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MOTILIUM 1MG/ML SUSPENSION

Active substance(s): DOMPERIDONE

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PATIENT INFORMATION LEAFLET

Motilium® 1mg/ml oral suspension
(domperidone)

This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help
by reporting any side effects you may get. See the end of section 4 for how to report side effects.
Read all of this leaflet carefully before you start taking this medicine.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the
same as yours.
If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or
pharmacist.
Your doctor may have given you this medicine before from another company. It may have looked slightly different.
However, either brand will have the same effect.
The name of your medicine is Motilium 1mg/ml Suspension, but will be referred to as Motilium throughout this leaflet.
In this leaflet:
1. What Motilium is and what it is used for
2. What you need to know before you take Motilium
3. How to take Motilium
4. Possible side effects
5. How to store Motilium
6. Contents of the pack and other information

1. WHAT MOTILIUM IS AND WHAT IT IS USED FOR
The active ingredient in this medicine is called domperidone. This belongs to a group of medicines called ‘dopamine
antagonists’.
This medicine is used in adults and in children to treat nausea (feeling sick) and vomiting (being sick).

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE MOTILIUM
Do not take Motilium if:
You are allergic (hypersensitive) to domperidone or any of the other ingredients of Motilium (listed in section 6: ‘Contents
of the pack and other information’). Signs of an allergic reaction include: a rash, swallowing or breathing problems,
swelling of your lips, face, throat or tongue.
You have a tumour of the pituitary gland (prolactinoma).
You have a blockage or tear in your intestines.
You have black, tarry bowel motions (stools) or notice blood in your bowel motions. This could be a sign of bleeding in the
stomach or intestines.
You have a moderate or severe liver disease.
Your ECG (electrocardiogram) shows a heart problem called ‘prolonged QT corrected interval’.
You have or had a problem where your heart cannot pump the blood round your body as well as it should (condition called
heart failure).
You have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood.
You are taking certain medicines (see ‘Other medicines and Motilium’)
Do not take Motilium if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking
Motilium.
Warnings and precautions
Before taking this medicine contact your doctor if:
You suffer from liver problems (liver function impairment or failure) (see ‘Do not take Motilium if’)
You suffer from kidney problems (kidney function impairment or failure). It is advisable to ask your doctor for advice in
case of prolonged treatment as you may need to take a lower dose or take this medicine less often, and your doctor may
want to examine you regularly.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Motilium. Do this even if
they have applied in the past.

Motilium may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more likely in
those over 60 years old or taking doses higher than 30mg per day. The risk also increases when Motilium is given together
with some drugs. Tell your doctor or pharmacist if you are taking drugs to treat infection (fungal infections or bacterial infection)
and/or if you have heart problems or AIDS/HIV (see ‘Other medicines and Motilium’).
Motilium should be used at the lowest effective dose in adults and children.
While taking Motilium, contact your doctor if you experience heart rhythm disorders such as palpitations, trouble breathing,
loss of consciousness. Treatment with Motilium should be stopped.
Other medicines and Motilium:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you
can buy without a prescription, including herbal medicines. This is because Motilium can affect the way some other medicines
work. Also, some medicines can affect the way Motilium works.
Do not take Motilium if you are taking medicine to treat:
Fungal infections such as azole anti-fungals, specifically oral ketoconazole, fluconazole or voriconazole.
Bacterial infections, specifically erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine (these are
antibiotics)
Heart problems or high blood pressure (e.g., amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol,
diltiazem, verapamil)
Psychoses (e.g., haloperidol, pimozide, sertindole)
Depression (e.g., citalopram, escitalopram)
Gastro-intestinal disorders (e.g., cisapride, dolasetron, prucalopride)
Allergy (e.g., mequitazine, mizolastine)
Malaria (in particular halofantrine)
AIDS/HIV (protease inhibitors)
Cancer (e.g., toremifene, vandetanib, vincamine)
Tell your doctor or pharmacist if you are taking drugs to treat infection, heart problems or AIDS/HIV.
Tell your doctor if you are taking antacids or other medicines that reduce stomach acid (such as cimetidine or sodium
bicarbonate). These medicines can be taken if you are also taking Motilium but they should not be taken at the same time as
they may affect how well Motilium works. Medicines that reduce stomach acid should be taken after a meal.
It is important to ask your doctor or pharmacist if Motilium is safe for you when you are taking any other medicines, including
medicines obtained without prescription.
Taking Motilium with food and drink
It is recommended to take Motilium before meals as when taken after meals the absorption of the medicine is slightly delayed.
Pregnancy and breast-feeding
Talk to your doctor or pharmacist before taking Motilium if:
You are pregnant, might become pregnant or think you may be pregnant.
You are breast-feeding. It is best not to take Motilium if you are breast-feeding.
Small amounts of Motilium have been detected in breast milk. Motilium may cause unwanted side effects affecting the heart in
a breast-fed baby. Motilium should be used during breast-feeding only if your physician considers this clearly necessary. Ask
your doctor for advice before taking this medicine.
Driving and using machines:
Motilium does not affect your ability to drive or use machines.
Important information about some of the ingredients of Motilium:
This medicine contains sorbitol. If you have been told that you cannot digest or tolerate some sugars, talk to your doctor before
taking Motilium.
This medicine also contains methylhydroxybenzoate (E218) and propylhydroxybenzoate (E216). These substances may
cause allergic reactions (possibly delayed), and exceptionally, bronchospasm.

3. HOW TO TAKE MOTILIUM
Follow these instructions closely unless your doctor has advised you otherwise. You should check with your doctor or
pharmacist if you are not sure.
Duration of treatment
Your doctor will decide how long you will need to take this medicine.
Symptoms usually resolve with 3-4 days of taking this medicine. Do not take Motilium for longer than 7 days without consulting
your doctor.

Taking this medicine
Take this medicine by mouth.
Adults and adolescents: take your medicine using the plastic measuring cup provided with Motilium. This cup is marked
in ml (millilitres) to help you measure out the correct amount of this medicine.
Children weighing under 35kg: should be given Motilium using a suitably graduated oral syringe. Your doctor or
pharmacist will supply you with this syringe. If you are not supplied with an oral syringe please speak to your doctor or
pharmacist.
Take your medicine 15 to 30 minutes before a meal.
The usual dose is:
Adults and adolescents 12 years of age and older with a body weight of 35kg or more
The usual dose is 10ml taken up to three times per day, if possible before meals. Do not take more than 30ml per day.
Children and adolescents from birth to a body weight of less than 35kg
Your doctor will work out the dose. This will depend on the weight of your child. Give the dose maximum 3 times a day, if
possible before meals/feeding. Do not give more than 3 times in a 24 hour time period.
People with kidney problems
Your doctor may tell you to take a lower dose or to take the medicine less often.
If you take more Motilium than you should:
If you have used or taken too much Motilium, contact your doctor, pharmacist or the poisons unit at your nearest hospital
casualty department immediately in particular if a child has taken too much. Take the carton and bottle containing any
remaining medicine with you. This is so the doctors know what you have taken. In the event of overdose, symptomatic
treatment could be implemented. An ECG monitoring could be undertaken, because of the possibility of a heart problem
called prolonged QT interval.
The signs of taking more than you should include feeling sleepy, confused, uncontrolled movements (especially in
children) which include unusual eye movements, unusual movements of the tongue or abnormal posture (such as a
twisted neck).
If you forget to take Motilium:
If you forget to take Motilium, take it as soon as you remember.
However if it is almost time for the next dose, wait until that is due and then continue as normal.
Do not take a double dose to make up for a forgotten dose.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Motilium can have side effects, although not everybody gets them.
Stop taking Motilium and see your doctor or go to a hospital straightaway if:
You get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing. You
could also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction
to Motilium.
You notice any uncontrolled movements. These include irregular eye movements, unusual movements of the tongue, and
abnormal posture such as a twisted neck, trembling and muscle stiffness. This is more likely to happen in children. These
symptoms should stop once you stop taking Motilium.
You have a very fast or unusual heart beat. This could be a sign of a life-threatening heart problem.
You have a fit (seizure)
Other side effects include:
Common (affects less than 1 in 10 people)
Dry mouth
Uncommon (affects less than 1 in 100 people)
Lowering of sexual drive (libido) in men
Feeling anxious
Feeling drowsy
Headaches
Diarrhoea
Itchy skin. You may also have a rash
Unusual production of breast milk in men and women
Painful or tender breasts
A general feeling of weakness

Not known (Frequency cannot be estimated from the available data)
Disorders of the cardiovascular system: heart rhythm disorders (rapid or irregular heart beat) have been reported; if this
happens, you should stop the treatment immediately. Motilium may be associated with an increased risk of heart rhythm
disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than 30mg per
day. Motilium should be used at the lowest effective dose in adults and children.
Feeling agitated or irritable
Feeling more nervous than usual
Abnormal eye movements
Inability to urinate
Breast enlargement in men
In women, menstrual periods may be irregular or stop
A blood test shows changes in the way your liver is working
Some patients who have used Motilium for conditions and dosages requiring longer term medical supervision have
experienced the following unwanted effects:
Restlessnes: swollen or enlarged breasts, unusual discharge from breasts, irregular menstrual periods in women, difficulty
breast-feeding, depression, hypersensitivity.
Side effects such as feeling drowsy, nervous, agitated or irritable or having a fit are more likely to happen in children.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects, you can help provide more information on the safety of this medicine.

5. HOW TO STORE MOTILIUM
Keep out of the sight and reach of children.
Do not store above 30°C.
Do not take your medicine after the expiry date which is stated on the carton and bottle label after ‘Exp’. The expiry date
refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to protect the environment.
If your medicine shows any signs of damage, take it to your pharmacist for advice.

6. CONTENTS OF THE PACK AND OTHER INFORMATION
What Motilium contains
Each ml contains 1mg domperidone as the active ingredient. It also contains sorbitol, microcrystalline cellulose and carmellose
sodium, methylparahydroxybenzoate, propylparahydroxybenzoate, sodium saccharin, polysorbate 20, sodium hydroxide and
purified water.
What Motilium looks like and contents of the pack
Each pack contains a 200ml white plastic bottle, with a plastic screw cap containing a white coloured liquid suspension. It also
contains a 20ml graduated plastic measuring cup and a 1.25ml spoon.
Manufactured by: Laboratorios Dr. Esteve, S.A., Barcelona, Spain.
Procured from within the EU and repackaged by Product Licence holder: B&S Healthcare, Unit 4, Bradfield Road,
Ruislip, Middlesex, HA4 0NU, UK.
Motilium 1mg/ml Suspension, PLPI No: 18799/2068
POM
Leaflet date: 20.07.2015
Motilium is a registered Trademark of Johnson & Johnson Inc.

PATIENT INFORMATION LEAFLET

Domperidone 1mg/ml oral suspension

This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help
by reporting any side effects you may get. See the end of section 4 for how to report side effects.
Read all of this leaflet carefully before you start taking this medicine.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the
same as yours.
If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or
pharmacist.
Your doctor may have given you this medicine before from another company. It may have looked slightly different.
However, either brand will have the same effect.
The name of your medicine is Domperidone 1mg/ml Suspension, but will be referred to as Domperidone throughout this
leaflet.
In this leaflet:
1. What Domperidone is and what it is used for
2. What you need to know before you take Domperidone
3. How to take Domperidone
4. Possible side effects
5. How to store Domperidone
6. Contents of the pack and other information

1. WHAT DOMPERIDONE IS AND WHAT IT IS USED FOR
The active ingredient in this medicine is called domperidone. This belongs to a group of medicines called ‘dopamine
antagonists’.
This medicine is used in adults and in children to treat nausea (feeling sick) and vomiting (being sick).

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE DOMPERIDONE
Do not take Domperidone if:
You are allergic (hypersensitive) to domperidone or any of the other ingredients of Domperidone (listed in section 6:
‘Contents of the pack and other information’). Signs of an allergic reaction include: a rash, swallowing or breathing
problems, swelling of your lips, face, throat or tongue.
You have a tumour of the pituitary gland (prolactinoma).
You have a blockage or tear in your intestines.
You have black, tarry bowel motions (stools) or notice blood in your bowel motions. This could be a sign of bleeding in the
stomach or intestines.
You have a moderate or severe liver disease.
Your ECG (electrocardiogram) shows a heart problem called ‘prolonged QT corrected interval’.
You have or had a problem where your heart cannot pump the blood round your body as well as it should (condition called
heart failure).
You have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood.
You are taking certain medicines (see ‘Other medicines and Domperidone ’)
Do not take Domperidone if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking
Domperidone .
Warnings and precautions
Before taking this medicine contact your doctor if:
You suffer from liver problems (liver function impairment or failure) (see ‘Do not take Domperidone if’)
You suffer from kidney problems (kidney function impairment or failure). It is advisable to ask your doctor for advice in
case of prolonged treatment as you may need to take a lower dose or take this medicine less often, and your doctor may
want to examine you regularly.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Domperidone . Do this even
if they have applied in the past.

Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more
likely in those over 60 years old or taking doses higher than 30mg per day. The risk also increases when Domperidone is
given together with some drugs. Tell your doctor or pharmacist if you are taking drugs to treat infection (fungal infections or
bacterial infection) and/or if you have heart problems or AIDS/HIV (see ‘Other medicines and Domperidone ’).
Domperidone should be used at the lowest effective dose in adults and children.
While taking Domperidone , contact your doctor if you experience heart rhythm disorders such as palpitations, trouble
breathing, loss of consciousness. Treatment with Domperidone should be stopped.
Other medicines and Domperidone :
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you
can buy without a prescription, including herbal medicines. This is because Domperidone can affect the way some other
medicines work. Also, some medicines can affect the way Domperidone works.
Do not take Domperidone if you are taking medicine to treat:
Fungal infections such as azole anti-fungals, specifically oral ketoconazole, fluconazole or voriconazole.
Bacterial infections, specifically erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine (these are
antibiotics)
Heart problems or high blood pressure (e.g., amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol,
diltiazem, verapamil)
Psychoses (e.g., haloperidol, pimozide, sertindole)
Depression (e.g., citalopram, escitalopram)
Gastro-intestinal disorders (e.g., cisapride, dolasetron, prucalopride)
Allergy (e.g., mequitazine, mizolastine)
Malaria (in particular halofantrine)
AIDS/HIV (protease inhibitors)
Cancer (e.g., toremifene, vandetanib, vincamine)
Tell your doctor or pharmacist if you are taking drugs to treat infection, heart problems or AIDS/HIV.
Tell your doctor if you are taking antacids or other medicines that reduce stomach acid (such as cimetidine or sodium
bicarbonate). These medicines can be taken if you are also taking Domperidone but they should not be taken at the same time
as they may affect how well Domperidone works. Medicines that reduce stomach acid should be taken after a meal.
It is important to ask your doctor or pharmacist if Domperidone is safe for you when you are taking any other medicines,
including medicines obtained without prescription.
Taking Domperidone with food and drink
It is recommended to take Domperidone before meals as when taken after meals the absorption of the medicine is slightly
delayed.
Pregnancy and breast-feeding
Talk to your doctor or pharmacist before taking Domperidone if:
You are pregnant, might become pregnant or think you may be pregnant.
You are breast-feeding. It is best not to take Domperidone if you are breast-feeding.
Small amounts of Domperidone have been detected in breast milk. Domperidone may cause unwanted side effects affecting
the heart in a breast-fed baby. Domperidone should be used during breast-feeding only if your physician considers this clearly
necessary. Ask your doctor for advice before taking this medicine.
Driving and using machines:
Domperidone does not affect your ability to drive or use machines.
Important information about some of the ingredients of Domperidone :
This medicine contains sorbitol. If you have been told that you cannot digest or tolerate some sugars, talk to your doctor before
taking Domperidone .
This medicine also contains methylhydroxybenzoate (E218) and propylhydroxybenzoate (E216). These substances may
cause allergic reactions (possibly delayed), and exceptionally, bronchospasm.

3. HOW TO TAKE DOMPERIDONE
Follow these instructions closely unless your doctor has advised you otherwise. You should check with your doctor or
pharmacist if you are not sure.
Duration of treatment
Your doctor will decide how long you will need to take this medicine.
Symptoms usually resolve with 3-4 days of taking this medicine. Do not take Domperidone for longer than 7 days without
consulting your doctor.

Taking this medicine
Take this medicine by mouth.
Adults and adolescents: take your medicine using the plastic measuring cup provided with Domperidone . This cup is
marked in ml (millilitres) to help you measure out the correct amount of this medicine.
Children weighing under 35kg: should be given Domperidone using a suitably graduated oral syringe. Your doctor or
pharmacist will supply you with this syringe. If you are not supplied with an oral syringe please speak to your doctor or
pharmacist.
Take your medicine 15 to 30 minutes before a meal.
The usual dose is:
Adults and adolescents 12 years of age and older with a body weight of 35kg or more
The usual dose is 10ml taken up to three times per day, if possible before meals. Do not take more than 30ml per day.
Children and adolescents from birth to a body weight of less than 35kg
Your doctor will work out the dose. This will depend on the weight of your child. Give the dose maximum 3 times a day, if
possible before meals/feeding. Do not give more than 3 times in a 24 hour time period.
People with kidney problems
Your doctor may tell you to take a lower dose or to take the medicine less often.
If you take more Domperidone than you should:
If you have used or taken too much Domperidone , contact your doctor, pharmacist or the poisons unit at your nearest
hospital casualty department immediately in particular if a child has taken too much. Take the carton and bottle containing
any remaining medicine with you. This is so the doctors know what you have taken. In the event of overdose, symptomatic
treatment could be implemented. An ECG monitoring could be undertaken, because of the possibility of a heart problem
called prolonged QT interval.
The signs of taking more than you should include feeling sleepy, confused, uncontrolled movements (especially in
children) which include unusual eye movements, unusual movements of the tongue or abnormal posture (such as a
twisted neck).
If you forget to take Domperidone :
If you forget to take Domperidone , take it as soon as you remember.
However if it is almost time for the next dose, wait until that is due and then continue as normal.
Do not take a double dose to make up for a forgotten dose.

4. POSSIBLE SIDE EFFECTS
Like all medicines, Domperidone can have side effects, although not everybody gets them.
Stop taking Domperidone and see your doctor or go to a hospital straightaway if:
You get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing. You
could also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction
to Domperidone .
You notice any uncontrolled movements. These include irregular eye movements, unusual movements of the tongue, and
abnormal posture such as a twisted neck, trembling and muscle stiffness. This is more likely to happen in children. These
symptoms should stop once you stop taking Domperidone .
You have a very fast or unusual heart beat. This could be a sign of a life-threatening heart problem.
You have a fit (seizure)
Other side effects include:
Common (affects less than 1 in 10 people)
Dry mouth
Uncommon (affects less than 1 in 100 people)
Lowering of sexual drive (libido) in men
Feeling anxious
Feeling drowsy
Headaches
Diarrhoea
Itchy skin. You may also have a rash
Unusual production of breast milk in men and women
Painful or tender breasts
A general feeling of weakness

Not known (Frequency cannot be estimated from the available data)
Disorders of the cardiovascular system: heart rhythm disorders (rapid or irregular heart beat) have been reported; if this
happens, you should stop the treatment immediately. Domperidone may be associated with an increased risk of heart
rhythm disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than
30mg per day. Domperidone should be used at the lowest effective dose in adults and children.
Feeling agitated or irritable
Feeling more nervous than usual
Abnormal eye movements
Inability to urinate
Breast enlargement in men
In women, menstrual periods may be irregular or stop
A blood test shows changes in the way your liver is working
Some patients who have used Domperidone for conditions and dosages requiring longer term medical supervision have
experienced the following unwanted effects:
Restlessnes: swollen or enlarged breasts, unusual discharge from breasts, irregular menstrual periods in women, difficulty
breast-feeding, depression, hypersensitivity.
Side effects such as feeling drowsy, nervous, agitated or irritable or having a fit are more likely to happen in children.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects, you can help provide more information on the safety of this medicine.

5. HOW TO STORE DOMPERIDONE
Keep out of the sight and reach of children.
Do not store above 30°C.
Do not take your medicine after the expiry date which is stated on the carton and bottle label after ‘Exp’. The expiry date
refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to protect the environment.
If your medicine shows any signs of damage, take it to your pharmacist for advice.

6. CONTENTS OF THE PACK AND OTHER INFORMATION
What Domperidone contains
Each ml contains 1mg domperidone as the active ingredient. It also contains sorbitol, microcrystalline cellulose and carmellose
sodium, methylparahydroxybenzoate, propylparahydroxybenzoate, sodium saccharin, polysorbate 20, sodium hydroxide and
purified water.
What Domperidone looks like and contents of the pack
Each pack contains a 200ml white plastic bottle, with a plastic screw cap containing a white coloured liquid suspension. It also
contains a 20ml graduated plastic measuring cup and a 1.25ml spoon.
Manufactured by: Laboratorios Dr. Esteve, S.A., Barcelona, Spain.
Procured from within the EU and repackaged by Product Licence holder: B&S Healthcare, Unit 4, Bradfield Road,
Ruislip, Middlesex, HA4 0NU, UK.
POM
Domperidone 1mg/ml Suspension; PLPI No: 18799/2068
Leaflet date: 20.07.2015

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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