GLIBENCLAMIDE 2.5MG TABLETS
Active substance(s): GLIBENCLAMIDE / GLIBENCLAMIDE / GLIBENCLAMIDE
Liamid 2.5mg Tablets
Liamid 5mg Tablets
Read all of this leaet carefully before you start taking this medicine because it
contains important information for you.
• Keep this leaﬂet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist or nurse.
• This medicine has been prescribed for you only. Do not pass it on to others. It
may harm them, even if their signs of illness are the same as yours.
• If you get any side effects talk to your doctor or pharmacist or nurse. This includes
any possible side effects not listed in this leaﬂet. See section 4.
What is in this leaet:
1. What Liamid Tablets are and what they are used for
2. What you need to know before you take Liamid Tablets
3. How to take Liamid Tablets
4. Possible side effects
5. How to store Liamid Tablets
6. Contents of the pack and other information
1. What Liamid tablets are and what they are used for
Liamid tablets contain an active ingredient Glibenclamide. Glibenclamide belongs to a
group of therapeutic medicines called sulphonylureas which are used for lowering your
blood sugar. Liamid Tablets are used for treatment of patients with Type ll maturity onset
and non-insulin dependent diabetes that do not respond to the diet changes alone..
What you need to know before you take Liamid Tablets
Do not take Liamid Tablets if you:
If you are allergic (hypersensitive) to Glibenclamide or any of the other ingredients of
Liamid Tablets (listed in section 6)
If you have severe liver or kidney disease
If you have type 1/juvenile diabetes or your diabetes is not stabilized
If you have severe thyroid or adrenal gland problems
If you have diabetes and have had ketosis or have experienced diabetic coma
If you are pregnant, after delivery of your baby glibenclamide therapy may be started
If you have a blood condition called porphyria
If you are breastfeeding
If you currently being treated with the medicine bosentan
If you have insulin dependent diabetes
When you are under unusual stress such as surgery, trauma or severe infection
You should talk to your doctor before taking this medicine if you are going to have an
operation, if you have a serious accident or severe infection, which can affect your
Warnings and precautions
Talk to your doctor or pharmacist before taking Liamid Tablets if you:
Start to have symptoms of jaundice such as yellowing of the eyes and skin. Your
doctor may stop your medication
Are elderly, seriously ill or malnourished as taking this medicine may lower your
blood sugar too much.
When you are about to do strenuous exercises as this medicine can cause blood sugar
levels to get too low known as “hypoglycaemia”. Early warning symptoms of low blood
sugar include faintness, sweating, trembling, confusion or headache. You will need to eat
and drink something sugary quickly.
Ask your doctor for more information about the symptoms of hypoglycaemia and what
you should do if it happens. It is important that relatives and close work mates know that
you have diabetes and are taking medication so that they can recognize the symptoms of
hypoglycaemia and help if necessary.
Other medicines and Liamid Tablets
Please inform your doctor or pharmacist if you are taking or have recently taken any other
medicines, even those not prescribed.
In particular tell your doctor if you are taking a medicine called bosentan which is used to
treat high blood pressure.
These medicines may increase the effect that glibenclamide has on lowering your blood
Anabolic steroids e.g. nandrolone
Analgesics used to treat pain e.g. aspirin, paracetamol and other Non-steroidal antiinﬂammatory drugs (NSAIDs) such as ibuprofen
Antibacterials or antifungal e.g. ﬂuconazole, sulphonamides, miconazole,
Anticoagulants to reduce blood clotting e.g. heparin, warfarin
Cholesterol lowering agents e.g. cloﬁbrate
Anti-depressants e.g. MAOIs, nortriptyline
Medicines used to treat heart conditions such as ACE inhibitors or beta-blockers
e.g. captopril, enalapril, atenolol
Medicines for stomach ulcers and dyspepsia e.g. cimetidine, ranitidine
Drugs for obesity and gout e.g. Sulphinpyrazone
Medicines used to treat arthritis e.g. cyclophosphamide, phenylbutazone
Medicines used to treat tuberculosis.
These medicines may decrease the hypoglycemic effect of glibenclamide:
Diuretics e.g. thiazide diuretics, furosemide, ethacrynic acid
Phenothiazines used to treat schizophrenia
Oral contraceptives containing oestrogen
Rifampicin, an antibiotic used to treat infections
Ciclosporin, a medicine used after organ transplants.
These medicines may lower the body's tolerance to glucose:
Calcium blockers used to treat heart conditions
Lithium used to treat depression.
Taking Liamid Tablets with food and drink:
Liamid tablets should be taken with or immediately after food.
Drinking alcohol while taking this medicine may affect the way that it works. Alcohol may
cause ﬂushes in some patients and can affect the levels of sugar in your blood. Talk to
your doctor if you want to drink alcohol while taking this medicine.
Pregnancy and breast-feeding
Ask your doctor or pharmacist if you are pregnant or planning to become pregnant..
Consult your doctor if you are breast feeding or plan to breastfeed as small amounts of
this medicine may pass into the mother's milk.
Driving and using machines
If you experience the symptoms of low blood sugar (hypoglycaemia) you should not drive
or operate machinery. Low blood sugar may occur at the beginning of treatment while
your doctor is trying to ﬁnd the dose that bests suits you. Your doctor will give you further
advice. When your blood sugar is stabilized you may drive or operate machinery.
Liamid Tablets contains lactose
This medicine contains lactose (a type of sugar), so if you have been told by your doctor
that you have intolerance to some sugars such as lactose talk to your doctor about taking
How to take Liamid Tablets
Always take Liamid Tablets exactly as your doctor has told you. You should check with
your doctor or pharmacist if you are unsure.
These tablets should be taken orally once a day with or immediately after breakfast or the
ﬁrst main meal of the day.
New diabetics: The usual starting dose for Liamid tablet is 2.5 – 5mg with elderly or ill
patients which can be increased by 2.5mg at intervals of one week as directed by your
doctor. The maximum daily dose is 15mg. You should continue to take these tablets for as
long as your doctor tells you to.
Patients changing from other sulphonylureas: The transfer can usually be carried out
without a break in treatment. Initial treatment with glibenclamide is 5mg daily. If necessary
this can be increased in steps of 2.5mg or 5mg. A dose of 5mg glibenclamide is
equivalent to 1,000mg tolbutamide, 250mg chlorpropamide, 25mg glibomuride and 5mg
03 03 16
Patients changing from biguanides: Glibenclamide treatment should be started with
2.5mg of glibenclamide and biguanide withdrawn. The dosage should then be adjusted by
increments of 2.5mg to achieve control.
Children: Liamid Tablets are unsuitable for children.
If you take more Liamid Tablets than you should
This medicine should be taken at regular intervals, as determined by the physician. If you
accidentally take too many Liamid Tablets seek immediate medical advice by contacting
your doctor or nearest hospital casualty department. Take your tablet pack with you. Low
blood sugar (hypoglycaemia) may be treated in the conscious patient by administration of
glucose or 3 or 4 lumps of table sugar in water. If the patient is comatose, glucose can be
administered as an intravenous infusion.
If you forget to take Liamid Tablets
If you forget to take a dose, take the missing dose as soon as you remember, with your
next meal. If it is time for the next dose do not double the dose to make up for the
How to store Liamid Tablets
Keep out of the sight and reach of children.
Do not use your medicine after the expiry date shown on the label.
The expiry date refers to the last day of the month.
These tablets should not be stored above 25°C and should be kept in their original
container to protect them from light and moisture.
Do not use this medicine if you notice any visible signs of deterioration. Do not throw
away medicines via waste water or household waste. Ask your pharmacist how to throw
away medicines you no longer use. These measures will help protect the environment.
Contents of the pack and other ingredients
What Liamid Tablets contain:
The active substance is Glibenclamide.
The 2.5mg tablet contains 2.5mg of glibenclamide and the 5.0mg tablet contains 5.0mg
If you stop taking Liamid Tablets
Keep taking your tablets until your doctor tells you to stop. Do not stop taking your tablets
just because you feel better. If you stop taking this medicine your symptoms may come
back. Do not stop taking this medicine without consulting your doctor or pharmacist.
If you have any further questions on the use of this medicine, ask your doctor or
What Liamid Tablets look like and the contents of the pack:
Liamid 2.5mg Tablets are white, circular tablets marked 'GL 2.5' on one face and plain on
The registered pack sizes are 10, 14, 28, 100, 500 and 1000 tablets.
POSSIBLE SIDE EFFECTS
The other ingredients are lactose, maize starch, povidone K30 and magnesium stearate.
Like all medicines, Liamid Tablets can cause some side effects, although not everybody
Liamid 5mg Tablets are white, dragee shaped tablets marked 'GL' and '5' either side of a
break line on one face and plain on the reverse
If the following happens, STOP taking this medicine and tell your doctor
immediately or go to the casualty department at your nearest hospital:
Allergic reactions (including inﬂammation of blood vessels, often with skin rash)
which may develop into serious reactions with difﬁculty in breathing, fall in blood
pressure and sometimes progressing to shock.
Abnormal liver function including yellowing of the skin and eyes (jaundice) problems
with the bile ﬂow (cholestasis), inﬂammation of the liver (hepatitis) or liver failure,
Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased
sensitivity to sun. Some mild allergic reactions may develop into serious reaction,
which causes severe blistering of the skin, mouth, eyes and genitals.
Severe hypoglycameia including loss of consciousness, seizures or coma. Some
patients experienced the following side effects whilst taking this medicine. Tell your
doctor if you experience any of the following symptoms:
The registered pack sizes are 28, 100, 500 and 1000 tablets.
Rare side effects (may affect up to 1 in 1000 people)
Lower blood sugar than normal (hypoglycaemia) (See Section 2 - Take special care
Decrease in the number of blood cells:
Blood platelets (which makes infections more likely)
Red blood cells (which can make the skin pale and cause weakness or
Very rare (may affect up to 1 in 10,000 people)
Stomach upsets such as nausea, vomiting, abdominal pain, diarrhoea, loss of
appetite or a metallic taste. Taking doses with food may reduce these problems. They
often get better spontaneously so you should continue to take the tablets unless your
stomach is upset and shows no sign of getting better after a few days.
Increased appetite and weight gain
decrease in the amount of sodium level in your blood (shown by blood tests)
If any of the side effects gets serious or if you notice any side effects not listed in this
leaﬂet, please tell your doctor or pharmacist.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any
possible side effects not listed in this leaﬂet. You can also report side effects directly via
the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects you
can help provide more information on the safety of this medicine.
Marketing Authorization Holder
Aurobindo Pharma Limited,
Ares, Odyssey Business Park,
West End Road,
South Ruislip HA4 6QD,
Ares, Odyssey Business Park,
West End Road,
South Ruislip HA4 6QD,
This leaet was last revised in 02/2016.
Source: Medicines and Healthcare Products Regulatory Agency
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.