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GLUCOSE 70% W/V CONCENTRATE FOR SOLUTION FOR INFUSION

Active substance(s): ANHYDROUS GLUCOSE

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PACKAGE LEAFLET: INFORMATION FOR THE PATIENT
Glucose 70% w/v Concentrate for Solution for Infusion
Anhydrous Glucose 70% w/v
Warnings and precautions

Read all of this leaflet carefully before you are given this
medicine because it contains important information for you.

Please tell your doctor if you have, or have had, any of the
following medical conditions:

• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or nurse.

• diabetes.

• If you get any side effects, talk to your doctor or nurse. This
includes any possible side effects not listed in this leaflet.
See section 4.

• kidney disease.
• an acute critical illness that has started recently and could
be life-threatening.

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• high pressure within the skull (intracranial hypertension).

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What is in this leaflet

• if you have had a head injury in the past 24 hours.

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1. What Glucose Concentrate is and what it is used for

• a stroke due to a clot in a blood vessel in the brain
(ischaemic stroke).

Throughout this leaflet, Glucose 70% w/v Concentrate for
Solution for Infusion will be called Glucose Concentrate.

2. What you need to know before you are given Glucose
Concentrate

• heart disease (heart failure).

3. How you will be given Glucose Concentrate

• lung disease (respiratory failure).

4. Possible side effects

• reduced production of urine (oliguiria or anuria).

5. How Glucose Concentrate is stored

• excess water in the body (water intoxication).

6. Contents of the pack and other information

• low level of sodium in the blood (hyponatraemia).

1. What Glucose Concentrate is and what it is used for

• allergy to corn (Glucose Concentrate contains sugar derived
from corn).

• precipitates. Because of the potential for life-threatening
events, caution should be taken to ensure that precipitates
Glucose Concentrate is a sterile solution of concentrated glucose.
have not formed in any parenteral nutrient admixture.
The glucose is used to provide energy and to increase the
amount of sugar in your blood.
• liver disorders. There have been reports of liver problems
and liver failure in patients who take intravenous nutrition
Glucose Concentrate is used if:
therapy. If you suffer symptoms such as nausea, vomiting,
• you are unable to take enough food by mouth. It is mixed
abdominal pain, yellowing of the skin or eyes, contact your
with other nutrition solutions that will be given to you by
doctor immediately.
infusion through your vein.
• catheter infection/sepsis. Certain medications and illnesses
• you have increased fluid pressure in your skull and are
can increase the risk of developing infection or sepsis
unconscious due to having low blood sugar. It will provide
(bacteria in the blood). There is a particular risk of infection
relief from the symptoms.
or sepsis when a tube (intravenous catheter) is placed in
your vein. Your doctor will carefully watch you for any signs
of infection. Patients who require parenteral nutrition (giving
2. What you need to know before you are given Glucose
nutrition through a tube in your vein) may be more likely
Concentrate
to develop infections from their medical conditions. Using
aseptic (“germ-free”) techniques when placing and caring
Do NOT receive Glucose Concentrate if you are suffering from
for the catheter and when making the nutritional formula
any of the following conditions:
(TPN) can reduce the risk of infection.
• a significantly higher level of sugar in your blood than normal If you are not sure if any of the above apply to you, talk to your
(hyperclycaemia).
doctor or nurse before having Glucose Concentrate.
• sensitivity (hypersensitivity) to glucose. The glucose in this
product is derived from corn.

When you are given Glucose Concentrate, your doctor will
monitor:
• the amount of electrolytes such as sodium and potassium in
your blood (your plasma electrolytes).
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• the amount of sugar (glucose).

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a low sodium level in the blood (hypoosmotic hyponatraemia)
and a disorder affecting the brain due to low levels of sodium
(hyponatraemic encephalopathy).

• the amount of fluid in your body (your fluid balance).
• the acidity of your blood and urine (changes in acid-base
balance).
Your doctor will adjust how much Glucose Concentrate you are
given according to the results of these tests. These tests will also
tell your doctor if you need extra potassium, an electrolyte (salt)
in your blood. If required, this can be given into a vein.

Other medicines and Glucose Concentrate
Tell your doctor or nurse if you are using, have recently used
or might use other medicines. Glucose Concentrate and other
medicines taken at the same time can affect each other.

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As Glucose Concentrate contains sugar (glucose), it can cause a
high level of sugar in your blood (hyperglycemia). If this occurs,
your doctor may:

Having blood transfusions while you are having Glucose
Concentrate

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Whilst you are having Glucose Concentrate you will not be given
a blood transfusion through the same tubing as the Glucose
Concentrate. Also, blood will not be given before or after using
the same infusion tube, as this may make the blood clot.

• adjust the speed of infusion.
• give insulin to reduce the amount of sugar in your blood.
• if necessary, give you extra potassium.

Pregnancy, breast-feeding and fertility

This is particularly important:

If you are pregnant or breast-feeding, think you may be pregnant
or are planning to have a baby, ask your doctor or nurse for
advice before taking this medicine.

• if you are diabetic.
• if your kidneys do not work as well as normal.

Pregnancy

• if you have recently had a stroke (acute ischaemic stroke).
High levels of sugar in the blood can worsen the effects of
stroke and affect recovery.

Glucose Concentrate can be used during pregnancy. However,
caution should be taken when glucose Concentrate is used
during child birth.

• if you have metabolic disturbances due to starvation or due
to a diet which does not provide the right proportion of the
necessary nutrients (malnutrition).

Fertility
There are no adequate data of the effect of Glucose on fertility.

• you have a low level of thiamine (vitamin B1). This can
happen if you suffer from chronic alcoholism.

Lactation
There are no adequate data of the effect of Glucose Concentrate
during breast-feeding. Glucose solutions have been used during
breast-feeding.

Children
Glucose Concentrate should be given with special care in
children.

Driving and using machines
Children must be given Glucose Concentrate by a doctor or nurse. Ask your doctor or nurse for advice before driving or using
The amount given must be decided by a doctor specialising in
machines.
the care of children and will depend upon the child’s age, weight,
and condition. If the Glucose Concentrate is used to deliver or
dilute another medicine, or if other medicines are given at the
3. How you will be given Glucose Concentrate
same time, this may affect the dose.
When the Glucose Concentrate is given to children, the child’s
Glucose Concentrate will be given to you by a doctor or nurse.
dotor will take blood and urine samples to monitor the amount of
electrolytes such as potassium in the blood (plasma electrolytes). The usual dose
Your doctor will decide how much of the medicine you will need
Newborns – especially those born premature and with low
and for how long it will be given to you. The dose will depend on:
birth weight – are at increased risk of developing a too low or
too high level of sugar in the blood (hypo- or hyperglycaemia)
• your age and weight
and therefore need close monitoring during treatment with
• the reason you are being given the medicine
intravenous glucose solutions to ensure adequate control of the
sugar levels in order to avoid potential long term adverse effects. How Glucose Concentrate is prepared and given
Low sugar levels in the newborn can cause prolonged seizures,
• Glucose Concentrate will be diluted with other nutrition
coma and brain damage. High sugar levels have been associated
solutions before it is given to you.
with bleeding into the brain, bacterial and fungal infection, damage
to the eye (retinopathy of prematurity), infections in the intestinal
• The dilution will be done under sterile conditions by a trained
track (necrotizing enterocolitits), lung problems (bronchopulmonary
and qualified person.
dysplasia), prolonged length of hospital stay and death.
• The diluted solution will be stored at 2 to 8°C and used
When administered to a newborn baby, the solution bag could
within 24 hours of mixing.
be connected to an infusion pump device, which allows exact
It will be given to you via a plastic tube, which will be placed very
delivery of the required quantity of solution across the defined
carefully into your vein, usually in your chest.
time interval. Your doctor or nurse will be monitoring the device
Your doctor will check that any medicines added to your infusion
to ensure safe administration.
are compatible with Glucose Concentrate.
Children (including neonates and older children) who are
given Glucose Concentrate are at a higher risk of developing
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If you are given more Glucose Concentrate than you should have

Reporting of side effects

If you are given too much Glucose Concentrate (over-infusion) or it is
given too fast, or too often, this may lead to the following symptoms:

If you get any side effects, talk to your doctor or nurse. This
includes any possible side effects not listed in this leaflet. You
can also report side effects directly (see details below). By
reporting side effects, you can help provide more information on
the safety of this medicine.

• build-up of liquid in the tissues causing swelling (oedema) or
water intoxication with lower level than normal of sodium in
the blood (hyponatraemia)

Yellow Card Scheme

• a higher amount of sugar in the blood than normal
(hyperglycaemia)

www.mhra.gov.uk/yellowcard

• the blood becomes too concentrated (hyperosmolarity)
• an increase in the amount of urine you produce (osmotic
diuresis)

Keep this medicine out of the sight and reach of children.
Hospital staff will ensure that the product is stored and disposed of
correctly and not used after the expiry date stated on the product.
The storage conditions should you need them are given below.

• a loss of water from the body (dehydration)

If you develop any of these symptoms, you must inform your doctor
immediately. Your infusion will be stopped or reduced. Insulin should
• Do not store above 25°C.
be administered and you will be given treatment depending on your
• Store in original packaging.
symptoms.

• Do not use Glucose Concentrate after the expiry date that is
stated on the label. The expiry date refers to the last date of
that month.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although • Glucose Concentrate must not be used if the solution is not
clear or the bag is damaged.
not everybody gets them.
Each bag will be used once. Any left-over concentrate will be
Side effects can include:
discarded.
• hypersensitivity reactions, including a serious allergic
reaction called anaphylaxis (potential manifestation in
6. Contents of the pack and other information
patients with allergy to corn).
• changes in the levels of the electrolytes in the blood.

This leaflet does not contain all the information about for this
medicine. If you have any questions or are not sure about
anything, ask your healthcare professional.

• a high level of sugar in the blood (hyperglycaemia).
• an excess of fluid in the blood vessels (haemodilution and
hypervolaemia).

What Glucose Concentrate contains

• sugar in your urine (glycosuria).

The active substance is Glucose Monohydrate 77% w/v
(770 g per 1000 ml), which is equivalent to Anhydrous Glucose
70% w/v (700 g per 1000 ml).

• reactions related to the route of administration:
–– fever, febrile reaction (pyrexia).

The other ingredient is sterile water (called ‘water for Injections’).
Glucose Concentrate can also sometimes contain small amount
–– escape of the Glucose Concentrate into the tissues around of hydrochloric acid. This is added to adjust the pH of the
the vein (extravasation). This can damage the tissues and Concentrate.
cause scarring.
What Glucose Concentrate looks like and contents of the pack
–– the formation of a blood clot (venous thrombosis) at the
Glucose Concentrate is as a clear, slightly yellow solution. It is
site of infusion, which causes pain, swelling and redness
available in flexible plastic bags, which contain 500 ml, 1000 ml
in the area of the clot.
or 1500 ml of concentrate. Not all pack sizes may be marketed.
–– irritation and inflammation of the vein into which the
Marketing Authorisation Holder and Manufacturers
solution was infused (phlebitis). This can cause redness,
The Marketing Authorisation holder is:
pain or burning and swelling along the path of the vein
Baxter Healthcare Ltd
into which the solution is infused.
Caxton Way, Thetford
–– local pain or reaction (redness or swelling at the site of
Norfolk, IP24 3SE
infusion).
United Kingdom
• shivering.
–– infection at the site of injection.

• sweating.
• formation of small particles blocking lung blood vessels.
If any side effects occur, the infusion must be stopped.
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5. How Glucose Concentrate is stored

• sugar in the urine (hyperglycosuria)

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Send all enquires to this address.
Glucose Concentrate can be made at either of these addresses:
Baxter Healthcare Ltd
Baxter Healthcare S.A.
Caxton Way, Thetford
Castlebar, Co. Mayo
Norfolk, IP24 3SE
Ireland
United Kingdom

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This leaflet was last revised in 03/2016.

For information about Glucose
Concentrate or to request this leaflet
in formats such as audio or large
print please contact the Marketing
Authorisation Holder:

Date:
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Tel: 01635 206345.
Baxter is a trademark of Baxter International Inc.

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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