Skip to Content

IMIGRAN 20MG/0.1ML NASAL SPRAY

Active substance(s): SUMATRIPTAN

View full screen / Print PDF » Download PDF ⇩
Transcript
PACKAGE LEAFLET: INFORMATION FOR THE USER

Imigran® 20mg/0.1ml Nasal Spray / Imigrane 20mg/0.1ml Nasal Spray
(sumatriptan)
This product is available using either of the above names but will be referred to as Imigran
Nasal Spray throughout the following leaflet. Please note that the leaflet also contains
information about other strength (Imigran 10mg/0.1ml Nasal Spray).
Read all of this leaflet carefully before you start taking this medicine because it
contains important information for you.





Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others - it may
harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible
side effects not listed in this leaflet. See section 4.

What is in this leaflet
1.
2.
3.
4.
5.
6.

What Imigran Nasal Spray is and what it is used for
What you need to know before you use Imigran Nasal Spray
How to use Imigran Nasal Spray
Possible side effects
How to store Imigran Nasal Spray
Contents of the pack and other information

1. What Imigran Nasal Spray is and what it is used for
Each Imigran Nasal Spray contains a single dose of sumatriptan, which belongs to a
group of medicines called triptans (also known as 5-HT1 receptor agonists).
Imigran Nasal Spray is used to treat migraine headache.
Migraine symptoms may be caused by the temporary widening of blood vessels in the
head. Imigran Nasal Spray is believed to reduce the widening of these blood vessels. This
in turn helps to take away the headache and relieve other symptoms of a migraine attack,
such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound.

If you feel pain or tightness in your chest after you use Imigran Nasal Spray
These effects may be intense but they usually pass quickly. If they don’t pass quickly, or
they become severe:
→ Get medical help immediately. Section 4 of this leaflet has more information about
these possible side effects.
Other medicines and Imigran Nasal Spray
Tell your doctor or pharmacist if you’re taking, have recently taken or might take any
other medicines. This includes any herbal products or medicines you’ve bought without a
prescription.
Some medicines must not be taken with Imigran Nasal Spray and others may cause
adverse effects if they’re taken with Imigran Nasal Spray. You must tell your doctor if
you are taking:
■ ergotamine also used to treat migraine, or similar medicines such as methysergide
(see Section 2). Don’t use Imigran Nasal Spray at the same time as these medicines.
Stop taking these medicines at least 24 hours before using Imigran Nasal Spray. Don’t
take any medicines which contain ergotamine or compounds similar to ergotamine again
for at least 6 hours after using Imigran Nasal Spray.
■ other triptans/5-HT1 receptor agonists (such as naratriptan, rizatriptan, zolmitriptan),
also used to treat migraine, (see Section 2). Don’t use Imigran Nasal Spray at the same
time as these medicines. Stop taking these medicines at least 24 hours before using
Imigran Nasal Spray.
Don’t take another triptan/5-HT1 receptor agonist again for at least 24 hours after using
Imigran Nasal Spray.
■ SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline
Reuptake Inhibitors) used to treat depression. Using Imigran Nasal Spray with these
medicines can cause serotonin syndrome (a collection of symptoms which can include
restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms,
shivering, increased heartbeat and shaking). Tell your doctor immediately if you are
affected in this way.
■ MAOIs (monoamine oxidase inhibitors) used to treat depression. Don’t use Imigran
Nasal Spray if you have taken these in the last 2 weeks.
■ St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s
Wort while you are using Imigran Nasal Spray may make side effects more likely.
Pregnancy and breast-feeding


2. What you need to know before you use Imigran Nasal Spray
Don’t use Imigran Nasal Spray:










If you’re allergic to sumatriptan, or any of the other ingredients of this medicine (listed
in Section 6).
If you have a heart problem such as narrowing of the arteries (Ischaemic heart
disease) or chest pains (angina), or have already had a heart attack.
If you have circulation problems in your legs that cause cramp-like pains when you
walk (peripheral vascular disease).
If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or
TIA).
If you have high blood pressure. You may be able to use Imigran Nasal Spray if your
high blood pressure is mild and is being treated.
If you have serious liver disease.
With other migraine medicines, including those which contain ergotamine, or similar
medicines such as methysergide or any triptan/5-HT1 receptor agonist (medicines which
are also used for treating migraine).
With anti-depressants called MAOIs (monoamine oxidase inhibitors), or if you have
taken these medicines in the last 2 weeks.

If any of these apply to you:
→ Tell your doctor, and don’t use Imigran Nasal Spray.
Take special care with Imigran Nasal Spray
Talk to your doctor or pharmacist before using Imigran Nasal Spray:
If you have any extra risk factors
■ If you are a heavy smoker, or are using nicotine replacement therapy, and especially
■ If you are a man aged over 40, or
■ If you are a woman who has been through the menopause.
In very rare cases, people have developed serious heart conditions after using Imigran
Nasal Spray, even though they had no signs of heart disease before. If any of the points
above applies to you it could mean you have a greater risk of developing heart disease so:
→ Tell your doctor so that your heart function can be checked before Imigran Nasal
Spray is prescribed for you.
If you have a history of fits (seizures)
Or if you have other conditions which might make it more likely that you’ll have a fit – for
example, a head injury or alcoholism.
→ Tell your doctor so that you can be supervised more closely.
If you have liver or kidney disease
→ Tell your doctor so that you can be supervised more closely.



Driving and using machines
Either the symptoms of migraine or your medicine may make you drowsy. If you are
affected, don’t drive or operate machinery.
3. How to use Imigran Nasal Spray
Only use Imigran Nasal Spray after your migraine headache begins
Don’t use Imigran Nasal Spray to try to prevent an attack.
Always use this medicine exactly as your doctor has told you. Check with your doctor or
pharmacist if you are not sure.
There’s a step-by-step guide to using the spray at the end of this section.
How much to use
Adults aged 18 to 65
■ The usual dose for adults aged 18 to 65 is one Imigran 20mg spray into just one
nostril.
®
But one Imigran 10 mg spray into one nostril is enough for some people.
Don’t use more than two sprays in 24 hours.
Adolescents aged 12 to 17
®
The usual dose for adolescents aged 12 to 17 is one Imigran 10 mg spray into one
nostril.



Children under 12
Imigran Nasal Spray is not recommended for children under 12 years old.



Older people (aged over 65)
Imigran Nasal Spray is not recommended for people aged over 65.



When to use Imigran Nasal Spray


It’s best to use Imigran Nasal Spray as soon as you feel a migraine coming on,
although it can be used at any time during an attack.

If your symptoms start to come back


If you are allergic to antibiotics called sulphonamides
If so, you may also be allergic to Imigran Nasal Spray. If you know you are allergic to an
antibiotic but you are not sure whether it is a sulphonamide:
→ Tell your doctor or pharmacist before using Imigran Nasal Spray.

If you are pregnant, think you may be pregnant or are planning to have a baby, ask
your doctor for advice before taking this medicine. There is only limited information
about the safety of Imigran Nasal Spray for pregnant women, though up till now there is
no evidence of any increased risk of birth defects. Your doctor will discuss with you
whether or not you should use Imigran Nasal Spray while you are pregnant.
Don’t breast-feed your baby for 12 hours after using Imigran Nasal Spray. If you
express any breast milk during this time, discard the milk and don’t give it to your baby.

You can use a second Imigran Nasal Spray after 2 hours, but don’t use more than two
sprays in 24 hours.

If the first spray has no effect


If you are taking anti-depressants called SSRIs
(Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake
Inhibitors)
→ Tell your doctor or pharmacist before using Imigran Nasal Spray.
Also see Other medicines and Imigran Nasal Spray, below.
If you use Imigran Nasal Spray frequently
Using Imigran Nasal Spray too often may make your headaches worse.
→ Tell your doctor if this applies to you. He or she may recommend you stop using
Imigran Nasal Spray.

Don’t use a second spray, or any other Imigran preparation for the same attack.
If Imigran doesn’t give you any relief:
→ Ask your doctor or pharmacist for advice.
If you use more Imigran Nasal Spray than you should


Don’t use more than two Imigran Nasal Sprays in 24 hours.
Using too much Imigran Nasal Spray could make you ill. If you have used more than two
sprays in 24 hours:
→ Contact your doctor for advice.
If you have any further questions on the use of this medicine, ask your doctor or
pharmacist.

Step-by-step guide to using your Imigran Nasal Spray
Don’t open a blister until you are ready to use a spray.
Each spray is sealed in a blister to keep it clean and safe.
If you carry a spray without a blister, or in an open blister, it may not work properly when
you need it.
Each spray contains just one dose of Imigran Nasal Spray.
Don’t press the plunger too soon or you will lose the dose.
Imigran Nasal Spray has three parts:

The part that you put into your nostril. The
spray comes out of a tiny hole in the top.

Hold this when you use the spray.

Press this to spray the whole dose into your
nostril in one go.
This only works once – don’t press the
plunger until you have put the nozzle into
your nostril or you will lose the dose.
How to use the nasal spray
1. Remove the nasal spray from the blister
packaging just before you want to use it.
2. Get into a comfortable position. You may prefer to
sit down.
3. Blow your nose if it feels blocked, or if you have a
cold.
4. Hold the nasal spray gently with your fingers and
thumb, as shown in picture A.
Don’t press the blue plunger yet.
5. Block one nostril by pressing a finger firmly on
the side of your nose. It doesn’t matter which
nostril you choose.
6. Put the nozzle of the nasal spray into the other
nostril, as far as feels comfortable - about 1 cm or
1/2 inch (picture B).
Breathe out gently through your mouth.
Hold your head upright and close your mouth.









Irritation or burning sensation in the nose or throat; nose bleeds.
Feeling sick (nausea) or being sick (vomiting), although this may be due to the migraine
itself.
Tiredness or drowsiness.
Dizziness, feeling weak, or getting hot flushes.
Temporary increase in blood pressure.
Shortness of breath.
Aching muscles.

Very rare side effects
(affect up to 1 in 10,000 people)
■ Liver function changes. If you have a blood test to check your liver function, tell your
doctor or nurse that you are using Imigran Nasal Spray.
Some patients may have the following side effects but it is not known how often they
occur
■ Seizures/fits, tremors, muscle spasm, neck stiffness.
■ Visual disturbances such as flickering, reduced vision, double vision, loss of vision and
in some cases even permanent defects (although these may be due to the migraine
attack itself).
■ Heart problems, where your heart beat may go faster, slower or change rhythm, chest
pains (angina) or heart attack.
■ Pale blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to
cold or stress (Raynaud’s phenomenon).
■ Feeling faint (blood pressure may go down).
■ Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis).
■ Diarrhoea.
■ Pain in the joints.
■ Feeling anxious.
■ Excessive sweating.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly via the
Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects, you can
help provide more information on the safety of this medicine.
5. How to store Imigran Nasal Spray







Keep out of the sight and reach of children.
You may wish to carry the Imigran Nasal Spray with you in case of a migraine attack.
Do not store above 30°C. Do not freeze.
Store in the sealed blister, preferably in the carton to protect from light.
Do not use Imigran Nasal Spray after the expiry date printed on the pack. The expiry
date refers to the last day of that month.
If your medicine become discoloured or show signs of any deterioration, consult your
doctor or pharmacist who will tell you what to do.

If your doctor stops your treatment do not keep any leftover nasal spray unless your doctor
tells you to. Return any unused nasal spray to your pharmacist for safe disposal.
Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help to
protect the environment.
Remember: This nasal spray is for YOU. Only a doctor can prescribe it for you. Never let
someone else use it. There may be reasons why it could harm that person.
6. Contents of the pack and other information
What Imigran Nasal Spray contains

7. Start to breathe in gently through your nose.
As you breathe in:
Press the blue plunger firmly with your thumb.
The plunger may feel a bit stiff and you may hear it
click. Keep breathing in while spraying (picture C).

The active substance is sumatriptan 20mg.
The other ingredients are potassium dihydrogen phosphate, sodium phosphate dibasic,
sulphuric acid, sodium hydroxide and purified water.
What Imigran Nasal Spray looks like and contents of the pack

8. Remove the spray and remove your finger from
the side of your nose.
Keep your head upright for 10-20 seconds,
breathing gently in through your nose and out
through your mouth. This helps the medicine stay
in your nose.
Your nose may feel wet inside and you may notice
a slight taste after using the spray - this is normal
and will soon pass.
9.

Your nasal spray is now empty. Throw it away safely and hygienically.

4. Possible side effects
Like all medicines, this medicine can cause side effects, but not everybody gets them.

This medicine is provided in a pre-filled nasal spray device and contains sumatriptan in 0.1
ml of a yellow-coloured solution.
Imigran Nasal Spray is packed in a box containing the nasal sprays individually sealed in
blisters. They are available in packs of 2 and 6 pre-filled nasal spray devices. Each nasal
spray contains one dose of Imigran Nasal Spray.
POM

PL No: 15814/0453

This product is manufactured by GlaxoSmithKline Manufacturing S.p.A., Strada Asolana
km 11 – 43056 San Polo di Torrile, Italy and is procured from within the EU and
repackaged by the Product Licence Holder:
O.P.D Laboratories Ltd, Unit 6 Colonial Way, Watford, Hertfordshire WD24 4PR
Leaflet revision and issue date (Ref.) 16.02.2015.
Imigran is a Trade Mark of GSK Group of Companies.

Some symptoms may be caused by the migraine itself.
To request a copy of this leaflet in Braille, large print or audio please call 01923 332 796.
Adverse events reported in adults have also been observed in adolescents. These include
very rare reports of heart attacks.
Allergic reaction: get doctor’s help straight away
The following side effects have occurred but their frequency is not known.
■ The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids,
face or lips; complete collapse.
If you get any of these symptoms soon after using Imigran Nasal Spray:
→ Don’t use any more. Contact a doctor straight away.
Very common side effects
(affect more than 1 in 10 people)
■ Unpleasant taste.
Common side effects
(affect up to 1 in 10 people)
■ Heaviness, pressure, tightness or pain in the chest, throat or other parts of the body,
or feelings of unusual sensations, including numbness, tingling and warmth or cold.
These effects may be intense but generally pass quickly.
If these effects continue or become severe (especially the chest pain):
→ Get medical help urgently. In a very small number of people these symptoms can be
caused by a heart attack.
Other common side effects include:

PACKAGE LEAFLET: INFORMATION FOR THE USER

Imigran® 20mg/0.1ml Nasal Spray / Imigrane 20mg/0.1ml Nasal Spray
(sumatriptan)
This product is available using either of the above names but will be referred to as Imigran
Nasal Spray throughout the following leaflet. Please note that the leaflet also contains
information about other strength (Imigran 10mg/0.1ml Nasal Spray).
Read all of this leaflet carefully before you start taking this medicine because it
contains important information for you.





Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others - it may
harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible
side effects not listed in this leaflet. See section 4.

What is in this leaflet
1.
2.
3.
4.
5.
6.

What Imigran Nasal Spray is and what it is used for
What you need to know before you use Imigran Nasal Spray
How to use Imigran Nasal Spray
Possible side effects
How to store Imigran Nasal Spray
Contents of the pack and other information

1. What Imigran Nasal Spray is and what it is used for
Each Imigran Nasal Spray contains a single dose of sumatriptan, which belongs to a
group of medicines called triptans (also known as 5-HT1 receptor agonists).
Imigran Nasal Spray is used to treat migraine headache.
Migraine symptoms may be caused by the temporary widening of blood vessels in the
head. Imigran Nasal Spray is believed to reduce the widening of these blood vessels. This
in turn helps to take away the headache and relieve other symptoms of a migraine attack,
such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound.

If you feel pain or tightness in your chest after you use Imigran Nasal Spray
These effects may be intense but they usually pass quickly. If they don’t pass quickly, or
they become severe:
→ Get medical help immediately. Section 4 of this leaflet has more information about
these possible side effects.
Other medicines and Imigran Nasal Spray
Tell your doctor or pharmacist if you’re taking, have recently taken or might take any
other medicines. This includes any herbal products or medicines you’ve bought without a
prescription.
Some medicines must not be taken with Imigran Nasal Spray and others may cause
adverse effects if they’re taken with Imigran Nasal Spray. You must tell your doctor if
you are taking:
■ ergotamine also used to treat migraine, or similar medicines such as methysergide
(see Section 2). Don’t use Imigran Nasal Spray at the same time as these medicines.
Stop taking these medicines at least 24 hours before using Imigran Nasal Spray. Don’t
take any medicines which contain ergotamine or compounds similar to ergotamine again
for at least 6 hours after using Imigran Nasal Spray.
■ other triptans/5-HT1 receptor agonists (such as naratriptan, rizatriptan, zolmitriptan),
also used to treat migraine, (see Section 2). Don’t use Imigran Nasal Spray at the same
time as these medicines. Stop taking these medicines at least 24 hours before using
Imigran Nasal Spray.
Don’t take another triptan/5-HT1 receptor agonist again for at least 24 hours after using
Imigran Nasal Spray.
■ SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline
Reuptake Inhibitors) used to treat depression. Using Imigran Nasal Spray with these
medicines can cause serotonin syndrome (a collection of symptoms which can include
restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms,
shivering, increased heartbeat and shaking). Tell your doctor immediately if you are
affected in this way.
■ MAOIs (monoamine oxidase inhibitors) used to treat depression. Don’t use Imigran
Nasal Spray if you have taken these in the last 2 weeks.
■ St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s
Wort while you are using Imigran Nasal Spray may make side effects more likely.
Pregnancy and breast-feeding


2. What you need to know before you use Imigran Nasal Spray
Don’t use Imigran Nasal Spray:










If you’re allergic to sumatriptan, or any of the other ingredients of this medicine (listed
in Section 6).
If you have a heart problem such as narrowing of the arteries (Ischaemic heart
disease) or chest pains (angina), or have already had a heart attack.
If you have circulation problems in your legs that cause cramp-like pains when you
walk (peripheral vascular disease).
If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or
TIA).
If you have high blood pressure. You may be able to use Imigran Nasal Spray if your
high blood pressure is mild and is being treated.
If you have serious liver disease.
With other migraine medicines, including those which contain ergotamine, or similar
medicines such as methysergide or any triptan/5-HT1 receptor agonist (medicines which
are also used for treating migraine).
With anti-depressants called MAOIs (monoamine oxidase inhibitors), or if you have
taken these medicines in the last 2 weeks.

If any of these apply to you:
→ Tell your doctor, and don’t use Imigran Nasal Spray.
Take special care with Imigran Nasal Spray
Talk to your doctor or pharmacist before using Imigran Nasal Spray:
If you have any extra risk factors
■ If you are a heavy smoker, or are using nicotine replacement therapy, and especially
■ If you are a man aged over 40, or
■ If you are a woman who has been through the menopause.
In very rare cases, people have developed serious heart conditions after using Imigran
Nasal Spray, even though they had no signs of heart disease before. If any of the points
above applies to you it could mean you have a greater risk of developing heart disease so:
→ Tell your doctor so that your heart function can be checked before Imigran Nasal
Spray is prescribed for you.
If you have a history of fits (seizures)
Or if you have other conditions which might make it more likely that you’ll have a fit – for
example, a head injury or alcoholism.
→ Tell your doctor so that you can be supervised more closely.
If you have liver or kidney disease
→ Tell your doctor so that you can be supervised more closely.



Driving and using machines
Either the symptoms of migraine or your medicine may make you drowsy. If you are
affected, don’t drive or operate machinery.
3. How to use Imigran Nasal Spray
Only use Imigran Nasal Spray after your migraine headache begins
Don’t use Imigran Nasal Spray to try to prevent an attack.
Always use this medicine exactly as your doctor has told you. Check with your doctor or
pharmacist if you are not sure.
There’s a step-by-step guide to using the spray at the end of this section.
How much to use
Adults aged 18 to 65
■ The usual dose for adults aged 18 to 65 is one Imigran 20mg spray into just one
nostril.
®
But one Imigran 10 mg spray into one nostril is enough for some people.
Don’t use more than two sprays in 24 hours.
Adolescents aged 12 to 17
®
The usual dose for adolescents aged 12 to 17 is one Imigran 10 mg spray into one
nostril.



Children under 12
Imigran Nasal Spray is not recommended for children under 12 years old.



Older people (aged over 65)
■ Imigran Nasal Spray is not recommended for people aged over 65.
When to use Imigran Nasal Spray


It’s best to use Imigran Nasal Spray as soon as you feel a migraine coming on,
although it can be used at any time during an attack.

If your symptoms start to come back


If you are allergic to antibiotics called sulphonamides
If so, you may also be allergic to Imigran Nasal Spray. If you know you are allergic to an
antibiotic but you are not sure whether it is a sulphonamide:
→ Tell your doctor or pharmacist before using Imigran Nasal Spray.

If you are pregnant, think you may be pregnant or are planning to have a baby, ask
your doctor for advice before taking this medicine. There is only limited information
about the safety of Imigran Nasal Spray for pregnant women, though up till now there is
no evidence of any increased risk of birth defects. Your doctor will discuss with you
whether or not you should use Imigran Nasal Spray while you are pregnant.
Don’t breast-feed your baby for 12 hours after using Imigran Nasal Spray. If you
express any breast milk during this time, discard the milk and don’t give it to your baby.

You can use a second Imigran Nasal Spray after 2 hours, but don’t use more than two
sprays in 24 hours.

If the first spray has no effect


If you are taking anti-depressants called SSRIs
(Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake
Inhibitors)
→ Tell your doctor or pharmacist before using Imigran Nasal Spray.
Also see Other medicines and Imigran Nasal Spray, below.
If you use Imigran Nasal Spray frequently
Using Imigran Nasal Spray too often may make your headaches worse.
→ Tell your doctor if this applies to you. He or she may recommend you stop using
Imigran Nasal Spray.

Don’t use a second spray, or any other Imigran preparation for the same attack.
If Imigran doesn’t give you any relief:
→ Ask your doctor or pharmacist for advice.
If you use more Imigran Nasal Spray than you should


Don’t use more than two Imigran Nasal Sprays in 24 hours.
Using too much Imigran Nasal Spray could make you ill. If you have used more than two
sprays in 24 hours:
→ Contact your doctor for advice.
If you have any further questions on the use of this medicine, ask your doctor or
pharmacist.

Step-by-step guide to using your Imigran Nasal Spray
Don’t open a blister until you are ready to use a spray.
Each spray is sealed in a blister to keep it clean and safe.
If you carry a spray without a blister, or in an open blister, it may not work properly when
you need it.
Each spray contains just one dose of Imigran Nasal Spray.
Don’t press the plunger too soon or you will lose the dose.
Imigran Nasal Spray has three parts:

The part that you put into your nostril. The
spray comes out of a tiny hole in the top.

Hold this when you use the spray

Press this to spray the whole dose into your
nostril in one go.
This only works once – don’t press the
plunger until you have put the nozzle into
your nostril or you will lose the dose.
How to use the nasal spray
1. Remove the nasal spray from the blister
packaging just before you want to use it.

Other common side effects include:
Irritation or burning sensation in the nose or throat; nose bleeds.
Feeling sick (nausea) or being sick (vomiting), although this may be due to the migraine
itself.
■ Tiredness or drowsiness.
■ Dizziness, feeling weak, or getting hot flushes.
■ Temporary increase in blood pressure.
■ Shortness of breath.
■ Aching muscles.



Very rare side effects
(affect up to 1 in 10,000 people)
■ Liver function changes. If you have a blood test to check your liver function, tell your
doctor or nurse that you are using Imigran Nasal Spray.
Some patients may have the following side effects but it is not known how often they
occur
■ Seizures/fits, tremors, muscle spasm, neck stiffness.
■ Visual disturbances such as flickering, reduced vision, double vision, loss of vision and
in some cases even permanent defects (although these may be due to the migraine
attack itself).
■ Heart problems, where your heart beat may go faster, slower or change rhythm, chest
pains (angina) or heart attack.
■ Pale blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to
cold or stress (Raynaud’s phenomenon).
■ Feeling faint (blood pressure may go down).
■ Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis).
■ Diarrhoea.
■ Pain in the joints.
■ Feeling anxious.
■ Excessive sweating.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaflet. You can also report side effects directly via the
Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects, you can
help provide more information on the safety of this medicine.
5. How to store Imigran Nasal Spray

2. Get into a comfortable position. You may prefer to
sit down.
3. Blow your nose if it feels blocked, or if you have a
cold.
4. Hold the nasal spray gently with your fingers and
thumb, as shown in picture A.








Keep out of the sight and reach of children.
You may wish to carry the Imigran Nasal Spray with you in case of a migraine attack.
Do not store above 30°C. Do not freeze.
Store in the sealed blister, preferably in the carton to protect from light.
Do not use Imigran Nasal Spray after the expiry date printed on the pack. The expiry
date refers to the last day of that month.
If your medicine become discoloured or show signs of any deterioration, consult your
doctor or pharmacist who will tell you what to do.

Don’t press the blue plunger yet.
5. Block one nostril by pressing a finger firmly on
the side of your nose. It doesn’t matter which
nostril you choose.
6. Put the nozzle of the nasal spray into the other
nostril, as far as feels comfortable - about 1 cm or
1/2 inch (picture B).
Breathe out gently through your mouth.
Hold your head upright and close your mouth.

If your doctor stops your treatment do not keep any leftover nasal spray unless your doctor
tells you to. Return any unused nasal spray to your pharmacist for safe disposal.
Medicines should not be disposed of via wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help to
protect the environment.
Remember: This nasal spray is for YOU. Only a doctor can prescribe it for you. Never let
someone else use it. There may be reasons why it could harm that person.
6. Contents of the pack and other information
What Imigran Nasal Spray contains

7. Start to breathe in gently through your nose.
As you breathe in:
Press the blue plunger firmly with your thumb.
The plunger may feel a bit stiff and you may hear it
click. Keep breathing in while spraying (picture C).

The active substance is sumatriptan 20mg.
The other ingredients are potassium dihydrogen phosphate, sodium phosphate dibasic,
sulphuric acid, sodium hydroxide and purified water.
What Imigran Nasal Spray looks like and contents of the pack

8. Remove the spray and remove your finger from
the side of your nose.
Keep your head upright for 10-20 seconds,
breathing gently in through your nose and out
through your mouth. This helps the medicine stay
in your nose.
Your nose may feel wet inside and you may notice
a slight taste after using the spray - this is normal
and will soon pass.
9.

Your nasal spray is now empty. Throw it away safely and hygienically.

4. Possible side effects
Like all medicines, this medicine can cause side effects, but not everybody gets them.

This medicine is provided in a pre-filled nasal spray device and contains sumatriptan in 0.1
ml of a yellow-coloured solution.
Imigran Nasal Spray is packed in a box containing the nasal sprays individually sealed in
blisters. They are available in packs of 2 and 6 pre-filled nasal spray devices. Each nasal
spray contains one dose of Imigran Nasal Spray.
POM

PL No: 15814/0453

This product is manufactured by GlaxoSmithKline S.p.A., Strada Asolana km 11 – 43056
San Polo di Torrile, Italy and is procured from within the EU and repackaged by the Product
Licence Holder:
O.P.D Laboratories Ltd, Unit 6 Colonial Way, Watford, Hertfordshire WD24 4PR
Leaflet revision and issue date (Ref.) 16.02.2015.
Imigran is a Trade Mark of GSK Group of Companies.

Some symptoms may be caused by the migraine itself.
To request a copy of this leaflet in Braille, large print or audio please call 01923 332 796.
Adverse events reported in adults have also been observed in adolescents. These include
very rare reports of heart attacks.
Allergic reaction: get doctor’s help straight away
The following side effects have occurred but their frequency is not known.
■ The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids,
face or lips; complete collapse.
If you get any of these symptoms soon after using Imigran Nasal Spray:
→ Don’t use any more. Contact a doctor straight away.
Very common side effects
(affect more than 1 in 10 people)
■ Unpleasant taste.
Common side effects
(affect up to 1 in 10 people)
■ Heaviness, pressure, tightness or pain in the chest, throat or other parts of the body,
or feelings of unusual sensations, including numbness, tingling and warmth or cold.
These effects may be intense but generally pass quickly.
If these effects continue or become severe (especially the chest pain):
→ Get medical help urgently. In a very small number of people these symptoms can be
caused by a heart attack.

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Hide