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Active substance(s): METOPROLOL TARTRATE

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Metoprolol Tartrate 50mg
and 100mg tablets
Read all of this leaflet carefully before you start
taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or
• This medicine has been prescribed for you. Do not
pass it on to others. It may harm them, even if their
symptoms are the same as yours.

• have difficulties in passing urine
• have low levels of potassium (hypokalaemia) or sodium
(hyponatraemia) in your blood
• have high levels of calcium (hypercalcaemia)
• suffer with gout due to high levels of uric acid (hyperuricaemia)
in your blood causing crystals to deposit in joints of hands or feet
causing pain
• are given other medicines for blood pressure by injection
especially verapamil, diltiazem or disopyramide.

1. What Metoprolol Tartrate tablets are and
what they are used for
2. Before you take
3. How to take
4. Possible side effects
5. How to store
6. Further information

Take special care with Metoprolol Tartrate tablets and tell
your doctor if you:

1. What Metoprolol Tartrate tablets are and what they
are used for
Metoprolol Tartrate belongs to a group of medicines called betablockers.
It is used to treat:
• high blood pressure
• angina pectoris (pain in the chest caused by blockages in the arteries
to the heart)
• irregular heart rhythm (arrhythmia)
• the symptoms caused by an overactive thyroid gland (thyrotoxicosis)
It is used to prevent:
• migraine
• heart damage and death due to heart attacks.

2. Before you take

Do not take Metoprolol Tartrate tablets and tell your doctor
if you:

• are allergic (hypersensitive) to metoprolol, other beta-blockers or any
of the other ingredients in Metoprolol Tartrate tablets (see section 6)
• suffer with heart conduction or rhythm problems
• have severe or uncontrolled heart failure
• are in shock caused by heart problems
• suffer with blocked blood vessels, including blood circulation
problems (which may cause your fingers and toes to tingle or turn
pale or blue)
• have a slow heart rate or have suffered a heart attack which has been
complicated by a significantly slow heart rate
• suffer from a tight, painful feeling in the chest in periods of rest
(Prinzmetal’s angina)
• suffer with untreated phaeochromocytoma (high blood pressure
due to a tumour near the kidney)
• suffer from increased acidity of the blood (metabolic acidosis)
• have low blood pressure
• have or have had breathing difficulties or asthma including COPD
(Chronic Obstructive Pulmonary Disease causing cough, wheezing or
breathlessness, phlegm or increase in chest infections)
• suffer with diabetes associated with frequent episodes of low blood
sugar (hypoglycaemia)
• have liver or kidney disease or failure
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• have a history of allergic reactions
• have diabetes mellitus (low blood sugar levels may be hidden by
this medicine)
• suffer from treated phaeochromocytoma (high blood pressure due
to tumour near the kidney)
• have an overactive thyroid (symptoms such as increased heart rate,
sweating, tremor, anxiety, increased appetite or weight loss may be
hidden by this medicine)
• have or have suffered from psoriasis (severe skin rashes)
• have a slow heart rate or blood vessel disorder
• have controlled heart failure
• have impaired liver or kidney function
• have liver cirrhosis
• are elderly.

Taking other medicines

Do not take Metoprolol Tartrate tablets if you are already taking:
• monoamine oxidase inhibitors (MAOIs) for depression
• other blood pressure lowering medicines such as verapamil,
nifedipine and diltiazem
• disopyramide or quinidine (to treat irregular heartbeat (arrhythmia)
Before taking Metoprolol Tartrate tablets, tell your doctor if you are
taking or have taken recently any of the following medicines or are
taking any non prescribed medicines:
• cimetidine (to treat stomach ulcers)
• hydralazine, clonidine or prazosin (to treat high blood pressure)
• amiodarone and propafenone (for irregular heart rhythm)
• tricyclic antidepressants (to treat depression)
• barbiturates (to treat epilepsy)
• phenothiazines (for mental illness)
• anaesthetics such as cyclopropane or trichloroethylene
• aldesleukin (to treat some cancers, particularly cancer of the kidney)
• alprostadil (to treat erectile dysfunction)
• anxiolytics or hypnotics (e.g. temazepam, nitrazepam, diazepam)
• indometacin or celecoxib (Non-Steroidal Anti-Inflammatory Drugs
• rifampicin (antibiotic) or terbinafine (antifungal)
• cocaine
• oestrogens such as a contraceptive pill or hormone replacement
• corticosteroids (e.g. hydrocortisone, prednisolone)
• other beta-blockers e.g. eye drops.
• adrenaline (epinephrine) or noradrenaline (norepinephrine), used
in anaphylactic shock or other sympathomimetics
• medicines used to treat diabetes
• lidocaine (a local anaesthetic)
• moxisylyte (used in Raynaud’s syndrome)
• mefloquine (to treat malaria)
• tropisetron (to prevent nausea and vomiting)
• xanthines such as aminophylline or theophylline (to treat asthma)
• medicines to treat migranes such as ergotamine
• cardiac glycosides e.g. digoxin (to treat heart conditions)
• hydroxychloroquine (to treat rheumatoid arthritis)
• diphenydramine (sedative antihistamine).
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Pregnancy and breast-feeding

Metoprolol Tartrate tablets are not recommended during pregnancy or breastfeeding. Ask your doctor or pharmacist for advice before taking any medicine.

Sugar intolerance

If you have been told you have an intolerance to some sugars, contact your
doctor before taking this medicine, as it contains lactose.


You are advised to avoid alcohol whilst taking this medicine. Alcohol may
increase the blood pressure lowering effect of Metoprolol Tartrate tablets.

Driving and using machines

Metoprolol Tartrate tablets may make you feel tired and dizzy. Make sure
you are not affected before you drive or operate machinery, particularly after
changing to another medicine or if taken with alcohol.

Anaesthetics and surgery

If you are going to have an operation or an anaesthetic, please tell your doctor
or dentist that you are taking Metoprolol Tartrate tablets, as your heart beat
might slow down too much.

3. How to take

Always take Metoprolol Tartrate tablets exactly as your doctor has told you. If
you are not sure, check with your doctor or pharmacist.
Swallow the tablet whole.
Usual doses:
• High blood pressure:
Initially 100mg metoprolol tartrate daily. The dose may be increased to
200mg daily in single or divided doses.
• Angina:
50-100mg metoprolol tartrate two or three times daily.
• Irregular heart beats (arrhythmia):
50mg metoprolol tartrate two or three times daily. The dose may be
increased to 300mg daily in divided doses.
• Heart attacks:
50mg metoprolol tartrate every six hours. The usual maintenance dose is
200mg daily in divided doses.
• Overactive thyroid gland (thyrotoxicosis):
50mg metoprolol tartrate four times daily.
• Prevention of migraine:
100-200mg metoprolol tartrate daily in divided doses (in the morning and
• Children:
Not recommended.
• Patients with impaired kidney or liver function:
In such cases the dose should be adjusted. Always follow your doctor’s

If you take more Metoprolol Tartrate tablets than you should

If you have accidentally taken more than the prescribed dose, contact your
nearest casualty department or tell your doctor or pharmacist at once.
Symptoms of overdose are low blood pressure (fatigue and dizziness), slow
pulse, heart conduction problems, heart failure, shock caused by heart
problems, cardiac arrest, shortness of breath, unconsciousness, coma, feeling
and being sick, blue colouring of the skin, low blood sugar levels and high
levels of potassium in the blood.

If you forget to take Metoprolol Tartrate tablets

If you forget to take a dose, take it as soon as you remember, unless it is nearly
time for your next dose. Then go on as before. Never double up on the next
dose to make up for the one missed.

If you stop taking Metoprolol Tartrate tablets

Do not suddenly stop taking Metoprolol Tartrate tablets as this may cause
worsening of heart failure and increase the risk of heart attack. Only change
the dose or stop the treatment in consultation with your doctor.

4. Possible side effects

Like all medicines, Metoprolol Tartrate tablets can cause side effects, although
not everybody gets them.
Stop treatment and contact a doctor at once if you have the following
symptoms of an:
• allergic reaction such as itching, difficulty breathing or swelling of the face,
lips, throat or tongue.
Tell your doctor if you notice any of the following side effects or notice
any other effects not listed:
• Common (occurs in less than 1 in 10 users): tiredness, dizziness, headache,
a slow heart rate, feeling faint on standing due to low blood pressure,
shortness of breath with or without strenuous physical activity, feeling or
being sick, stomach pain
• Rare (occurs in less than 1 in 1,000 users): depression, nightmares, inability
to think clearly, sleepiness or difficulty in sleeping, tingling or ‘pins and
needles’, difficulty breathing, heart failure, irregular heart rate, palpitation,
water retention causing swelling, Raynaud’s phenomenon (causing pain,
numbness, coldness and blueness of the fingers), diarrhoea or constipation,
skin rash, muscle cramps
• Very rare (occurs in less than 1 in 10,000 users): changes in the results
of blood tests, effects on blood clotting causing easy or unexplained
bruising, changes in personality, hallucinations, visual disturbances, dry
or irritated eyes, ringing in the ears, loss of hearing with high doses, heart
conduction problems, chest pain, gangrene in patients with severe poor
circulation, runny nose, dry mouth, weight gain sensitivity to light, increased
sweating, hair loss, worsening or new psoriasis, joint inflammation (arthritis),
disturbances of sexual desire and performance, changes in liver function
• Not known: worsening or development of limping, hepatitis (symptoms
include fever, sickness and yellowing of the skin or whites of the eyes),
Peyronie’s syndrome (bending of the penis), symptoms of high levels of the
thyroid hormone or low blood sugar may be hidden, confusion, increase in
blood fats or decrease in cholesterol.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card Scheme at:
By reporting side effects you can help provide more information on the
safety of this medicine.

5. How to store

Keep out of the reach and sight of children.
Store below 25°C in a dry place. Protect from light.
Do not take the tablets after the expiry date which is stated on
the carton.
Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help to
protect the environment.

6. Further information
What Metoprolol Tartrate tablets contain

• the active substance (the ingredient that makes the tablets
work) is metoprolol tartrate. Each tablet contains either 50mg
or 100mg of the active substance.
• the other ingredients are silica colloidal anhydrous, lactose
monohydrate, magnesium stearate, maize starch, cellulose
microcrystalline, povidone.

What Metoprolol Tartrate tablets look like and
contents of the pack

Metoprolol Tartrate 50mg and 100mg tablets are white to offwhite, circular, biconvex, uncoated tablets.
Pack sizes are 28 and 56.
Marketing Authorisation Holder and Manufacturer
Actavis, Barnstaple, EX32 8NS, UK.

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This leaflet was last revised in
April 2014
Actavis, Barnstaple, EX32 8NS, UK

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.