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Active substance(s): METRONIDAZOLE

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METROLYL® Metronidazole Suppositories 500 mg and 1g


Read all of this leaflet carefully before you start to use your medicine.
• Keep the leaflet. You may want to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same
as yours.
• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

In this leaflet:
1. What Metrolyl® are and what they are used for
2. Before you use Metrolyl®
3. How to use Metrolyl®
4. Possible side effects
5. How to store Metrolyl®
6. Further Information


What Metrolyl® are and what they are used for

The name of your medicine is Metrolyl® (Metronidazole)
Suppositories 500 mg or 1 g. Metrolyl® (Metronidazole)
Suppositories are antibacterials used to treat infections.

Metrolyl® works by killing the bacteria in our body.
It can be used to treat:
• Treat infections in the blood, brain, lung, bones, genital tract,
pelvic area and stomach
• Prevent infections after surgery
If you need any further information about your illness, speak to
your doctor.


Before you use Metrolyl®

Do not use Metrolyl® if:
• You are allergic to metronidazole, or any of the other
ingredients in this medicine (see section 6 Further
Information). Signs of an allergic reaction are: rash, swallowing
or breathing problems, swelling of the face, lips, tongue or
throat. Do not use Metrolyl® if any of the above applies to you,
if you are not sure ask your doctor or pharmacist.

Take special care with Metrolyl®:
• If you have or have had a liver disease.
• If you have kidney failure and are having dialysis (see section
3 People having kidney dialysis).
• If you have a disease of the nervous system.

If you are not sure speak to you doctor or pharmacist.

Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines obtained
without a prescription. This includes herbal medicines.

It is important that you tell your doctor if you are taking:
• Phenobarbitone, primidone, phenytoin (used for epilepsy and
• Anticoagulants such as warfarin (used to prevent blood clots),

• Lithium (used to treat depressive illness),
• Cimetidine (used to treat stomach ulcers),
• Cytotoxics such as fluorouracil and busulfan (used to treat cancer),
• Disulfiram (used to treat alcohol abuse),
• Ciclosporin to prevent rejection of organs after transplant.
If you are not sure speak to your doctor or pharmacist before
using Metrolyl®.
Using Metrolyl® with food and drink
Do not drink alcohol while taking metronidazole and for 48 hours
after the course of the medicine has finished as you may get an
unpleasant reaction, such as feeling or being sick, stomach pain,
hot flushes, palpitations (sensation of feeling your heart beating)
and headaches.
Pregnancy and breast-feeding
Talk to your doctor before using Metrolyl® (Metronidazole)
Suppositories if you are pregnant or think you may be pregnant.

Do not use Metronidazole while breast-feeding as it is secreted in
breast milk in small amounts.

Driving and using machines
If you experience any dizziness, drowsiness, hallucinations
(seeing or hearing things that are not there), confusion, have fits
(convulsions), blurred or double vision, if you are affected do not
drive or operate machinery until you have consulted a doctor.

Your doctor may want to carry out some laboratory tests if you are
using this medicine for more than 10 days.


How to use Metrolyl®

Always use Metrolyl® exactly as your doctor has told you. You
should check with your doctor or pharmacist if you are not sure.
The usual doses are shown below. Doctors sometimes prescribe
different doses to these: if this applies to you, discuss it with the
doctor, if you have not already done so.

Treatment with metronidazole will normally be for 7 days. Shorter
or longer treatment may be prescribed if your doctor feels this is
necessary. If treatment is to continue for longer than 10 days your
doctor will keep a close eye on you.

Continued on the next page >>

Metrolyl® should be inserted into the anus (rectum). They may be
given on their own or with other medicines which kill bacteria.

The usual dose is:
• Suppositories are normally used for 3 days
• As soon as possible after starting treatment with the suppositories,
your doctor will suggest changing to a medicine taken by mouth.
• After 3 days, if you r doctor wants your child to continue using
the suppositories, you will probably be told to use the
suppositories every 12 hours.

The usual dose for adult and children using suppositories are below:

For the treatment of infections
Metrolyl® may be used to treat a number of different infections.
Your doctor will decide on the appropriate dosage depending on
the type of infection.
The usual dosage is as follows:

Adults and children over 10 years:
• Use one 1 g suppository every 8 hours for 3 days. See above
for the dosing over 3 days.

Children aged 5 – 10 years:
• Use one 500 mg suppository, every 8 hours for 3 days See
above for the dosing over 3 days.

Children aged 1-5 years:
• Use one half of a 500 mg suppository, every 8 hours for 3 days
See above for the dosing over 3 days.

Infants under 1 year old:
• Use one quarter of a 500 mg suppository, every 8 hours for 3
days See above for the dosing over 3 days.

To prevent infections form happening after surgery
Adults and children over 10 years
• Use one 1 g suppository 2 hours before surgery.
• Repeat every 8 hours up to 3 days. See above for dosing after
3 days.
Children aged 5-10 years
• Use one 500 mg suppository 2 hours before surgery.
• Repeat every 8 hours up to 3 days. See above for dosing after
3 days.

People having kidney dialysis
Your doctor may tell you to stop using Metrolyl® during dialysis
and start using it again once you gave finished.
People with liver problems
Your doctor may give you a lower dose or tell you to use this
medicine less often.

If you use more Metrolyl® than you should
If you use more suppositories than you should, tell your doctor or
go to a hospital casualty department straight away, taking the
pack and the suppositories you have left with you, to show your
doctor what you have used.

If you forget to use Metrolyl®
If you forget to take a dose, take the missed dose as soon as you
remember. If is nearly time for your next dose, have a single dose
straight away and skip the next.
If you stop using Metrolyl®
You should always complete the prescribed course, unless your
doctor tells you to stop.
If you have any further questions on the use of this product, ask
your doctor or pharmacist.


Possible side effects

Like all medicines, Metrolyl® can cause side effects, although not
everybody gets them.

Stop using Metrolyl® and seek immediate medical help if:
• You get swelling of the hands, feet, ankles, face, lips, mouth or
throat, this could cause breathing or swallowing problems,
itchy lumpy rash (hives) or nettle rash (urticaria). This could be
caused by an allergic reaction to Metrolyl®.
• A very rare serious side effect is a brain disease
(encephalopathy, the symptoms include stiff neck, fever,
headaches, seeing or hearing things that are not there,
confusion, problems using your arms or legs, speech problems.

Talk your doctor straight away if you notice the following
side effects:
• Yellowing of the whites of the eyes and the skin, this could be
due to jaundice (liver problem)
• Unexpected infections, mouth ulcers, bruising, bleeding gums
or severe tiredness (could be blood problems)
• Severe stomach pain which may reach through to your back

Tell your doctor or pharmacist f you notice any of the
following side effects:
Very rare (effects less than 1 in 10,000 people)
• Fits (convulsions)
• Darkening of the urine
• Feeling sleepy or dizzy
• Pains in the muscles or joints

Not known (frequency estimated from the available data)
• Numbness, tingling, pain or a feeling of weakness in the arms
or legs
• Unpleasant taste in the mouth
• Furred tongue
• Feeling sick (nausea), being sick (vomiting, upset stomach
pain or diarrhoea
• Loss of appetite
• Fever
• Feeling depressed

If any of the side effects gets serious, or if you notice any side
effects not listed in this leaflet, please tell your doctor or pharmacist.


How to store Metrolyl®

Keep all medicines out of the reach and sight of children.

Do not use Metrolyl® (Metronidazole) Suppositories 500 mg or 1
g after the expiry date shown on the label. The expiry date refers
to the last day of that month. Any out of date medicines should be
returned to your pharmacist for disposal.
Do not store above 25°C. Protected from light.

If you notice any defects in the suppositories, take them to your
pharmacist for advice before using them.

Medicines should not be disposed of via wastewater or household
waste. Ask your pharmacist how to dispose of medicines no longer
required. These measures will help to protect the environment.


Further information

What Metrolyl® contain:
Each suppository contains 500 mg or 1 g of the active ingredient
metronidazole BP.
The other ingredient is hard fat suppository base.

The suppositories are supplied in packs of 10.

Marketing Authorisation Holder and Manufacturer
The marketing authorisation holder and manufacturer is:
Sandoz Ltd, Frimley business Park, Frimley, Camberley, Surrey,
GU16 7SR, UK.
This leaflet was last approved in: 04/2011 (tbaaa).


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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.