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HYPOVASE 1MG TABLETS

Active substance(s): PRAZOSIN / PRAZOSIN HYDROCHLORIDE

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Ref: 1758/020518/1/F

®

Hypovase 1mg tablets
(prazosin hydrochloride)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
yours.
* If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
Your medicine is called Hypovase 1mg tablets but will be referred to as
Hypovase throughout the leaflet.

surgery which can be managed if your specialist is prepared in advance.
Please inform your eye specialist before the operation that you are using
or have previously used Hypovase.
* you have prolonged erection of the penis. If erection persists longer than 4
hours, seek immediate medical help.
Some patients who take Hypovase for the treatment of high blood pressure
or prostate enlargement may experience dizziness or light-headedness,
which may be caused by low blood pressure upon sitting or standing up
quickly. Certain patients have experienced these symptoms when taking
drugs for erectile dysfunction (impotence) with Hypovase. In order to reduce
the likelihood that these symptoms occur, you should be on a regular daily
dose of Hypovase before you start drugs for erectile dysfunction.
Remember to tell your doctor that you are taking Hypovase if you have any
tests, such as a urine test, as Hypovase may affect the result.

1

What Hypovase is and what it is used for

2

What you need to know before you take Hypovase

3

How to take Hypovase

4

Possible side effects

5

How to store Hypovase

6

Contents of the pack and other information

Other medicines and Hypovase
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines, including medicines obtained without a
prescription. Some medicines can affect the way Hypovase works. If you are
taking any of the following medicines tell your doctor before you start the
treatment:
* calcium antagonists, ACE inhibitors or beta-blockers which are usually
given to treat angina and/or high blood pressure.
* medicines for erectile dysfunction (impotence).

What Hypovase is and what it is used for

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are
planning to have a baby, ask your doctor or pharmacist for advice before
taking this medicine.

What is in this leaflet:

1

Hypovase contains the active substance prazosin hydrochloride, which is
one of a group of medicines called alpha-blockers.
It is usually used to treat high blood pressure (hypertension). It may also be
used to treat heart failure, painful cold fingers (Raynaud’s Disease) or mild
enlargement of the prostate gland (prostatic hyperplasia) in men.

Driving and using machines
Hypovase may cause dizziness, drowsiness or weakness. If you experience
these symptoms, do not drive or use any tools or machinery.

3

In patients with high blood pressure (hypertension) Hypovase works by
relaxing blood vessels so that blood passes through them more easily. It can
be used alone or in combination with other drugs used to treat hypertension.
In patients with heart failure, Hypovase works by relaxing the main blood
vessels of the heart, allowing the heart to pump blood more easily.

How to take Hypovase

Always take this medicine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure.
Hypovase tablets are to be taken by mouth.
Hypovase can be taken before or after food and drinks.

Hypovase is usually used in heart failure when other drugs are either no
longer working or have not worked at all.
In patients with Raynaud’s Disease the treatment relaxes blood vessels in
the hands, so blood can reach the fingers more easily. This helps to prevent
coldness and stiffness.
In patients with enlargement of the prostate gland the treatment is taken to
treat poor and/or frequent passing of urine. This is common in patients with
enlargement of the prostate gland. The treatment works by relaxing muscle
around the bladder and prostate gland so urine is passed more easily.
You should ask your doctor if you are unsure why you have been given
Hypovase, if you do not feel better or if you feel worse.

2

What you need to know before you take Hypovase

Do not take Hypovase:
* If you are allergic (hypersensitive) to prazosin, or to any similar drugs
(known as quinazoline drugs) or any of the other ingredients of this
medicine (listed in section 6). This may have caused itching, reddening of
the skin or difficulty in breathing.
* If you are under 12 years of age.
Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Hypovase.
Medicines are not always suitable for everyone. Your doctor needs to know
before you take Hypovase if any of the following apply to you:
* you have heart failure because of another heart condition, e.g. heart valve
disease, or a recent heart attack. If you have heart failure, Hypovase can
gradually become less helpful over several months. If this happens you
may notice swelling of your legs or ankles due to retention of fluid. This is
called ‘oedema’. If you develop oedema or weight gain, tell your doctor as
your doctor may need to change the dose of Hypovase or other medicines
you are taking.
* you have ever fainted after passing urine.
* you have liver or kidney disease.
* you are undergoing eye surgery because of a cataract (cloudiness of the
lens). This is because Hypovase may cause complications during the

Sometimes Hypovase can make you feel light-headed or weak particularly
when you first take it. This can happen when standing up and can
occasionally cause fainting. If the treatment makes you feel light-headed or
weak; lie down until you feel better. Get up slowly when you feel better. If
you are concerned, tell your doctor.
Hypovase is usually started at the lowest possible dose and gradually
increased, depending on how you respond to treatment. Do not change the
dose or stop taking the tablets without first checking with your doctor. Make
sure you get a new prescription before your tablets run out.
In elderly patients, Hypovase will always be started at the lowest possible
dose.
High blood pressure (hypertension)
The recommended starting dose is one 0.5 mg tablet, two or three times a
day for 3 to 7 days with the starting dose taken in the evening.
The dose is usually then increased to a 1 mg tablet taken two or three times
a day for a further 3 to 7 days. Your doctor may then advise you to gradually
increase the dose further (up to a maximum of 20 mg daily) depending on
how your blood pressure has responded to treatment.
Heart failure
The recommended starting dose is one 0.5 mg tablet taken two, three or
four times a day.
Your doctor may then advise you to increase the dose further (up to a
maximum of 20 mg daily) depending on how you have responded to
treatment.
Raynaud’s disease
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7
days.
Your doctor may then advise you to increase the dose further (up to 2 mg
twice a day) depending on how you have responded to treatment.

Ref: 1758/020518/1/B

®

Hypovase 1mg tablets
(prazosin hydrochloride)
Patient Information Leaflet (continued)
Enlarged prostate
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7
days, with the initial dose taken in the evening. Your doctor may then advise
you to increase the dose further (up to 2 mg twice a day) depending on how
you have responded to treatment.
Patients with moderate to severe kidney disease and liver disease
The recommended starting dose is one 0.5 mg tablet taken daily. Your
doctor will monitor your response to the treatment and any dose increase will
be made by your doctor with caution.
If you take more Hypovase than you should
If you accidentally take too much Hypovase, contact your doctor immediately
or go to your nearest hospital casualty department. Always take the labelled
medicine package with you, whether there is any Hypovase left or not.
If you forget to take Hypovase
If you forget to take a dose, take it as soon as you remember unless it is
time for your next dose. Do not take a double dose to make up for a
forgotten dose.
If you stop taking Hypovase
Do not stop taking Hypovase unless your doctor tells you to. Your condition
may return if you stop using Hypovase.
If you have any further questions on the use of this medicine, ask your
doctor or pharmacist.

*
*
*
*
*
*
*
*

Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed on this leaflet. You can also report side
effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects, you can help provide more information on the
safety of this medicine.

5

*
*
*
*
*
*

4

flushing (redness)
positive ANA (a blood test that checks function of the immune system)
abnormal breast tissue development, especially in men
persistent erection of the penis
an increased tendency to fall asleep if you have a sleep disorder
(narcolepsy)
leaking of urine (incontinence)
fever or pain
inflammation of blood vessels

Possible side effects

How to store Hypovase
Keep out of the sight and reach of children.
Do not store above 30°C.
Do not take Hypovase after the expiry date which is stated on the blister
label or carton. The expiry date refers to the last day of the month.
If your doctor tells you to stop taking this medicine, return any unused
tablets to your pharmacist (chemist) for safe disposal. Only keep this
medicine if your doctor tells you to.
If the tablets become discoloured or show any other signs of deterioration,
you should seek the advice of your pharmacist who will tell you what to do.
Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines that are no longer
required. These measures will help to protect the environment.

Like all medicines, this medicine may cause side effects, although not
everybody gets them.
Tell your doctor or call an ambulance immediately if you experience any
of the following symptoms of an allergic reaction after taking this medicine.
Although they are very rare, the symptoms can be severe and you may need
urgent medical attention or hospitalisation:
* Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips,
rash or itching (especially affecting the whole body).
The following side effects have been reported with Hypovase:
Common side-effects (may affect up to 1 in 10 people):
* feeling faint, fainting or feeling dizzy, particularly on standing-up (see
section 3)
* headache, drowsiness or weakness
* unpleasant sensation of forceful beating of the heart (palpitations)
* feeling or being sick
* lack of energy, depression or nervousness
* constipation or diarrhoea
* dry mouth, nasal stuffiness or blurred vision
* shortness of breath or rash
* swelling of the feet, ankles or legs
* increase in frequency of passing urine
If any of these cause you problems or if they last for more than one week,
you should contact your doctor.
Other side effects that have been reported are listed below:
Uncommon side-effects (may affect up to 1 in 100 people)
* stomach discomfort and/or pain
* chest pain or abnormally fast heart beat
* tingling sensation or numbness
* buzzing or ringing in the ear
* nose bleeds, eye pain or red eyes
* difficulty sleeping
* sweating, itching or itchy skin rash
* painful joints
* inability or difficulty in achieving erection of the penis
Rare side-effects (may affect up to 1 in 1000 people)
* abnormal blood tests that check for liver function
* pain or infection in the pancreas
* abnormally slow heartbeat
* hallucinations (imagining things which are not really there)
* hair loss
* low blood pressure

6

Contents of the pack and other information

What Hypovase contains:
Each tablet contains 1 mg of prazosin (as hydrochloride). Also contains
calcium phosphate dibasic anhydrous, gluten-free corn starch,
microcrystalline cellulose, magnesium stearate blend, sodium lauryl sulfate.
What Hypovase looks like and contents of the pack
Hypovase are white oblong tablets scored on both sides and engraved M6
on one side.
Each pack contains 60 Tablets.
Manufacturer and Licence Holder
Manufactured by FARMASIERRA MANUFACTURING, S.L., Ctra. N-I, Km
26,200, 28700 San Sebastian de los Reyes, Madrid, Spain and is procured
from within the EU and repackaged by the Product Licence Holder: Lexon
(UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch,
Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1758

Hypovase 1mg tablets

Hypovase is a registered trademark of Pfizer Products Inc.

Revision date: 05/02/18

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 to obtain the leaflet
in a format suitable for you

Ref: 1758/050218/2/F

Prazosin 1mg tablets
(prazosin hydrochloride)
Patient Information Leaflet
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
* Keep this leaflet. You may need to read it again.
* If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
yours.
* If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
Your medicine is called Prazosin 1mg tablets but will be referred to as
Prazosin throughout the leaflet.

surgery which can be managed if your specialist is prepared in advance.
Please inform your eye specialist before the operation that you are using
or have previously used Prazosin.
* you have prolonged erection of the penis. If erection persists longer than 4
hours, seek immediate medical help.
Some patients who take Prazosin for the treatment of high blood pressure or
prostate enlargement may experience dizziness or light-headedness, which
may be caused by low blood pressure upon sitting or standing up quickly.
Certain patients have experienced these symptoms when taking drugs for
erectile dysfunction (impotence) with Prazosin. In order to reduce the
likelihood that these symptoms occur, you should be on a regular daily dose
of Prazosin before you start drugs for erectile dysfunction.
Remember to tell your doctor that you are taking Prazosin if you have any
tests, such as a urine test, as Prazosin may affect the result.

1

What Prazosin is and what it is used for

2

What you need to know before you take Prazosin

3

How to take Prazosin

4

Possible side effects

5

How to store Prazosin

6

Contents of the pack and other information

Other medicines and Prazosin
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines, including medicines obtained without a
prescription. Some medicines can affect the way Prazosin works. If you are
taking any of the following medicines tell your doctor before you start the
treatment:
* calcium antagonists, ACE inhibitors or beta-blockers which are usually
given to treat angina and/or high blood pressure.
* medicines for erectile dysfunction (impotence).

What Prazosin is and what it is used for

Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are
planning to have a baby, ask your doctor or pharmacist for advice before
taking this medicine.

What is in this leaflet:

1

Prazosin contains the active substance prazosin hydrochloride, which is one
of a group of medicines called alpha-blockers.
It is usually used to treat high blood pressure (hypertension). It may also be
used to treat heart failure, painful cold fingers (Raynaud’s Disease) or mild
enlargement of the prostate gland (prostatic hyperplasia) in men.

Driving and using machines
Prazosin may cause dizziness, drowsiness or weakness. If you experience
these symptoms, do not drive or use any tools or machinery.

3

In patients with high blood pressure (hypertension) Prazosin works by
relaxing blood vessels so that blood passes through them more easily. It can
be used alone or in combination with other drugs used to treat hypertension.
In patients with heart failure, Prazosin works by relaxing the main blood
vessels of the heart, allowing the heart to pump blood more easily.

How to take Prazosin

Always take this medicine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure.
Prazosin tablets are to be taken by mouth.
Prazosin can be taken before or after food and drinks.

Prazosin is usually used in heart failure when other drugs are either no
longer working or have not worked at all.
In patients with Raynaud’s Disease the treatment relaxes blood vessels in
the hands, so blood can reach the fingers more easily. This helps to prevent
coldness and stiffness.
In patients with enlargement of the prostate gland the treatment is taken to
treat poor and/or frequent passing of urine. This is common in patients with
enlargement of the prostate gland. The treatment works by relaxing muscle
around the bladder and prostate gland so urine is passed more easily.
You should ask your doctor if you are unsure why you have been given
Prazosin, if you do not feel better or if you feel worse.

2

What you need to know before you take Prazosin

Do not take Prazosin:
* If you are allergic (hypersensitive) to prazosin, or to any similar drugs
(known as quinazoline drugs) or any of the other ingredients of this
medicine (listed in section 6). This may have caused itching, reddening of
the skin or difficulty in breathing.
* If you are under 12 years of age.
Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Prazosin.
Medicines are not always suitable for everyone. Your doctor needs to know
before you take Prazosin if any of the following apply to you:
* you have heart failure because of another heart condition, e.g. heart valve
disease, or a recent heart attack. If you have heart failure, Prazosin can
gradually become less helpful over several months. If this happens you
may notice swelling of your legs or ankles due to retention of fluid. This is
called ‘oedema’. If you develop oedema or weight gain, tell your doctor as
your doctor may need to change the dose of Prazosin or other medicines
you are taking.
* you have ever fainted after passing urine.
* you have liver or kidney disease.
* you are undergoing eye surgery because of a cataract (cloudiness of the
lens). This is because Prazosin may cause complications during the

Sometimes Prazosin can make you feel light-headed or weak particularly
when you first take it. This can happen when standing up and can
occasionally cause fainting. If the treatment makes you feel light-headed or
weak; lie down until you feel better. Get up slowly when you feel better. If
you are concerned, tell your doctor.
Prazosin is usually started at the lowest possible dose and gradually
increased, depending on how you respond to treatment. Do not change the
dose or stop taking the tablets without first checking with your doctor. Make
sure you get a new prescription before your tablets run out.
In elderly patients, Prazosin will always be started at the lowest possible
dose.
High blood pressure (hypertension)
The recommended starting dose is one 0.5 mg tablet, two or three times a
day for 3 to 7 days with the starting dose taken in the evening.
The dose is usually then increased to a 1 mg tablet taken two or three times
a day for a further 3 to 7 days. Your doctor may then advise you to gradually
increase the dose further (up to a maximum of 20 mg daily) depending on
how your blood pressure has responded to treatment.
Heart failure
The recommended starting dose is one 0.5 mg tablet taken two, three or
four times a day.
Your doctor may then advise you to increase the dose further (up to a
maximum of 20 mg daily) depending on how you have responded to
treatment.
Raynaud’s disease
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7
days.
Your doctor may then advise you to increase the dose further (up to 2 mg
twice a day) depending on how you have responded to treatment.

Ref: 1758/050218/2/B

Prazosin 1mg tablets
(prazosin hydrochloride)
Patient Information Leaflet (continued)
Enlarged prostate
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7
days, with the initial dose taken in the evening. Your doctor may then advise
you to increase the dose further (up to 2 mg twice a day) depending on how
you have responded to treatment.
Patients with moderate to severe kidney disease and liver disease
The recommended starting dose is one 0.5 mg tablet taken daily. Your
doctor will monitor your response to the treatment and any dose increase will
be made by your doctor with caution.
If you take more Prazosin than you should
If you accidentally take too much Prazosin, contact your doctor immediately
or go to your nearest hospital casualty department. Always take the labelled
medicine package with you, whether there is any Prazosin left or not.
If you forget to take Prazosin
If you forget to take a dose, take it as soon as you remember unless it is
time for your next dose. Do not take a double dose to make up for a
forgotten dose.
If you stop taking Prazosin
Do not stop taking Prazosin unless your doctor tells you to. Your condition
may return if you stop using Prazosin.
If you have any further questions on the use of this medicine, ask your
doctor or pharmacist.

*
*
*
*
*
*
*
*

Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed on this leaflet. You can also report side
effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects, you can help provide more information on the
safety of this medicine.

5

*
*
*
*
*
*

4

flushing (redness)
positive ANA (a blood test that checks function of the immune system)
abnormal breast tissue development, especially in men
persistent erection of the penis
an increased tendency to fall asleep if you have a sleep disorder
(narcolepsy)
leaking of urine (incontinence)
fever or pain
inflammation of blood vessels

Possible side effects

How to store Prazosin
Keep out of the sight and reach of children.
Do not store above 30°C.
Do not take Prazosin after the expiry date which is stated on the blister
label or carton. The expiry date refers to the last day of the month.
If your doctor tells you to stop taking this medicine, return any unused
tablets to your pharmacist (chemist) for safe disposal. Only keep this
medicine if your doctor tells you to.
If the tablets become discoloured or show any other signs of deterioration,
you should seek the advice of your pharmacist who will tell you what to do.
Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines that are no longer
required. These measures will help to protect the environment.

Like all medicines, this medicine may cause side effects, although not
everybody gets them.
Tell your doctor or call an ambulance immediately if you experience any
of the following symptoms of an allergic reaction after taking this medicine.
Although they are very rare, the symptoms can be severe and you may need
urgent medical attention or hospitalisation:
* Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips,
rash or itching (especially affecting the whole body).
The following side effects have been reported with Prazosin:
Common side-effects (may affect up to 1 in 10 people):
* feeling faint, fainting or feeling dizzy, particularly on standing-up (see
section 3)
* headache, drowsiness or weakness
* unpleasant sensation of forceful beating of the heart (palpitations)
* feeling or being sick
* lack of energy, depression or nervousness
* constipation or diarrhoea
* dry mouth, nasal stuffiness or blurred vision
* shortness of breath or rash
* swelling of the feet, ankles or legs
* increase in frequency of passing urine
If any of these cause you problems or if they last for more than one week,
you should contact your doctor.
Other side effects that have been reported are listed below:
Uncommon side-effects (may affect up to 1 in 100 people)
* stomach discomfort and/or pain
* chest pain or abnormally fast heart beat
* tingling sensation or numbness
* buzzing or ringing in the ear
* nose bleeds, eye pain or red eyes
* difficulty sleeping
* sweating, itching or itchy skin rash
* painful joints
* inability or difficulty in achieving erection of the penis
Rare side-effects (may affect up to 1 in 1000 people)
* abnormal blood tests that check for liver function
* pain or infection in the pancreas
* abnormally slow heartbeat
* hallucinations (imagining things which are not really there)
* hair loss
* low blood pressure

6

Contents of the pack and other information

What Prazosin contains:
Each tablet contains 1 mg of prazosin (as hydrochloride). Also contains
calcium phosphate dibasic anhydrous, gluten-free corn starch,
microcrystalline cellulose, magnesium stearate blend, sodium lauryl sulfate.
What Prazosin looks like and contents of the pack
Prazosin are white oblong tablets scored on both sides and engraved M6 on
one side.
Each pack contains 60 Tablets.
Manufacturer and Licence Holder
Manufactured by FARMASIERRA MANUFACTURING, S.L., Ctra. N-I, Km
26,200, 28700 San Sebastian de los Reyes, Madrid, Spain and is procured
from within the EU and repackaged by the Product Licence Holder: Lexon
(UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch,
Worcestershire, B98 0RE.
If you have any questions or are not sure about anything, ask your doctor or
pharmacist. They will have additional information about this medicine and
will be able to advise you.

POM

PL 15184/1758

Prazosin 1mg tablets

Revision date: 05/02/18

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 to obtain the leaflet
in a format suitable for you

+ Expand Transcript

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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