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MERECAPTOPURINE 50MG TABLETS

Active substance(s): MERCAPTOPURINE

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PURI-NETHOL® 50mg TABLETS /
MERCAPTOPURINE 50mg TABLETS
(mercaptopurine)
Patient Information Leaflet

By Aneela Mahmood at 4:26 pm, Jul 29, 2010

This product is known as any of the above names but will usually be referred to as Puri-Nethol
throughout this leaflet.

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In this leaflet:
1. What Puri-Nethol is and what it is used for
2. Before you take Puri-Nethol
3. How to take Puri-Nethol
4. Possible side effects
5. How to store Puri-Nethol
6. Further information

1. What Puri-Nethol is and what it is used for:
Puri-Nethol tablets contain a medicine called mercaptopurine. This belongs to a group of
medicines called cytotoxics (also called chemotherapy). Puri-Nethol is used to treat leukaemia
(cancer of the blood). It works by reducing the number of new blood cells your body makes.
Puri-Nethol is used for:
• Acute myelogenous leukaemia (also called acute myeloid leukaemia or AML) - a
fast-growing disease that increases the number of white blood cells produced by the bone
marrow. This can cause infections and bleeding.
• Acute lymphoblastic leukaemia (also called acute lymphocytic leukaemia or ALL) - a
fast-growing disease which increases the number of immature white blood cells.
These immature white blood cells are unable to grow and work properly. They therefore
cannot fight infections and may cause bleeding.
• Chronic granulocytic leukaemia (also called chronic myeloid leukaemia) - a disease that
increases the number of white blood cells. This can cause infections and bleeding.

WARNING!

Notes:

PROOF HISTORY:
v.2 - waymade - 20/07/10

Leaflet Flat Size = 148 x 400

Read all of this leaflet carefully before you start taking this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions about your illness or your medicine, ask your doctor, nurse
or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them,
even if their symptoms are the same as yours.
• If any of the side effects get serious, or if you notice any side effects not listed in this leaflet,
please tell your doctor, nurse or pharmacist.

Ask your doctor if you would like more explanation about these diseases.

Do not take Puri-Nethol if:
• You are allergic (hypersensitive) to mercaptopurine or any of the other ingredients of
Puri-Nethol tablets (See section 6: Further information)
Do not take if the above applies to you. If you are not sure, talk to your doctor or pharmacist
before taking Puri-Nethol.

DATE:

CUSTOMER
APPROVED:

2. Before you take Puri-Nethol:

Take special care with Puri-Nethol
Before you take Puri-Nethol, tell your doctor or pharmacist if:
• you have a liver problem, your doctor will monitor your liver function
• you have a condition where your body produces too little of something called TPMT or
‘thiopurine methyltransferase’.

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other
medicines, including medicines obtained without a prescription. This includes herbal medicines.
In particular, tell your doctor or pharmacist if you are taking any of the following:
• other cytotoxic drugs (chemotherapy) - when used with Puri-Nethol there is a greater chance
of side effects, such as breathing problems
• allopurinol (used to treat gout)
• warfarin (used to thin the blood)
• olsalazine or mesalazine (used for a bowel problem called ulcerative colitis)
• sulfasalazine (used for rheumatoid arthritis or ulcerative colitis).

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Having vaccines while you are taking Puri-Nethol
If you are going to have a vaccination speak to your doctor or nurse before you have it. This is
because some vaccines (like polio, measles, mumps and rubella) may give you an infection if
you have them whilst you are taking Puri-Nethol.

CODE:

20/07/10
DATE OF PROOF:

DATE:

DT
ARTWORKER:
PRODUCT:

Puri-Nethol 50mg tabs

05-0269
CUSTOMER: Waymade

PRE-PRESS NO.:

Q.A.
APPROVED:

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before
taking Puri-Nethol.

Pregnancy and breast-feeding
Do not take Puri-Nethol if you are planning to have a baby. This applies to both men and
women.
Puri-Nethol may harm your sperm or eggs. Reliable contraceptive precautions must be taken to
avoid pregnancy whilst you or your partner is taking these tablets. Ask your doctor for advice.
If you are already pregnant, it is important to talk to your doctor before taking Puri-Nethol.
Do not breast-feed while taking Puri-Nethol. Ask your doctor or midwife for advice.
Important information about some of the ingredients of Puri-Nethol
Puri-Nethol tablets contain lactose. If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before you take Puri-Nethol tablets.

3. How to take Puri-Nethol:
Puri-Nethol should only be given to you by a specialist doctor who is experienced in treating
blood problems.
Always take Puri-Nethol exactly as your doctor has told you. It is important to take your
medicine at the right times. The label on your pack will tell you how many tablets to take and
how often to take them. If the label doesn’t say or if you are not sure, ask your doctor, nurse or
pharmacist.
• Swallow your tablets whole with a glass of water.
• If you need to break your tablet in half, do not inhale any tablet powder. Wash your hands
afterwards.
• When you take Puri-Nethol your doctor will take regular blood tests. This is to check the
number and type of cells in your blood and to ensure your liver is working correctly.
• Your doctor may also ask for other blood and urine tests to monitor your uric acid levels.
Uric acid is a natural body chemical, levels of which can rise while taking Puri-Nethol.
• Your doctor may sometimes change your dose of Puri-Nethol as a result of these tests.

Colour
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Black

WARNING!

Mock‐Up 

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

000-0000D

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

Assessed against UK PIL dated September 2008

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

The dose of Puri-Nethol you are given will be worked out by your doctor based on:
• Your body size (surface area)
• The results of your blood tests
• The usual starting dose for adults and children is 2.5 mg per kilogram of your body weight
each day.
• Elderly patients will have their kidney and liver function tested and if necessary the dose may
need to be reduced.
If you take more Puri-Nethol than you should
If you take more Puri-Nethol than you should, tell your doctor immediately or go to a hospital
straight away.
Take the medicine pack with you.
If you forget to take Puri-Nethol
Tell your doctor. Do not take a double dose to make up for a forgotten dose.

4. Possible side effects:
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If you get any of the following, talk to your specialist doctor or go to hospital straight
away:
• allergic reaction, the signs may include:
- skin rashes
- high temperature
- joint pain
- swollen face
• any signs of fever or infection (sore throat, sore mouth or urinary problems)
• any unexpected bruising or bleeding, as this could mean that too few blood cells of a
particular type are being produced
• if you suddenly feel unwell (even with a normal temperature)
• any yellowing of the whites of the eyes or skin (jaundice)
• if you have diarrhoea
• if you feel sick (nausea) or you are sick (vomiting).
Talk to your doctor if you have any of the following side effects which may also happen with this
medicine:
Very common (affects more than 1 in 10 people)
• a drop in the number of white blood cells and platelets

WARNING!

Common (affects less than 1 in 10 people)
• feeling or being sick (nausea or vomiting)
• liver problems - this may show up in your blood tests

Rare (affects less than 1 in 1,000 people)
• mouth ulcers
• inflammation of the pancreas which can give you abdominal pain or make you sick
• hair loss
Very rare (affects less than 1 in 10,000 people)
• leukaemia
• ulcers in the intestines
• in men: low sperm count
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.







Keep out of the reach and sight of children.
Do not use Puri-Nethol after the expiry date which is stated on the pack after ‘EXP’.
Do not store your Puri-Nethol tablets above 25°C. Keep the container tightly closed.
Store in a dry place. Protect from light.
If your doctor tells you to stop taking the tablets, it is important to return any which are
left over to your pharmacist, who will destroy them according to disposal of dangerous
substance guidelines.
Only keep the tablets if your doctor tells you to.

6. Further information:
Your medicine is called Puri-Nethol 50mg tablets/Mercaptopurine 50mg tablets.
Each tablet contains 50mg of the active ingredient mercaptopurine in a pale yellow, round tablet
that is marked ‘GX’ and ‘EX2’ either side of a breakline on one side and plain on the reverse.

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Puri-Nethol 50mg tablets/Mercaptopurine 50mg tablets also contain the following:
lactose, maize starch, feculose, magnesium stearate, stearic acid and purified water.

CODE:

20/07/10
DATE OF PROOF:

DATE:

DT
ARTWORKER:
Puri-Nethol 50mg tabs
PRODUCT:

CUSTOMER: Waymade

PRE-PRESS NO.:

05-0269

Q.A.
APPROVED:

5. How to store Puri-Nethol:

Puri-Nethol 50mg tablets/Mercaptopurine 50mg tablets are available in bottles of 25 tablets.
POM

PL No: 06464/2801

This product is manufactured by EXCELLA GmbH, Nürnberger Strasse 12, 90537 Feucht,
Germany and is procured from within the EU and repackaged by the Product Licence holder:
Waymade plc, Miles Gray Road, Basildon, Essex SS14 3FR
Leaflet revision and issue date (Ref.) 12.7.2010
Puri-Nethol is a registered trademark of The Wellcome Foundation Limited

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Black

000-0000D

WARNING!

DATE:

CUSTOMER
APPROVED:

Uncommon (affects less than 1 in 100 people)
• a drop in red blood cells which may make you tired, weak or breathless - called anaemia
• loss of appetite

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

Notes:

PROOF HISTORY:
v.2 - waymade - 20/07/10

Leaflet Flat Size = 148 x 400

Like all medicines, Puri-Nethol can cause side effects, although not everybody gets them.

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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