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MEDIKINET XL 50MG MODIFIED RELEASE CAPSULES HARD

Active substance(s): METHYLPHENIDATE HYDROCHLORIDE

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Package Leaflet: Information for the user

Medikinet® XL 50 mg modified-release capsules, hard
Medikinet® XL 60 mg modified-release capsules, hard
(Methylphenidate hydrochloride)
The name of your medicine is Medikinet® XL 50mg modified-release capsules, hard or Medikinet® XL 60mg
modified-release capsules, hard but will be referred to as Medikinet® XL throughout this leaflet. Medikinet®
XL contains the active substance ‘methylphenidate hydrochloride’. The name ‘methylphenidate’ will also be
used in this leaflet.

Important things you need to know about your medicine
This medicine is used to treat ADHD
• The full name for ADHD is ‘Attention Deficit Hyperactivity Disorder’.
• The medicine helps with your brain activity. It can help improve your attention, help you concentrate, and
make you less impulsive.
• You need to have other treatments for ADHD as well as this medicine.
Read section 1 for more information.
Before you take this medicine, talk to your doctor if:
• You have heart, circulation, or mental health problems - you may not be able to take this medicine.
• You are taking any other medicines - this is because methylphenidate can affect how other medicines
work.
Read section 2 for more information.
While taking this medicine:
• See your doctor regularly. This is because your doctor will want to check how the medicine is working.
• Do not stop taking the medicine without first talking to your doctor.
• Your doctor may stop your medicine to see if it is still needed, if you take it for more than a year.
• The most common side effects are feeling nervous, not being able to sleep or having a headache.
Read sections 3 and 4 for more information.
Talk to your doctor straight away if any of the following happen:
• Your mood and how you feel changes.
• You feel any problems with your heart.
Read section 4 for more information.
The rest of this leaflet includes more detail and other important information on the safe and effective
use of this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
• If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects not
listed in this leaflet.
Read section 4 for more information.
The leaflet has been written in sections:
- Sections 1 to 6 are for parents and carers (sometimes called ‘your guardians’).
- The last section is a special section for a child or young person to read.
- However, all sections are written as though the child or young person taking the medicine is reading them.
The sections are:
1. What Medikinet® XL is and what it is used for
2. What you need to know before you take Medikinet® XL
3. How to take Medikinet® XL
4. Possible side effects
5. How to store Medikinet® XL
6. Contents of the pack and other information
Information for children and young people
Now read the rest of this leaflet before you start taking this medicine.

1.

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What Medikinet XL is and what it is used for

What it is used for
Medikinet® XL is used to treat ‘attention deficit hyperactivity disorder’ (ADHD).
• It is used in children and young people between the ages of 6 and 18.
• It is used only after trying treatments which do not involve medicines. Such as counselling and behavioural
therapy.
Medikinet® XL is not for use as a treatment for ADHD in children under 6 years of age or in adults.
If you have been successfully treated with Medikinet® XL as an adolescent for ADHD, if your symptoms
persist into adulthood and a need for further therapy has been determined, it might be appropriate to
continue taking Medikinet® XL when you become an adult. Your doctor will advise you about this.
How it works
Medikinet® XL improves the activity of certain parts of the brain which are under-active.
The medicine can help improve attention (attention span), concentration and reduce impulsive behaviour.
The medicine is given as part of a treatment programme, which usually includes:
• psychological
• educational and
• social therapy.
Medikinet® XL treatment must only be initiated by, and used under the supervision of, a specialist in
childhood and/or adolescent behavioural disorders. Although there is no cure for ADHD, it can be managed
using treatment programmes.
About ADHD
Children and young people with ADHD find it:
• hard to sit still and
• hard to concentrate.
It is not their fault that they cannot do these things.
Many children and young people struggle to do these things. However, with ADHD they can cause problems
with everyday life. Children and young people with ADHD may have difficulty learning and doing homework.
They find it hard to behave well at home, at school or in other places.
ADHD does not affect the intelligence of a child or young person.

2.

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What you need to know before you take Medikinet XL

Do not take Medikinet® XL if:
• you are allergic to methylphenidate or any of the other ingredients of this medicine (listed in section 6)
• you have a thyroid problem
• you have increased pressure in your eye (glaucoma)
• you have a tumour of your adrenal gland (phaeochromocytoma)
• you have an eating problem when you do not feel hungry or want to eat - such as ‘anorexia nervosa’
• you have very high blood pressure or narrowing of the blood vessels, which can cause pain in the arms
and legs
• you have ever had heart problems - such as a heart attack, uneven heartbeat, pain and discomfort in the
chest, heart failure, heart disease or were born with a heart problem

• you have had a problem with the blood vessels in your brain - such as a stroke, swelling and weakening of
part of a blood vessel (aneurysm), narrow or blocked blood vessels, or inflammation of the blood vessels
(vasculitis)
• you are currently taking or have taken within the last 14 days an antidepressant (known as a monoamine
oxidase inhibitor) – see ‘Other medicines and Medikinet® XL’
• you have mental health problems such as:
- a ‘psychopathic’ or ‘borderline personality’ problem
- abnormal thoughts or visions or an illness called ‘schizophrenia’
- signs of a severe mood problem like:
o feeling like killing yourself
o severe depression, where you feel very sad, worthless and hopeless
o mania, where you feel unusually excitable, over-active, and un-inhibited
• you have a history of pronounced lack of gastric acid (anacidity of the stomach) with a pH value above 5.5
• are taking medicines to reduce secretion of gastric acid or to treat excessive acidity of the stomach (H2
receptor blocker or antacid treatment).
Do not take methylphenidate if any of the above apply to you. If you are not sure, talk to your doctor or
pharmacist before you take methylphenidate. This is because methylphenidate can make these problems
worse.
Warnings and precautions
Talk to your doctor before taking Medikinet® XL if:
• you have liver or kidney problems
• you have problems with swallowing or swallowing whole tablets
• you have a narrowing or blockage of the gut or food-pipe
• you have had fits (seizures, convulsions, epilepsy) or any abnormal brain scans (EEGs)
• you have ever abused or been dependent on alcohol, prescription medicines or street drugs
• you are a girl and have started your periods (see the ‘Pregnancy and breast-feeding’ section below)
• you have hard-to-control, repeated twitching of any parts of the body or you repeat sounds and words
• you have high blood pressure
• you have a heart problem which is not in the ‘Do not take’ section above
• you have a mental health problem which is not in the ‘Do not take’ section above.
Other mental health problems include:
- mood swings (from being manic to being depressed - called ‘bipolar disorder’)
- starting to be aggressive or hostile, or your aggression gets worse
- seeing, hearing or feeling things that are not there (hallucinations)
- believing things that are not true (delusions)
- feeling unusually suspicious (paranoia)
- feeling agitated, anxious or tense
- feeling depressed or guilty.
Tell your doctor or pharmacist if any of the above apply to you before starting treatment. This is because
methylphenidate can make these problems worse. Your doctor will want to monitor how the medicine affects
you.
Checks that your doctor will make before you start taking methylphenidate
These checks are to decide if methylphenidate is the correct medicine for you. Your doctor will talk to you
about:
• any other medicines you are taking
• whether there is any family history of sudden unexplained death
• any other medical problems (such as heart problems) you or your family may have
• how you are feeling, such as feeling high or low, having strange thoughts or if you have had any of these
feelings in the past
• whether there is a family history of ‘tics’ (hard-to-control, repeated twitching of any parts of the body or
repeating sounds and words)
• any mental health or behaviour problems you or other family members have ever had.
Your doctor will discuss whether you are at risk of having mood swings (from being manic to being
depressed - called ‘bipolar disorder’). They will check your mental health history, and check if any of your
family have a history of suicide, bipolar disorder or depression.
It is important that you provide as much information as you can. This will help your doctor decide if
methylphenidate is the correct medicine for you. Your doctor may decide that other medical tests are needed
before you start taking this medicine.
Drug testing
This medicine may give a positive result when testing for drug use. Athletes must be aware that this
medicinal product may cause a positive reaction to ‘anti-doping’ tests.
Other medicines and Medikinet® XL
Please tell your doctor or pharmacist if you are taking, have recently taken or may take any other medicines.
Do not take methylphenidate if you:
• are taking a medicine called a ‘monoamine oxidase inhibitor’ (MAOI) used for depression, or have taken
an MAOI in the last 14 days. Taking an MAOI with methylphenidate may cause a sudden increase in your
blood pressure.
If you are taking other medicines, methylphenidate may affect how well they work or may cause side effects.
If you are taking any of the following medicines, check with your doctor or pharmacist before taking
methylphenidate:
• other medicines for depression
• medicines for severe mental health problems
• medicines for epilepsy
• medicines used to reduce or increase blood pressure
• some cough and cold remedies which contain medicines that can affect blood pressure.
It is important to check with your pharmacist when you buy any of these products.
• medicines that thin the blood to prevent blood clots.
Medikinet® XL must not be taken together with H2 receptor blockers or antacids which are used to reduce
gastric acid secretion or to counteract excessive acidity in the stomach, as this could lead to a faster release
of the total amount of active substance.
If you are in any doubt about whether any medicines you are taking are included in the list above, ask your
doctor or pharmacist before taking methylphenidate.
Having an operation
Tell your doctor if you are going to have an operation. Methylphenidate should not be taken on the day of
your surgery if a certain type of anaesthetic is used. This is because there is a chance of a sudden rise in
blood pressure during the operation.
Taking methylphenidate with alcohol
Do not drink alcohol while taking this medicine. Alcohol may make the side effects of this medicine worse.
Remember that some foods and medicines contain alcohol.
Pregnancy and breast-feeding
It is not known if methylphenidate will affect an unborn baby. Tell your doctor or pharmacist before using
methylphenidate if you are:
• having sex. Your doctor will discuss contraception with you.
• pregnant or think you might be pregnant. Your doctor will decide whether methylphenidate should be
taken.
• breast-feeding or planning to breast-feed. It is possible that methylphenidate is passed into human breast
milk. Therefore, your doctor will decide whether you should breast-feed while taking methylphenidate.
Driving and using machines
You may feel dizzy, have problems focussing or have blurred vision when taking methylphenidate. If these
happen it may be dangerous to do things such as drive, use machines, ride a bike or horse or climb trees.
The medicine can affect your ability to drive as it may make you sleepy or dizzy.
• Do not drive while taking this medicine until you know how it affects you.
• It is an offence to drive if this medicine affects your ability to drive.
• However, you would not be committing an offence if:
• The medicine has been prescribed to treat a medical or dental problem and
• You have taken it according to the instructions given by the prescriber or in the information provided with
the medicine and
• It was not affecting your ability to drive safely
Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this
medicine.
Medikinet® XL contains sucrose.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before
taking this medicinal product.
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Information for children and young people
This info is to help you learn the main things about your medicine called Medikinet® XL.
If you don’t enjoy reading, someone like your mum, dad or carer (sometimes called ‘your guardian’) can
read it to you and answer any questions.
It may help if you read small bits at a time.
Why have I been given this medicine?
This medicine can help children and young people with ‘ADHD’.
• ADHD can make you:
- run about too much
- not be able to pay attention
- act quickly without thinking about what will happen next (impulsive).
• It affects learning, making friends and how you think about yourself. It is not your fault.
While you are taking this medicine
• as well as taking this medicine you will also get help with ways to you cope with your ADHD such as
talking to ADHD specialists.
• this medicine should help you. But it does not cure ADHD.
• you will need to go to your doctor several times a year for check ups. This is to make sure the
medicine is working and that you are growing and developing OK.
• if you take the medicine for more than one year, your doctor may stop your medicine to see if it is still
needed. This will probably happen in a school holiday.

• if you take this medicine more than once a day, you may have to remember to take it at school or
college. You or your mum, dad or carer will need to find out what the school rules are about this.
• do not drink alcohol. Alcohol may make the side effects of this medicine worse.
• If you are having sex, please talk to your doctor about contraception. Girls must tell their doctor
straight away if they think they may be pregnant. We do not know how this medicine affects unborn
babies.
Some people cannot have this medicine
You cannot have this medicine if:
• you have a problem with your heart
• you feel very unhappy, depressed or have a mental illness.
Some people need to talk to their doctor before they start having this medicine
You need to talk to your doctor if:
• you have epilepsy (fits)
• you are pregnant or breastfeeding
• you have a lack of gastric acid or take medicines for binding gastric acid.
• you are taking other medicines – your doctor needs to know about all the medicines you are taking.

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3.

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How to take Medikinet XL

How much to take
You should always take Medikinet® XL exactly as your doctor has told you. You should check with your
doctor or pharmacist if you are not sure.
The maximum daily dose is 60mg.
• Your doctor will usually start treatment with a low dose and increase it gradually as required.
• Your doctor will tell you what strength of capsule to take each day.
• Do not split the dose of a capsule; take the entire contents of the capsule.
• Medikinet® XL should not be taken too late in the morning as it may cause disturbances in sleep.
Your doctor will do some tests
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• before you start – to make sure that Medikinet XL is safe and will be of benefit.
• after you start – they will be done at least every 6 months, but possibly more often. They will also be done
when the dose is changed.
• these tests will include:
- checking your appetite
- measuring height and weight
- measuring blood pressure and heart rate
- checking whether you have any problems with your mood, state of mind or any other unusual feelings.
Or if these have got worse while taking Medikinet® XL.
How to take
The medicinal product is intended for oral use.
Take Medikinet® XL in the morning with or after breakfast. This is very important in order to obtain
sufficiently prolonged action. The capsules may be swallowed whole with a drink of water.
Alternatively, you can open the capsules, sprinkle the capsule contents onto a small amount (tablespoon) of
apple sauce or yoghurt and take it immediately. In this case food should be eaten as well, of course. Do not
store for future use.
The capsules and the capsule contents must not be crushed or chewed.
If you do not feel better after 1 month of treatment
If you do not feel better, tell your doctor. They may decide a different treatment is needed.
Long-term treatment
Medikinet® XL does not need to be taken for ever. If you take Medikinet® XL for more than a year, your
doctor should stop treatment for a short time, this may happen during a school holiday. This will show if the
medicine is still needed.
Not using Medikinet® XL properly
If Medikinet® XL is not used properly, this may cause abnormal behaviour. It may also mean that you start to
depend on the medicine. Tell your doctor if you have ever abused or been dependent on alcohol,
prescription medicines or street drugs.
If you take more Medikinet® XL than you should
If you take too much medicine, talk to a doctor or call an ambulance straight away. Tell them how much has
been taken.
Signs of overdose may include: being sick, feeling agitated, shaking, increased uncontrolled movements,
muscle twitching, fits (may be followed by coma), feeling very happy, being confused, seeing, feeling or
hearing things that are not real (hallucinations), sweating, flushing, headache, high fever, changes in heart
beat (slow, fast or uneven), high blood pressure, dilated pupils and dry nose and mouth.
If you forget to take Medikinet® XL
Do not take a double dose to make up for a forgotten dose. If you forget a dose, wait until it is time for the
next dose.
If you stop taking Medikinet® XL
If you suddenly stop taking this medicine, the ADHD symptoms may come back or unwanted effects such as
depression may appear. Your doctor may want to gradually reduce the amount of medicine taken each day,
before stopping it completely. Talk to your doctor before stopping Medikinet® XL.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4.

Possible side effects

Like all medicines, this medicine can cause side effects, but not everybody gets them. Although some people
get side effects, most people find that methylphenidate helps them. Your doctor will talk to you about these
side effects.
Some side effects could be serious. If you have any of the side effects below, see a doctor straight
away:
Common: may affect up to 1 in 10 people
• uneven heartbeat (palpitations)
• mood changes or mood swings or changes in personality.
Uncommon: may affect up to 1 in 100 people
• thinking about or feeling like killing yourself
• seeing, feeling, or hearing things that are not real, these are signs of psychosis
• uncontrolled speech and body movements (Tourette’s)
• signs of allergy such as rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of
the body, shortness of breath, wheezing or trouble breathing.
Rare: may affect up to 1 in 1,000 people
• feeling unusually excited, over-active and un-inhibited (mania).
Very rare: may affect up to 1 in 10,000 people
• heart attack
• fits (seizures, convulsions, epilepsy)
• skin peeling or purplish red patches
• muscle spasms which you cannot control affecting your eyes, head, neck, body and nervous system - due
to a temporary lack of blood supply to the brain
• paralysis or problems with movement and vision, difficulties in speech (these can be signs of problems
with the blood vessels in your brain)
• decrease in number of blood cells (red cells, white cells and platelets) which can make you more likely to
get infections, and make you bleed and bruise more easily
• a sudden increase in body temperature, very high blood pressure and severe convulsions (‘Neuroleptic
Malignant Syndrome’). It is not certain that this side effect is caused by methylphenidate or other drugs
that may be taken in combination with methylphenidate.
Not known: frequency cannot be estimated from available data
• unwanted thoughts that keep coming back
• unexplained fainting, chest pain, shortness of breath (these can be signs of heart problems).
If you have any of the side effects above, see a doctor straight away.
Other side effects include the following, if they get serious, please tell your doctor or pharmacist:
Very common: may affect more than 1 in 10 people
• headache
• feeling nervous
• not being able to sleep.

Common: may affect up to 1 in 10 people
• joint pain
• dry mouth
• high temperature (fever)
• unusual hair loss or thinning
• feeling unusually sleepy or drowsy
• loss of appetite or decreased appetite
• itching, rash or raised red itchy rashes (hives)
• cough, sore throat or nose and throat irritation
• high blood pressure, fast heart beat (tachycardia)
• feeling dizzy, movements which you cannot control, being unusually active
• feeling aggressive, agitated, anxious, depressed, irritable and abnormal behaviour
• stomach pain, diarrhoea, feeling sick, stomach discomfort and being sick. These usually occur at the
beginning of treatment and may be reduced by taking the medicine with food.
Uncommon: may affect up to 1 in 100 people
• constipation
• chest discomfort
• blood in the urine
• shaking or trembling
• double vision or blurred vision
• muscle pain, muscle twitching
• shortness of breath or chest pain
• increases in liver test results (seen in a blood test)
• anger, feeling restless or tearful, excessive awareness of surroundings, problems sleeping.
Rare: may affect up to 1 in 1,000 people
• changes in sex drive
• feeling disorientated
• dilated pupils, trouble seeing
• swelling of the breasts in men
• excessive sweating, redness of the skin, red raised skin rash.
Very rare: may affect up to 1 in 10,000 people
• heart attack
• sudden death
• muscle cramps
• small red marks on the skin
• inflammation or blocked arteries in the brain
• abnormal liver function including liver failure and coma
• changes in test results – including liver and blood tests
• suicidal attempt, abnormal thinking, lack of feeling or emotion, doing things over and over again, being
obsessed with one thing
• fingers and toes feeling numb, tingling and changing colour (from white to blue, then red) when cold
(‘Raynaud’s phenomenon’).
Not known: frequency cannot be estimated from available data
• migraine
• very high fever
• slow, fast or extra heart beats
• a major fit (‘grand mal convulsions’)
• believing things that are not true, confusion
• severe stomach pain, often with feeling and being sick
• problems with the blood vessels of the brain (stroke, cerebral arteritis or cerebral occlusion)
• dry skin
• erectile dysfunction
• excessive uncontrolled talking.
Effects on growth
When used for more than a year, methylphenidate may cause reduced growth in some children. This affects
less than 1 in 10 children.
• There may be lack of weight gain or height growth.
• Your doctor will carefully watch your height and weight, as well as how well you are eating.
• If you are not growing as expected, then your treatment with methylphenidate may be stopped for a short
time.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed
in this leaflet. You can also report side effects directly via the Yellow Card Scheme, website:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on the safety of this medicine.

5.

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How to store Medikinet XL

Make sure you keep your medicine in a safe place, so that no one else takes it, especially younger brothers
or sisters.
Keep out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the label. The expiry date refers to the last
day of that month.
Do not store above 30°C.
Store in the original package in order to protect from moisture.
If your medicine becomes discoloured or shows any signs of deterioration consult your pharmacist who will
advise you what to do.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures will help to protect the environment.

6.

Contents of the pack and other information

What Medikinet® XL contains:
The active substance is: methylphenidate hydrochloride
Medikinet® XL 50 mg modified-release capsules, hard
Each modified-release capsule, hard contains 50 mg methylphenidate hydrochloride equivalent to 43.25 mg
methylphenidate.
Medikinet® XL 60 mg modified-release capsules, hard
Each modified-release capsule, hard contains 60 mg methylphenidate hydrochloride equivalent to 51.90 mg
methylphenidate.
The other ingredients are:
Capsule content: Sugar spheres (containing Sucrose and Maize starch), Methacrylic acid-ethylacrylate
copolymer 1:1, Talc, Triethyl citrate, Polyvinyl alcohol, Macrogol 3350, Polysorbate 80, Sodium hydroxide,
Sodium laurilsulfate, Simeticone, Colloidal anhydrous silica, Methylcellulose, Sorbic acid and Indigo carmine
aluminium lake (E132).
Capsule shell: Gelatin, Erythrosine (E127), Titanium dioxide (E171), Sodium laurilsulfate, Purified water,
Black iron oxide (E172) and Indigo carmine (E132).
What Medikinet® XL looks like and contents of the pack:
Medikinet® XL 50 mg modified-release capsules, hard
Violet and dark violet capsules containing white and blue pellets
Medikinet® XL 60 mg modified-release capsules, hard
Dark violet capsules containing white and blue pellets
Pack sizes:
Boxes containing 30 or 40 modified-release capsules, hard packed in blisters.
Manufacturer:
The manufacturer is Medice Arzneimittel Pütter GmbH & Co. KG, Kuhloweg 37, 58638 Iserlohn, Germany.
Procured from within the EU and repackaged in the UK by the Parallel Import Product Licence holder, CD
Pharma Ltd, Unit 3, Manor Point, Manor Way, Borehamwood, Herts. WD6 1EE.
Medikinet XL 50 mg modified-release capsules, hard
Medikinet XL 60 mg modified-release capsules, hard

PL: 20492/0497
PL: 20492/0498

Date of preparation: 25th November 2015
POM

How do I take my medicine (capsules)?
• Swallow your medicine with water with or after a meal.
• If you have problems to swallow the capsules, the capsules may be opened, the capsule contents
sprinkled onto a small amount (tablespoon) of apple sauce or yoghurt and taken immediately. The
capsules and the capsule contents must not be crushed or chewed.
• Your doctor will tell you how many times a day you should take your medicine.
• Do not stop taking the medicine without talking to your doctor first.
Possible side effects
Side effects are the unwanted things that can happen when you take a medicine. If any of the following
happen, tell an adult you trust straight away. They can then talk to your doctor.
The main things that could affect you are:
• Feeling worried or nervous
• Feeling dizzy, or getting head aches
• Being very depressed and unhappy or wanting to hurt yourself
• Having different moods than usual, not being able to get to sleep
• Skin rashes, bruising easily, getting out of breath

CD

• The medicine can also make you feel sleepy. If you feel sleepy, it is important not to do outdoor
sports like riding a horse or bike, swimming or climbing trees. You could hurt yourself and others.
• Your heart beating faster than usual.
If you feel unwell in any way while you are taking your medicine please tell an adult you trust
straight away.
Other things to remember
• make sure you keep your medicine in a safe place, so that no one else takes it, especially younger
brothers or sisters.
• the medicine is special for you - do not let anyone else have it. It may help you, but it could hurt
someone else.
• if you forget to take your medicine don’t take two capsules the next time. Just take one capsule at the
next normal time.
• if you do take too much medicine, tell your mum, dad or carer right away.
• it is important not to take too much medicine or you will get ill.
• don’t stop taking your medicine until your doctor says it’s OK.
Who should I ask if there is anything I don’t understand?
Your mum, dad, carer, doctor, nurse or pharmacist will be able to help you.

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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