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Active substance(s): METOPROLOL TARTRATE

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LOPRESOR® Tablets 50 and 100 mg
(metoprolol tartrate)
Patient Information Leaflet
What you need to know about Lopresor Tablets
Your doctor has decided that you need this medicine to help treat your condition.
Please read this leaflet carefully before you start to take your medicine. It contains
important information. Keep the leaflet in a safe place because you may want to read it
If you have any other questions, or if there is something you don’t understand, please ask your
doctor or pharmacist.
This medicine has been prescribed for you. Never give it to someone else. It may not be the
right medicine for them even if their symptoms seem to be the same as yours.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
In this leaflet:
What Lopresor Tablets are and what they are used for
Things to consider before you start to take Lopresor Tablets
How to take Lopresor Tablets
Possible side effects
How to store Lopresor Tablets
Further information
1. What Lopresor Tablets are and what they are used for
Metoprolol tartrate, the active ingredient in Lopresor Tablets, is one of a group of medicines
called beta-blockers. Beta-blockers slow the heart beat, lessen the force with which the heart
muscle contracts and reduce blood vessel contraction in the heart, brain, and throughout the
• Lopresor Tablets are used to treat a number of different conditions including:
High blood pressure
Angina (chest pain)
Some heart disorders, for example, heart attack or irregular heart beats.
• They can also be used as part of the treatment for an overactive thyroid gland.
• Lopresor Tablets can be taken to help prevent migraine attacks.
2. Things to consider before you start to take Lopresor Tablets
Some people MUST NOT take Lopresor Tablets. Talk to your doctor if:
• you think you may be allergic to metoprolol or to any of the other ingredients of Lopresor
Tablets, (These are listed at the end of the leaflet.)
• you are allergic to any other beta-blocker drugs,
• you have severe asthma or severe attacks of wheezing,

you have certain serious heart or blood vessel disorders which shouldn’t be treated with
beta-blockers (your doctor should be aware of these),
you have low blood pressure,
you been told that you have high blood pressure due to a tumour near your kidney
you have been told that your blood is more acidic than normal (a condition called
metabolic acidosis).

You should also ask yourself these questions before taking Lopresor Tablets. If the
answer to any of these questions is YES, discuss your treatment with your doctor or
pharmacist because Lopresor Tablets might not be the right medicine for you.

Do you suffer from asthma, bronchitis or any similar lung disorder?
Do you have problems with your heart (such as slow heart rate) or circulation? (Taking
Lopresor Tablets may make these worse.)
Do you have diabetes?
Do you suffer from any serious liver disease?
Are you pregnant or breast-feeding?
Have you ever had a severe allergic reaction to anything?
Do you suffer from a rare form of angina called Prinzmetal's angina?
Will you be having an operation which requires a general anaesthetic?
Do you have psoriasis?

Are you taking other medicines?
Lopresor interacts with a large number of other medicines. Make sure your doctor knows if
you are taking any of the following because you may need to change your treatment:
• Medicines for high blood pressure (including prazosin, clonidine and drugs called calcium
channel blockers such as verapamil or diltiazem)
• Other beta-blockers (including those used in the form of eye drops)
• Drugs which affect the peripheral circulation (fingers and toes) such as ergotamine which
can be used to treat migraine
• Medicines to treat depression
• Medicines to treat other mental illnesses
• Antiretroviral drugs used to treat AIDS and some other conditions
• Antihistamines (including medicines that you can buy without a prescription for hayfever
and other allergies, colds and other conditions)
• Drugs to prevent malaria
• Medicines to treat fungal infections
• Medicines which affect liver enzymes, such as cimetidine used to treat stomach ulcers and
rifampicin used to treat tuberculosis
• Medicines for heart problems including angina, such as amiodarone, digoxin, nitrates and
anti-arrhythmic drugs
• Insulin and other drugs to treat diabetes
• Drugs called NSAIDs used to treat pain and inflammation
• A local anaesthetic called lignocaine.
Always tell your doctor or pharmacist about all the medicines you are taking. This means
medicines you have bought yourself as well as medicines on prescription from your doctor.
Will there be any problems with driving or using machinery?

If you feel dizzy or sleepy, or if you have problems with your eyes when you start to take these
tablets, do not drive or use machinery until these effects have worn off.
Other special warnings
• Be careful when drinking alcohol - it may affect you more than usual.
• If you are going to have a general anaesthetic, tell the doctor or dentist in charge that you
are taking Lopresor.
• If you are diabetic, take particular care with your blood sugar control since Lopresor may
make you less aware of low blood sugar levels.
• The doctor will want to keep an eye on your heart and thyroid function while you are
taking Lopresor. You might also need regular eye examinations.
3. How to take Lopresor Tablets
The doctor will tell you how many Lopresor Tablets to take and when to take them. The dose
you are prescribed will depend on the condition you have and how severe it is. Always follow
the doctor’s instructions carefully. The dose will be on the pharmacist’s label. Check the label
carefully. If you are not sure, ask your doctor or pharmacist. Keep taking your tablets for as
long as you have been told, unless you have any problems. In that case, check with your
The usual doses are:
High blood pressure
The usual starting dose is 100 mg a day. This can be increased by your doctor if necessary.
Angina (Chest pain)
The usual dose is 50-100 mg taken two or three times a day.
For other conditions, the usual total daily dose is between 100 and 200 mg. Your doctor will
choose a suitable starting dose and monitor your progress.

Swallow your tablets whole with a drink of water.
Do not stop taking your tablets suddenly as this may cause your condition to get worse.
Ask your doctor first.
Lopresor is not recommended for children.
People with liver problems may be told to take a lower dose.

What if you forget to take a dose?
If you forget to take a dose, take it when you remember and then take your next dose
at the usual time. However, it is important not to take two doses at the same time.
What if you take too many tablets?
If you accidentally take too many Lopresor tablets, tell your doctor at once or contact
your nearest hospital casualty department. Take your medicine pack with you so that people
can see what you have taken.
4. Possible side effects
Lopresor Tablets are suitable for most people, but, like all medicines, they can sometimes
cause side effects.

The side effects listed below have been reported.
Up to 1 in 10 people have experienced:
• Headache, dizziness, or unusual tiredness.
• Slow heart beat.
• Low blood pressure which might make you faint or dizzy.
• Feeling short of breath when exercising.
• Feeling or being sick, stomach ache.
Up to 1 in 1,000 people have experienced:
• Sleep disorders such as sleepiness, sleeplessness or nightmares.
• Feeling less alert.
• Coldness, numbness or tingling in your hands and feet.
• Depression.
• Muscle cramps
• Heart failure or irregular heart beat.
• Water retention (oedema).
• Breathlessness or wheeziness (bronchospasm).
• Diarrhoea or constipation.
• Skin rash and/or itching.
Up to 1 in 10,000 people have experienced:
• Weight gain.
• Hallucinations or personality disorders.
• Dry or sore eyes or problems with vision.
• Tinnitus or hearing problems.
• Gangrene.
• Runny nose, dry mouth.
• Changes in the results of liver function tests.
• Bruising or increased sensitivity of the skin to sunlight, worsening of psoriasis.
• Increased sweating, loss of hair.
• Impotence or loss of libido.
• Painful joints.
• Chest pain.
The following have also been reported:
• Confusion
• Abnormal levels of certain types of fats such as cholesterol or triglycerides in the blood.
• Abnormal curvature of the penis with painful erections (known as Peyronie’s disease)
• Retroperitoneal fibrosis where abnormal scar tissue occurs behind the membrane that lines
the cavity of the abdomen. This may present with pain in the back, groin or the lower
• Hepatitis.
Do not be alarmed by this list - most people take Lopresor Tablets without any
If any of the symptoms become troublesome, or if you notice anything else not
mentioned here, please go and see your doctor. He/she may want to give you a
different medicine.

5. How to store Lopresor Tablets
Store in a dry place.
Keep out of the reach and sight of children.
Do not take Lopresor Tablets after the expiry date which is printed on the outside of the pack.
If your doctor tells you to stop taking the tablets, please take any unused tablets back to your
pharmacist to be destroyed. Do not throw them away with your normal household water or
waste. This will help to protect the environment.

Further information

The tablets come in two strengths containing either 50 mg or 100 mg of the active ingredient,
metoprolol tartrate.
The tablets also contain the inactive ingredients cellulose, povidone, silicon dioxide, sodium
starch glycollate, magnesium stearate, hydroxypropyl methylcellulose, polysorbate, talc,
titanium dioxide (E171), red iron oxide (E172) (50mg tablets only), indigocarmine E132 (100mg
tablets only).
Both the 50mg and 100mg tablets come in blister packs containing 56 tablets.
Marketing Authorisation holder
Recordati Pharmaceuticals Limited
200 Brook Drive, Green Park, Reading, RG2 6UB, United Kingdom
Lopresor Tablets are made by Novartis Pharmaceuticals UK Limited, Horsham, West Sussex
RH12 5AB, England.
This leaflet was revised in January 2016.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.