MAFAMOZ 250 mg/100 mg
Package leaflet: Information for the user
Read all of this leaflet carefully before you start using this medicine because it
contains important information for you.
s Keep this leaflet. You may need to read it again.
s If you have any further questions, ask your doctor or pharmacist.
s This medicine has been prescribed for you only. Do not pass it on to others. It
may harm them, even if their signs of illness are the same as yours.
s If you get any side effects, talk to your doctor or pharmacist. This includes any
possible side effects not listed in this leaflet. See section 4.
7HAT IS IN THIS LEAFLET
1. What Mafamoz 250 mg/100 mg Film-coated Tablets are and what they are
2. What you need to know before you use Mafamoz 250 mg/100 mg Film-coated
3. How to use Mafamoz 250 mg/100 mg Film-coated Tablets
4. Possible side effects
5. How to store Mafamoz 250 mg/100 mg Film-coated Tablets
6. Contents of the pack and other information
1 What Mafamoz 250 mg/100 mg Film-coated Tablets are and what
they are used for
Mafamoz belongs to a group of medicines called antimalarials. It contains two
active ingredients, atovaquone and proguanil hydrochloride.
Mafamoz has two uses:
s TO PREVENT MALARIA IN ADULTS AND CHILDREN WHO WEIGH AT LEAST KG
s TO TREAT MALARIA IN ADULTS AND CHILDREN WHO WEIGH AT LEAST KG
Malaria is spread by the bite of an infected mosquito, which passes the malaria
parasite (Plasmodium falciparum) into the bloodstream. Mafamoz prevents
malaria by killing this parasite. For people who are already infected with
malaria, Mafamoz also kills these parasites.
Protect yourself from catching malaria
People of any age can get malaria. It is a serious disease, but is preventable. As
well as taking Mafamoz, it is very important that you also take steps to avoid
being bitten by mosquitoes.
s 5SE INSECT REPELLENT ON EXPOSED AREAS OF THE SKIN
s 7EAR LIGHT COLOURED CLOTHING THAT COVERS MOST OF THE BODY ESPECIALLY AFTER
sunset as this is the time when mosquitoes are most active
s 3LEEP IN A SCREENED ROOM OR UNDER A MOSQUITO NET IMPREGNATED WITH
s #LOSE WINDOWS AND DOORS AT SUNSET IF THEY ARE NOT SCREENED
s #ONSIDER USING AN INSECTICIDE MATS SPRAY PLUG
INS TO CLEAR A ROOM OF INSECTS
or to deter mosquitoes from entering the room.
If you need further advice, talk to your doctor or pharmacist.
It is still possible to get malaria after taking the necessary precautions. Some
types of malaria infection take a long time to cause symptoms, so the illness may
not start until several days, weeks or even months after returning from abroad.
See a doctor immediately if you get symptoms such as high temperature,
headache, shivering and tiredness after returning home.
2 What you need to know before you use Mafamoz 250 mg/100 mg
Do not use Mafamoz:
s IF YOU ARE ALLERGIC TO ATOVAQUONEPROGUANIL OR ANY OF THE OTHER INGREDIENTS OF
this medicine (listed in section 6)
s FOR PREVENTING MALARIA IF YOU HAVE SEVERE KIDNEY PROBLEMS
If any of the above applies to you, talk to your doctor before you start taking
Warnings and precautions
Talk to your doctor before taking Mafamoz.
If you are sick (vomit):
For preventing malaria:
s IF YOU ARE SICK VOMIT WITHIN HOUR OF TAKING YOUR TABLET TAKE ANOTHER DOSE
s IT IS IMPORTANT TO TAKE THE FULL COURSE OF -AFAMOZ )F YOU HAVE TO TAKE EXTRA
tablets due to sickness, you may need another prescription.
s IF YOU HAVE BEEN VOMITING IT IS ESPECIALLY IMPORTANT TO USE EXTRA PROTECTION
such as repellents and bednets. Mafamoz may not be as effective, as the
amount absorbed will be reduced.
For treating malaria:
s IF YOU HAVE VOMITING AND DIARRHOEA TELL YOUR DOCTOR YOU WILL NEED REGULAR
blood tests. Mafamoz will not be as effective, as the amount absorbed will be
reduced. The tests will check whether the malaria parasite is being cleared
from your blood.
Other medicines and atovaquone/proguanil
4ELL YOUR DOCTOR OR PHARMACIST IF YOU ARE TAKINGUSING HAVE RECENTLY TAKENUSED
OR MIGHT TAKEUSE ANY OTHER MEDICINE
Some medicines can affect the way Mafamoz works, or Mafamoz itself can
strengthen or weaken the effectiveness of other medicines taken at the same
time. These include:
s METOCLOPRAMIDE USED TO TREAT NAUSEA AND VOMITING
s THE ANTIBIOTICS TETRACYCLINE RIFAMPICIN AND RIFABUTIN
s EFAVIRENZ OR CERTAIN HIGHLY ACTIVE PROTEASE
INHIBITORS USED TO TREAT ()6
s WARFARIN AND OTHER MEDICINES THAT STOP BLOOD CLOTTING
s ETOPOSIDE USED TO TREAT CANCER
Tell your doctor if you are taking any of these. Your doctor may decide that
-AFAMOZ IS NOT SUITABLE FOR YOU OR THAT YOU NEED EXTRA CHECK UPS WHILE YOURE
Remember to tell your doctor before you start taking any other medicines while
you are taking Mafamoz.
If any of the above apply to you (or you are not sure), talk to your doctor or
pharmacist before using Mafamoz.
Pregnancy, breast-feeding and fertility
)F YOU ARE PREGNANT OR BREAST
FEEDING THINK YOU MAY BE PREGNANT OR ARE
planning to have a baby, ask your doctor or pharmacist for advice before using
If you are pregnant, do not use this medicine unless your doctor recommends it.
Ask your doctor or pharmacist for advice before using this medicine.
$O NOT BREAST
FEED WHILE USING -AFAMOZ AS THE INGREDIENTS MAY PASS INTO
breast milk and may harm your baby.
Driving and using machines
If you feel dizzy, do not drive. This medicine makes some people feel dizzy. If this
happens to you, do not drive, use machines or take part in activities where you may
put yourself or others at risk.
3 How to use Mafamoz 250 mg/100 mg Film-coated Tablets
!LWAYS USE THIS MEDICINE EXACTLY AS YOUR DOCTOR HAS TOLD YOU #HECK WITH YOUR
doctor or pharmacist if you are not sure.
The recommended dose is:
To prevent malaria in adults and children weighing at least 40 kg.
4HE USUAL DOSE FOR ADULTS IS TABLET ONCE A DAY TAKEN AS BELOW
Not recommended for preventing malaria in children, or in adults who weigh
LESS THAN KG 4HERE MAY BE A DIFFERENT TYPE OF ATOVAQUONEPROGUANIL TABLET
AVAILABLE FOR CHILDREN WEIGHING LESS THAN KG
To prevent malaria:
s START TAKING -AFAMOZ TO DAYS BEFORE TRAVELLING TO AN AREA WHICH HAS
s CONTINUE TAKING IT EVERY DAY DURING YOUR STAY
s CONTINUE TAKING IT FOR ANOTHER DAYS AFTER YOUR RETURN TO A MALARIA
To treat malaria in adults and children who weigh at least 11 kg
The usual dose for adults is 4 tablets once a day for 3 days.
For children the dose depends on their bodyweight:
KG n TABLET ONCE A DAY FOR DAYS
KG n TABLETS ONCE A DAY FOR DAYS
KG n TABLETS ONCE A DAY FOR DAYS
s OVER KG n DOSE AS FOR ADULTS
.OT RECOMMENDED FOR TREATING MALARIA IN CHILDREN WHO WEIGH LESS THAN KG