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IMIGRAN 50 MG TABLETS

Active substance(s): SUMATRIPTAN

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Patient Information Leaflet

IMIGRAN® 50 mg Tablets
(sumatriptan succinate)
Read all of this leaflet carefully before you start taking this
medicine because it contains important information for you.
Your medicine is called Imigran 50 mg Tablets but throughout this
leaflet will be referred to as Imigran.
Imigran® is available in other strengths and formats





Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on
to others - it may harm them, even if their signs of illness are the
same as yours.
If you get any side effects, talk to your doctor or pharmacist.
This includes any possible side effects not listed in this leaflet. See
section 4.

What is in this leaflet
1.
2.
3.
4.
5.
6.

What Imigran is and what it is used for
What you need to know before you use Imigran
How to use Imigran
Possible side effects
How to store Imigran
Contents of the pack and other information

1. What Imigran is and what it is used for
Each Imigran capsule-shaped tablet contains a single dose of
sumatriptan, which belongs to a group of medicines called triptans
(also known as 5-HT1 receptor agonists).
Imigran is used to treat migraine headache.
Migraine symptoms may be caused by the temporary widening of
blood vessels in the head. Imigran is believed to reduce the widening
of these blood vessels. This in turn helps to take away the headache
and relieve other symptoms of a migraine attack, such as feeling or
being sick (nausea or vomiting) and sensitivity to light and sound.

2. What you need to know before you use Imigran
Don’t use Imigran:
• If you’re allergic to sumatriptan, or any of the other ingredients
of this medicine (listed in section 6)
• If you have a heart problem such as narrowing of the arteries
(Ischaemic heart disease) or chest pains (angina), or have already
had a heart attack
• If you have circulation problems in your legs that cause cramplike pains when you walk (peripheral vascular disease)
• If you have had a stroke or a mini-stroke (also called a transient
ischaemic attack or TIA)
• If you have high blood pressure. You may be able to use Imigran
if your high blood pressure is mild and is being treated
• If you have serious liver disease
• With other migraine medicines, including those which contain
ergotamine, or similar medicines such as methysergide maleate;
or any triptan or 5-HT1 agonist (such as naratriptan or zolmitriptan)
• With any of the following anti-depressants:
• MAOIs (monoamine oxidase inhibitors) or if you have taken
an MAOI in the last 2 weeks
• SSRIs (selective serotonin reuptake inhibitors) including
citalopram, fluoxetine, fluvoxamine, paroxetine and sertaline
• SNRIs (serotonin noradrenaline reuptake inhibitors) including
venlafaxine and duloxetine
• For children under 18 years of age.
If any of these apply to you:
→ Tell your doctor, and don’t use Imigran tablets.
Take special care with Imigran
Talk to your doctor or pharmacist before using Imigran.
If you have any extra risk factors
• If you are a heavy smoker, or using nicotine replacement
therapy, and especially
• If you are a man aged over 40, or
• If you are a woman who has been through the menopause.

In very rare cases, people have developed serious heart conditions after
using Imigran, even though they had no signs of heart disease before.
If any of the points above applies to you it could mean you have a
greater risk of developing heart disease - so:
→ Tell your doctor so that your heart function can be checked before
Imigran is prescribed for you.
If you have a history of fits (seizures)
Or if you have other conditions which might make it more likely that
you’ll have a fit - for example, a head injury or alcoholism:
→ Tell your doctor so that you can be supervised more closely.
If you have had high blood pressure Imigran may not be suitable
for you
→ Tell your doctor or pharmacist before using Imigran.
If you have liver or kidney disease
If either of these apply to you:
→ Tell your doctor or pharmacist before using Imigran.
If you have an intolerance to some sugars
→ Tell your doctor so that you can be supervised more closely.
If you are allergic to antibiotics called sulphonamides
If so, you may also be allergic to Imigran. If you know you are allergic
to an antibiotic but you are not sure whether it is a sulphonamide:
→ Tell your doctor or pharmacist before using Imigran.
If you are taking anti-depressants called SSRIs
(Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin
Noradrenaline Reuptake Inhibitors)
→ Tell your doctor or pharmacist before using
Imigran. Also see Other medicines and Imigran, below.
If you use Imigran frequently.
Using Imigran too often may make your headaches worse.
→ Tell your doctor if this applies to you. He or she may recommend
you stop using Imigran.
If you feel pain or tightness in your chest after you use Imigran
These effects may be intense but they usually pass quickly. If they don’t
pass quickly, or they become severe:
→ Get medical help immediately.
Section 4 (overleaf) has more information about these possible side
effects.
Other medicines and Imigran
Tell your doctor or pharmacist if you’re taking, have recently taken
or might take any other medicines. This includes any herbal products or
medicines you’ve bought without a prescription.
Some medicines must not be taken with Imigran and others may cause
adverse effects if they’re taken with Imigran.
You must tell your doctor if you are taking:
• ergotamine also used to treat migraine, or similar medicines such
as methysergide (see section 2 Don’t use Imigran). Don’t use
Imigran at the same time as these medicines. Stop taking these
medicines at least 24 hours before using Imigran. Don’t take any
medicines which contain ergotamine or compounds similar to
ergotamine again for at least 6 hours after using Imigran.
• other triptans/5-HT1 receptor agonists (such as naratriptan,
rizatriptan, zolmitriptan), also used to treat migraine, (see section 2
Don’t use Imigran). Don’t use Imigran at the same time as these
medicines. Stop taking these medicines at least 24 hours before
using Imigran. Don’t take another triptan/5-HT1 receptor agonist
again for at least 24 hours after using Imigran.
• MAOIs used to treat depression. Don’t use Imigran if you have
taken these in the last 2 weeks.
• SSRIs and SNRIs used to treat depression. Using Imigran with
these medicines can cause serotonin syndrome (a collection of
symptoms which can include restlessness, confusion, sweating,
hallucinations, increased reflexes, muscle spasms, shivering,
increased heartbeat and shaking). Tell your doctor immediately
if you are affected in this way.
• St John’s Wort (Hypericum perforatum). Taking herbal remedies
that contain St John’s Wort together with Imigran may make side
effects more likely.
Pregnancy and breast-feeding
• If you are pregnant, think you may be pregnant or are planning
to have a baby, ask your doctor for advice before taking this
medicine. There is only limited information about the safety of
Imigran for pregnant women, though up till now there is no evidence
of any increased risk of birth defects. Your doctor will discuss with
you whether or not you should use Imigran while you are pregnant
• Don’t breast-feed your baby for 12 hours after using Imigran.
If you express any breast milk during this time, discard the milk and
don’t give it to your baby.

Driving and using machines
Either the symptoms of migraine or your medicine may make you
drowsy. If you are affected, don’t drive or operate machinery.

3. How to use Imigran
Always take this medicine exactly as your doctor has told you.
Check with your doctor or pharmacist if you are not sure.
When to take Imigran
• It’s best to take Imigran as soon as you feel a migraine coming
on, although - you can take it at any time during an attack
• Don’t use Imigran to try to prevent an attack - only use it after your
migraine symptoms start.
How much to take
Adults aged 18 to 65
• The usual dose for adults aged 18 to 65 is one Imigran 50 mg
tablet, swallowed whole with water. Some patients may need a
100 mg dose - you should follow your doctor’s advice.
Children under 18
• Imigran is not recommended for children under 18 years old.
Elderly (aged over 65)
• Imigran is not recommended for people aged over 65.
If your symptoms start to come back

You can take a second Imigran tablet if at least 2 hours have
passed since the first tablet. Don’t take more than 300 mg in total
in 24 hours.
If the first tablet has no effect

Don’t take a second tablet or any other Imigran preparation for
the same attack. Imigran can still be used for your next attack.
If Imigran doesn’t give you any relief:
→ Ask your doctor or pharmacist for advice.
If you take more Imigran than you should
• Don’t take more than six 50 mg tablets or three 100 mg tablets
(300 mg in total) in any 24 hours.

Very rare side effects
(affect up to 1 in 10,000 people)
• Liver function changes. If you have a blood test to check your liver
function, tell your doctor or nurse that you are taking Imigran.
Some patients may get the following side effects but it is not
known how often they occur
• Seizures/fits, tremors, muscle spasm, neck stiffness
• Visual disturbances such as flickering, reduced vision, double vision,
loss of vision, and in some cases even permanent defects (although
these may be due to the migraine attack itself)
• Heart problems, where your heartbeat may go faster, slower or
change rhythm, chest pains (angina) or heart attack
• Pale, blue-tinged skin and/or pain in your fingers, toes, ears, nose or
jaw in response to cold or stress (Raynaud’s phenomenon)
• Feeling faint (blood pressure may go down)
• Pain in the lower left side of the stomach and bloody diarrhoea
(ischaemic colitis)
• Diarrhoea
• Pain in the joints
• Feeling anxious
• Excessive sweating
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet.
You can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the
safety of this medicine.

5. How to store Imigran
Keep out of the sight and reach of children
Do not use Imigran after the expiry date shown on the carton.
The expiry date refers to the last day of that month.
Do not store above 30°C
Medicines should not be disposed of via waste water or household
waste. Ask your pharmacist how to dispose of medicines no longer
required, these measures will help to protect the environment.

Taking too much Imigran could make you ill. If you have taken more
than 300 mg in 24 hours:
→ Contact your doctor for advice.

6. Contents of the pack and other information

If you have any further questions about the use of this medicine, ask
your doctor or pharmacist.

What Imigran contains
• The active substance is sumatriptan (50 mg)
• The other ingredients in the tablets are lactose monohydrate,
lactose anhydrous, microcrystalline cellulose, croscarmellose
sodium and magnesium stearate. The coating is Opadry Pink.

4. Possible side effects
Like all medicines, this medicine can cause side effects, but not
everybody gets them.
Some symptoms may be caused by the migraine itself.
Allergic reaction: get doctor’s help straight away

What Imigran looks like and contents of the pack
Imigran 50 mg tablets are pink, capsule shaped, biconvex tablet,
engraved "GX ES3" on one face and plain on the other face.
They are available in blister packs containing 2 tablets and 6 tablets.

The following side effects have occurred but their exact frequency is not
known.
• The signs of allergy include rash, hives (itchy rash); wheezing;
swollen eyelids, face or lips; complete collapse.

Manufactured by:
GLAXO OPERATIONS UK LIMITED,
Priory Street, Ware, Hertfordshire SG12 0DJ, UK.
Or
GlaxoSmithKline Pharmaceuticals SA,
189, Grunwaldzka St, 60-322 Poznan, Poland.

If you get any of these symptoms soon after using Imigran:
→ Don’t use any more. Contact a doctor straight away.

Procured from within the EU.

Common side effects
(affect up to 1 in 10 people)
• Pain, heaviness, pressure or tightness in the chest, throat or other
parts of the body, or unusual sensations, including numbness,
tingling and warmth or cold. These effects may be intense but
generally pass quickly.
If these effects continue or become severe
(especially the chest pain):
→ Get medical help urgently. In a very small number of people
these symptoms can be caused by a heart attack.
Other common side effects include:
• Feeling sick (nausea) or being sick (vomiting), although this may be
due to the migraine itself
• Tiredness or drowsiness
• Dizziness, feeling weak, or getting hot flushes
• Temporary increase in blood pressure
• Shortness of breath
• Aching muscles.

Product Licence Holder: Ecosse Pharmaceuticals Limited,
3 Young Place, East Kilbride, G75 0TD.
Re-packaged by: Munro Wholesale Medical Supplies Limited,
3 Young Place, East Kilbride, G75 0TD.
PL 19065/0298
POM
This leaflet was last revised on 23/06/2016
E0298-5
Imigran® is a registered trade mark of GlaxoSmithKline group of
companies

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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