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OCTIM NASAL SPRAY

Active substance(s): DESMOPRESSIN

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OCTIM ® Nasal Spray
Desmopressin acetate

PATIENT INFORMATION
Read all of this leaflet carefully before you start using
this medicine.
• Keep this leaflet, you may need to read it again
• If you have further questions, please ask your doctor or
pharmacist
• This medicine has been prescribed for you personally and
you should not pass it on to others. It may harm them even
if their symptoms are the same as yours.
• If any of the side effects gets serious, or if you notice any
side effects not listed in this leaflet, please tell your doctor
or pharmacist.
Important things that you need to know:
• Octim Nasal Spray is used
- during surgery or following trauma in patients with
mild to moderate haemophilia (blood condition) or
von Willebrand’s disease (blood clotting condition)
- to test for fibrinolytic response
• You should avoid drinking large amounts of fluid while you
are being treated with Octim Nasal Spray.
• If you experience unusually bad or prolonged headache,
confusion, unexplained weight gain, ankle swelling, nausea
or vomiting stop using Octim Nasal Spray.
In this leaflet:
1. What Octim Nasal Spray is and what it is used for
2. Before you use Octim Nasal Spray
3. How to use Octim Nasal Spray
4. Possible side effects
5. Storing Octim Nasal Spray
6. Further information

1. What Octim Nasal Spray is and what it is
used for
Octim Nasal Spray is a solution for nasal use only. It contains
Desmopressin acetate, an antidiuretic (reduces urine production).
It is used:
• during surgery or following trauma in patients with mild to
moderate haemophilia (blood condition) or von Willebrand’s
disease (blood clotting condition) to increase blood clotting
factors (Note: Octim Nasal Spray is not suitable for every
patient or for the treatment of all types of haemophilia or
von Willebrand’s disease).
• to test for fibrinolytic response (a test to measure the
capacity of the body to dissolve blood clots once they
have formed)

2. Before you use Octim Nasal Spray
Do not use Octim Nasal Spray if you:
• are allergic to any of the ingredients listed in section 6 of
this leaflet
• drink unusually large quantities of fluids including
alcohol, or if you experience excessive thirst
To be used during surgery or following trauma in
patients with mild to moderate haemophilia or von
Willebrand’s disease:
Do not use Octim Nasal Spray if you:
• suffer from angina
• suffer from Type IIB (classed as moderate to
severe) von Willebrand’s disease

To test for fibrinolytic response:
Do not use Octim Nasal Spray if you:
• have high blood pressure or heart problems
• are taking diuretics (water tablets)
Please consult your doctor before using Octim Nasal
Spray if you:
• have an illness causing fluid and/or electrolyte imbalance e.g.
vomiting, diarrhoea, infections or fever
• have a medical condition that could be made worse by
fluid and/or electrolyte disturbance (conditions where your
blood sodium levels are too low or you are likely to build
up too much water in your body) e.g. Hyponatremia.
• suffer from serious heart or kidney disease
• have cystic fibrosis
Taking/using other medicines:
Please inform your doctor or pharmacist if you:
• are taking or have recently taken or used any other
medicines - even those not prescribed.
• are on medication for depression or epilepsy
• are taking a medicine for pain and/or inflammation
containing non-steroidal anti-inflammatory drugs (also known
as NSAIDs) e.g. indomethacin or ibuprofen
Taking Octim Nasal Spray with food or drink:
• you should avoid drinking large amount of fluid while you
are being treated with Octim Nasal Spray as this could
lead to build up of water which dilutes the salt in the
body. This is a serious problem and may lead to
convusions. You should only drink enough fluids to satisfy
your thirst.
• when used to test for fibrinolytic response, limit fluid intake
to no more than 500ml, from 1 hour before until 8 hours
after the dose
Pregnancy:
If you are pregnant or planning a pregnancy, please inform your
doctor before you use Octim Nasal Spray as blood pressure
monitoring is recommended due to the increased risk of
pre-eclampsia (a condition in pregnant women that can cause
serious complications). Symptoms of pre-eclampsia include
high blood pressure, oedema (swelling due to the build up of
fluid) and proteinuria (protein in the urine).
Breast-feeding:
If you are breast-feeding ask your doctor or pharmacist for
advice before using Octim Nasal Spray.
Important information about some of the ingredients in
Octim Nasal Spray:
Octim Nasal Spray contains Benzalkonium Chloride which may
cause bronchospasm (when your breathing airway
suddenly narrows, causing coughing and difficulty in
breathing).

3. How to use Octim Nasal Spray

6. Further information

For details on use of this product see the patient instructions
section at the end of this leaflet.

Your medicine is called Octim Nasal Spray. It is a solution for
nasal use only.
• it is presented in a glass vial with a pump spray device.
Each vial contains a volume of 2.5ml to allow the delivery
of 25 sprays
• each spray contains 150 micrograms of the active ingredient,
Desmopressin acetate
• other ingredients in Octim Nasal Spray are citric acid
monohydrate, disodium phophate dihydrate, sodium chloride,
benzalkonium chloride solution 50% and purified water.

Do NOT use more than the prescribed dose in any 24 hour
period.
If you have the impression that the effect of Octim Nasal Spray
is too strong or too weak, talk to your doctor or pharmacist.
The usual doses are:
During surgery or following trauma in patients with mild
to moderate haemophilia and von Willebrand’s disease
to increase blood clotting factors:
Adults (including the elderly): One spray into each nostril half
an hour before surgery or at bleeding.
Under direct medical supervision, further doses may be
administered at 12 hourly intervals.
If you have been given Octim Nasal Spray to use occasionally
as the need arises, there should be an interval of at least 3
days between doses unless your doctor has specifically
instructed you otherwise.
Fibrinolytic response test:
Adults (including the elderly): One spray into each nostril.
If you used more Octim Nasal Spray than you should:
If you have used more Octim Nasal Spray than you should,
talk to your doctor or pharmacist immediately.
If you forget to use Octim Nasal Spray:
Please consult your doctor or pharmacist for advice.

Marketing Authorisation Holder: Ferring Pharmaceuticals Ltd.,
Drayton Hall, Church Road, West Drayton, UB7 7PS, (UK).
Manufacturer: Ferring GmbH, Wittland 11, D-24109 Kiel,
Germany.
®

OCTIM Nasal Spray: PL 03194/0056
This leaflet was last revised in October 2015.
.

PATIENT INSTRUCTIONS
It is important to use your medicine as directed by your doctor.
The pharmacy label on the bottle will tell you when to use your
medicine and how much to use. If it does not, or you are not
sure, ask your doctor or pharmacist.
How to use OCTIM Nasal Spray:
1. Remove the protective cap.

4. Possible side effects
Like all medicines, Octim Nasal Spray can cause side effects.
STOP USING OCTIM NASAL SPRAY if you experience:
• allergic reactions including; itching, skin rashes, swelling
of the face, lips or throat, difficulty in breathing,
wheeziness, chest tightness or coughing
• unusually bad or prolonged headache
• confusion
• unexplained weight gain
• ankle swelling
• nausea or vomiting
If you experience any of the above side effects, you should
contact your doctor or go to the nearest casualty
department immediately.
Low level of sodium in your blood can lead to fits. This is
more likely to happen if you drink large amounts of fluid while
receiving this medication.
Most people using Octim Nasal Spray find it causes them no
problems. However, common side effects can include:
• headache
• stomach pain
• blocked or runny nose, nose bleeds
Very rare cases of emotional disorders including aggression
in children have also been reported.
If you experience one or more of these side effects or any other
undesirable effects, please inform your doctor or pharmacist.

5. Storing Octim Nasal Spray
Keep Octim Nasal Spray out of the reach and sight of children.
Do not store above 25°C. Keep vial in the outer carton in order
to protect it from light. Do not freeze.
Use by date: Do NOT use Octim Nasal Spray past the expiry
date on the packaging. The expiry date refers to the last day
of that month.
If you are unsure about the storage, ask your pharmacist.
It is best to return all old and unused medication to your
pharmacist for safe disposal.

2. When first used, press the spray several times until a
consistent, fine spray is seen.

3. Ensure that the dip-tube is in the liquid when using Octim
Nasal Spray. With your head tilted slightly back, place the
nozzle just inside your nostril.

4. Hold your breath (DO NOT SNIFF) and press the spray once.
5. Repeat this procedure using alternate nostrils until the
prescribed dose has been given.
6. Replace the protective cap after use.
7. Do not store above 25°C. Keep vial in the outer carton in
order to protect it from light. Do not freeze.
8. If the spray is not used within 7 days of the previous dose,
press the spray at least once, until a consistent, fine spray
is seen.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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