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This product is available using either of the above names but will be referred to as Hypovase throughout this
leaflet. Please note that the leaflet also contains information about other strength (Hypovase 0.5 mg
Read all of this leaflet carefully before you start taking this medicine.

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor or pharmacist.

This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell
your doctor or pharmacist.
In this leaflet:
1. What Hypovase is and what it is used for
2. Before you take Hypovase
3. How to take Hypovase
4. Possible side effects
5. How to store Hypovase
6. Further information

Hypovase is one of a group of medicines called alpha-blockers.
It is usually used to treat high blood pressure (hypertension). It may also be used to treat heart failure,
painful cold fingers (Raynaud’s Disease) or mild enlargement of the prostate gland (prostatic hyperplasia) in
In patients with high blood pressure (hypertension) Hypovase works by relaxing blood vessels so that blood
passes through them more easily. It can be used alone or in combination with other drugs used to treat
In patients with heart failure, Hypovase works by relaxing the main blood vessels of the heart, allowing the
heart to pump blood more easily. Hypovase is usually used in heart failure when other drugs are either no
longer working or have not worked at all.
In patients with Raynaud’s Disease the treatment relaxes blood vessels in the hands, so blood can reach
the fingers more easily. This helps to prevent coldness and stiffness.
In patients with enlargement of the prostate gland the treatment is taken to treat poor and/or frequent
passing of urine. This is common in patients with enlargement of the prostate gland. The treatment works by
relaxing muscle around the bladder and prostate gland so urine is passed more easily.
You should ask your doctor if you are unsure why you have been given Hypovase.

Do not take Hypovase if you:
• are allergic (hypersensitive) to prazosin, or to any similar drugs (known as quinazoline drugs) or any of
the other ingredients listed in section 6. This may have caused itching, reddening of the skin or difficulty
in breathing.
• are under 12 years of age.
Take special care with Hypovase
Medicines are not always suitable for everyone. Your doctor needs to know before you take Hypovase if any
of the following apply to you:
• you have heart failure because of another heart condition, e.g. heart valve disease, or a recent heart
attack. If you have heart failure, Hypovase can gradually become less helpful over several months. If this
happens you may notice swelling of your legs or ankles due to retention of fluid. This is called ‘oedema’.
If you develop oedema or weight gain tell your doctor as your doctor may need to change the dose of
Hypovase or other medicines you are taking.
• you have ever fainted after passing urine.
• you have liver or kidney disease.
• you are undergoing eye surgery because of a cataract (cloudiness of the lens). This is because
Hypovase may cause complications during the surgery which can be managed if your specialist is
prepared in advance. Please inform your eye specialist before the operation that you are using or have
previously used Hypovase.
Remember to tell your doctor that you are taking Hypovase if you have any tests, such as a urine test, as
Hypovase may affect the result.
Taking other medicines
Some medicines can affect the way Hypovase works. If you are taking any of the following medicines tell
your doctor before you start the treatment:
• calcium antagonists, ACE inhibitors or beta-blockers which are usually given to treat angina and/or high
blood pressure.
• medicines for erectile dysfunction (impotence).
Some patients who take Hypovase for the treatment of high blood pressure or prostate enlargement may
experience dizziness or light-headedness, which may be caused by low blood pressure upon sitting or
standing up quickly. Certain patients have experienced these symptoms when taking drugs for erectile
dysfunction (impotence) with Hypovase. In order to reduce the likelihood that these symptoms occur, you
should be on a regular daily dose of Hypovase before you start drugs for erectile dysfunction.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including
medicines obtained without a prescription.
Taking Hypovase with food and drink
Hypovase can be taken before or after food and drinks.
Pregnancy and Breast-feeding
If you are pregnant, planning to get pregnant or are breast-feeding, tell your doctor before you take
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
Hypovase may cause dizziness, drowsiness or weakness. If you experience these symptoms, do not drive
or use any tools or machinery.

Always take Hypovase exactly as you doctor has told you. You should check with your doctor or pharmacist
if you are not sure.
Hypovase tablets are to be taken by mouth.
Sometimes Hypovase can make you feel light-headed or weak particularly when you first take it. This can
happen when standing up and can occasionally cause fainting. If the treatment makes you feel light-headed
or weak; lie down until you feel better. Get up slowly when you feel better. If you are concerned, tell your
Hypovase is usually started at the lowest possible dose and gradually increased, depending on how you
respond to treatment. Do not change the dose or stop taking the tablets without first checking with your
doctor. Make sure you get a new prescription before your tablets run out.
High blood pressure (hypertension)
The recommended starting dose is one 0.5 mg tablet, two or three times a day for 3 to 7 days with the
starting dose taken in the evening.
The dose is usually then increased to a 1 mg tablet taken two or three times a day for a further 3 to 7 days.
Your doctor may then advise you to gradually increase the dose further (up to a maximum of 20 mg daily)
depending on how your blood pressure has responded to treatment.

Heart failure
The recommended starting dose is one 0.5 mg tablet taken two, three or four times a day.
Your doctor may then advise you to increase the dose further (up to a maximum of 20 mg daily) depending
on how you have responded to treatment.
Raynaud’s disease
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7 days.
Your doctor may then advise you to increase the dose further (up to 2 mg twice a day) depending on how
you have responded to treatment.
Enlarged prostate
The recommended starting dose is one 0.5 mg tablet, twice a day for 3 to 7 days, with the initial dose taken
in the evening. Your doctor may then advise you to increase the dose further (up to 2 mg twice a day)
depending on how you have responded to treatment.
If you take more Hypovase than you should
If you accidentally take too much Hypovase, contact your doctor immediately or go to your nearest hospital
casualty department. Always take the labelled medicine package with you, whether there is any Hypovase
left or not.
If you forget to take Hypovase
If you forget to take a dose, take it as soon as you remember unless it is time for your next dose. Do not
take a double dose to make up for a missed dose.
If you stop taking Hypovase
Do not stop taking Hypovase unless your doctor tells you to. Your condition may return if you stop using
If you have any further questions on how to take this product, ask your doctor or pharmacist.

Hypovase, like most medicines may cause side effects, but not everybody gets them.
Tell your doctor immediately if you experience any of the following symptoms after taking this medicine.
Although they are very rare, the symptoms can be severe:
• Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially
affecting the whole body).
The following side effects have been reported with Hypovase:
Common side effects (occurring in less than 1 in 10 patients):
• feeling faint, fainting or feeling dizzy, particularly on standing-up (see section 3 ‘How to take Hypovase’
• headache, drowsiness or weakness
• unpleasant sensation of forceful beating of the heart (palpitations)
• feeling or being sick
• lack of energy, depression or nervousness
• constipation or diarrhoea
• dry mouth, nasal stuffiness or blurred vision
• shortness of breath or rash
• swelling of the feet, ankles or legs
• increase in frequency of passing urine
If any of these cause you problems or if they last for more than one week, you should contact your doctor.
Other side effects that have been reported are listed below:
Uncommon side-effects (occurring in less than 1 in 100 patients)
• stomach discomfort and/or pain
• chest pain or abnormally fast heart beat
• tingling sensation or numbness
• buzzing or ringing in the ear
• nose bleeds, eye pain or red eyes
• difficulty sleeping
• sweating, itching or itchy skin rash
• painful joints
• inability or difficulty in achieving erection of the penis
Rare side effects (occurring in less than 1 in 1000 patients)
• abnormal blood tests that check for liver function
• pain or infection in the pancreas
• abnormally slow heartbeat
• hallucinations (imagining things which are not really there)
• hair loss
• low blood pressure
• flushing (redness)
• positive ANA (a blood test that checks function of the immune system)
• abnormal breast tissue development, especially in men
• persistent erection of the penis
• an increased tendency to fall asleep if you have a sleep disorder (narcolepsy)
• leaking of urine (incontinence)
• fever or pain
• inflammation of blood vessels
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: By reporting side effects you can help provide more information on the safety
of this medicine.

• Keep out of the sight and reach of children.
• Do not store above 30°C.
• Do not use Hypovase after the expiry date which is stamped on the pack after EXP. The expiry date
refers to the last day of that month.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to
dispose of medicines no longer required. These measures will help to protect the environment
• If the tablets becomes discoloured or show any other signs of deterioration, you should seek the advice
of your pharmacist who will tell you what to do.

What Hypovase contains
Each tablet contains 1 mg of prazosin (as hydrochloride).
The other ingredients in each tablet are: microcrystalline cellulose, calcium phosphate dibasic anhydrous,
corn starch, magnesium stearate and sodium lauryl sulfate.
What Hypovase looks like and contents of the pack
Hypovase is a white and oblong shaped tablet, scored on both sides and engraved “M6” on one side.
Hypovase is available in blister packs containing 60 tablets.
PL: 15814/1152


Manufactured by Farmasierra Manufacturing, S.L., Madrid, Spain.
Procured from within the EU and repackaged by the Product Licence holder: O.P.D. Laboratories Ltd., Unit
6 Colonial Way, Watford, Herts WD24 4PR.
Leaflet revision and issue date (Ref.): 06.11.2015.
Hypovase is a registered Trade Mark of Pfizer Products Inc.
To request a copy of this leaflet in Braille, large print or audio please call 01923 332 796.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.