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LISKONUM TABLETS

Active substance(s): LITHIUM CARBONATE

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22555401
GSK-ContractMfg-Eur-DEUGermany-Wuelfing

Package Leaflet: Information for the User

United Kingdom-GBR

Liskonum® 450 mg tablets
lithium carbonate

Liskonum

• Keep this leaflet. You may need to read it again.
• If you have further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass
it on to others. It may harm them, even if their signs of illness
are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist.
This includes any possible side effects not listed in this leaflet.
See section 4.

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What is in this leaflet:
1 What Liskonum is and what it is used for
2 What you need to know before you take Liskonum
3 How to take Liskonum
4 Possible side effects
5 How to store Liskonum
6 Contents of the pack and other information

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1 What Liskonum is and what it is used for

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Liskonum tablets contain the active substance lithium carbonate.
Liskonum is used in adults and children over 12 years of age to:
• prevent you feeling overactive, overly elated (happy) or
overly irritable
• stop big changes in your mood. You may go from feeling very
sad and unworthy to feeling overactive, overly elated (happy)
or overly irritable. In some people the change can be reversed.
Liskonum tablets are ‘controlled release’ tablets. This means the
lithium carbonate is slowly released into your body, which stops
large changes in the levels of lithium in your blood.

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2 What you need to know before you take Liskonum
Do not take Liskonum if:
• you are allergic (hypersensitive) to lithium or any of the
other ingredients of this medicine (listed in section 6)
• you have kidney or heart problems
• you have thyroid problems that are not being treated.
Signs of thyroid problems include: tiredness, lethargy, muscle
weakness, cramps, feeling cold, a slow heart rate, dry and
flaky skin, hair loss, a deep and husky voice and weight gain
• you are dehydrated, such as when you are being sick
(vomiting) or have diarrhoea
• you are on a low sodium diet
• you have Addison’s Disease. This is when your adrenal
glands are not working properly which may cause weakness,
tiredness, weight loss and low blood pressure
• you or someone in your family has a condition called
Brugada syndrome (a hereditary disease that affects the
heart).
Do not take if any of the above apply to you. If you are not sure,
talk to your doctor or pharmacist before taking Liskonum.

9pt
95%
8.5pt
No

PHARMA CODE N° 200

8.5pt

Warnings and Precautions
Talk to your doctor or pharmacist before taking Liskonum if:
• you have an infection
• you have an intolerance to some sugars. Each Liskonum
450 mg tablet contains 62 mg lactose per dose. This should
be taken into account in patients with sugar diabetes
(diabetes mellitus)
• you have kidney impairment. Patients with severe kidney
impairment who received lithium for more than 10 years
may have a risk of developing a benign or malignant kidney
tumour (microcysts, oncocytoma or collecting duct renal
carcinoma)
•  you have a family history of cardiac arrest or sudden death.
Children under the age of 12 years:
This medicine is not recommended for use in children under
12 years of age.
Other medicines and Liskonum
Tell your doctor or pharmacist if you are taking, have recently
taken or might take any other medicines, including medicines
obtained without a prescription. This includes herbal medicines.
This is because Liskonum can affect the way some other
medicines work. Also some other medicines can affect the way
Liskonum works.

In particular tell your doctor or pharmacist if you are taking any
of the following medicines:
• diuretics (water tablets) - used to increase the amount of
urine produced (such as furosemide and bendroflumethiazide)
• non-steroidal anti-inflammatory medicines (NSAIDs),
including Cox-II inhibitors - used for pain and rheumatism
(such as ibuprofen, diclofenac, celecoxib and etoricoxib)
• selective serotonin re-uptake inhibitors (SSRIs) – used
for depression (such as fluvoxamine and fluoxetine)
• neuroleptic medicines - used for nervous disorders like
schizophrenia (such as haloperidol)
• medicines for epilepsy (such as carbamazepine)
• metronidazole - used to treat infections
• medicines used to relax muscles during surgery
• medicines used to treat high blood pressure and some
other heart problems (such as methyldopa, ACE inhibitors,
calcium channel blockers and angiotensin II antagonists)
• medicines containing sodium bicarbonate - used to treat
heartburn and indigestion (such as antacids)
• urea - used to treat skin conditions
• xanthines - used in the treatment of asthma (such as
theophylline and aminophylline).

PHARMA CODE N° 200

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

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Electric shock treatment (electroconvulsive therapy or ECT)
• Because of the increased risk of side effects such as severe
confusion (delirium) and fits that may last longer than usual
(prolonged seizures), your doctor may take a blood sample
to check the level of Lithium in your blood before receiving
electric shock treatment.
If you are not sure if any of the above apply to you, talk to your
doctor or pharmacist before taking Liskonum.
Pregnancy and breast-feeding
Do not take Liskonum if you are pregnant, might become
pregnant or breast-feeding, unless your doctor tells you to. Talk
to your doctor before taking this medicine if you are not sure.
Driving and using machines
You may feel drowsy, dizzy or see, feel or hear things that
are not there (hallucinations) while taking Liskonum. If this
happens, do not drive or use any tools or machines.
Liskonum contains lactose
If you have been told by your doctor that you have an intolerance
to some sugars, contact your doctor before taking this medicinal
product.

3 How to take Liskonum
Always take this medicine exactly as your doctor or pharmacist
has told you. Check with your doctor or pharmacist if you are
not sure.
Taking this medicine
• Your doctor will tell you how much Liskonum to take and
how often. This depends on your condition. It is usually taken
twice a day.
• Your doctor will do blood tests to check the amount of lithium
in your blood.
• Swallow the tablets with a glass of water.
• Do not crush or chew the tablets. If you struggle to swallow
the tablets they can be broken in half, but you must try to
swallow each half, do not chew it.
• You should try to take your medicine at the same time each day.
• If you feel the effect of your medicine is too weak or too
strong do not change the dose yourself, talk to your doctor.
• Do not stop taking Liskonum suddenly as this may worsen
your underlying symptoms. If your doctor feels that your
treatment should be stopped, then your dose should usually
be gradually reduced rather than immediately stopped.
• Do not take more Liskonum than your doctor has recommended.
Thoughts of harming or killing yourself
If you have a mood disorder, you can sometimes have thoughts
of harming or killing yourself. These may be increased when first
starting Liskonum or changing your dose of Liskonum. Like other
medicines of this kind, Liskonum may not relieve your symptoms
straight away. If you have thoughts of harming or killing
yourself or worsening of your symptoms at any time, contact
your doctor or go to a hospital straight away.

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You may find it helpful to tell a relative, close friend or
carer that you have a mood disorder, and ask them to read
this leaflet. You might ask them to tell you if they think your
mood disorder is getting worse, or if they are worried about
changes in your behaviour.

United Kingdom-GBR

Use in children
Liskonum is not suitable for children under 12 years of age.

Liskonum

Use in the elderly (over 65 years)
Older people may need to start on a lower dose.
Salt and water intake while taking Liskonum
Your salt and water intake affects the way that lithium is
removed from your body. This means you need to maintain a
sufficient and steady supply of both salt and water.
Drink about the same amount of water every day (the usual range
is 4-6 pints) and avoid any dramatic changes in your fluid intake.
• If you usually drink less than 4-6 pints of fluid each day, and
blood tests show that your lithium level is stable, there is no
need to drink more water.
• However, do not ignore any feelings of thirst. Have a drink
when you feel you need to.
Keep to your normal, daily amount of salt.
• Tell your doctor before you begin any new diets. Do not start
a low sodium diet while taking Liskonum.
• Do not fast while taking Liskonum.

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If you take more Liskonum than you should
If you take more Liskonum than you should, talk to a doctor or
go to a hospital straight away. Take the medicine pack with you.
If you forget to take Liskonum
• If you forget a dose, miss out that dose completely.
• Take your next dose at the usual time.
• Do not take a double dose (two doses at once) to make up
for a forgotten dose.

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If you stop taking Liskonum
• Take Liskonum for as long as your doctor recommends. Do not
stop suddenly as your illness may get worse. If you need to stop
taking it, your doctor will usually reduce your dose gradually.

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4 Possible side effects
Like all medicines, this medicine can cause side effects, although
not everybody gets them.
Tell your doctor straight away and stop taking Liskonum
if you notice any of the following side effects:
• being sick (vomiting) or diarrhoea
• lack of co-ordination (clumsiness), increased shaking of your
hands and lower jaw, muscle twitching or jerking movements,
numbness and weakness of the arms and legs, fingers and toes,
loss of sensation and pins and needles, joint pain or muscle pain
• dizziness, blurred vision or worsening of eyesight
• ringing in your ears.
Do not take any further doses of your medicine unless your doctor
advises you to do so. The amount of Liskonum in your blood may
be too high and you may need to stop taking this medicine.
The following side effects may also happen with this medicine:
Heart and circulation
• water retention and swelling (oedema)
• changes in your heart rate, most commonly a slow heartbeat,
or a drop in blood pressure (hypotension)
• blood tests can show an increase in white blood cells
(leukocytosis), increased blood sugar (hyperglycaemia) or
increased calcium levels.

9pt
95%
8.5pt
No

PHARMA CODE N° 200

8.5pt

Nervous system
• slurred speech or feeling dazed
• spinning sensation (vertigo)
• sleepiness, memory loss or hallucinations (sensing things that
are not real)
• mild shaking of your hands or jerky muscle movements when
you first start to take Liskonum
• seizures, fits or convulsions, decreased or loss of
consciousness (coma)
• headache.
Skin and hair
• acne, swelling and redness (inflammation) around hair
follicles and rashes, which can be itchy or raised (papular)
can occur. If you suffer from psoriasis, this may get worse
• unusual hair loss or thinning can also occur
• numbness, tingling and colour changes (white, blue then red)
in your fingers and toes when they are cold.
Stomach and gut
• feeling sick (nausea)
• inflamed stomach (gastritis) which may cause pain, vomiting
blood or blood in your bowel motions
• taste disturbance
• loss of appetite or weight gain.

Thyroid
• lower (hypothyroidism) or, rarely, higher activity
(hyperthyroidism) of your thyroid gland can occur.
Hypothyroidism may make you feel very tired and slow.
Hyperthyroidism may increase your appetite, result in loss of
weight, intolerance to heat, increased sweating and tremors
• increases in the activity of your parathyroid gland
(hyperparathyroidism) can also occur and can cause
tiredness, vomiting and bone pain or tenderness
• increase in the size of your thyroid gland with normal thyroid
activity (euthyroid goitre).
Others
• kidney problems. Frequency unknown of benign/malignant
kidney tumours (microcysts, oncocytoma, or collecting duct
renal carcinoma) in long-term therapy.
• muscle weakness, giddiness
• rapid, uncontrollable eye movements
• you may feel thirsty while taking Liskonum and need to drink
more liquids (see advice under Salt and water intake while
taking Liskonum in section 3)
• you may need to pass water (urinate) more often
• you may have a dry mouth, or find you are producing more
saliva than normal
• sexual dysfunction.

PHARMA CODE N° 200

GSK-ContractMfg-Eur-DEUGermany-Wuelfing

Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. You can
also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information
on the safety of this medicine.

5 How to store Liskonum
• Keep out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated
on the foil and carton. The expiry date refers to the last day
of that month.
• Do not store Liskonum tablets above 25°C.
• Do not throw away medicines via wastewater or household
waste. Ask your pharmacist how to throw away medicines
you no longer use. These measures will help protect the
environment.

6 Contents of the pack and other information
What Liskonum contains
• The active substance is lithium (present as lithium carbonate)
450 mg
• The other ingredients are povidone, maize starch, lactose
(see section 2), gelatin, calcium carboxymethylcellulose,
talc (E553[b]), calcium arachinate, titanium dioxide (E171),
magnesium stearate (E572), polyethylene glycol 6000,
eudragit E12.5
What Liskonum looks like and contents of the pack
Liskonum tablets are white, oblong, film-coated tablets, with a
score (breakline) on both sides. Liskonum tablets come in packs
of 60 tablets, arranged in six blister strips of 10 tablets.
Marketing authorisation holder and manufacturer
Marketing Authorisation Holder: Smith Kline and French
Laboratories Limited, Stockley Park West, Uxbridge, Middlesex
UB11 1BT
Manufacturer: Glaxo Operations UK Limited (trading as
Glaxo Wellcome Operations), Harmire Road, Barnard Castle,
County Durham, DL12 8DT
Other formats
To listen to or request a copy of this leaflet in Braille, large print
or audio please call, free of charge:

0800 198 5000 (UK Only)
Please be ready to give the following information:
Product name
Reference number

Liskonum 450 mg tablets
00002/0083

This is a service provided by the Royal National Institute of Blind
People.
This leaflet was last revised in November 2015
Liskonum is a registered trade mark of the GSK group of
companies
© 2015 GSK group of companies. All rights reserved

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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