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DOXYCYCLINE CAPSULES BP 50MG

Active substance(s): DOXYCYCLINE

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Doxycycline 50mg and 100mg capsules
Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your
doctor, pharmacist or nurse.
•  This medicine has been prescribed for you only.
Do not pass it on to others. It may harm them,
even if their signs of illness are the same as yours.
•  If you get any side effects, talk to your doctor,
pharmacist or nurse. This includes any possible
side effects not listed in this leaflet. See section 4.

What is in this leaflet
1 What Doxycycline capsules are and
what they are used for
2 What you need to know before you take
Doxycycline capsules
3 How to take Doxycycline capsules
4 Possible side effects
5 How to store Doxycycline capsules
6 Contents of the pack and other
information

1 What Doxycycline capsules are and what they are
used for
Doxycycline belongs to a group of medicines called tetracycline
antibiotics. It is also known as a broad-spectrum antibiotic and may
be used to treat a wide range of infections caused by bacteria,
these include:
• r espiratory tract infections
• u rinary tract infections
• s exually transmitted diseases
• s kin infections such as acne
• infections of the eye
• r ickettsial infections such as Q fever or tick fever
• o ther infections such as malaria, cholera, brucellosis, leptospirosis,
psittacosis and fevers caused by lice or ticks.
or prevent:
• t ravellers diarrhoea, scrub typhus and leptospirosis.

2 What you need to know before you take
Doxycycline capsules
Do not take Doxycycline capsules if you:

• are allergic to doxycycline, other similar antibiotics (such as
minocycline or tetracycline) or any of the other ingredients of this
medicine (listed in section 6)
• a re giving it to a child under 12 years old.

Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking
Doxycyline capsules if you:
• have liver disease or are taking medicines which affect
your liver
• have porphyria (a genetic disorder of the blood)
• suffer from myasthenia gravis, a condition characterised
by muscle weakness, difficulty chewing and swallowing
and slurred speech
• are sensitive to sunlight
• have systemic lupus erythematosus (SLE) a condition
characterised by a rash (especially on the face), hair loss,
fever, malaise and joint pain.
Children and adolescents
Doxycycline capsules are not recommended for use in
children under 12 years of age as it can cause permanent
discolouration of tooth enamel and affect bone
development.
Other medicines and Doxycyline capsules

Tell your doctor or pharmacist if you are taking, have recently
taken or might take any other medicines.
•w
 arfarin or other anticoagulants (to stop the blood clotting)
•p
 enicillin or rifampicin (to treat infections)
•m
 edicines such as antacids containing aluminium, calcium or
magnesium or other medicines containing iron, bismuth or
zinc salts. Do not take at the same time as Doxycycline capsules,
as absorption of doxycycline may be reduced. phenobarbital,
carbamazepine, phenytoin or primidone (to treat epilepsy)
•m
 ethoxyflurane (an anaesthetic), if you need an operation, tell
your doctor or dentist you are taking Doxycycline capsules
• c iclosporin (used following organ transplants).

Pregnancy and breastfeeding

If you are pregnant, breast-feeding, think or may be pregnant or
are planning to become pregnant ask your doctor or pharmacist
for advice before taking any medicine as doxycycline could harm
the baby.

3 How to take Doxycycline capsules

Always take this medicine exactly as your doctor has told you.
Check with your doctor or pharmacist if you are not sure.
You should not drink alcohol whilst taking Doxycycline capsules,
speak to your doctor if you have any questions.
Swallow the capsules whole with a full glass of water, if the
capsules irritate your stomach take them with food or milk.
You should take the capsules either sitting down or standing up
and well before you go to bed for the night to stop irritation and
ulceration of your gullet. It is important not to lie down for at least
thirty minutes after taking Doxycycline capsules.

Continued top of next column

Continued over page

148x210 Leaflet Reel Fed Profile (BST)

Doxycycline Hyclate 50mg and 100mg Capsules PIL - UK
item no: AAAI7797

dimensions: 148 x 210

print proof no: 3

pharmacode:

origination date: 16.02.16

min pt size: 7

1. Black
2.

revision date: 05.04.16

Technical Approval

revised by: S.Anson

date sent: n/a

supplier: Actavis UK

technically app. date: n/a

Doxycycline 50 & 100mg x 8,28 &
50’s (UK)
JDE No.:

50889741

4.

Dimensions: 148x210 (Reel Fed)
Component: Leaflet for Blisters

5.

Pharmacode: 6658

3.

6.

originated by: S.Anson
approved for print/date

colours/plates:

Non Printing Colours
1. Print safe Area
2.
3.

Date Sent:
12/02/2016
Technologist: R.Wrey
Technically Approved
Actavis BST - Packing Technical
BSTCutterGuideReq@actavis.com

The recomended dose is for at least 10 days unless otherwise directed by
your doctor:
Adults, Elderly and Children 12 years or over:
•G
 eneral infections: 200mg on the first day as a single or two 100mg
doses, followed by 100mg a day. For severe infections your doctor may
increase the dose to 200mg a day.
Specific infections:
•A
 cne vulgaris -50mg a day with food or fluid for 6-12 weeks.
• S exually transmitted disease - 100mg twice a day for 7-10 days
• S yphilis - 300mg a day in divided doses for 10 days.
• F evers caused by lice or ticks - a single dose of 100-200mg depending
upon severity of infection.
•M
 alaria - 200mg a day for at least 7 days, should be given with other
drugs such as quinine.
• P revent infection with scrub typhus - 200mg as a single dose.
• P revent traveller’s diarrhoea - 200mg on the first day of travel followed
by 100mg a day throughout the duration of the stay. Do not use for
more than 3 weeks unless advised by your doctor.
• P revent leptospirosis infections - 200mg once a week throughout the
stay in the infected area and 200mg at the end of the trip. Do not use for
more than 3 weeks unless advised by your doctor.

If you take more Doxycycline capsules than you should

If you (or someone else) swallow a lot of capsules at the same time, or
you think a child may have swallowed any contact your nearest hospital
casualty department or tell your doctor immediately.

If you forget to take Doxycycline capsules

Do not take a double dose to make up for a forgotten dose. If you forget
to take a dose take it as soon as you remember it and then take the next
dose at the right time.

If you stop taking Doxycycline capsules

Do not stop taking the capsules because you feel better, it is very
important to take all the capsules your doctor has prescribed for you, if
you do not your condition may recur or get worse.
If you have any further questions on the use of this medicine, ask your
doctor, pharmacist or nurse.

4 Possible side effects
Like all medicines, this medicine can cause side effects, although not
everybody gets them.
Stop taking the capsules immediately and seek urgent medical advice
if:
• y ou notice that your skin is very sensitive to light (you may get a skin
rash, itching, redness or severe sunburn when out in sunlight or after
using a sun bed).
Contact your doctor at once if the following reactions happen:
•w
 heeziness, difficulty in breathing, fever, sudden swellings of the face,
lips, throat, tongue, hands or feet, fast heart rate, low blood pressure,
rash or itching (especially affecting the whole body), pericarditis
(inflammation of the membrane surrounding the heart)
• s wollen tongue, watery diarrhoea, fever and cramps
(pseudomembranous colitis), soreness and itching around the back
passage and/or genital areas, inflammation around the vagina, or thrush
of the vagina or mouth
•w
 orsening of systemic lupus erythematosus (SLE)
• a ltered numbers of certain types of blood cells, you may notice that you
bruise easily, have nose bleeds, or suffer from infections and sore throats,
porphyria (sensitivity of the skin to sunlight, inflammation of nerves and
stomach pains)
• t innitus (ringing or buzzing in the ears)

• inflammation of the liver (hepatitis), jaundice (yellowing of the skin
or white of the eyes), liver failure and inflammation of the pancreas
(pancreatitis)
• severe skin reactions such as erythema multiforme (circular, irregular red
patches), Stevens-Johnson syndrome (rash with flushing, fever, blisters
or ulcers), toxic epidermal necrolysis (reddening, peeling and swelling
that resembles burns).
Tell your doctor if you notice any of the following side effects or notice
any other effects not listed:
•G
 lands and hormones: discolouration of thyroid tissue (does not affect
thyroid function).
•C
 entral nervous system: headache, increased pressure in the
skull (severe headaches, blurred and/or double vision, blind spots),
permanent loss of vision, bulging fontanelles (soft spot on head) of
infants.
• Gastrointestinal tract: stomach pain, loss of appetite, feeling or being
sick, heartburn, diarrhoea, difficulty swallowing, sore or painful tongue
or mouth, inflammation and/or ulcers of the gullet, discolouration or
underdevelopment of teeth.
• L iver: changes in liver function tests.
• Skin: detachment of the nail from finger bed.
•M
 uscles and bones: muscle or joint pain.
•K
 idneys: an increase in urea in the blood.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This
includes any possible side effects not listed in this leaflet. You can also
report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information on the
safety of this medicine.

5 How to store Doxycycline capsules

Keep out of the sight and reach of children.
Store below 25ºC in a dry place.
Do not use Doxycycline capsules after the expiry date stated on the label/
carton/bottle. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste.
Ask your pharmacist how to dispose of medicines no longer required.
These measures will help to protect the environment.

6 Contents of the pack and other information
What Doxycycline capsules contain

• The active substance (the ingredient that makes the capsule
work) is Doxycycline hyclate. Each capsules contains either
50mg or 100mg of Doxycycline base.
• The other ingredients are gelatin, magnesium stearate,
shellac glaze, sodium lauryl sulfate, starch, quinoline yellow
(E104), erythrosine (E127), patent blue V (E131), titanium
dioxide (E171), iron oxide black (E172), and propylene
glycol.

What Doxycycline capsules look like and contents
of the pack

Doxycycline 50mg are green and white hard gelatin capsules
and Doxycycline 100mg are green hard gelatin capsules.
Doxycycline 50mg capsules are available in pack sizes of
28 capsules.
Doxycycline 100mg capsules are available in pack sizes of
8 & 50 capsules.
Marketing Authorisation Holder and Manufacturer
Actavis, Barnstaple, EX32 8NS, UK
This leaflet was last revised in April 2016.

Continued top of next column
50889741 AAAI7797

Actavis, Barnstaple, EX32 8NS, UK

148x210 Leaflet Reel Fed Profile (BST)

Doxycycline Hyclate 50mg and 100mg Capsules PIL - UK
item no: AAAI7797

dimensions: 148 x 210

print proof no: 3

pharmacode:

origination date: 16.02.16

min pt size: 7

1. Black
2.

revision date: 05.04.16

Technical Approval

revised by: S.Anson

date sent: n/a

supplier: Actavis UK

technically app. date: n/a

Doxycycline 50 & 100mg x 8,28 &
50’s (UK)
JDE No.:

50889741

4.

Dimensions: 148x210 (Reel Fed)
Component: Leaflet for Blisters

5.

Pharmacode: 6658

3.

6.

originated by: S.Anson
approved for print/date

colours/plates:

Non Printing Colours
1. Print safe Area
2.
3.

Date Sent:
12/02/2016
Technologist: R.Wrey
Technically Approved
Actavis BST - Packing Technical
BSTCutterGuideReq@actavis.com

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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