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Active substance(s): CEFRADINE

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This leaflet has been provided to help you understand about Nicef and the way in
which it should be taken to ensure that you gain most benefit from the product.
Please read it carefully and follow the instructions given. If you have any questions
or are not sure about anything, ask your doctor or pharmacist.

The Name of Your Medicine is Nicef Syrup
What is Nicef?
Nicef contains cefradine, one of a group of antibiotics called cephalosporins. It is
available as a powder for the preparation of a cherry flavoured syrup. When prepared
by the pharmacist, each bottle of syrup contains 100ml.
Each 5ml spoonful of Nicef Syrup contains 250mg of cefradine. The other ingredients
are methylcellulose, sodium citrate, anhydrous citric acid, cherry flavour and sucrose.
The Marketing Authorisation holder is Co-pharma Ltd, Unit 4 Metro Centre, Tolpits
Lane, Watford, Hertfordshire, WD1 8SS. The product is manufactured by PDMS,
Almac House, 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK.

What Does Nicef Syrup Do?
It is used to kill bacteria which cause infections in your body. These include throat,
chest and ear infections, sinus infections, infections of skin and soft tissue and urinary
tract infections.

Before Taking Your Medicine
Before taking this product, please answer the following question:
- Have you had any allergic reaction (e.g. rash, itching, shortness of breath) to any
cephalosporin antibiotic in the past (e.g. cefalexin, cefuroxime or cefaclor) or to other
antibiotics known as penicillins?
If you answer YES to this question you should NOT take this product. Speak to your
Now answer these questions:

- Are you pregnant or breast feeding?
- Do you suffer from kidney disease?
- Are you on kidney dialysis?
- Are you diabetic? (Cefradine can interfere with some urine sugar tests.)
If the answer to any of these questions is YES, it is important that you tell your doctor
or pharmacist before taking this medicine. It may still be safe for you to take
cefradine. Ask your doctor or pharmacist’s advice.
Please tell your doctor or pharmacist if you are taking or have recently taken any
other medicines, including those without a prescription.
In particular, tell your doctor if you are taking:
- diuretics or ‘water tablets’ e.g. furosemide
- probenecid (used to treat gout).
If you are having a blood test, it is important that you tell your doctor that you are
taking this medicine as it may affect the result.
Other warnings:

Each 5ml spoonful contains 17.59mg of sodium. If this product
is taken in high doses it may be harmful to people on a low
sodium diet. If you are on a low sodium diet please seek your
doctor or pharmacist’s advice before taking this product.
Each 5ml spoonful contains 2.45grams of sucrose. As a result
this product is unsuitable for patients with hereditary fructose
intolerance, glucose-galactose malabsorption syndrome or
sucrase-isomaltase deficiency. If you suffer from any of the
above conditions you should NOT take this product.
Nicef Syrup may cause dizziness. If you experience dizziness
while taking this medicine, do not drive or operate machinery.

Taking Your Medicine
How much should I take and how often?
This product should be taken orally (by mouth).
The usual adult dose is 250mg (one 5ml spoonful) four times daily or 500mg (two
5ml spoonfuls) twice daily but this may be increased for severe infections. The usual
dose for children will depend on the child’s weight.
Doctors may sometimes prescribe different doses to these. It is important to read the
label on your bottle as it will tell you exactly what dose to take.

Keep taking your Nicef Syrup until you have finished the full course of treatment that
your doctor has prescribed for you. This will make sure that the infection is
completely cleared. Do not stop taking the medicine just because you feel better.

What should I do if I forget to take a dose?
If you forget to take a dose of your medicine, take it as soon as you remember and
then continue as before.
What should I do if I take too much?
It is always important to follow the dose recommended on the label. If you
accidentally take too much, contact your doctor or pharmacist who will recommend
what steps to take.
After Taking Your Medicine
Are there any side effects?
Some people find that cefradine makes them feel sick or vomit. It may also cause
heartburn, abdominal pain or diarrhoea. If you develop diarrhoea which becomes
severe or contains blood or mucus you should tell your doctor. Sometimes this
product may cause vaginal discharge or irritation.
Tell your doctor immediately if you start suffering from a rash or any other skin
trouble (especially if there are numerous red/purple patches on the skin or if skin
shedding occurs), itching, joint pain or if you have difficulty breathing. These may be
signs of an allergy and you should stop taking this product at once and contact your
doctor if this happens to you. You should also tell your doctor if you start to feel
weak or if you develop a sore throat or your tongue becomes swollen or inflamed
while taking this product.
Other side effects include:
- headache
- confusion
- dizziness
- nervousness
- difficulty sleeping
- hyperactivity
- sore tongue or mouth
- kidney inflammation, which could cause reduced urine output, cloudy or bloody
urine, swelling and pain
- temporary liver problems which can cause dark urine, pale stools, fever, yellowing
of your eyes and skin
-temporary blood disorders which could cause you to have more infections than usual
and can also make your skin pale and cause weakness, breathlessness and tiredness.

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly via
the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the safety of this

Storing Your Medicine
How should I store Nicef Syrup?
Nicef Syrup should be stored in the fridge (between 2 and 8oC) where children cannot
reach it. Syrup which has been kept in the fridge may be used for fourteen days.
Throw away any medicine that has not been used after fourteen days.
Keep the lid tightly closed and do not use after the expiry date shown on the label.
If your doctor tells you to stop your treatment, return any left over medicine to the
pharmacist. Only keep it if the doctor tells you to.
Remember - As with all medicines, do NOT share this product with any other person.
Date of Revision: March 2015

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.