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ISOCARBOXAZID TABLETS 10MG

Active substance(s): ISOCARBOXAZID / ISOCARBOXAZID / ISOCARBOXAZID

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Artwork Information
Product Title:

Isocarboxazid 10mg tablets

Date:

10-04-17

Product Size:

140 x 402 mm

Label Number:

16-248

Colours Used:

BLACK

Fonts Used:

Futura Condensed

Font size (min):

9pt

Version:

3

Magenta text, keylines and shading are NOT to be printed

Package leaflet: Information for the user

Isocarboxazid tablets 10mg
Read all of this leaflet carefully before you start using this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if
their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not
listed in this leaflet. See section 4.
What is in this leaflet:
1. What Isocarboxazid tablets are and what they are used for
2. What you need to know before you take Isocarboxazid tablets
3. How to take Isocarboxazid tablets
4. Possible side effects
5. How to store Isocarboxazid tablets
6. Contents of the pack and other information
1. What Isocarboxazid tablets are and what they are used for
Isocarboxazid is one of the group of medicines known as Monoamine Oxidase Inhibitors (MAOIs). These are
drugs that block the action of a substance called monoamine oxidase which is present in the brain and which
plays an important part in controlling mood.
Isocarboxazid tablets are used in the treatment of depression.
You must talk to a doctor if you do not feel better or if you feel worse.
2. What you need to know before you take Isocarboxazid tablets
Do not take these tablets if:
• You are allergic to Isocarboxazid or any of the other ingredients of this medicine (listed in section 6).
• You have severe heart disease or any disease of the blood vessels of the brain
• You have phaeochromocytoma which is a tumour of the adrenal glands causing high blood pressure
• You have known liver damage
• You are taking any medications for the treatment of depression and/or anxiety.
Warnings and precautions
Talk to your doctor or pharmacist before taking these tablets if you:








are elderly or in a weak state of health
have any sort of heart problem
suffer from seizures/fits (epilepsy)
have diabetes
have kidney damage
have any disease affecting the blood cells
are going to have surgery or dental work that requires an anaesthetic within the next two weeks - it may
affect the choice of anaesthetic.

This medicine may occasionally affect your liver. Your doctor may send you for a blood test to check your
liver function.
Thoughts of suicide and worsening of your depression or anxiety disorder.
• If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or
killing yourself. These may be increased when first starting antidepressants, since these medicines all
take time to work, usually about two weeks but sometimes longer.
You may be more likely to think like this:
• If you have previously had thoughts about killing or harming yourself.
• If you are a young adult. Information from clinical trials has shown an increased risk of suicidal
behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an
antidepressant.
If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital
straight away.
• You may find it helpful to tell a relative or close friend that you are depressed or have an
anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your
depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Children and adolescents
Isocarboxazid tablets are not recommended for use in children
Other medicines and Isocarboxazid
Tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines. This includes
medicines obtained without a prescription.
In particular, you should tell your doctor about:
• All other medicines which treat depression or anxiety including other MAOIs, selective serotonin
reuptake inhibitors (SSRIs) and tricyclic antidepressants, eg clomipramine and imipramine
• Medicines for high blood pressure, e.g. reserpine, methyldopa
• Medicines to treat diabetes, e.g. insulin, metformin
• Medicines used for cough and colds such as decongestants (these may contain substances called
sympathomimetic agents, eg ephedrine, pseudoephedrine)
• Medicines used for asthma or heart problems which contain sympathomimetic agents such as
adrenaline and noradrenaline
• Medicines used to suppress the central nervous system such as anticonvulsants for epilepsy and
phenothiazines for severe mental problems, eg chlorpromazine, fluphenazine
• Medicines to control appetite, eg amphetamine and fenfluramine
• Medicines that treat Parkinson’s disease, e.g. levodopa
• Strong pain killers, e.g. pethidine and morphine
• Barbiturates used to treat severe sleeping problems, eg amylobarbitone
• Medicines called antimuscarinics which are used in Parkinson’s disease, stomach and bladder problems
• Diuretic medicines (“water tablets”)
Isocarboxazid with food, drink and alcohol
You should NOT take alcohol (especially red wine) whilst you are taking Isocarboxazid tablets. This includes
non-alcoholic beer or lager.
Isocarboxazid tablets stop the breakdown of a substance called tyramine which is found in large amounts of
certain foods. If this substance is not broken down, it can cause very high blood pressure. So, while you are
taking Isocarboxazid and for two weeks after the course of treatment has finished, you should avoid the
following foods:
• Matured cheeses (e.g. cheddar or processed cheese made from mature cheese)
• Yeast extracts (e.g. Bovril or Marmite)

• Meat, fish or poultry which is not fresh or has been pickled
• Broad bean pods
• Over-ripe fruit
Pregnancy and breast-feeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your
doctor or pharmacist for advice before taking this medicine.
Isocarboxazid should not be used during pregnancy or breast feeding unless your doctor thinks it is essential
to do so.
Driving and using machines
Isocarboxazid tablets may make you feel drowsy or dizzy or affect your concentration. You should not drive
or use machines when you first start to take this medicine until you are certain that you are not getting these
side effects. If in any doubt, speak to your doctor before you drive or use machines.
Isocarboxazid tablets contain Lactose
These tablets contain lactose. If you have been told by your doctor that you have an intolerance to some
sugars, contact your doctor before taking this medicinal product.
3. How to take Isocarboxazid tablets
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or
pharmacist if you are not sure.
The recommended dose is between one and three tablets daily, taken at different times or all together.
Sometimes this medicine needs to be taken for several weeks before you begin to feel better. Your symptoms
should improve within a month but if no improvement is obtained in this time your doctor may increase the
dose. It is very important to persist with the treatment course recommended by your doctor to obtain the
maximum benefit from this medicine
Use in children and adolescents
Isocarboxazid tablets are not recommended for use in children.
Route and method of administration
For oral use only
If you take more Isocarboxazid tablets than you should
If you swallow too many tablets or someone else accidentally takes your medicine, contact your doctor,
pharmacist or nearest accident and emergency department straight away. Take the medicine pack or this
leaflet and any remaining tablets with you.
If you forget to take Isocarboxazid tablets
If you miss a dose, take it as soon as you remember provided that this is on the same day. You can take the
full day's dose in one go, but do not take more than this on any one day.
If you have any further questions on the use of this product ask your doctor or pharmacist.
4. Possible side effects
Like all medicines Isocarboxazid tablets can sometimes cause side-effects, although not everybody gets them.
• All medicines can cause allergic reactions although serious allergic reactions are very
rare. Any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or
lips, rash or itching (especially affecting your whole body) should be reported to a
doctor immediately.
• The most common side effects are as follows, and can usually be controlled by reducing the dose:
Dizziness or fainting, especially on first standing up from a sitting or lying position; drowsiness or
blurred vision; dryness of the mouth; heart palpitations; swelling of the feet or ankles; stomach upsets
(feeling sick and vomiting); constipation; weakness, fatigue or difficulty in sleeping.
You should obtain medical help immediately if you experience all or some of the symptoms of unusually
high blood pressure. These are severe chest pain and headache, enlarged pupils with sensitivity to light,
sweating, stiff or sore neck, feeling sick and vomiting, fast or slow heartbeat.
• Less common side effects are mild headaches; sweating; abnormal tingling sensations and pain in the
limbs; increased reflexes; feeling agitated or hyperactive; muscle tremors; confusion; difficulty in
passing urine, obtaining an erection or ejaculating; skin rashes; disorders of blood cells causing purple
spots under the skin or increased susceptibility to infection; changes in appetite and putting on weight.
Reporting of side effects
If you get any side effects, talk to your doctor, nurse or pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Isocarboxazid tablets
Keep this medicine out of the sight and reach of children - preferably in a locked cupboard or medicine cabinet.
Do not use this medicine after the expiry date which is stated on the tablet container after EXP. The expiry
date refers to the last day of that month.
Return any left-over medicine to your pharmacist - only keep it if your doctor tells you to. The tablets should
be stored at normal room temperature, below 25°C. Keep the bottle tightly closed.
REMEMBER this medicine is for you. Only a doctor can prescribe it for you. Never give it to others. It may
harm them even if their symptoms are the same as yours.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Isocarboxazid tablets contain
The active substance is Isocarboxazid. Each tablet contains 10mg of Isocarboxazid. The other ingredients are
starch, lactose, talc, magnesium stearate, gelatin, yellow and red iron oxides E172
What Isocarboxazid tablets look like and contents of pack
Each bottle of tablets contains 56 tablets.
Marketing Authorisation holder
Alliance Pharmaceuticals Limited, Avonbridge House, Bath Road, Chippenham, Wiltshire, SN15 2BB, UK.
Manufacturer
Pharmaserve Ltd, Clifton Technology Park, Wynne Avenue, Swinton, Manchester M27 8FF.
This leaflet was last revised in April 2017
Alliance and associated devices are registered trademarks of Alliance Pharmaceuticals Limited.
© Alliance Pharmaceuticals 2017

Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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