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ERYTHROMYCIN 250 MG GASTRO-RESISTANT TABLETS

Active substance(s): ERYTHROMYCIN

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Pregnancy, breast-feeding and fertility
Erythromycin should be used by women during
pregnancy only if clearly needed.

Package leaflet: Information for the user

Erythromycin 250mg
Gastro-resistant Tablets

If you are pregnant or think you may be pregnant, or
if you are breast-feeding, please consult your doctor
before taking this medicine.

Erythromycin

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Read all of this leaflet carefully before you start
taking this medicine because it contains
important information for you.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or
pharmacist.
This medicine has been prescribed for you only. Do not pass
it on to others. It may harm them, even if their signs of illness
are the same as yours.
If you get any side effects gets serious, or if you notice any
side effects not listed in this leaflet, please tell your doctor or
pharmacist.

The Erythromycin 250mg Gastro-resistant Tablets will be
referred to as Erythromycin Tablets throughout this leaflet.

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before receiving erythromycin. Alternatively if you were
treated for early stages of syphilis during your pregnancy,
and your child is under 1 year and is prescribed
erythromycin, consult your doctor before giving
erythromycin to your child.
are treating a young child with antibiotics and they are
irritable or vomit when fed, you should contact your
physician immediately.
suffer from a condition called myasthenia gravis, which
causes muscle weakness; consult your doctor before
receiving erythromycin.
are taking erythromycin with 'statins' such as simvastatin or
lovastatin (used to lower cholesterol) as serious side effects
can occur.

Driving and using machines
Erythromycin Tablets are not expected to affect your
ability to drive or operate machinery.
3. How to take Erythromycin Tablets
Always take Erythromycin Tablets exactly as your doctor has told
you. You should check with your doctor if you are not sure.
For oral use only. Swallow whole with a glass of water. Do not
crush or chew.
The usual dose of Erythromycin Tablets for adults and children
over 8 years is:

If any of these apply to you, or if you are not sure, tell your doctor.
What is in this leaflet:
1. What Erythromycin Tablets are and what they are used for
2. What you need to know before you take Erythromycin
Tablets
3. How to take Erythromycin Tablets
4. Possible side effects
5. How to store Erythromycin Tablets
6. Contents of the pack and other information
1. What Erythromycin tablets are and what they are used
for
Erythromycin tablets contains the active ingredient erythromycin
which belongs to a group of medicines called macrolide
antibiotics. Erythromycin tablets are used to prevent and treat
infections such as:
! Throat and sinus infections
! Chest infections, such as bronchitis and pneumonia Ear
infection
! Mouth and dental infections
! Eye infections
! Skin and tissue infections, such as acne
! Stomach end intestinal infections
! Prevention of infection following burns, operations or dental
procedures
! Other infections, such as sexually transmitted diseases,
bone infections or scarlet fever
2. What you need to know before you take Erythromycin
tablets
Do not take Erythromycin Tablets if you:
! have allergic (hypersensitive) to erythromycin or any of the
other ingredients in this medicine (listed in section 6).
Warning and precautions:
Talk to your doctor or pharmacist before taking Erythromycin
Tablets if you :
! are taking ergotamine or dihydroergotamine (used to treat
migraines) while taking erythromycin as this may cause
serious side effects. are taking terfenadine or astemizole
(widely taken for hayfever and allergies), cisapride (for
stomach disorders) or pimozide (for psychiatric conditions)
while receiving erythromycin, as combining these drugs can
sometimes cause serious disturbances in heart rhythm.
Consult your doctor for advice on alternative medicines you
can take instead.
! are taking colchicine (used for treatment of gout end
arthritis) whilst taking erythromycin as this may cause
serious side effects.
! have any liver problems or have been told that any drugs
you are taking can cause liver problems
! have previously experienced diarrhoea following the use of
antibiotics.
! are pregnant and have been told that you have a sexually
transmitted disease called syphilis. In this case
erythromycin may not be effective for preventing the
transfer of this infection to your baby. Consult your doctor

SIZE : 160 X 270 (mm) Front

Other medicines and Erythromycin Tablets
Tell your doctor or pharmacist if you are taking, have recently
taken or might take any other medicines.
This is especially important if you are taking medicines from the
following families:
! tolterodine (used to treat urinary incontinence)
! astemizole, terfenadine or mizolastine (used to treat
allergies such as hayfever);
! amisulpride, pimozide (used to treat mental problems);
! ergotamine or dihydroergotamine (used to relieve
migraine);
! cisapride (used to treat stomach disorders);
! statins (used to help lower cholesterol levels e.g. lovastatin
and simvastatin);
! protease inhibitors (used to treat viral infections e.g.
saquinavir);
! Oral contraceptives;
This is also important if you are taking medicines called:
! colchicine (used to treat gout and arthritis);
! cimetidine and omeprazole (used to treat acid reflux and
other related conditions);
! clarithromycin, rifabutin, or rifampicin (medicines used treat
different types of bacterial infection);
! fluconazole, ketoconazole and itraconazole (medicines
used to treat fungal infections);
! digoxin, quinidine or disopyramide (used to treat heart
problems);
! cilostazol (a medicine used to treat peripheral circulation
problems);
! hexobarbitone, phenobarbital or midazolam (used as
sedatives);
! warfarin and acenocoumarol (used to help thin the blood);
! valproate, carbamazepine or phenytoin (used to control
epilepsy);
! theophylline (used to treat asthma and other breathing
problems);
! ciclosporin or tacrolimus (used following organ transplants);
! Bromocriptine (used to treat Parkinson's disease);
zopiclone or triazolam/alprazolam (used to help you sleep
or relieve states of anxiety);
! alfentanil (a medicine used to provide pain relief);
! methylprednisolone (used to help suppress the body's
immune system this is useful in treating a wide range of
conditions);
! St John's Wort (a herbal medicine used to treat depression);
! verapamil (used to treat high blood pressure and chest
pain);
! vinblastine (used to treat certain types of
cancer);
! Sildenafil (used to treat erectile
dysfunction).
If you or your child goes for any medical test, tell
your doctor that you are taking Erythromycin as
it may interfere with some test results.

1-2 g daily in divided doses i.e. four to eight 250 mg tablets daily
or two to four 500 mg tablets daily, taken just before or with meals
or food. If you have a bad infection you may be told to take up to 4
g daily.
Continue to take this medicine until the course is completed or
until your doctor tells you to stop; do not stop taking your
medicine, even if you feel better. If you stop the treatment too
early your problem could come back.
If you take more Erythromycin Tablets than you should:
If you accidentally take more medicine in one day than your
doctor has told you to, or if a child has taken some of the
medicine by mistake, contact your doctor or go to your nearest
hospital emergency department immediately.
An overdose of Erythromycin Tablets could cause temporary
hearing loss, nausea, vomiting and diarrhoea.
If you forget to take Erythromycin Tablets:
If you forget to take a dose of your medicine, take it as soon as
you remember. Do not take more medicine in one day than your
doctor tells you to.
If you have any further questions on the use of this product, ask
your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects,
although not everyone gets them.
If you notice any of the following, contact your doctor
immediately:
! Difficulty breathing;
! fainting;
! swelling of the face, lips or throat;
! Skin rashes;
! Severe skin reactions including large fluid-filled blisters,
sores and ulcers;
! Ulcers in the mouth and throat,
as these may be signs of an allergic reaction.
Other side effects of Erythromycin tablets include:
! Diarrhoea which may be severe or prolonged and may
contain blood or mucus;
! feeling sick or being sick;
! Increase in a particular type of white blood cells
(eosinophilia);
! Stomach pains; these may be a symptom of on inflamed
pancreas (pancreatitis);
! ringing in the ears (tinnitus);
! Reversible loss of hearing (usually associated with high
doses or in patients with kidney problems);
! Various liver or gall-bladder problems, which can cause
yellowing of the skin and/or eyes (jaundice) or pale stools
with dark urine;

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Chest pains;
Abnormal heart rhythms (including palpitations);
Fever;
Anorexia;
Confusion;
fits (seizures);
Vertigo (problems with balance that can result in feelings of
dizziness or sickness - particularly on standing);
Hallucinations (seeing or hearing things that aren't there);
feeling generally unwell (malaise);
inflammation of the kidneys (a condition known as interstitial
nephritis);
Low blood pressure;
serious skin rashes that may involve blistering and can
cover large areas of the torso, face and limbs (conditions
known as Stevens Johnson syndrome, toxic epidermal
necrolysis and erythema multiforme).

If any of the side effects becomes severe, or if you notice any
side effects not listed in this leaflet, please tell your doctor or
pharmacist.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This
includes any possible side effects not listed in this leaflet. You
can also report side effects directly via Yellow Card Scheme
Website: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information
on the safety of this medicine.
5. How to store Erythromycin tablets
Keep this medicine out of the sight and reach of children.
Do not store Erythromycin Tablets above 25˚C. Store in the
original package and keep the container tightly closed.
Do not use these tablets after the expiry date which is stated on
the package after EXP. The expiry date refers to the last day of
that month.
Do not throw away any medicines via wastewater or household
waste. Ask your pharmacist how to throw away medicines you
no longer use. These measures will help protect the
environment.
6. Contents of the pack and other information
What Erythromycin Tablets contain
The active substance is erythromycin, 250mg per tablet.
The other ingredients are Maize starch, Croscarmellose sodium
Type A, Povidone, Talc, Magnesium stearate (E572),
Hypromellose (E464), Macrogol 6000, Erythrosine (E127),
Methacrylic acid ethylacrylate copolymer (1:1) and Polysorbate
80 (E433).
What Erythromycin Tablets look like and contents of the
pack
The tablets are reddish-orange biconvex, coated tablets.
They are available in containers of 500 tablets, and also in blister
packs of 28 tablets.
Not all pack sizes may be marketed.
Marketing Authorisation Holder and Manufacturer
Brown & Burk UK Ltd
5 Marryat Close, Hounslow West
Middlesex, TW4 5DQ, UK.
This leaflet was last approved on February
2014

UKI-020

SIZE : 160 X 270 (mm) Back

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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