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HYPOVASE 0.5 MG TABLETS

Active substance(s): PRAZOSIN HYDROCHLORIDE

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Package leaflet: Information for the user
UNITED KINGDOM

HYPOVASE® 0.5 mg and
1 mg tablets
(prazosin hydrochloride)

Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.

What is in this leaflet

1 What Hypovase is and what it is used for
2 What you need to know before you take
Hypovase
3 How to take Hypovase
4 Possible side effects
5 How to store Hypovase
6 Contents of the pack and other information

Hypovase contains the active substance prazosin hydrochloride,
which is one of a group of medicines called alpha-blockers.
It is usually used to treat high blood pressure (hypertension).
It may also be used to treat heart failure, painful cold fingers
(Raynaud’s Disease) or mild enlargement of the prostate gland
(prostatic hyperplasia) in men.
In patients with high blood pressure (hypertension) Hypovase
works by relaxing blood vessels so that blood passes through
them more easily. It can be used alone or in combination with
other drugs used to treat hypertension.
In patients with heart failure, Hypovase works by relaxing the
main blood vessels of the heart, allowing the heart to pump blood
more easily. Hypovase is usually used in heart failure when other
drugs are either no longer working or have not worked at all.
In patients with Raynaud’s Disease the treatment relaxes blood
vessels in the hands, so blood can reach the fingers more
easily. This helps to prevent coldness and stiffness.
In patients with enlargement of the prostate gland the treatment
is taken to treat poor and/or frequent passing of urine. This is
common in patients with enlargement of the prostate gland.
The treatment works by relaxing muscle around the bladder and
prostate gland so urine is passed more easily.
You should ask your doctor if you are unsure why you have been
given Hypovase, if you do not feel better or if you feel worse.

2. W
 hat you need to know before you
take Hypovase
Do not take Hypovase:

• If you are allergic (hypersensitive) to prazosin, or to any
similar drugs (known as quinazoline drugs) or any of the
other ingredients of this medicine (listed in section 6). This
may have caused itching, reddening of the skin or difficulty
in breathing.
• If you are under 12 years of age.

Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Hypovase.
Medicines are not always suitable for everyone. Your doctor needs
to know before you take Hypovase if any of the following apply
to you:
• you have heart failure because of another heart condition,
e.g. heart valve disease, or a recent heart attack. If you have
heart failure, Hypovase can gradually become less helpful over
several months. If this happens you may notice swelling of your
legs or ankles due to retention of fluid. This is called ‘oedema’.
If you develop oedema or weight gain, tell your doctor as your
doctor may need to change the dose of Hypovase or other
medicines you are taking.
• you have ever fainted after passing urine.
• you have liver or kidney disease.
• you are undergoing eye surgery because of a cataract
(cloudiness of the lens). This is because Hypovase may cause
complications during the surgery which can be managed if
your specialist is prepared in advance. Please inform your
eye specialist before the operation that you are using or have
previously used Hypovase.
• you have prolonged erection of the penis. If erection persists
longer than 4 hours, seek immediate medical help.
Some patients who take Hypovase for the treatment of high blood
pressure or prostate enlargement may experience dizziness or lightheadedness, which may be caused by low blood pressure upon
sitting or standing up quickly. Certain patients have experienced
these symptoms when taking drugs for erectile dysfunction
(impotence) with Hypovase. In order to reduce the likelihood that
these symptoms occur, you should be on a regular daily dose of
Hypovase before you start drugs for erectile dysfunction.
Remember to tell your doctor that you are taking Hypovase if you
have any tests, such as a urine test, as Hypovase may affect the
result.

Other medicines and Hypovase

Tell your doctor or pharmacist if you are taking, have recently
taken or might take any other medicines, including medicines
obtained without a prescription.

Some medicines can affect the way Hypovase works. If you are
taking any of the following medicines tell your doctor before you
start the treatment:
• calcium antagonists, ACE inhibitors or beta-blockers which
are usually given to treat angina and/or high blood pressure.
• medicines for erectile dysfunction (impotence).

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be
pregnant or are planning to have a baby, ask your doctor or
pharmacist for advice before taking this medicine.

Driving and using machines

Hypovase may cause dizziness, drowsiness or weakness. If you
experience these symptoms, do not drive or use any tools or
machinery.

3. How to take Hypovase
Always take this medicine exactly as your doctor or pharmacist
has told you. Check with your doctor or pharmacist if you are
not sure.
Hypovase tablets are to be taken by mouth.
Hypovase can be taken before or after food and drinks.
Sometimes Hypovase can make you feel light-headed or weak
particularly when you first take it. This can happen when standing
up and can occasionally cause fainting. If the treatment makes you
feel light-headed or weak; lie down until you feel better. Get up
slowly when you feel better. If you are concerned, tell your doctor.
Hypovase is usually started at the lowest possible dose
and gradually increased, depending on how you respond to
treatment. Do not change the dose or stop taking the tablets
without first checking with your doctor. Make sure you get a
new prescription before your tablets run out.
In elderly patients, Hypovase will always be started at the
lowest possible dose.



• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor
or pharmacist.
• This medicine has been prescribed for you only. Do
not pass it on to others. It may harm them, even if
their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet. See section 4.

1. What Hypovase is and what it is used for

You will find more about HYPOVASE on the back of this leaflet

High blood pressure (hypertension)

The recommended starting dose is one 0.5 mg tablet, two or
three times a day for 3 to 7 days with the starting dose taken in
the evening.
The dose is usually then increased to a 1 mg tablet taken two
or three times a day for a further 3 to 7 days. Your doctor may
then advise you to gradually increase the dose further (up to
a maximum of 20 mg daily) depending on how your blood
pressure has responded to treatment.

Heart failure

The recommended starting dose is one 0.5 mg tablet taken two,
three or four times a day.
Your doctor may then advise you to increase the dose further
(up to a maximum of 20 mg daily) depending on how you have
responded to treatment.

Raynaud’s disease

The recommended starting dose is one 0.5 mg tablet, twice a
day for 3 to 7 days.
Your doctor may then advise you to increase the dose further
(up to 2 mg twice a day) depending on how you have responded
to treatment.

Enlarged prostate

The recommended starting dose is one 0.5 mg tablet, twice a day
for 3 to 7 days, with the initial dose taken in the evening. Your doctor
may then advise you to increase the dose further (up to 2 mg
twice a day) depending on how you have responded to treatment.

Patients with moderate to severe kidney
disease and liver disease

The recommended starting dose is one 0.5 mg tablet taken
daily. Your doctor will monitor your response to the treatment
and any dose increase will be made by your doctor with caution.

If you take more Hypovase than you should

If you accidentally take too much Hypovase, contact your doctor
immediately or go to your nearest hospital casualty department.
Always take the labelled medicine package with you, whether
there is any Hypovase left or not.

If you forget to take Hypovase

If you forget to take a dose, take it as soon as you remember
unless it is time for your next dose. Do not take a double dose
to make up for a forgotten dose.

If you stop taking Hypovase

Do not stop taking Hypovase unless your doctor tells you to.
Your condition may return if you stop using Hypovase.
If you have any further questions on the use of this medicine,
ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine may cause side effects,
although not everybody gets them.
Tell your doctor or call an ambulance immediately if you
experience any of the following symptoms of an allergic
reaction after taking this medicine. Although they are very rare,
the symptoms can be severe and you may need urgent medical
attention or hospitalisation:
• Sudden wheeziness, difficulty in breathing, swelling of eyelids,
face or lips, rash or itching (especially affecting the whole body).
The following side effects have been reported with Hypovase:
Common side-effects (may affect up to 1 in 10 people):
• feeling faint, fainting or feeling dizzy, particularly on
standing-up (see section 3)
• headache, drowsiness or weakness
• unpleasant sensation of forceful beating of the heart
(palpitations)
• feeling or being sick
• lack of energy, depression or nervousness
• constipation or diarrhoea
• dry mouth, nasal stuffiness or blurred vision
• shortness of breath or rash
• swelling of the feet, ankles or legs
• increase in frequency of passing urine
If any of these cause you problems or if they last for more than
one week, you should contact your doctor.
Other side effects that have been reported are listed below:
Uncommon side-effects (may affect up to 1 in 100 people)
• stomach discomfort and/or pain
• chest pain or abnormally fast heart beat
• tingling sensation or numbness
• buzzing or ringing in the ear
• nose bleeds, eye pain or red eyes
• difficulty sleeping

• sweating, itching or itchy skin rash
• painful joints
• inability or difficulty in achieving erection of the penis
Rare side-effects (may affect up to 1 in 1000 people)
• abnormal blood tests that check for liver function
• pain or infection in the pancreas
• abnormally slow heartbeat
• hallucinations (imagining things which are not really there)
• hair loss
• low blood pressure
• flushing (redness)
• positive ANA (a blood test that checks function of the
immune system)
• abnormal breast tissue development, especially in men
• persistent erection of the penis
• an increased tendency to fall asleep if you have a sleep
disorder (narcolepsy)
• leaking of urine (incontinence)
• fever or pain
• inflammation of blood vessels
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist.
This includes any possible side effects not listed in this leaflet.
You can also report side effects via the Yellow Card Scheme
website: www.mhra.gov.uk/yellowcard. By reporting side effects
you can help provide more information on the safety of this
medicine.

5. How to store Hypovase
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated
on the carton and blister after EXP. The expiry date refers to the
last day of that month.
Store below 30°C.
Do not throw away medicines via wastewater or household
waste. Ask your pharmacist how to throw away medicines
you no longer use. These measures will help protect the
environment.

6. C
 ontents of the pack and other
information
What Hypovase contains

The active substance is prazosin hydrochloride. Hypovase tablets
come in two strengths, 500 microgram (0.5 mg) and 1 mg.
The other ingredients are microcrystalline cellulose, calcium
phosphate dibasic anhydrous, magnesium stearate, maize
starch and sodium lauryl sulfate.

What Hypovase looks like and contents of the pack
The 0.5 mg tablets are white and round marked “Pfizer” on
one side.
The 1 mg tablets are white and oblong shaped scored on both
sides and engraved “M6” on one side.
Each pack of 0.5 mg tablets contains 4 blister strips of
15 tablets (60 tablets in total).
Each pack of 1 mg tablets contains 4 blister strips of 15 tablets
(60 tablets in total).
Not all pack sizes may be marketed.

Marketing Authorisation Holder and
Manufacturer

Marketing Authorisation Holder
Pfizer Limited, Ramsgate Road, Sandwich,
Kent , CT13 9NJ, United Kingdom.
Manufacturer
Fareva Amboise,
Zone Industrielle,
29 route des Industries,
37530 Pocé-sur-Cisse,
France.
Company Contact Address
For any information about this medicine, please contact Medical
Information at Pfizer Limited, Walton Oaks, Dorking Road,
Tadworth, Surrey KT20 7NS, 01304 616161
This leaflet was last revised in 05/2017
Ref: HY 13_1

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Further information

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