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OCTIM INJECTION

Active substance(s): DESMOPRESSIN ACETATE

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Octim® Injection
Desmopressin acetate

PATIENT INFORMATION

Read all of this leaflet carefully before you
start using this medicine.
• Keep this leaflet, you may need to read it again
• If you have further questions, please ask your
doctor or pharmacist
• This medicine has been prescribed for you
personally and you should not pass it on to
others. It may harm them even if their
symptoms are the same as yours.
• If any of the side effects gets serious, or if you
notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
Important things that you need to know:
• Octim Injection is used:
- during surgery or following trauma in
patients with mild to moderate haemophilia
(blood condition) or von Willebrand’s
disease (blood clotting condition)
- to test for fibrinolytic response
• You should avoid drinking large amounts of
fluid while you are being treated with Octim
Injection.
• If you experience unusually bad or prolonged
headache, confusion, unexplained weight gain,
ankle swelling, nausea or vomiting stop using
Octim Injection.

In this leaflet:
1. What Octim Injection is and what it is used for
2. Before Octim Injection is given
3. How Octim Injection will be given
4. Possible side effects
5. Storing Octim Injection
6. Further information

1. What Octim Injection is and what
it is used for
Octim Injection is a clear, colourless solution. It
contains Desmopressin acetate, an antidiuretic
(reduces urine production). It is used:




during surgery or following trauma in patients
with mild to moderate haemophilia (blood
condition) or von Willebrand’s disease (blood
clotting condition) to increase blood clotting
factors (Note: Octim Injection is not suitable
for every patient or for the treatment of all
types of haemophilia or von Willebrand’s
disease)
to test for fibrinolytic response (a test to
measure the capacity of the body to dissolve
blood clots once they have formed)

2. Before Octim Injection is given
Octim Injection will not be given if you:
• are allergic to any of the ingredients listed in
section 6
• drink unusually large quantities of fluids,
including alcohol, or if you experience
excessive thirst

Octim Injection will not be given to increase
blood clotting factors if you:
• suffer from angina
• suffer from moderate to severe type IIB
von Willebrand’s disease
Octim Injection will not be given to test your
fibrinolytic response if you:
• have high blood pressure or heart problems
• are taking diuretics (water tablets)
Please consult your doctor before Octim
Injection is given if you:
• have an illness causing fluid and/or electrolyte
imbalance e.g. vomiting, diarrhoea, infections
or fever
• have a medical condition that could be made
worse by fluid and/or electrolyte disturbance
(conditions where your blood sodium levels
are too low or you are likely to build up too
much water in your body. e.g. Hyponatremia
• suffer from serious heart or kidney disease
Taking/using other medicines:
Please inform your doctor or pharmacist if you:
• are taking or have recently taken or used any
other medicines - even those not prescribed
• are on medication for depression or epilepsy
• are taking a medicine for pain and/or
inflammation containing non-steroidal
anti-inflammatory drugs (also known as
NSAIDs) e.g. indomethacin or ibuprofen
Taking Octim Injection with food or drink:
• you should avoid drinking large amount of
fluid while you are being treated with Octim
Injection as this could lead to build up of
water which dilutes the salt in the body.
This is a serious problem and may lead to
convulsions. You should only drink enough
fluid to satisfy your thirst.
• when used to test fibrinolytic response, limit
fluid intake to no more than 500ml, from
1 hour before until 8 hours after the dose.
Pregnancy:
If you are pregnant or planning a pregnancy,
please inform your doctor before you use Octim
Injection as blood pressure monitoring is
recommended due to the increased risk of
pre-eclampsia (a condition in pregnant women
that can cause serious complications). Symptoms
of pre-eclampsia include high blood pressure,
oedema (swelling due to the build up of fluid) and
proteinuria (protein in the urine).
Breast-feeding:
If you are breast-feeding ask your doctor or
pharmacist for advice before using Octim
Injection.

3. How Octim Injection will be given

5. Storing Octim Injection

Depending on the condition that you are being
treated for, the doctor will administer the
appropriate dose by injection, either just under the
skin (subcutaneous) or directly into one of your
veins (intravenous).

Octim Injection should be stored in a refrigerator
at 2°C to 8°C. Keep container in the outer carton.

During surgery or following trauma in
patients with mild to moderate haemophilia
and von Willebrand’s disease to increase
blood clotting factors:
The dose for adults, children and infants is 0.3
micrograms per kilogram body weight,
administered just under the skin (subcutaneous) or
directly into one of your veins (intravenous) over a
period of 20 minutes. This dose should be given
before surgery or following trauma. Further doses
may be administered at 12 hourly intervals.
Fibrinolytic response test:
The dose for adults and children is 0.3
micrograms per kilogram body weight,
administered just under the skin (subcutaneous)
or directly into one of your veins (intravenous)
over a period of 20 minutes.
If you are given more Octim Injection than
you should:
As this medicine will be given to you whilst you
are in hospital it is unlikely that you will be given
too much, however, avoid drinking any more fluid
and seek medical advice if you have any
concerns.

4. Possible side effects

Like all medicines, Octim Injection can cause side
effects.

STOP USING OCTIM INJECTION if you
experience:
• allergic reactions including; itching, skin
rashes, swelling of the face, lips or throat,
difficulty in breathing, wheeziness, chest
tightness or coughing
• unusually bad or prolonged headache
• confusion
• unexplained weight gain
• ankle swelling
• nausea or vomiting
If you experience any of the above side effects,
you should contact your doctor or go to the
nearest casualty department immediately.
Low levels of sodium in your blood can lead to
fits. This is more likely to happen if you drink large
amounts of fluid while receiving this medication.
Most people using Octim Injection find it causes
them no problems. However, common side effects
can include:
• headache
• stomach pain
Very rare cases of emotional disorders
including aggression in children have also been
reported.
If you experience one or more of these side effects
or any other undesirable effects, please inform
your doctor or pharmacist.

Use by date: Do NOT use Octim Injection past
the expiry date on the packaging. The expiry date
refers to the last day of that month.
This product should only be given by a doctor or
qualified nurse and will be safely disposed of by
them.

6. Further information
Your medicine is called Octim Injection.
• it is supplied in clear glass ampoules and
each ampoule contains 1ml of a clear, sterile
colourless solution.
• each 1ml of the solution contains 15
micrograms of the active ingredient
Desmopressin acetate dissolved in water for
injection.
• other ingredients in Octim Injection are sodium
chloride and hydrochloric acid.
Marketing Authorisation Holder:
Ferring PharmaceuticalsLtd.,
The Courtyard,
Waterside Drive,
Langley,
Berkshire,
SL3 6EZ (UK).
Manufacturer:
FERRING GmbH, Wittland 11, Kiel, Germany
Fibrinolytic Response Testing:
Besoksadress: Hojdrodergatan 16, 212 39 Malmo
®

Octim Injection PL 03194/0055
This leaflet was last revised in March 2011.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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