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GLYCERYL TRINITRATE TABLETS BP 500MCG

Active substance(s): GLYCERYL TRINITRATE

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Package leaflet: Information for the patient

Glyceryl Trinitrate tablets
500micrograms and 600micrograms
Read all of this leaflet carefully
before you start taking this medicine
because it contains important
information for you.
•  Keep this leaflet. You may need to
read it again.
•  If you have any further questions, ask
your doctor, pharmacist or nurse.
• This medicine has been prescribed
for you only. Do not pass it on to
others. It may harm them, even if
their signs of illness are the same as
yours.
•  If you get any side effects, talk to your
doctor or pharmacist. This includes
any possible side effects not listed in
this leaflet. See section 4.

2
3
4
5
6

What is in this leaflet
1 What Glyceryl Trinitrate tablets
are and what they are used for
What you need to know before you take
Glyceryl Trinitrate tablets
How to take Glyceryl Trinitrate Tablets
Possible side effects
How to store Glyceryl Trinitrate Tablets
C
 ontents of the pack and other
information

1 What Glyceryl Trinitrate tablets are and

what they are used for

Glyceryl Trinitrate belongs to a group of medicines
called nitrate vasodilators. These medicines work by
relaxing the blood vessels of the heart. This reduces
the strain on the heart by making it easier to pump
blood.
Glyceryl Trinitrate tablets may be used to:
• prevent or stop chest pain caused by angina pectoris
• stop spasms in the blood vessels of the heart.

2 What you need to know before you take

Glyceryl Trinitrate tablets

Do not take Glyceryl Trinitrate tablets if you:

• are allergic to glyceryl trinitrate, nitrates or any of
the ingredients of this medicine (listed in section
6). An allergic reaction may include a rash, itching,
difficulty breathing or swelling of the face, lips, throat
or tongue.
•h
 ave anaemia.
•h
 ave raised pressure in your head including that
caused by an accident to your head or bleeding on
the brain, causing painful eyes, changes in vision and
a bad headache especially behind the eyes.
•h
 ave increased pressure in the eye (glaucoma).
• a re taking sildenafil (Viagra) or similar medicines (such
as tadalafil or vardenafil) used for the treatment of
erection problems
• s uffer from a heart condition called hypertrophic
obstructive cardiomyopathy
Continued top of next column

Warnings and precautions

Talk to your doctor or pharmacist before taking
Glyceryl Trinitrate tablets if you have:
• s evere liver or kidney problems
• a n under active thyroid gland
•h
 ad a recent heart attack
• l ow body temperature (hypothermia)
•p
 oor nutrition due to an unbalanced diet or digestion
problems (malnutrition).
• a bnormally low levels of oxygen in the blood
(hypoxaemia)
• v ery low blood pressure, low blood volume or
conditions that lower blood volume in the heart
• a ny of the following heart conditions: narrowing of
heart valves, inflammation of the heart, build up of
fluid around the heart or heart failure, disease of the
blood vessels supplying the brain (cerebrovascular
disease).

Children and adolescents

Do not give this medicine to children.

Other medicines and Glyceryl Trinitrate
Tablets

Tell your doctor or pharmacist if you are taking, have
recently taken or might take any other medicines,
including medicines obtained without a prescription.
Especially:
• s ildenafil (Viagra), tadalafil (Cialis) or vardenafil
(Levitra) used to treat erection problems
•h
 eparin used to thin the blood
•n
 -acetylcysteine used in paracetamol overdose
• l ong acting nitrates (isosorbide dinitrate, isosorbide
mononitrate)
•m
 edicines used to treat high blood pressure
•m
 edicines that can cause dry mouth (amitriptyline,
disopyramide, atropine and propantheline, tricyclic
antidepressants)
•a
 pomorphine used to treat Parkinson’s disease.
•m
 edicines used to treat migraine (ergot alkaloids)

Glyceryl Trinitrate tablets with alcohol

You are advised not to drink alcohol with Glyceryl
Trinitrate tablets, as some of the effects of this
medicine are increased.

Pregnancy and breast feeding

If you are pregnant or breast-feeding, think you may
be pregnant or are planning to have a baby, ask your
doctor or pharmacist for advice before taking this
medicine.

Driving and using machines

As glyceryl trinitrate can cause dizziness you should
make sure you are not affected before driving or
operating machinery, especially if taken with alcohol.

Glyceryl Trinitrate Tablets contain lactose

If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before
taking this medicine.

Continued over page

3 How to take Glyceryl Trinitrate Tablets
Always take this medicine exactly as your doctor or
pharmacist has told you. Check with your doctor or
pharmacist if you are not sure.
Do not swallow the tablets.

The recommended dose is:

Adult: Take the tablets sat down when taking to stop angina
pectoris. 1 tablet should be placed under the tongue and
allowed to dissolve slowly; this dose should be repeated
after 5 minutes if symptoms are not relieved. If pain persists
after a total of 3 doses in 15 minutes you should seek
medical advice immediately.
Older people: When taking to prevent or stop angina
pectoris take the tablets sat down to reduce possible
fainting or low blood pressure.
Your doctor will change the dose to suit your condition.
If you notice that your tablets are not working as well at
relieving pain as they have done, contact your pharmacist or
doctor. If you need more tablets than before to help, tell the
doctor who will advise what to do.

If you take more Glyceryl Trinitrate Tablets than
you should

If you (or someone else) swallow a lot of tablets at the
same time, or you think a child may have swallowed any
contact your nearest hospital casualty department or
tell your doctor immediately. Symptoms of an overdose
include being sick, restlessness, low blood pressure, fainting,
blueness of the skin, methaemoglobin in the blood,
breathing difficulties, lack of oxygen in tissues, slow heart
beat and mental illness.

4 Possible side effects

Like all medicines, this medicine can cause side effects,
although not everybody gets them.

If any of the following serious side effects
happen, stop taking the medicine and tell
your doctor immediately or go to your nearest
hospital:

Worsening of angina symptoms, chest pains, hypoxaemia
(difficulty breathing, increased rate of breathing),
methaemoglobinaemia (breathing problems, headache,
tiredness), difficulty breathing, blue colouring of the lips,
fingers or toes (cyanosis), rapid (tachycardia) or slowed
(bradycardia) heartbeat, blindness in one eye, cerebral
ischaemia which may cause weakness in one arm or leg, or
weakness in one entire side of the body, difficulty speaking,
slurred speech, loss of coordination, loss of consciousness,
allergic skin reactions

Other side effects:

Very common (may affect more than 1 in 10 people)
• t hrobbing headache
Common (may affect up to 1 in 10 people)
• s pinning sensation, fall in blood pressure when seated or
standing up, dizziness, drowsiness
•w
 eakness
Uncommon (may affect up to 1 in 100 people)
• f ainting
• f acial flushing
• f eeling or being sick
• localised burning sensation
• t ongue blistering
• c irculatory collapse

Continued top of next column
50895130 AAAI9110

Very rare (may affect up to 1 in 10,000 people)
• r estlessness
•h
 eartburn
•b
 ad breath, itchy, flaky or red skin, skin rash
Not known (frequency cannot be estimated from the
available data)
•p
 ain around the eye, changes in vision

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more
information on the safety of this medicine.

5 How to store Glyceryl Trinitrate Tablets

Keep this medicine out of the sight and reach of children.
The active medicine quickly evaporates from the tablet
and you should observe the following conditions to ensure
continued potency of the tablets.
• If you do not use the tablets within 8 weeks of first opening
the bottle, obtain a fresh supply and return the old tablets
to your pharmacist. (Fresh tablets should produce a slight
burning sensation when placed under the tongue; if this
does not occur, obtain a fresh supply). In any event do not
use the tablets after the expiry date shown.
• Your Glyceryl Trinitrate tablets will be in a glass airtight
container with a foil-lined cap. Keep them in this.
•A
 fter each use close the bottle cap tightly.
•D
 o not put cotton wool, other medicines, or anything else
in the bottle with the tablets.
• S tore the tablets below 25oC in a dry place, protected from
light. If you need to carry them with you do not carry them
close to your body, rather in a purse, wallet or handbag.
Do not use this medicine after the expiry date stated on the
bottle. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or
household waste. Ask your pharmacist how to throw away
medicines you no longer use. These measures will help
protect the environment.

6 C
 ontents of the pack and other information
What Glyceryl Trinitrate tablets contain
• T he active substance (the ingredient that
makes the tablets work) is glyceryl trinitrate
BP. Each tablet contains either 0.525mg or
0.630mg of the active ingredient Glyceryl
trinitrate 2% adsorbate which is equivalent
to 500micrograms and 600micrograms of
Glyceryl trinitate.
• T he other ingredients are lactose, stearic acid,
magnesium stearate, colloidal silicon dioxide,
mannitol and acacia.

What Glyceryl Trinitrate tablets look
like and contents of the pack

Glyceryl Trinitrate are white, circular, uncoated
tablets.
Pack size is 100.
Marketing Authorisation Holder and
Manufacturer
Actavis, Barnstaple, EX32 8NS, UK
This leaflet was last revised in April 2016.

Actavis, Barnstaple, EX32 8NS, UK

+ Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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