOSE A NEW SITE FOR EACH SUBCUTANEOUS INJECTION SO
SUFFERING FROM CIRRHOSIS CHRONIC LIVER DISEASE 
THAT YOU DO NOT IRRITATE A PARTICULAR AREA 0ATIENTS WHO
4REATMENT WITH /CTREOTIDE HELPS TO CONTROL BLEEDING
WILL BE INJECTING THEMSELVES MUST RECEIVE PRECISE
AND REDUCE TRANSFUSION REQUIREMENTS
INSTRUCTIONS FROM THE DOCTOR OR NURSE
s TO TREAT PITUITARY TUMOURS THAT PRODUCE TOO MUCH
)F YOU STORE THE MEDICINE IN THE REFRIGERATOR IT IS
THYROID STIMULATING HORMONE 43(  4OO MUCH
RECOMMENDED THAT YOU ALLOW IT TO REACH ROOM
THYROID STIMULATING HORMONE 43( LEADS TO
TEMPERATURE BEFORE USING IT 4HIS WILL REDUCE THE RISK OF
HYPERTHYROIDISM
PAIN AT THE SITE OF INJECTION 9OU CAN WARM IT UP IN YOUR
/CTREOTIDE IS USED TO TREAT PEOPLE WITH PITUITARY
HAND BUT DO NOT HEAT IT
TUMOURS THAT PRODUCE TOO MUCH THYROID STIMULATING
! FEW PEOPLE EXPERIENCE PAIN AT THE SITE OF THE
HORMONE 43( 
SUBCUTANEOUS INJECTION 4HIS PAIN USUALLY ONLY LASTS A
s WHEN OTHER TYPES OF TREATMENT SURGERY OR
SHORT TIME )F THIS HAPPENS TO YOU YOU CAN RELIEVE THIS BY
RADIOTHERAPY ARE NOT SUITABLE OR HAVE NOT WORKED
s AFTER RADIOTHERAPY TO COVER THE INTERIM PERIOD UNTIL GENTLY RUBBING THE SITE OF INJECTION FOR A FEW SECONDS
AFTERWARDS
THE RADIOTHERAPY BECOMES FULLY EFFECTIVE
"EFORE USING AN /CTREOTIDE VIAL CHECK THE SOLUTION FOR
What you need to know before you use
PARTICLES OR A CHANGE OF COLOUR $O NOT USE IT IF YOU SEE
Octreotide
ANYTHING UNUSUAL
If you use more Octreotide than you should
Do not use Octreotide
.O LIFE THREATENING REACTIONS HAVE BEEN REPORTED AFTER
s IF YOU ARE ALLERGIC TO OCTREOTIDE OR ANY OF THE OTHER
OVERDOSE OF /CTREOTIDE
INGREDIENTS OF THIS MEDICINE LISTED IN SECTION  

TEVA UK Ref:

Version:

231-30-61204-C LEA OCTREOTIDE A/S SOLN TEVAH
3

05 February 2015

If you stop using Octreotide
)F YOU INTERRUPT YOUR TREATMENT WITH /CTREOTIDE YOUR
SYMPTOMS MAY COME BACK 4HEREFORE DO NOT STOP USING
/CTREOTIDE 4EVA UNLESS YOUR DOCTOR TELLS YOU TO
)F YOU HAVE ANY FURTHER QUESTIONS ON THE USE OF THIS
MEDICINE ASK YOUR DOCTOR NURSE OR PHARMACIST

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Possible side effects

,IKE ALL MEDICINES THIS MEDICINE CAN CAUSE SIDE EFFECTS
ALTHOUGH NOT EVERYBODY GETS THEM
Some side effects can be serious. Tell your doctor
straight away if you get any of the following:
Very common MAY AFFECT MORE THAN  IN  PEOPLE 
s 'ALLSTONES LEADING TO SUDDEN BACK PAIN
s 4OO MUCH SUGAR IN THE BLOOD
Common MAY AFFECT UP TO  IN  PEOPLE 
s 5NDERACTIVE THYROID GLAND HYPOTHYROIDISM CAUSING
CHANGES IN HEART RATE APPETITE OR WEIGHT TIREDNESS
FEELING COLD OR SWELLING AT THE FRONT OF THE NECK
s #HANGES IN THYROID FUNCTION TESTS
s )NFLAMMATION OF THE GALLBLADDER CHOLECYSTITIS 
SYMPTOMS MAY INCLUDE PAIN IN THE UPPER RIGHT
ABDOMEN FEVER NAUSEA YELLOWING OF THE SKIN AND
EYES JAUNDICE
s 4OO LITTLE SUGAR IN THE BLOOD
s )MPAIRED GLUCOSE TOLERANCE
s 3LOW HEARTBEAT
Uncommon MAY AFFECT UP TO  IN  PEOPLE 
s 4HIRST LOW URINE OUTPUT DARK URINE DRY FLUSHED SKIN
s &AST HEARTBEAT
Other serious side effects
s (YPERSENSITIVITY ALLERGIC REACTIONS INCLUDING SKIN RASH
s ! TYPE OF AN ALLERGIC REACTION ANAPHYLAXIS WHICH
CAUSES DIFFICULTY IN BREATHING OR DIZZINESS
s !N INFLAMMATION OF THE PANCREAS GLAND PANCREATITIS 
SYMPTOMS MAY INCLUDE SUDDEN PAIN IN THE UPPER
ABDOMEN NAUSEA VOMITING DIARRHOEA
s ,IVER INFLAMMATION HEPATITIS  SYMPTOMS MAY INCLUDE
YELLOWING OF THE SKIN AND EYES JAUNDICE NAUSEA
VOMITING LOSS OF APPETITE GENERALLY FEELING UNWELL
ITCHING LIGHT COLOURED URINE
s )RREGULAR HEARTBEAT
4ELL YOUR DOCTOR STRAIGHT AWAY IF YOU NOTICE ANY OF THE
SIDE EFFECTS ABOVE
Other side effects:
4ELL YOUR DOCTOR PHARMACIST OR NURSE IF YOU NOTICE ANY OF
THE SIDE EFFECTS LISTED BELOW 4HEY ARE USUALLY MILD AND
TEND TO DISAPPEAR AS TREATMENT PROGRESSES
Very common MAY AFFECT MORE THAN  IN  PEOPLE 
s $IARRHOEA
s !BDOMINAL PAIN
s .AUSEA
s #ONSTIPATION
s &LATULENCE WIND
s (EADACHE
s ,OCAL PAIN AT INJECTION SITE
Common MAY AFFECT UP TO  IN  PEOPLE 
s 3TOMACH DISCOMFORT AFTER A MEAL DYSPEPSIA 
s 6OMITING
s &EELING OF FULLNESS IN THE STOMACH
s &ATTY STOOLS
s ,OOSE STOOLS
s $ISCOLOURATION OF FAECES
s $IZZINESS
s ,OSS OF APPETITE
s #HANGES IN LIVER FUNCTION TESTS
s (AIR LOSS
s 3HORTNESS OF BREATH
s 7EAKNESS
)F YOU GET ANY SIDE EFFECTS PLEASE TELL YOUR DOCTOR NURSE
OR PHARMACIST
! FEW PEOPLE EXPERIENCE PAIN AT THE SITE OF THE
SUBCUTANEOUS INJECTION 4HIS PAIN USUALLY ONLY LASTS A
SHORT TIME )F THIS HAPPENS TO YOU YOU CAN RELIEVE THIS BY
GENTLY RUBBING THE SITE OF INJECTION FOR A FEW SECONDS
AFTERWARDS

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s Acromegaly
4REATMENT IS USUALLY STARTED AT  TO  MG EVERY  OR
 HOURS BY SUBCUTANEOUS INJECTION )T IS THEN CHANGED
ACCORDING TO ITS EFFECT AND RELIEF OF SYMPTOMS SUCH AS
TIREDNESS SWEATING AND HEADACHE  )N MOST PATIENTS THE
OPTIMAL DAILY DOSE WILL BE  MG  TIMESDAY ! MAXIMUM
DOSE OF  MGDAY SHOULD NOT BE EXCEEDED
s Tumours of the gastrointestinal tract
4REATMENT IS USUALLY STARTED AT  MG ONCE OR TWICE A
DAY BY SUBCUTANEOUS INJECTION $EPENDING ON RESPONSE
AND TOLERABILITY THE DOSAGE CAN BE GRADUALLY INCREASED TO
 MG TO  MG  TIMESDAY )N CARCINOID TUMOURS
THERAPY SHOULD BE DISCONTINUED IF THERE IS NO
IMPROVEMENT AFTER  WEEK OF TREATMENT AT THE MAXIMUM
TOLERATED DOSE

5

Keep this medicine out of the sight and reach of children.
$O NOT USE THIS MEDICINE AFTER THE EXPIRY DATE WHICH IS
STATED ON THE LABEL AFTER %80 4HE EXPIRY DATE REFERS TO
THE LAST DAY OF THAT MONTH
Storage conditions:
Before opening: 3TORE IN A REFRIGERATOR BETWEEN   #
PROTECTED FROM LIGHT $O NOT FREEZE
After opening:
4HE PRODUCT MUST BE USED IMMEDIATELY AND ANY UNUSED
DRUG PRODUCT MUST BE DISCARDED
After dilution: /CTREOTIDE OCTREOTIDE ACETATE IS
PHYSICALLY AND CHEMICALLY STABLE FOR  HOURS IN STERILE
PHYSIOLOGICAL SALINE SOLUTIONS OR STERILE SOLUTIONS OF
DEXTROSE GLUCOSE  IN WATER (OWEVER BECAUSE
/CTREOTIDE CAN AFFECT GLUCOSE HOMEOSTASIS IT IS
RECOMMENDED THAT PHYSIOLOGICAL SALINE SOLUTIONS BE USED
RATHER THAN DEXTROSE 4HE DILUTED SOLUTIONS ARE PHYSICALLY
AND CHEMICALLY STABLE FOR AT LEAST  HOURS BELOW  #
&ROM A MICROBIOLOGICAL POINT OF VIEW THE DILUTED
SOLUTION SHOULD PREFERABLY BE USED IMMEDIATELY )F THE
SOLUTION IS NOT USED IMMEDIATELY STORAGE PRIOR TO USE IS
THE RESPONSIBILITY OF THE USER AND SHOULD BE AT  TO  #
"EFORE ADMINISTRATION THE SOLUTION HAS TO BE BROUGHT TO
ROOM TEMPERATURE AGAIN 4HE TOTAL TIME BETWEEN
RECONSTITUTION DILUTION WITH INFUSION MEDIA STORAGE IN A
REFRIGERATOR AND END OF ADMINISTRATION MUST NOT BE
LONGER THAN  HOURS
$O NOT USE THIS MEDICINE UNLESS THE SOLUTION IS CLEAR AND
FREE FROM VISIBLE PARTICLES
&OR SINGLE USE ONLY
$O NOT THROW AWAY ANY MEDICINES VIA WASTEWATER OR
HOUSEHOLD WASTE !SK YOUR PHARMACIST HOW TO THROW
AWAY MEDICINES YOU NO LONGER USE 4HESE MEASURES WILL
HELP PROTECT THE ENVIRONMENT

6

Contents of the pack and other information

What Octreotide contains
s 4HE ACTIVE SUBSTANCE IS OCTREOTIDE AS THE ACETATE 
%ACH ML OF SOLUTION FOR INJECTION OR CONCENTRATE FOR
SOLUTION FOR INFUSION CONTAINS  MICROGRAMS
 MICROGRAMS AND  MICROGRAMS OCTREOTIDE
s 4HE OTHER INGREDIENTS ARE GLACIAL ACETIC ACID SODIUM
ACETATE TRIHYDRATE % MANNITOL % AND WATER
FOR INJECTIONS
What Octreotide looks like and contents of the pack
/CTREOTIDE  MICROGRAMSML  MICROGRAMSML AND
 MICROGRAMSML SOLUTION FOR INJECTION OR CONCENTRATE
FOR SOLUTION FOR INFUSION IS A CLEAR AND COLOURLESS SOLUTION
4HE SOLUTION IS SUPPLIED IN COLOURLESS GLASS VIALS CLOSED
WITH SERUM RUBBER STOPPERS AND SEALED WITH ALUMINIUM
FLIP OFF CAPS FITTED WITH PLASTIC FLIP OFF DISCS 4HE PRODUCT
IS PACKED IN CARDBOARD BOXES
/CTREOTIDE  MICROGRAMSML  MICROGRAMSML AND
 MICROGRAMSML SOLUTION FOR INJECTION OR CONCENTRATE
FOR SOLUTION FOR INFUSION IS AVAILABLE IN PACK SIZES OF  
    AND  VIALS
.OT ALL PACK SIZES MAY BE MARKETED
Marketing Authorisation Holder
4EVA 5+ ,IMITED %ASTBOURNE ". !' 5NITED
+INGDOM
Manufacturer
4EVA 0HARMACEUTICAL 7ORKS 0RIVATE ,IMITED #OMPANY
(  'ÚDÚLLÚ
4ÈNCSICS -IHÈLY ÞT 
(UNGARY
This leaflet was last revised in November 2014.
0, 
0, 

 #
 #

s Complications following pancreatic surgery
4HE USUAL DOSAGE IS  MG  TIMESDAY BY
SUBCUTANEOUS INJECTION FOR  WEEK STARTING AT LEAST 
HOUR BEFORE SURGERY
s Bleeding gastro-oesophageal varices
4HE RECOMMENDED DOSAGE IS  MICROGRAMSHOUR FOR
 DAYS BY CONTINUOUS INTRAVENOUS INFUSION -ONITORING
OF BLOOD SUGAR LEVEL IS NECESSARY DURING TREATMENT
s TSH-secreting pituitary adenomas
4HE DOSAGE MOST GENERALLY EFFECTIVE IS  MICROGRAMS
THREE TIMES A DAY BY SUBCUTANEOUS INJECTION 4HE DOSE
CAN BE ADJUSTED ACCORDING TO THE RESPONSES OF 43( AND
THYROID HORMONES !T LEAST  DAYS OF TREATMENT WILL BE
NEEDED TO JUDGE THE EFFICACY

 #
 #

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)F YOU ARE ADMINISTERING /CTREOTIDE 4EVA BY
SUBCUTANEOUS INJECTION IT MAY HELP TO REDUCE THE RISK OF
GASTROINTESTINAL SIDE EFFECTS IF YOU AVOID EATING MEALS
AROUND THE TIME OF INJECTION )T IS THEREFORE
RECOMMENDED THAT YOU INJECT /CTREOTIDE 4EVA BETWEEN
MEALS OR WHEN YOU GO TO BED
Reporting of side effects
)F YOU GET ANY SIDE EFFECTS TALK TO YOUR DOCTOR
PHARMACIST OR NURSE 4HIS INCLUDES ANY POSSIBLE SIDE
If you forget to use Octreotide
!DMINISTER ONE DOSE AS SOON AS YOU REMEMBER AND THEN EFFECTS NOT LISTED IN THIS LEAFLET 9OU CAN ALSO REPORT SIDE
EFFECTS DIRECTLY VIA THE 9ELLOW #ARD 3CHEME AT
CONTINUE AS USUAL )T WILL NOT DO ANY HARM IF YOU MISS A
DOSE BUT YOU COULD GET SOME TEMPORARY RE APPEARANCE WWWMHRAGOVUKYELLOWCARD
"Y REPORTING SIDE EFFECTS YOU CAN HELP PROVIDE MORE
OF SYMPTOMS UNTIL YOU GET BACK ON SCHEDULE
INFORMATION ON THE SAFETY OF THIS MEDICINE
$O NOT INJECT A DOUBLE DOSE OF /CTREOTIDE TO MAKE UP
FOR FORGOTTEN INDIVIDUAL DOSES
How to store Octreotide
4HE SYMPTOMS OF OVERDOSE ARE IRREGULAR HEARTBEAT LOW
BLOOD PRESSURE CARDIAC ARREST REDUCED SUPPLY OF OXYGEN
TO THE BRAIN SEVERE UPPER STOMACH PAIN YELLOW SKIN AND
EYES NAUSEA LOSS OF APPETITE DIARRHOEA WEAKNESS
TIREDNESS LACK OF ENERGY WEIGHT LOSS ABDOMINAL SWELLING
DISCOMFORT AND HIGH LEVEL OF LACTIC ACID IN THE BLOOD
)F YOU THINK THAT AN OVERDOSE HAS HAPPENED AND YOU
EXPERIENCE SUCH SYMPTOMS TELL YOUR DOCTOR STRAIGHT AWAY

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