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NEOSTIGMINE METHYLSULFATE INJECTION BP 2.5MG IN 1ML

Active substance(s): NEOSTIGMINE METHYLSULFATE

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Patient Information Leaflet

hameln

Neostigmine Methylsulfate Injection BP 2.5 mg
Important information about your medicine
Your doctor or nurse will give you the injection
► If this injection causes you any problems talk to your doctor, nurse or pharmacist
► Please tell your doctor or pharmacist, if you have any other medical conditions or have an allergy to
any of the ingredients of this medicine
► Please tell your doctor or pharmacist, if you are taking any other medicines


• Read all of this leaflet carefully before you start using this medicine. In some circumstances
this may not be possible and this leaflet will be kept in a safe place should you wish to read it.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, please ask your doctor or your pharmacist.
• This medicine has been prescribed for you personally and you should not pass it on to others.
It may harm them, even if their symptoms are the same as yours.

Where to find information in this leaflet
1. What Neostigmine Methylsulfate Injection is and what it is used for
2. Before you are given Neostigmine Methylsulfate Injection
3. How to use Neostigmine Methylsulfate Injection
4. Possible side effects
5. Storing Neostigmine Methylsulfate Injection
6. Further information

1. What Neostigmine Methylsulfate Injection
is and what it is used for
Neostigmine injection belongs to a group of
medicines used to:
• Treat abnormally tired and weak muscles
(myasthenia gravis).
• Reverse the effects of muscle relaxants.
• Improve movement in the small intestine.
• Reduce urine retention after surgical
procedures.

2. Before you are given Neostigmine
Methylsulfate Injection
You should NOT be given Neostigmine
Methylsulfate Injection if you:
• are sensitive or allergic to neostigmine or
any of the other ingredients in this injection.
• have an intestinal obstruction or cannot
urinate.
• have peritonitis (an infection or inflammation
of the outer layer of your stomach or intestines).
• have a condition where your bowel may no
longer be functioning.
• you are receiving certain muscle relaxants
(e.g. Suxamethonium).

Please tell your doctor or nurse before
being given the injection if you have:
• asthma
• epilepsy
• a slow pulse
• any heart disease
• vagotonia (you may suffer from sweating,
constipation and involuntary movements)
• an overactive thyroid gland
• a stomach ulcer
• Parkinson’s Disease
• an anastomosis (an opening created by
surgery, trauma, or disease) in your intestine
• a controlled low sodium diet (this medicinal
product contains approximately 3.54 mg sodium
per ml)

Using other medicines:
Please tell your doctor or nurse if you are taking or
have recently taken any other medicines, including

medicines obtained without a prescription. This is
especially important with the following medicines
as they may interact with your Neostigmine
Methylsulfate Injection :
• you are receiving antibiotics known as
aminoglycosides.

Pregnancy or breast feeding:
Please tell your doctor or nurse before being
given this injection if you are pregnant or
breast feeding. The doctor will then decide if
the injection is suitable for you.

Driving and using machines:
You should not drive or use machinery
if you are affected by the administration of
Neostigmine Methylsulfate Injection .

3. How to use Neostigmine Methylsulfate
Injection
Your nurse or doctor will give you the
injection.
Your doctor will decide the correct dosage for
you and how and when the injection will be

given.
Since the injection will be given to you by a doctor
or nurse, it is unlikely that you will be given too
much. If you think you have been given
too much, you must tell the person giving you
the injection.

4. Possible side effects
Like all medicines, Neostigmine Methylsulfate
Injection can cause side effects, although not
everybody gets them. You may:
• feel or actually be sick
• produce more saliva than usual
• produce more tears than usual
• suffer from bronchial spasm and increased

bronchial secretion

• suffer from diarrhoea and stomach cramps
• have constricted (pin-point) pupils in your eye
• suffer from urinary incontinence (you pass
urine when you do not mean to)
• suffer from excessive sweating
• have a slow pulse
• suffer from hypotension (blood pressure that

is much lower than usual)
• suffer from muscle spasms
If you experience any of the side effects listed
this may mean that you have been given
an overdose and you should tell a doctor
immediately.
If you think this injection is causing you any
problems, or you are at all worried, talk to
your doctor, nurse or pharmacist.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse: This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide
more information on the safety of this medicine.

5. Storing
Injection

Neostigmine

Methylsulfate

Your injection will be stored at less than 25°C
and protected from light. The nurse or doctor will
check that the injection is not past its expiry date
before giving you the injection.

6. Further information
What
Neostigmine
Injection contains:

Methylsulfate

This injection contains the active ingredient
Neostigmine Methylsulfate. Each 1 ml of solution
contains 2.5 mg neostigmine methylsulfate.
This injection contains the following inactive
ingredients: Sodium Chloride, Sterile Water for
Injections.

What
Neostigmine
Methylsulfate
Injection looks like and contents of the
pack:
Neostigmine Methylsulfate Injection is a clear
colourless solution in clear glass ampoules
containing 2.5 mg neostigmine methylsulfate in 1
ml. 10 ampoules are supplied in each carton.
The marketing authorisation number of this
medicine is: PL 01502/0023

Marketing Authorisation Holder:
hameln pharmaceuticals ltd
Gloucester, United Kingdom

Manufacturer:
hameln pharmaceuticals gmbh
Langes Feld 13, 31789 Hameln, Germany
hameln rds a.s.
Horná 36, 900 01 Modra, Slovak Republic
HBM Pharma s.r.o.
03680 Martin, Sklabinská 30, Slovak Republic

For
any
information
about
this
medicine, please contact the Marketing
Authorisation Holder
This leaflet was last approved November 2014

43849/03/15

Patient Information Leaflet

hameln

Neostigmine Methylsulfate Injection BP 2.5 mg
Important information about your medicine
Your doctor or nurse will give you the injection
► If this injection causes you any problems talk to your doctor, nurse or pharmacist
► Please tell your doctor or pharmacist, if you have any other medical conditions or have an allergy to
any of the ingredients of this medicine
► Please tell your doctor or pharmacist, if you are taking any other medicines


• Read all of this leaflet carefully before you start using this medicine. In some circumstances
this may not be possible and this leaflet will be kept in a safe place should you wish to read it.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, please ask your doctor or your pharmacist.
• This medicine has been prescribed for you personally and you should not pass it on to others.
It may harm them, even if their symptoms are the same as yours.

Where to find information in this leaflet
1. What Neostigmine Methylsulfate Injection is and what it is used for
2. Before you are given Neostigmine Methylsulfate Injection
3. How to use Neostigmine Methylsulfate Injection
4. Possible side effects
5. Storing Neostigmine Methylsulfate Injection
6. Further information

1. What Neostigmine Methylsulfate Injection
is and what it is used for
Neostigmine injection belongs to a group of
medicines used to:
• Treat abnormally tired and weak muscles
(myasthenia gravis).
• Reverse the effects of muscle relaxants.
• Improve movement in the small intestine.
• Reduce urine retention after surgical
procedures.

2. Before you are given Neostigmine
Methylsulfate Injection
You should NOT be given Neostigmine
Methylsulfate Injection if you:
• are sensitive or allergic to neostigmine or
any of the other ingredients in this injection.
• have an intestinal obstruction or cannot
urinate.
• have peritonitis (an infection or inflammation
of the outer layer of your stomach or intestines).
• have a condition where your bowel may no
longer be functioning.
• you are receiving certain muscle relaxants
(e.g. Suxamethonium).

Please tell your doctor or nurse before
being given the injection if you have:
• asthma
• epilepsy
• a slow pulse
• any heart disease
• vagotonia (you may suffer from sweating,
constipation and involuntary movements)
• an overactive thyroid gland
• a stomach ulcer
• Parkinson’s Disease
• an anastomosis (an opening created by
surgery, trauma, or disease) in your intestine
• a controlled low sodium diet (this medicinal
product contains approximately 3.54 mg sodium
per ml)

Using other medicines:
Please tell your doctor or nurse if you are taking or
have recently taken any other medicines, including

medicines obtained without a prescription. This is
especially important with the following medicines
as they may interact with your Neostigmine
Methylsulfate Injection :
• you are receiving antibiotics known as
aminoglycosides.

Pregnancy or breast feeding:
Please tell your doctor or nurse before being
given this injection if you are pregnant or
breast feeding. The doctor will then decide if
the injection is suitable for you.

Driving and using machines:
You should not drive or use machinery
if you are affected by the administration of
Neostigmine Methylsulfate Injection .

3. How to use Neostigmine Methylsulfate
Injection
Your nurse or doctor will give you the
injection.
Your doctor will decide the correct dosage for
you and how and when the injection will be

given.
Since the injection will be given to you by a doctor
or nurse, it is unlikely that you will be given too
much. If you think you have been given
too much, you must tell the person giving you
the injection.

4. Possible side effects
Like all medicines, Neostigmine Methylsulfate
Injection can cause side effects, although not
everybody gets them. You may:
• feel or actually be sick
• produce more saliva than usual
• produce more tears than usual
• suffer from bronchial spasm and increased

bronchial secretion

• suffer from diarrhoea and stomach cramps
• have constricted (pin-point) pupils in your eye
• suffer from urinary incontinence (you pass
urine when you do not mean to)
• suffer from excessive sweating
• have a slow pulse
• suffer from hypotension (blood pressure that

is much lower than usual)
• suffer from muscle spasms
If you experience any of the side effects listed
this may mean that you have been given
an overdose and you should tell a doctor
immediately.
If you think this injection is causing you any
problems, or you are at all worried, talk to
your doctor, nurse or pharmacist.

Reporting of side effects
If you get any side effects, talk to your doctor,
pharmacist or nurse: This includes any possible
side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide
more information on the safety of this medicine.

5. Storing
Injection

Neostigmine

Methylsulfate

Your injection will be stored at less than 25°C
and protected from light. The nurse or doctor will
check that the injection is not past its expiry date
before giving you the injection.

6. Further information
What
Neostigmine
Injection contains:

Methylsulfate

This injection contains the active ingredient
Neostigmine Methylsulfate. Each 1 ml of solution
contains 2.5 mg neostigmine methylsulfate.
This injection contains the following inactive
ingredients: Sodium Chloride, Sterile Water for
Injections.

What
Neostigmine
Methylsulfate
Injection looks like and contents of the
pack:
Neostigmine Methylsulfate Injection is a clear
colourless solution in clear glass ampoules
containing 2.5 mg neostigmine methylsulfate in 1
ml. 10 ampoules are supplied in each carton.
The marketing authorisation number of this
medicine is: PL 01502/0023

Marketing Authorisation Holder:
hameln pharmaceuticals ltd
Gloucester, United Kingdom

Manufacturer:
hameln pharmaceuticals gmbh
Langes Feld 13, 31789 Hameln, Germany
hameln rds a.s.
Horná 36, 900 01 Modra, Slovak Republic
HBM Pharma s.r.o.
03680 Martin, Sklabinská 30, Slovak Republic

For
any
information
about
this
medicine, please contact the Marketing
Authorisation Holder
This leaflet was last approved November 2014
58175/03/15

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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