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OCTREOTIDE 100 MICROGRAMS/ML SOLUTION FOR INJECTION

Active substance(s): OCTREOTIDE ACETATE

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PH - 151

08 October 2014

2
Version:

231-30-61204-B LEA OCTREOTIDE A/S SOLN TEVAH TEVA UK Ref:

PH - 151

4HEFOLLOWINGINFORMATIONISINTENDEDFORMEDICALOR
HEALTHCAREPROFESSIONALSONLY

)NSTRUCTIONSFORUSE HANDLINGANDDISPOSAL

&ORSINGLEUSEONLY

/CTREOTIDEISANINJECTIONANDACONCENTRATEFORSOLUTION
FORINFUSION4HISMUSTBEHANDLEDWITHCAUTION4HE
DILUTIONMUSTBEDONEUNDERASEPTICCONDITIONS BY
TRAINEDSTAFFANDINASPECIFICAREA4HECONTACTOF
/CTREOTIDEWITHSKINANDMEMBRANESSHOULDBEAVOIDED

)FTHESOLUTIONCOMESINTOCONTACTWITHTHESKINWASH
WITHWATERANDSOAP)FTHESOLUTIONCOMESINTOCONTACT
WITHMEMBRANES WASHIRRIGATE THEAFFECTEDAREA
WITHWATER
4OREDUCELOCALDISCOMFORT LETTHESOLUTIONREACH
ROOMTEMPERATUREBEFOREINJECTING!VOIDMULTIPLE
INJECTIONSATSHORTINTERVALSATTHESAMETIME

Storage:
Storage conditions:
"EFOREOPENING3TOREINAREFRIGERATOR  #
PROTECTEDFROMLIGHT$ONOTFREEZE
!FTEROPENING4HEPRODUCTMUSTBEUSEDIMMEDIATELY

PH - 151

PH - 151

'ROWTHHORMONESECRETINGPITUITARYTUMOURSMAY
SOMETIMESEXPANDANDCAUSEPROBLEMS4ELLYOURDOCTOR
IFYOUEXPERIENCEANYPROBLEMSWITHYOUREYESORSIGHT

4ELLYOURDOCTORIFYOURSTOMACHORBOWELPROBLEMS
PACKAGE LEAFLET:
GETWORSE
INFORMATION FOR THE USER

4AKINGOTHERMEDICINES
Octreotide 50 micrograms/ml,
100 micrograms/ml and 500 micrograms/ml 0LEASETELLYOURDOCTORORPHARMACISTIFYOUARETAKING
ORHAVERECENTLYTAKENANYOFTHEFOLLOWINGMEDICINES
Solution for injection or Concentrate for INCLUDINGMEDICINESOBTAINEDWITHOUTAPRESCRIPTION
solution for infusion
s )NSULINOROTHERDRUGSFORDIABETES
Read all of this leaflet carefully before you start
s #ICLOSPORINADRUGUSEDAFTERATRANSPLANT
using this medicine.
s #IMETIDINEADRUGUSEDTOREDUCESTOMACHACID
s +EEPTHISLEAFLET9OUMAYNEEDTOREADITAGAIN
s "ROMOCRIPTINEADRUGUSEDIN0ARKINSONSDISEASE
s )FYOUHAVEANYFURTHERQUESTIONS ASKYOURDOCTOR ORINACROMEGALYORTOSUPPRESSBREASTMILK
ORPHARMACIST
s -EDICINESTOCONTROLBLOODPRESSUREBETA BLOCKERS
s )FANYOFTHESIDEEFFECTSGETSSERIOUS ORIFYOU
ORCALCIUMCHANNELBLOCKERS ORAGENTSTOCONTROL
NOTICEANYSIDEEFFECTSNOTLISTEDINTHISLEAFLET
FLUIDANDELECTROLYTEBALANCEDIURETICS
PLEASETELLYOURDOCTORORPHARMACIST
s -EDICINESMETABOLISEDBYTHELIVERFOREXAMPLE
CARBAMAZEPINEADRUGUSEDINPSYCHIATRICDISORDERS
IN THIS LEAFLET:

EPILEPSY TRIGEMINALNEURALGIAANDNEUROPATHY
1. What Octreotide is and what it is used for
DIGOXINMEDICINEFORCERTAINHEARTPROBLEMS AND
2. Before Octreotide is used
WARFARINADRUGUSEDTOTHINTHEBLOOD AND
3. How to use Octreotide
TERFENADINETORELIEVEALLERGICSYMPTOMS 
4. Possible side effects
0LEASETELLYOURDOCTORORHOSPITALPHARMACISTIFYOU
5. How to store Octreotide
ARETAKINGORHAVERECENTLYTAKENANYOTHERMEDICINES
6. Further information
INCLUDINGMEDICINESOBTAINEDWITHOUTAPRESCRIPTION

1 WHAT OCTREOTIDE IS AND WHAT IT IS
Pregnancy and breast-feeding
USED FOR
!SKYOURDOCTORORPHARMACISTFORADVICEBEFORE

TAKINGANYMEDICINES9OUSHOULDNOTUSE/CTREOTIDE
/CTREOTIDEISASYNTHETICFORMOFAHORMONECALLED
IFYOUAREPREGNANTUNLESSYOUHAVEBEENTOLDBYYOUR
SOMATOSTATINWHICHOCCURSNATURALLYINTHEBODY)T
DOCTORTHATITISABSOLUTELYNECESSARYFORYOUTODOSO
HELPSSTOPTHERELEASEOFSOMEHORMONES INCLUDING 9OUSHOULDNOTBREAST FEEDYOURINFANTWHILST
GROWTHHORMONE INTHEBODY
RECEIVINGTREATMENTWITHOCTREOTIDE UNLESSYOUHAVE

BEENTOLDTODOSO
/CTREOTIDEISUSED

s 4OTREATACROMEGALY
$RIVINGANDUSINGMACHINES
!CROMEGALYISACONDITIONWHERETHEBODYPRODUCES /CTREOTIDEMAYMAKEYOUFEELDIZZY)FTHISHAPPENS
TOOMUCHGROWTHHORMONE4HELEVELOFGROWTH
DONOTDRIVEOROPERATEMACHINERY2EMEMBERTHATIF
HORMONECONTROLSTHEGROWTHOFTISSUES ORGANSAND YOUAREUNWELLYOURABILITYTOOPERATEMACHINERY
BONES4OOMUCHHORMONEMEANSTHESIZEOFBONES MAYBEAFFECTED
ANDTISSUES ESPECIALLYINTHEHANDSANDFEET IS

LARGERTHANNORMAL4HESYMPTOMSOFACROMEGALY )MPORTANTINFORMATIONABOUTSOMEOFTHE
INCLUDEHEADACHE EXCESSIVEPERSPIRATION NUMB
ingredients of Octreotide
HANDSANDFEET TIREDNESSANDJOINTPAIN)NMOST
/CTREOTIDEMICROGRAMSML MICROGRAMSML
CASES THEOVERPRODUCTIONOFGROWTHHORMONEIS
ANDMICROGRAMSML3OLUTIONFORINJECTIONOR
CAUSEDBYANENLARGEMENTINTHEPITUITARYGLANDA #ONCENTRATEFORSOLUTIONFORINFUSIONCONTAINSLESS
PITUITARYADENOMA 
THANMMOLSODIUMPERDOSE IEESSENTIALLY
/CTREOTIDEISUSEDTOTREATPEOPLEWITHACROMEGALY hSODIUM FREEv
s WHENOTHERTYPESOFTREATMENTFORACROMEGALY
/THER3PECIAL7ARNINGS
SURGERYORRADIOTHERAPY ARENOTSUITABLEOR
s 4ELLYOURDOCTORIFYOURSTOMACHORBOWEL
HAVENOTWORKED
s AFTERRADIOTHERAPY TOCOVERTHEINTERIMPERIOD SYMPTOMSGETWORSE
UNTILTHERADIOTHERAPYBECOMESFULLYEFFECTIVE s /CTREOTIDESHOULDONLYBEUSEDINPREGNANCYIF
CLEARLYNEEDED4ELLYOURDOCTORIFYOUAREPREGNANT
s BEFORESURGERYONTHEPITUITARYGLAND

ORWANTTOBECOMEPREGNANT
s 4ORELIEVESTOMACHORBOWELSYMPTOMSASSOCIATED s 7OMENOFCHILDBEARINGPOTENTIALMUSTUSEAN
with certain tumours known as
EFFECTIVECONTRACEPTIVEMETHODDURINGTREATMENT
@GASTROENTEROPANCREATICTUMOURSRARETUMOURSOF WITH/CTREOTIDE
THESTOMACH BOWELSORPANCREAS
/VERPRODUCTIONOFSPECIFICHORMONESANDOTHER
3 HOW TO USE OCTREOTIDE
RELATEDNATURALSUBSTANCESCANBECAUSEDBYSOME
RARECONDITIONSOFTHESTOMACH BOWELSOR
!LWAYSUSE/CTREOTIDEEXACTLYASYOURDOCTORHAS
PANCREAS4HISUPSETSTHENATURALHORMONAL
TOLDYOU9OUSHOULDCHECKWITHYOURDOCTOROR
BALANCEOFTHEBODY ANDRESULTSINAVARIETYOF
PHARMACISTIFYOUAREUNSUREOFANYTHING
SYMPTOMS SUCHASFLUSHING DIARRHOEA LOWBLOOD
9OURMEDICINEMUSTBEINJECTEDSUBCUTANEOUSLYIE
PRESSURE RASHANDWEIGHTLOSS4REATMENTWITH
INTOTHETISSUEUNDERTHESKIN9OURDOCTORORNURSE
/CTREOTIDEHELPSTOCONTROLTHESESYMPTOMS
WILLSHOWYOUHOWTODOTHIS)FYOUAREUNSURE GO
s 4OPREVENTCOMPLICATIONSFOLLOWINGPANCREATIC
BACKANDASKFORADVICE9OUMUSTUSEACLEAN STERILE
surgery
SYRINGEANDNEEDLEEVERYTIME

/CTREOTIDECANBEUSEDINSOMEPATIENTSWHEN
4HEUPPERARMS THIGHSANDSTOMACHAREGOODAREAS
THEYHAVEANOPERATIONONTHEPANCREAS)TMAY
HELPREDUCESOMEOFTHEPROBLEMSWHICHCANOCCUR FORSUBCUTANEOUSINJECTION#HOOSEADIFFERENTPLACE
EACHTIMESOTHATYOUDONTIRRITATEAPARTICULARAREA
INTHEABDOMENAFTERTHEOPERATION SUCHAS
+EEPCHANGINGTHEINJECTIONSITE$ONTINJECTINTOTHE
INFLAMMATIONSWELLING ANDINFECTION
SAMEPLACETOOFREQUENTLY


2 BEFORE OCTREOTIDE IS USED
4OAVOIDSIDEEFFECTSLIKESTOMACHACHE WIND
DIARRHOEAANDCONSTIPATIONDONOTINJECTATMEALTIMES
9OUSHOULD./4BEGIVEN/CTREOTIDE
)NJECTBETWEENMEALSORBEFOREGOINGTOBED
s IFYOUAREALLERGICHYPERSENSITIVE TOOCTREOTIDE

ACETATEORANYOFTHEOTHERINGREDIENTSOF
)NRARECASES/CTREOTIDEWILLHAVETOBEINJECTED
/CTREOTIDESEESECTION
INTRAVENOUSLYINTOAVEIN )FTHISISNECESSARYTHE
s IFYOUAREBREAST FEEDING
DOCTORORNURSEWILLDOITANDMONITORYOUCLOSELY9OU

MUST./4INJECT/CTREOTIDEINTOYOURVEINSYOURSELF
4AKESPECIALCAREWITH/CTREOTIDE

s IFYOUAREPREGNANT
4HEUSUALDOSAGESAREGIVENBELOWHOWEVERYOUR
s ASOCTREOTIDEMAYAFFECTYOURBLOODSUGARLEVELS
DOCTORWILLDECIDEWHATDOSAGETOGIVETOYOU ASTHIS
9OUORYOURDOCTORSHOULDCLOSELYMONITORYOUR
DEPENDSONTHENATUREOFYOURTREATMENT YOURAGE
BLOODSUGARLEVELS
ANDYOURMEDICALCONDITION

s IFYOUHAVEANYTHYROIDPROBLEMS ORHAVEHADA
For the treatment of acromegaly
DISEASEWHICHMAYHAVEAFFECTEDYOURTHYROID
s IFYOUHAVEANYPROBLEMSWITHYOURLIVER ORHAVEYOU s 4HEUSUALDOSEISTOMGTHREETIMESADAY
BYSUBCUTANEOUSINJECTION$EPENDINGONHOW
HADADISEASEWHICHMAYHAVEAFFECTEDYOURLIVER
s IFYOUHAVEEVERSUFFEREDFROMGALLSTONESOROTHER YOURESPOND YOURDOCTORWILLADJUSTTHEDOSEUNTIL
THEYFINDTHERIGHTDOSE
STOMACHPROBLEMS
s IFYOUHAVEAHISTORYOF6ITAMIN"DEFICIENCY
4ORELIEVESYMPTOMSCAUSEDBYOVER PRODUCTIONOF
9OURDOCTORMAYNEEDTOMONITORYOURVITAMIN" some hormones
LEVELSDURINGTHERAPYWITHOCTREOTIDE
s 9OURDOCTORWILLUSUALLYSTARTYOURTREATMENTWITH

9OURDOCTORMAYWANTTOGIVEYOUACHECKUPFROMTIME MGONCEORTWICEDAILYBYSUBCUTANEOUS
TOTIMEWHILEYOUAREBEINGTREATEDWITH/CTREOTIDE INJECTION$EPENDINGONHOWYOURESPOND YOUR
DOCTORMAYGRADUALLYINCREASETHEDOSEUNTILTHEY

FINDYOURIDEALDOSE

PH - 151

4OPREVENTCOMPLICATIONSFOLLOWINGPANCREATICSURGERY Uncommon:
s MGTHREETIMESADAYFORSEVENDAYSSTARTINGON s $EHYDRATION
s &ASTHEARTBEAT
THEDAYOFTHEOPERATION

08 October 2014

2
Version:

231-30-61204-B LEA OCTREOTIDE A/S SOLN TEVAH TEVA UK Ref:

PH - 151

ANDANYUNUSEDDRUG PRODUCTMUSTBEDISCARDED
After dilution:4HECHEMICALANDPHYSICALSTABILITYOF
/CTREOTIDESOLUTIONDILUTEDINMGML
SODIUMCHLORIDESOLUTIONFORINFUSIONHASBEEN
DEMONSTRATEDFORHOURSWHENSTOREDBELOW #
&ROMAMICROBIOLOGICALPOINTOFVIEW THEPRODUCT
SHOULDBEUSEDIMMEDIATELY IFNOTUSEDIMMEDIATELY
STORAGETIMESANDCONDITIONSARETHERESPONSIBILITYOF
THEUSER UNLESSDILUTIONHASTAKENPLACEINCONTROLLED
ANDVALIDATEDASEPTICCONDITIONS














$ONOTUSEUNLESSTHESOLUTIONISCLEARANDFREEFROM
VISIBLEPARTICLES

$ISPOSAL
!NYUNUSEDPRODUCTORWASTEMATERIALSHOULDBE
DISPOSEDOFINACCORDANCEWITHLOCALREQUIREMENTS

 "












PH - 151

 "

PH - 151

0EOPLEWITHLIVERORKIDNEYPROBLEMSMAYBEGIVENA Frequency not known:
s !NAPHYLAXISATYPEOFALLERGICREACTIONWHICH
SMALLERDOSE
CAUSESDIFFICULTYINBREATHINGORDIZZINESS
4HEREISVERYLITTLEEXPERIENCEOFUSINGOCTREOTIDEIN
ALLERGYHYPERSENSITIVITYREACTIONS
CHILDREN
s )TCHYRASH

s )NFLAMMATIONOFTHEPANCREAS
)FYOURECEIVEMORE/CTREOTIDETHANYOUSHOULD
)FYOUARECONCERNEDTHATYOUMAYHAVEBEENGIVENTOO s ,IVERINFLAMMATIONHEPATITIS SYMPTOMSMAY
MUCH/CTREOTIDE TELLYOURDOCTORORNURSEIMMEDIATELY INCLUDEYELLOWINGOFTHESKINANDEYESJAUNDICE
NAUSEA VOMITING LOSSOFAPPETITE GENERALLY

FEELINGUNWELL ITCHING LIGHT COLOUREDURINE
If you miss a dose of Octreotide
s )RREGULARHEARTBEAT
!SYOUWILLBEGIVENTHISMEDICINEUNDERCLOSE
s ,IVERDYSFUNCTION
SUPERVISION ITISVERYUNLIKELYTHATYOUWILLMISSA
DOSE)FYOUTHINKTHATYOUHAVEMISSEDADOSEOF
)FANYOFTHESIDEEFFECTSGETSSERIOUS ORIFYOUNOTICE
TREATMENT TELLADOCTORORNURSEATONCE
ANYSIDEEFFECTSNOTLISTEDINTHISLEAFLET PLEASETELL

)FYOUHAVEANYFURTHERQUESTIONSONTHEUSEOFTHIS YOURDOCTORORPHARMACIST
PRODUCT ASKYOURDOCTORORPHARMACIST

5 HOW TO STORE OCTREOTIDE
4 POSSIBLE SIDE EFFECTS
+EEPOUTOFTHEREACHANDSIGHTOFCHILDREN
,IKEALLMEDICINES /CTREOTIDECANCAUSESIDEEFFECTS
$ONOTUSE/CTREOTIDEAFTERTHEEXPIRYDATEWHICHIS
ALTHOUGHNOTEVERYBODYGETSTHEM
STATEDONTHELABELAFTER%804HEEXPIRYDATEREFERS

-OSTPEOPLEWHOAREPRESCRIBED/CTREOTIDEBENEFITFROM TOTHELASTDAYOFTHATMONTH
TAKINGIT BUTAFEWPEOPLECANBEUPSETBYIT)FYOU
ARERECEIVINGTHISMEDICINEONALONGTERMBASISTHEN Storage conditions:
"EFOREOPENING3TOREINAREFRIGERATOR  #
YOUWILLGOTOHOSPITALFROMTIMETOTIMETOHAVE
PROTECTEDFROMLIGHT$ONOTFREEZE
REGULARCHECK UPS


4HEREISNONEEDTOWORRYIFYOUSUFFERFROMANYOFTHE !FTEROPENING4HEPRODUCTMUSTBEUSEDIMMEDIATELY
ANDANYUNUSEDDRUG PRODUCTMUSTBEDISCARDED
FOLLOWINGCOMMONREACTIONSATTHESITEOFINJECTION

s 0AIN STINGING TINGLING BURNING REDNESSANDSWELLING After dilution:4HECHEMICALANDPHYSICALSTABILITYOF
4HESERARELYLASTFORMORETHANMINUTESANDWILLBE /CTREOTIDESOLUTIONDILUTEDINMGML
LESSIFYOULETYOURMEDICINEREACHROOMTEMPERATURE SODIUMCHLORIDESOLUTIONFORINFUSIONHASBEEN
BEFOREINJECTING
DEMONSTRATEDFORHOURSWHENSTOREDBELOW #
3OMESIDEEFFECTSCANBESERIOUS3TOPTAKING/CTREOTIDE &ROMAMICROBIOLOGICALPOINTOFVIEW THEPRODUCT
and tell your doctor straight away if you notice that: SHOULDBEUSEDIMMEDIATELY IFNOTUSEDIMMEDIATELY
STORAGETIMESANDCONDITIONSARETHERESPONSIBILITYOF
s 9OURFACEBECOMESFLUSHEDORSWOLLENORYOU
THEUSER UNLESSDILUTIONHASTAKENPLACEINCONTROLLED
DEVELOPSPOTSORARASH
s 9OURCHESTFEELSTIGHT YOUBECOMESHORTOFBREATH ANDVALIDATEDASEPTICCONDITIONS

ORWHEEZY
$ONOTUSEUNLESSTHESOLUTIONISCLEARANDFREEFROM
s 9OUFEELFAINT POSSIBLYASARESULTOFAFALLINBLOOD VISIBLEPARTICLES

PRESSURE
&ORSINGLEUSEONLY
4HESEMIGHTBEARESULTOFANALLERGICREACTION

)FYOUDEVELOPANYOFTHEFOLLOWINGSEEYOURDOCTOR -EDICINESSHOULDNOTBEDISPOSEDOFVIAWASTEWATER
ORHOUSEHOLDWASTE!SKYOURPHARMACISTHOWTO
immediately:
DISPOSEOFMEDICINESNOLONGERREQUIRED4HESE
s 0ROLONGEDTROUBLESOMEBLOATINGOFTHESTOMACH
MEASURESWILLHELPTOPROTECTTHEENVIRONMENT
WITHPAIN

s .AUSEAVOMITINGASSOCIATEDWITHDROWSINESS
s &EELINGRESTLESSORGIDDY
6 FURTHER INFORMATION

s 9ELLOWINGOFTHESKINORWHITESOFYOUREYES
s !CUTEPANCREATITISSUDDEN SEVERE BURNINGPAINS What Octreotide contains
INTHESTOMACH 4HISMAYHAPPENWITHINTHEFIRST
FEWHOURSORDAYSOFTREATMENTANDRESOLVESITSELF s 4HEACTIVESUBSTANCEISOCTREOTIDEASTHEACETATE 
%ACHMLOFSOLUTIONFORINJECTIONORCONCENTRATEFOR
UPONDRUGWITHDRAWAL
SOLUTIONFORINFUSIONCONTAINSMICROGRAMS
MICROGRAMSANDMICROGRAMSOCREOTIDE
4HEFOLLOWINGSIDEEFFECTSHAVEALSOBEENREPORTED
s 4HEOTHERINGREDIENTSAREGLACIALACETICACID
ANDTHEAPPROXIMATEFREQUENCIESSHOWN
SODIUMACETATETRIHYDRATE% MANNITOL%
6ERYCOMMON•
ANDWATERFORINJECTIONS
#OMMON•TO
7HAT/CTREOTIDELOOKSLIKEANDCONTENTSOFTHEPACK
5NCOMMON• TO
/CTREOTIDEMICROGRAMSML MICROGRAMSML
2ARE• TO 
ANDMICROGRAMSML3OLUTIONFORINJECTIONOR
6ERYRARE 
.OTKNOWNCANNOTBEESTIMATEDFROMTHEAVAILABLEDATA #ONCENTRATEFORSOLUTIONFORINFUSIONISACLEARAND
COLOURLESSSOLUTION4HESOLUTIONISSUPPLIEDIN
Very common:
COLOURLESSGLASSVIALSCLOSEDWITHSERUMRUBBER
s 3TOMACHACHE NAUSEA WIND DIARRHOEAOR
STOPPERSANDSEALEDWITHALUMINIUMFLIP OFFCAPS
CONSTIPATION4HESEWILLBELESSIFYOUINJECT
FITTEDWITHPLASTICFLIP OFFDISCS4HEPRODUCTISPACKED
BETWEENMEALSORBEFOREGOINGTOBED
INCARDBOARDBOXES

s #HANGESINBLOODSUGARLEVELSHYPERGLYCAEMIA
/CTREOTIDEMICROGRAMSML MICROGRAMSML
s (EADACHE
ANDMICROGRAMSMLSOLUTIONFORINJECTIONOR
s 'ALLSTONES
CONCENTRATEFORSOLUTIONFORINFUSIONISAVAILABLEIN
s ,OCALPAINATTHESITEOFINJECTION
PACKSIZESOF     ANDVIALS

Common:
.OTALLPACKSIZESMAYBEMARKETED
s 3LOWHEARTBEAT

s (AIRLOSS
Marketing Authorisation Holder and Manufacturer
s )TCHING
Marketing Authorisation Holder
s 2ASH
4EVA5+,IMITED %ASTBOURNE ".!'
s 3HORTNESSOFBREATH
5NITED+INGDOM
s $IZZINESS

s ,OSSOFAPPETITE
Manufacturer
s #HANGESINBLOODSUGARLEVELSHYPOGLYCAEMIA
4EVA0HARMACEUTICAL7ORKS0RIVATE,IMITED#OMPANY
s )MPAIREDGLUCOSETOLERANCE
( 'ÚDÚLLÚ
s 3TOMACHDISCOMFORTAFTERAMEAL
4ÈNCSICS-IHÈLYÞT
s 6OMITING
(UNGARY
s "LOATEDSTOMACH
4HISLEAFLETWASLASTREVISEDIN/CTOBER
s ,OOSEFAECESSTOOLS
s $ISCOLOURATIONOFFAECES
0,
s &ATINYOURFAECESPALEANDFATTYLOOSESTOOLS
0, 
s )NFLAMMATIONOFTHEGALLBLADDER
s "ILIARYSLUDGE
s 9ELLOWSKINANDEYES
s !BNORMALLIVERFUNCTIONTESTRESULTS
s #HANGESINACTIVITYOFTHETHYROIDGLAND
HYPOTHYROIDISM CAUSINGCHANGESINHEARTRATE
APPETITEORWEIGHT TIREDNESS FEELINGCOLDOR
 "
SWEATINGTOOMUCH ANXIETYORSWELLINGATTHE
FRONTOFTHENECK
 "

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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