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EVOREL CONTI TRANSDERMAL PATCHES

Active substance(s): ESTRADIOL HEMIHYDRATE / NORETHISTERONE ACETATE

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5

Possible side effects

Like all medicines, this medicine can cause side effects, although not
everybody gets them.
The following diseases are reported more often in women using HRT
compared to women not using HRT:
• breast cancer
• abnormal growth or cancer of the lining of the womb (endometrial
hyperplasia or cancer)
• ovarian cancer
• blood clots in the veins of the legs or lungs (venous thromboembolism)
• heart disease
• stroke
• probable memory loss if HRT is started over the age of 65
For more information about these side effects, see Section 3.
Take off the patch and tell your doctor straight away if you notice or
suspect any of the following. You may need urgent medical treatment.
• Sudden swelling of the face or throat which may cause difficulty in
swallowing or breathing, rapid swelling of the hands and feet and stomach
cramps
• Blood clots (thrombosis) (affects less than 1 in 1000 people) or stroke
(frequency not known)
• Yellowing of the skin or whites of the eyes (jaundice), or other liver
problems
• Migraine-type headaches for the first time or more frequent (affects less
than 1 in 100 people)
• An increase in blood pressure (affects less than 1 in 10 people)
• Breast or ovarian cancer, endometrial cancer or hyperplasia (long, heavy or
irregular periods)
• Widespread rash with peeling skin and blistering in the mouth, eyes and
genitals (Stevens-Johnson syndrome) (frequency not known)
• Convulsions or fits (affects less than 1 in 1,000 people)
Tell your doctor if you notice any of the following side effects while
using Evorel Conti:
Very common (affects more than 1 in 10 people)
• Irritated, itchy, red skin and rash where the patch is applied
Common (affects less than 1 in 10 people)
Allergic reaction (hypersensitvity)
• Being unable to sleep
• Feeling depressed, nervous or anxious
• Headache
• Being aware of your heartbeat (palpitations)
• Varicose veins
• Flushing, skin reddening
• Breast pain
• Numb or tingling hands or feet
• Feeling sick (nausea)
• Diarrhoea
• Stomach ache
• Pain including pain in the back or joints
• Painful periods
• Discharge from the vagina
• Irregular, heavy or prolonged bleeding from the vagina, including after sex
• Water retention or build-up of fluid under the skin (oedema)
• Feeling tired
• Weight gain
Uncommon (affects less than 1 in 100 people)
• Vaginal infections such as thrush
• Less interest in sex than usual
• Wind
• Itchy skin
• Rash
• Swelling of the hands and feet (peripheral oedema)
• Muscle pain
Frequency not known
• Mood swings
• Feeling dizzy
• Bloated feeling
• Gallstones
• Fuller breasts
The following side effects have been reported with other combined
HRTs:
Very common (affects more than 1 in 10 people)
• Tender breasts
Common (affects less than 1 in 10 people)
• Mood changes
• Indigestion
• Acne
• Dry skin
• Pain in extremity (e.g. back pain, arms, legs, wrists, ankles)
• Severe contractions of the uterus
• Vaginal infection (white or yellowish discharge from the vagina)
Uncommon (affects less than 1 in100 people)
• Dizziness
• Being sick
• Skin discolouration
• Abnormal liver function tests

Page 4

Evorel ® Conti Transdermal Patches

Rare (affects less than 1 in 1,000 people)
• Gallstones
• Muscle weakness
• Benign growths in the uterus smooth muscle
• Cysts close to the fallopian tube

(estradiol hemihydrate, norethisterone acetate)

Patient Information Leaflet

Very Rare (affects less than 1 in 10,000 people)
• Yellowing of the skin, itching, dark coloured urine

Your medicine is called Evorel Conti Transdermal Patches, and will be
referred to as Evorel Conti throughout this leaflet.

Frequency not known
• Hair loss

Read all of this leaflet carefully before you start using this medicine
because it contains important information for you.
• Keep this leaflet. You may need to read it again
• If you have any further questions, ask your doctor or pharmacist
• This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
yours
• If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 5.

The following side effects have been reported in association with
oestrogen/progestogen treatment










Gall bladder disease
Brown patches on your face or body (chloasma)
Rash with painful reddish skin nodules(eythema nodosum)
Rash with target shaped reddening or sores (erythema multiforme)
Rash with red or purple coloured spots (vascular purpura)
Loss of memory (Dementia) (see section 2)
Dry eyes
Change to composition of tears

Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also report
side effects directly via the Yellow Card
Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on the
safety of this medicine

What is in this leaflet:
1 What Evorel Conti is and what it is used for
2 What you need to know before you use Evorel Conti
3 Safety of HRT
4 How to use Evorel Conti
5 Possible side effects
6 How to store Evorel Conti
7 Contents of the pack and other information

1
6

7

What Evorel Conti is and what it is used for

How to store Evorel Conti

KEEP OUT OF THE SIGHT AND REACH OF CHILDREN.
Do not store above 25°C.
Do not use a patch if its protective sachet is open.
Do not take this medicine after the expiry date shown on the carton or sachet
label. If your doctor tells you to stop taking the medicine, take any
remaining medicine back to the pharmacist for safe disposal. Only keep this
medicine if your doctor tells you to.
If your medicine becomes discoloured or shows any signs of deterioration,
ask your pharmacist who will advise you what to do.
Medicines should not be disposed of via waterwaste or household waste.
Ask your pharmacist how to dispose of medicines no longer required. These
measures will help to protect the environment.

Further Information

The active substances in Evorel Conti are estradiol hemihydrate and
norethisterone acetate. Each Evorel Conti patch contains 3.2 mg of estradiol
hemihydrate and 11.2 mg of norethisterone acetate. Each Evorel Conti patch
delivers 50 micrograms of estradiol and 170 micrograms of norethisterone
acetate a day.
The other ingredients are acrylate copolymer, guar gum, polyester and
polyethylene terephthalate.
What Evorel Conti looks like and contents of the pack
Evorel Conti comes in a memory pack containing eight patches.
The patches are square with rounded corners. They are clear with a sticky
backing that can be stuck to the skin. Each patch has a surface area of
16 cm2 and is marked in the centre of the lower margin on the outside of the
backing film: CEN1. Each patch is enclosed in a protective,
hermetically-sealed sachet.
Manufacturer and Licence Holder
The patches are manufactured by Janssen Pharmaceutica NV,
Turnhoutseweg 30, B-2340 Beerse, Belgium and are procured from within
the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited,
Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire,
B98 0RE.

POM

PL Number:

15184/1350

Evorel is a registered trademark of Janssen-Cilag.
Leaflet revision date: 12/07/16

Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Lexon (UK) Limited,
Tel: 01527 505414 for help.

Ref:1350/120716/1/F

The name of your medicine is Evorel Conti. It belongs to a group of
medicines called hormone replacement therapy (HRT). Evorel Conti contains
two medicines:
• An oestrogen (estradiol)
• A progestogen (norethisterone)
They are both female hormones.
Evorel Conti comes in a ‘memory pack’. This can be used to help you
remember when to change your patches. Each pack contains eight or twentyfour patches.
The hormones are spread evenly in each patch. They pass slowly into your
body through the skin.
What Evorel Conti is used for
Evorel Conti is used:
• For the symptoms of the menopause (see ‘What is the menopause?’). It is
suitable for women who have not had a period (menstrual bleed) for at
least 18 months
• To prevent osteoporosis (fragile bones) in women who have had the
menopause and are most likely to have bone problems. Evorel Conti is
only used if other medicines for osteoporosis have been tried first and they
have not worked
What is the menopause?
Women produce oestrogen hormones from their ovaries throughout their
adult life. These hormones are important in sexual development and control
of the menstrual cycle. The menopause happens when the level of hormones
produced by the ovaries goes down. This is a gradual process. During this
time the levels of oestrogen can go up and down. This can cause:
• Hot flushes, night sweats or mood swings
• Vaginal problems such as dryness or itching
• Uncomfortable or painful sexual intercourse
You may get the same symptoms if you have had your ovaries taken out in
an operation.
How Evorel Conti works
Evorel Conti is known as ‘continuous combined’ HRT. This is because both
hormones in the patch are released all the time.
Evorel Conti patches replace the oestrogen that is normally released by the
ovaries. However, in women who still have a womb, taking an oestrogen
hormone regularly may cause the lining of your womb to build up and get
thicker.
• This means it is necessary to add a progestogen hormone to the oestrogen
• This helps shed the lining of the womb and stop any problems happening
Most women do not have a regular monthly period with Evorel Conti.
However, bleeding or spotting does often occur in the first few months until
treatment settles down.
Evorel Conti is not a contraceptive. If it is less than 12 months since your last
menstrual period or you are under 50 years old, you may still need to use
additional contraception to prevent pregnancy. Speak to your doctor for
advice.

2

What you need to know before you use Evorel Conti

Do not use Evorel Conti if:
• You are allergic to anything in the patches (listed in section 7)
• You have (or have ever had), or think you may have, breast cancer
• You have (or are suspected of having) or ever had a cancer that was made
worse by oestrogens (such as endometrial cancer)
• You have a thickening of the lining of the womb (endometrial
hyperplasia) which has not been treated
• You have vaginal bleeding you cannot explain
• You have ever had blood clots in a vein (thrombosis), such as in the legs
(deep vein thrombosis) or a blood clot that has travelled to your lung
(pulmonary embolism)
• You have problems with your blood which increases the likelihood of
developing a blood clot (thrombosis) (such as protein C, protein S or
antithrombin deficiency)
• You have (or have ever had) a liver disease and your liver function tests
have not returned to normal
• You have a blood problem called ‘porphyria’
• You have ever had blocked arteries (arterial thrombo-embolic disease) that
gave you angina or a heart attack resulted in a stroke
Do not use this medicine if any of the above applies to you. If you are not
sure, talk to your doctor or pharmacist before using Evorel Conti.
Stop using Evorel Conti at once if any of the above appears for the first
time and talk to your doctor immediately.
Evorel Conti should not be used by children.
Medical check-ups
Before taking HRT, your doctor should ask about you and your family’s
medical history. Your doctor may decide to examine your breasts or your
tummy, and may do an internal examination. They will only do this if it is
necessary for you, or if you have any special concerns.
Once you have started on HRT, see your doctor for regular check-ups
(at least once a year). At these check-ups, your doctor may discuss the
benefits and risks of continuing to take HRT.
Make sure that you:
• Go for regular breast screening and cervical smear tests
• Regularly check your breasts for any changes such as dimpling of the skin,
changes in the nipple, or any lumps you can see or feel
Tell your doctor if you have ever had any of the following. You may
need these checks more often.
• A problem caused by growth of the womb lining:
• Inside the womb (fibroids)
• Outside the womb (endometriosis)
• Thickening of the lining of the womb (endometrial hyperplasia)
• Increased risk of blood clots (see ‘Blood clots’ in section 3 below)
• A family history of increased risk of cancers related to oestrogens
(see ‘Breast cancer’ in section 3 below) such as having a mother, sister or
grandmother who has had breast cancer
• High blood pressure (hypertension). Your doctor may tell you to stop using
Evorel Conti if your blood pressure goes up
• Diabetes
• Gallstones
• Migraine or severe headaches
• Systemic lupus erythematosus (SLE). This is an allergic condition that
causes joint pain, skin rashes and fever
• Epilepsy
• Asthma
• A disease affecting the eardrum and hearing(otosclerosis)
• A liver disorder, such as a benign liver tumour
• Fluid retention due to heart or kidney problems
• High levels of fat (triglycerides) in your blood as you may have a higher risk
of pancreatitis (inflammation of the pancreas, which causes severe pain in
the abdomen and back)
• Any breast problems
• Thyroid problems
• History of sudden swelling of the face or throat, which may cause difficulty
in swallowing or breathing, rapid swelling of the hands and feet and
stomach cramps
You may still be able to use Evorel Conti, but you should discuss this with
your doctor first. Also tell your doctor if these illnesses return or get worse
while you are using Evorel Conti.
If you have had a premature menopause the risk of using HRT may be
different. Talk to your doctor about the risks.
Stop using Evorel Conti and see a doctor immediately
If you notice any of the following when using Evorel Conti
• any of the conditions mentioned in the ‘DO NOT use Evorel Conti’ section
• yellowing of your skin or the whites of your eyes (jaundice). These may be
signs of a liver disease
• a large rise in your blood pressure (symptoms may be headache, tiredness,
dizziness)
• migraine-like headaches which happen for the first time
• if you become pregnant
• if you notice signs of a blood clot, such as:
- painful swelling and redness of the legs
- sudden chest pain
- difficulty in breathing
Page 1

For more information, see ‘Blood clots in a vein (thrombosis)
Other medicines and Evorel Conti
Tell your doctor or pharmacist if you are taking, have recently taken or might
take any other medicines. This includes medicines that you buy without a
prescription or herbal medicines.
In particular, tell your doctor or pharmacist if you are taking any of the
following:
• Medicines for epilepsy such as phenobarbital, phenytoin or carbamazepine
• Medicines for tuberculosis such as rifampicin or rifabutin,
• Medicines for HIV infection, such as nevirapine, efavirenz, ritonavir and
nelfinavir
• Medicine for Hepatitis C infection, telaprevir
• Bosentan - for high blood pressure in the blood vessels of the lungs
• St. John’s Wort - for depression
Taking these medicines with Evorel Conti can stop Evorel Conti from working
as well. Because of this you may get some bleeding, like a period, when you
are not expecting it.

• A medicine for epilepsy called lamotrigine. Using Evorel Conti with
lamotrigine could affect control of your epilepsy
Operations or tests
Tell your doctor if you are going to have surgery. You may need to stop taking
HRT about 4 to 6 weeks before the operation to reduce the risk of a blood
clot. Your doctor will tell you when you can start taking HRT again.
If you visit a hospital or your family doctor for a blood or urine test, tell them
that you are taking Evorel Conti. This is because this medicine may affect the
results of the tests.
Pregnancy and breast-feeding
Do not use this medicine if you are pregnant, think you may be pregnant or
might become pregnant. This is because it may affect the baby.
Evorel Conti is for postmenopausal women only. If you become pregnant,
contact your doctor straight away and remove the patch.
Do not use this medicine if you are breast-feeding.
Ask your doctor or pharmacist for advice before taking any medicine if you
are pregnant or breast-feeding.
Driving or using machines
There is no information about whether Evorel Conti affects your ability to
drive or use machines. See how this medicine affects you before you drive or
use any tools or machines.

3

Safety of HRT

As well as benefits, HRT has some risks. Consider the following when
deciding to take or continue HRT.

Blood clots in a vein (thrombosis)
HRT may increase the risk of blood clots in the veins (also called deep vein
thrombosis, or DVT). The risk of blood clots in the veins is about 1.3 to 3
times higher in HRT users than in non-users, especially during the first year
of taking it.
These blood clots are not always serious. However, if a clot travels to the
lungs, it can cause chest pain, breathlessness, collapse or even death. This
is called pulmonary embolism, or PE.

HRT will not help to prevent heart disease.
Women over the age of 60 years who use oestrogen-progestogen HRT are
slightly more likely to develop heart disease than those not taking any HRT.
If you get a pain in your chest that spreads to your arm and neck
• See a doctor as soon as possible
• Do not take any more HRT until your doctor says you can
This pain may be a sign of heart disease.

How likely is endometrial cancer?
Looking at women aged 50 to 65 who still have a womb, on average:
• In women not taking HRT - 5 in 1000 will get endometrial cancer
• In women taking oestrogen-only HRT- between 10 and 60 in1000 will
get endometrial cancer, (i.e. between 5 and 55 extra cases) depending
on the dose and how long you take it for.
The addition of a progestogen to oestrogen-only HRT substantially reduces
the risk of endometrial cancer.

How likely is a blood clot?
Looking at women in their 50s, on average, over 5 years:
• In women not taking HRT – between 4 and 7 in 1000 would be expected
to get a blood clot
• In women taking oestrogen-progestogen HRT - 9 and 12 in 1000 would
be expected to get a blood clot (an extra 5 cases)

Ovarian cancer
Ovarian cancer (cancer of the ovaries) is rare, much rarer than breast
cancer. The use of oestrogen-only or combined oestrogen-progestogen HRT
has been associated with a slightly increased risk of ovarian cancer. The risk
of ovarian cancer varies with age. For example, in women aged 50 to 54 who
are not taking HRT, about 2 women in 2000 will be diagnosed with ovarian
cancer over a 5-year period. For women who have been taking HRT for 5
years, there will be about 3 cases per 2000 users (i.e. about 1 extra case).

If you get painful swelling in your leg, sudden chest pain or have difficulty
breathing:
• See a doctor as soon as possible
• Do not take any more HRT until your doctor says you can
These may be signs of a blood clot.

Breast cancer
Women who have breast cancer, or have had breast cancer in the past,
should not take HRT.
Taking HRT slightly increases the risk of breast cancer. The risk is also
slightly increased if you have a later menopause.
• Postmenopausal women taking oestrogen-only HRT for 5 years - the risk is
about the same as for a woman of the same age who is still having periods
over that time, and not taking HRT
• Women taking oestrogen plus progestogen HRT - the risk is higher than for
oestrogen-only HRT. However, oestrogen plus progestogen HRT is
beneficial for the endometrium (see ‘Endometrial cancer’)
For all kinds of HRT, the extra risk of breast cancer goes up the longer you
take it. However, it returns to normal within about 5 years after stopping HRT.
Your risk of breast cancer is also higher if:
• You have a close relative (mother, sister or grandmother) who has had
breast cancer
• You are very overweight
How likely is breast cancer?
Looking at women aged 50 to 79, on average, over the next 5 years:
• In women not taking combined HRT between 9 and 17 in 1000 will get
breast cancer
• In women taking oestrogen-progestogen HRT at age 50 to 79 and take it
for 5 years, between 13 and 23 in 1000 will get breast cancer
(an extra 4-6 cases)
If you notice any changes in your breast, such as:
• Dimpling of the skin
• Changes in the nipple
• Any lumps you can see or feel
Make an appointment to see your doctor as soon as possible.

How likely is a stroke?

the nurse/healthcare professional who is actually taking the x-ray that you
use HRT, as this medication may increase the density of your breasts which
may affect the outcome of the mammogram. Where the density of the breast
is increased, mammography may not detect all lumps.

Looking at women in their 50s, on average, over 5 years:
• In women not taking HRT - 8 in 1000 would be expected to have a stroke
• In women taking HRT - 11 in 1000 would be expected to have a stroke
(an extra 3 cases)
If you get migraine-type headaches which you cannot explain:
• See a doctor as soon as possible
• Do not take any more HRT until your doctor says you can
These headaches may be an early warning sign of a stroke.

If you get breakthrough bleeding or spotting, it is usually nothing to worry
about, especially during the first few months of taking HRT.
But if the bleeding or spotting:
• Carries on for more than the first few months
• Starts after you have been on HRT for a while
• Carries on even after you’ve stopped taking HRT
Make an appointment to see your doctor as soon as possible. It could be
a sign that your endometrium has become thicker.

Dementia
Evorel Conti and medicines like it will not stop memory loss (dementia).
Women who start using medicines like Evorel Conti after the age of 65 may
have a small increase in the risk of dementia.

Additionally, you are advised to join mammography screening programs
when offered to you. For mammography screening, it is important that you
inform

Excessive thickening of the lining of the womb (endometrial
hyperplasia) and cancer of the lining of the womb (endometrial cancer)

4

How to use Evorel Conti

Always use Evorel Conti exactly as your doctor has told you. You should
check with your doctor or pharmacist if you are not sure. Your doctor will aim
to reduce your symptoms with the lowest possible dose for the shortest
amount of time.

NEVER apply patch
in this area
Correct area for
applying patch

Putting a patch on
Do not use a patch if its protective pouch is already open.
Step 1: Open and Peel
• Using the notches as a guide, tear along two edges of the pouch. Remove
the patch
• With the protective backing facing you, bend and peel off half the backing.
Don’t touch the sticky side - it may not stick properly if you do

Step 2: Apply and Press
• Apply the open half of the patch to your skin
• Remove the remaining backing and press down the rest of the patch
• Press the patch with the palm of your hand to make sure it is firmly stuck

Removing a patch
• Peel an edge of the patch smoothly away from the skin
• Fold the patch in half, so that the sticky side sticks to itself
• Put it in with the household rubbish, safely out of the reach of children and
pets
• Do not flush used patches down the toilet When you remove the patch
some glue may remain on your skin. It will disappear with time, or you can
use baby oil to remove it.

When to start using Evorel Conti
You may put an Evorel Conti patch on at any time if:
• You have not been using another type of HRT
Put an Evorel Conti patch on at the end of a treatment cycle or one
week after you finish using another HRT product if:
• You are changing from an HRT medicine that gives you a withdrawal bleed

If a patch falls off
Apply a new patch but keep to your original ‘patch change’ days. If you have
just had a bath or a shower, wait until your skin cools before applying the
new patch.

If you are using another type of HRT:
• The day you start will depend on the type of HRT you have been using
Talk to your doctor if you are not sure which type of HRT you are using.

Talk to your doctor if you need more patches.

Using the patches
The patches need to be changed twice a week.

If you forget to change the patch
Change it as soon as you remember and then keep to your original ‘patch
change’ days. You may get some bleeding and spotting like a period during
this time.

Start a new pack of Evorel Conti as soon as you finish one. Do not leave a
break between packs.
Changing your patches
• You must change the patches twice a week to give your body a steady
supply of hormones. There is enough hormone in each patch to last for
several days
• Change your patch on the same two days every week. This will mean that
one patch is on for three days and the next patch for four days
• For example, if you apply your first patch on a Monday, change it on
Thursday and again on the following Monday. You can work out your two
days from the following table, starting from the first day of use:
If you put your
first patch on:

Change on:

Change again on:

Monday



Thursday

&

Monday

Tuesday



Friday

&

Tuesday

Wednesday



Saturday

&

Wednesday

Thursday



Sunday

&

Thursday

Friday



Monday

&

Friday

Taking oestrogen-only HRT for a long time can increase the risk of
cancer of the lining of the womb (the endometrium). Taking a
progestogen as well as the oestrogen helps to lower the extra risk.

Saturday



Tuesday

&

Saturday

Sunday



Wednesday

&

Sunday

If you still have your womb, your doctor will usually prescribe a
progestogen as well as oestrogen. These may be prescribed separately, or
as a combined HRT product.

To help you remember your two “patch change" days, mark them here or on
the pack. They are written on the pack like this:
MON
THUR

Page 2

Where to apply the patch
Stick the patch onto a hairless area of skin below the waist. Most women
prefer to wear the patch on the thigh or bottom.
• Do not apply on or near the breasts
• Do not put it on top of cuts, spots or anywhere the skin is irritated
• Do not use cream, moisturiser or talc before applying the patch
• Do not apply the patch on the same area of skin twice in a row
• It can be worn under loose areas of clothing
• Do not wear a patch under elasticated areas or a tight waistband
• Apply the patch to clean, dry, cool skin as soon as you open the protective
pouch

HRT and Cancer

Stroke
Research suggests that HRT slightly increases the risk of having a stroke.
Other things that can increase the risk of stroke include:
• Getting older
• High blood pressure
• Smoking
• Drinking too much alcohol
• An irregular heartbeat
If you are worried about any of these things, or if you have had a stroke in
the past, talk to your doctor to see if you should take HRT.

The risk of getting stroke is about 1.5 times higher in HRT users than in
non-users. The number of extra cases of stroke due to use of HRT will
increase with age.

If you have had your womb removed because of endometriosis, any
endometrium left in your body may be at risk of cancer. This means your
doctor may prescribe HRT that includes a progestogen as well as an
oestrogen.
Your product, Evorel Conti, contains a progestogen.

You are more likely to get a blood clot if:
• You are very overweight (BMI above 30 kg/m2)
• You are getting older
• You have had a blood clot before
• You are taking medicine containing an oestrogen
• You have cancer
• Any of your close family have had blood clots
• You are pregnant or have just had a baby
• You have had one or more miscarriages
• You have any blood clotting problem that needs treatment with a medicine
such as warfarin
• You are off your feet for a long time because of major surgery, injury or
illness
• You are going on a long journey and will not be moving about for some
time
• You have a rare illness called SLE (Systemic lupus erythematosus)
If any of these things apply to you, talk to your doctor to see if you should
take HRT

Effect of HRT on heart and circulation
Heart disease (heart attack)
HRT is not recommended for women who have had heart disease recently.
If you have ever had heart disease, talk to your doctor to see if you should
be taking HRT.

If you have had your womb removed (a hysterectomy), your doctor will
discuss with you whether you can safely take oestrogen without a
progestogen.

TUE
FRI

WED
SAT

THUR
SUN

FRI
MON

SAT
TUE

SUN
WED

If you use more Evorel Conti than you should
It is unlikely that you will have too much of the hormones in Evorel Conti. The
most common symptoms of having too much oestrogen or progestogen in
your body are:









Tender breasts
Feeling sick (nausea) or being sick
Unexpected vaginal bleeding
Feeling depressed
Tiredness
Acne
Growth of body or facial hair
Removing the patch can reverse the effects of too much oestrogen and/or
progestogen. Talk to your doctor or pharmacist before using any more
patches.
Contraception while using Evorel Conti
The levels of hormone from the patches are too low to act as a
contraceptive. Use non-hormonal contraceptive methods (such as a condom,
diaphragm or coil) until your periods have completely stopped.
Everyday activities
• You can have a bath or shower as normal. Do not scrub too hard as this
can loosen the edges of the patch
• You can go swimming. The patch will not be affected
• You can exercise and play sports. However, do not wear the patch under
tight clothing or waist bands
• You can sunbathe. However, keep the patch covered, out of direct sunlight
If you have any further questions on the use of this product, ask your doctor
or pharmacist.

Ref:1350/120716/1/B

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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