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GLIPIZIDE TABLETS 5MG

Active substance(s): GLIPIZIDE / GLIPIZIDE / GLIPIZIDE

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Package leaflet: Information for the patient

Glipizide 5 mg Tablets
(glipizide)

Read all of this leaflet carefully before
you start taking this medicine because it
contains important information for you.
• Keep this leaflet. You may need to read it
again.
• If you have any further questions, ask your
doctor or pharmacist.
• This medicine has been prescribed for you
only. Do not pass it on to others. It may
harm them, even if their signs of illness
are the same as yours.
• If you get any side effects talk to your
doctor or pharmacist. This includes any
possible side effects not listed in this
leaflet. See section 4.

What is in this leaflet:

1. What Glipizide is and what it is used for
2. What you need to know before you take
Glipizide
3. How to take Glipizide
4. Possible side effects
5. How to store Glipizide
6. Contents of the pack and other information

1. What Glipizide is and what it is
used for
This medicine contains glipizide which is one
of a group of medicines called sulfonylureas.
Glipizide is used to treat diabetes (Type II,
non-insulin-dependent diabetes) and helps
to lower your blood glucose (sugar) levels,
when a change in diet alone is not enough to
control the condition.
Diabetics produce too much glucose due
to a lack of insulin in the body. This can be
controlled by glipizide, which reduces high
blood glucose (sugar) levels by increasing
insulin production.
You must talk to a doctor if you do not feel
better or if you feel worse after taking this
medicine.

2. What you need to know before
you take Glipizide
Do not take Glipizide if you:

• are allergic to glipizide, similar antidiabetic
medicines (sulfonylureas or sulfonamides)
or any of the other ingredients of this
medicine (listed in section 6)
• have insulin-dependent diabetes (also
called juvenile or Type I diabetes) which
would have probably started in your
childhood
• have ketone bodies and sugar in your
urine (this may mean you have diabetic
ketoacidosis)
• suffer from episodes of unconsciousness
(this may mean you have diabetic coma)
• have problems with your kidneys or liver
• suffer from thyroid problems
• are pregnant, planning to become pregnant
or breast-feeding
• are currently taking miconazole to treat a
fungal infection

Warnings and precautions

Talk to your doctor or pharmacist before
taking Glipizide if:
• you have been told that you have problems
with your adrenal or pituitary glands
• you are about to have major surgery, have
had a recent injury (trauma) or develop a
fever or severe infection. (See Section 3
“If you are going to have an operation” for
further information).
• you suffer from G6PD deficiency (a disease
that causes abnormal destruction of your
red blood cells).
You should test your blood and urine glucose
regularly, particularly if you are elderly,
debilitated or malnourished. If the results of
the tests are outside the limits recommended
by your doctor you should contact them
immediately.
Glipizide can cause hypoglycaemia (low
blood sugar levels), which is characterised
by confusion, faintness, sweating, dizziness,
drowsiness, headache, shakiness (tremor) and
visual disturbances. (These symptoms may
also be unrelated to hypoglycaemia). Low
blood sugar levels can be prevented by taking
a regular intake of carbohydrates (e.g. bread,
or other products containing starch/sugar).
You should eat regular meals, and not exercise
heavily or for a long period without eating
something first.

Other medicines and Glipizide

Tell your doctor or pharmacist if you are
taking, have recently taken or might take
any other medicines, including medicines
obtained without a prescription.

Affiliate Item Code 1124632
Superceded Affiliate Item Code 598525
TrackWise PR No. 1124632
MA No. 04569/0308
Packing Site/Printer NA
Supplier Code LT1324AJ

Taking the following medicines with
Glipizide may reduce your blood sugar
levels too much:

• Fluconazole or voriconazole (used to treat
fungal infections).
• Non-steroidal anti-inflammatory agents
(used to treat muscle and joint pain e.g.
phenylbutazone).
• Aspirin or aspirin like medicines known as
salicylates (usually used as pain killers).
• Beta-blockers (used to treat high blood
pressure and certain heart conditions e.g.
propranolol).
• Angiotensin converting enzyme (ACE)
inhibitors (used to treat high blood pressure
e.g. captopril).
• Cimetidine (used to treat stomach and
duodenal ulcers and other digestive
disorders).
• Sulfonamides or chloramphenicol (used to
treat bacterial infections).
• Quinolones (used to treat bacterial
infections).
• Monoamine oxidase inhibitors (used to treat
depression).
• Probenecid (drugs used to treat gout).
• Coumarin anticoagulants (used to treat
blood clots e.g. warfarin).
• Fibrates (used to treat high cholesterol e.g.
clofibrate).
• Medicines to treat bacterial infections called
quinolones (e.g. ciprofloxacin)

Taking the following medicines with
Glipizide may increase your blood sugar
levels:

• Danazol (a hormone treatment).
• Phenothiazines tranquillisers (used to treat
psychiatric conditions e.g. chlorpromazine,
thioridazine).
• Corticosteroids (used to treat inflammatory
conditions (e.g. prednisolone).
• Sympathomimetic agents, such as nasal
decongestants and bronchodilators used
to treat asthma (e.g. salbutamol, ritodrine,
terbutaline, isoprenaline).
• Hormonal agents containing progesterone
or oestrogen, including oral contraceptives
(the Pill) and hormone replacement therapy
(HRT).
• Thiazides or other diuretics (water tablets
e.g. bendroflumethiazide).
• Thyroid products (used to treat patients
with a low production of thyroid hormones).
• Phenytoin (used to treat epilepsy).
• Nicotinic acid (used in vitamin supplements
and to lower cholesterol and other lipid
levels).
• Calcium channel blocking agents (used to
treat angina and high blood pressure e.g.
nifedipine or verapamil).
• Isoniazid (used to treat tuberculosis).

Glipizide with food, drink and alcohol

As food may delay absorption of the drug,
each dose should be taken 30 minutes before
food.
Try to avoid alcohol. Alcoholic drinks
(wine, beer, spirits) can further increase the
reduction in blood sugar levels and could
cause unconsciousness (hypoglycaemic
coma).

Pregnancy and breast-feeding

Glipizide must not be taken during pregnancy
or if you are breast-feeding (see section 2,
“Do not take Glipizide”). If you are pregnant,
think you may be pregnant or are planning to
have a baby, ask your doctor or pharmacist for
advice before taking this medicine.

Driving and using machines

Do not drive or operate machinery if you
feel dizzy, drowsy, suffer from headaches or
have difficulty concentrating after taking this
medicine.

Glipizide contains lactose.

If your doctor has told you that you have an
intolerance to some sugars, such as lactose,
contact your doctor before taking this
medicine.

3. How to take Glipizide
Always take this medicine exactly as your
doctor or pharmacist has told you. Check with
your doctor or pharmacist if you are not sure.
Glipizide should only be taken by mouth.
It is important that you take your tablets
according to the instructions of your doctor.
These will be written on the label of the pack.
Do not take more Glipizide than your doctor
has recommended.
Your dose will be adapted to your individual
requirements. Some patients, whose
condition is usually controlled by diet alone,
may only require Glipizide for a short time.

Date: 01 Jun 2017

Description Glipizide 5 mg 56,28
Component Type Leaflet

Do not take Glipizide with miconazole (used
to treat fungal infections) (see ‘Do not take
Glipizide’).

Pharma Code 143
SAP No. NA
Vendor Job No. 303516
Trackwise Proof No. 4
Client Market United Kingdom
Keyline/Drawing No. NA
Barcode Info NA

No. of colours
Colours

1

Time: 15:15
Page Count

1/2

Black

Non-Print
Colours
Equate CMYK
with
Main Font Myriad Pro
Dimensions 170 x 480 mm

Body Text Size 10 pt
Min Text Size used 10 pt

Sign-offs

v2/Oct 2016

The recommended dose is:
Adults
The initial dose is usually 5 mg, taken
approximately 30 minutes before breakfast or
the midday meal, although this may be lower
in some patients.
If you are elderly, have mild diabetes or suffer
from liver or kidney problems you may be
started on 2.5 mg daily.
If your doctor feels your dose needs to be
altered, they will instruct you to adjust the
dose in small increments, usually in 2.5 – 5 mg
steps.
The maximum recommended daily dose is
20 mg.
The label on the pack will tell you what dose
you should take and how often to take it.
If you are still not sure, ask your doctor or
pharmacist.
Do not stop taking the tablets or adjust your
dosage without seeing your doctor. Stopping
the medicine may make your diabetes worse.
The tablet can be divided into equal doses.
Elderly patients, patients with poor diets
and patients with kidney or liver disease
Your doctor may start you on the lower dose
of half a tablet (2.5 mg) a day before gradually
increasing your dose, as you may be more
sensitive to the effects of Glipizide.
Use in children
Glipizide is not recommended for use in
children.

If you take more Glipizide than you should:
• If you accidentally take too many tablets,
seek medical advice immediately.
• If you suffer faintness, confusion,
drowsiness, headache, dizziness, sweating
or shakiness and visual disturbances, these
may be symptoms of low blood sugar. You
should eat or drink something sugary.
• If you suffer fits or loss of consciousness
occur, someone should seek urgent medical
assistance for you.

If you forget to take Glipizide

If you miss a dose, it is important that you
take your medicine as soon as you remember
or feel faint, otherwise your blood sugar will
become too high and you may go into a coma
(or fall unconscious). Do not take a double
dose to make up for a forgotten dose.

If you stop taking Glipizide

Do not stop taking your tablets or alter the
dose you are currently taking without seeing
your doctor first. Stopping these tablets may
make your diabetes worse.

If you are going to have an operation

If you are going to have major surgery or
you have recently suffered a severe illness or
infection, diabetic control may be lost. At such
times it may be necessary to temporarily stop
using Glipizide and take insulin.
If you have any further questions on the use of
this medicine, ask your doctor or pharmacist.

4. Possible side effects
Like all medicines, this medicine can cause side
effects, although not everybody gets them.
Tell your doctor immediately if you experience
any of the following symptoms after taking
this medicine:
• An allergic reaction such as wheeziness,
difficulty breathing or swelling of the
eyelids, face or lips, rash or itching
(especially affecting the whole body)
• Reductions in blood cells and blood
platelets. This can make the skin pale yellow,
cause weakness or breathlessness, or make
bruising, bleeding or infections more likely.
• Liver inflammation which can cause nausea,
vomiting, loss of appetite, feeling generally
unwell, fever, itching, light coloured bowel
movements, dark coloured urine and
jaundice which causes yellowing of the skin
and whites of the eyes.
• A blood pigment disorder. This can cause
blistering or peeling of skin exposed to
sunlight, skin darkening or excessive hair
growth

Uncommon (may affect up to 1 in
100 people):
• Dizziness, drowsiness/sleepiness
• Shakiness (tremor), blurred vision, being sick
• Eczema (inflammation of the skin)
Not known (frequency cannot be estimated
from the available data):
• Headache
• A reduction in your blood sodium. This can
occur if you are dehydrated.
• Confusion
• Double vision, changes in vision (you may
find it more difficult to focus or see clearly)
• Constipation
• General feeling of being unwell
• Increased sensitivity of the skin to sunlight
• Skin redness (erythema)
• Itchy skin
• Rash (red, bumpy or measle-like)
• Itching, skin redness or inflammation
(dermatitis allergic)
• Pale red, raised, itch bumps (urticaria)
• Abnormal liver function
• Abnormal laboratory results that can be
seen with a blood test
The results of some laboratory tests have
been affected by this medicine but it is rare
for patients to have any symptoms.

Reporting of side effects

If you get any side effects talk to your doctor
or pharmacist. This includes any possible side
effects not listed in this leaflet.
You can also report side effects
directly via the Yellow Card Scheme at
www.mhra.gov.uk/yellowcard. By reporting
side effects you can help provide more
information on the safety of this medicine.

5. How to store Glipizide
Keep this medicine out of the sight and reach
of children.
Do not use this medicine after the expiry
date which is stated on the packaging after
“EXP”. The expiry date refers to the last day of
that month.
Store below 25°C and keep in the original
package in order to protect from light.
Do not throw away any medicines via
wastewater or household waste. Ask your
pharmacist how to throw away medicines
you no longer use. These measures will help
protect the environment.

6. Contents of the pack and other
information
What Glipizide contains

The active substance is glipizide. Each tablet
contains 5 mg of glipizide.
The other ingredients are lactose
monohydrate (see section 2, ‘Glipizide
contains lactose’), maize starch, pregelatinised
maize starch and stearic acid.

What Glipizide looks like and contents
of the pack

Tablets are white, oval, uncoated and marked
“GP” breakline “5” on one side and “G” on the
other side.
Glipizide Tablets are available in bottles of 20,
30, 50, 60, 100, 250 and 500 tablets and blister
packs of 20, 28, 30, 50, 56, 60 and 100 tablets.
Not all pack sizes may be marketed.

Marketing Authorisation Holder
Mylan
Potters Bar, Hertfordshire, EN6 1TL,
United Kingdom

Manufacturer

Gerard Laboratories,
35/36 Baldoyle Industrial Estate, Grange Road,
Dublin 13, Ireland
Generics [UK] Ltd., Potters Bar, Hertfordshire,
EN6 1TL, United Kingdom
This leaflet was last revised in May 2017.

In some people, a sudden, severe reaction
to alcohol can occur. You may experience a
sudden ‘hangover’ feeling with a throbbing
headache, flushed skin, increased heart rate,
shortness of breath, feeling or being sick,
vision problems, confusion and low blood
pressure which may make you dizzy especially
on standing up from lying or sitting.
Other side effects that may occur include:
Common (may affect up to 1 in 10 people):
• Low blood sugar (hypoglycaemia – for signs
of hypoglycaemia see section 2)
• Feeling sick, diarrhoea or stomach pains.
These side effects usually improve if your
doctor divides up your dosage during the day

Date: 01 Jun 2017

Description Glipizide 5 mg 56,28
Component Type Leaflet
Affiliate Item Code 1124632
Superceded Affiliate Item Code 598525
TrackWise PR No. 1124632
MA No. 04569/0308
Packing Site/Printer NA
Supplier Code LT1324AJ

1124632
LT1324AJ

Pharma Code 143
SAP No. NA
Vendor Job No. 303516
Trackwise Proof No. 4
Client Market United Kingdom
Keyline/Drawing No. NA
Barcode Info NA

No. of colours
Colours

1

Time: 15:15
Page Count

2/2

Black

Non-Print
Colours
Equate CMYK
with
Main Font Myriad Pro
Dimensions 170 x 480 mm

Body Text Size 10 pt
Min Text Size used 10 pt

Sign-offs

v2/Oct 2016

Expand Transcript

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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