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Active substance(s): DOXYCYCLINE HYCLATE

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#100 mg


#100 mg




Doxycycline 100 mg
Capsules, Hard

Package leaflet: Information for the patient


8 capsules
Each capsule contains: Doxycycline hyclate
equivalent to 100 mg of doxycycline.
Dosage: For oral use as directed by a doctor.
Read the package leaflet before use.
Keep out of sight and reach of children.
Store in the original package in order to protect
from light and moisture. Store below 25°C
PL 04569/0035 POM
836398 LL0448AF
Mylan, Potters Bar, Herts, EN6 1TL, UK.

Doxycycline belongs to the tetracycline group
of antibiotics. Doxycycline can be used to
treat a variety of infections, including bacterial
infections that affect the eyes, nose, throat and
respiratory system (chest infections), sexually
transmitted diseases and infections of the
urinary tract; malaria, fevers associated with lice,
fleas and tick bites or diseases spread by animals
(e.g. leptospirosis); and in the prevention of
traveller's diarrhoea, scrub typhus, leptospirosis
and malaria.


Read all of this leaflet carefully before you
start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your
doctor or pharmacist.


What Doxycycline looks like and the contents of
the pack.
Your medicine comes as green capsules,
containing yellow powder marked with 'DE 100'
with 'G'
Doxycycline is available in glass or plastic bottles
or blister packs of 5, 7, 8, 10, 14, 20, 21, 25, 28, 30,
50, 56, 60, 84, 90, 100 and 250 capsules.
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Mylan, Potters Bar, Hertfordshire, EN6 1TL, UK
Gerard Laboratories, 35/36 Baldoyle Industrial
Estate, Grange Road, Dublin 13, Ireland.


6. Contents of the pack and other information
What Doxycycline contains
• The active substance is doxycycline hyclate,
equivalent to 100 mg of doxycycline.
• The other ingredients are magnesium stearate,
talc, maize starch. The capsule shell is made
of gelatin and contains the colourings patent
blue (E131), titanium dioxide (E171) and iron
oxides (E172). The printing ink contains shellac,
titanium dioxide (E171), propylene glycol, and
either ammonium hydroxide and simeticone, or
sodium hydroxide and povidone.

This leaflet was last revised in 03/2016





1. What Doxycycline is and what it is used for

• This medicine has been prescribed for you
only. Do not pass it on to others. It may harm
them, even if their signs of illness are the same
as yours.
• If you get any side effects, talk to your doctor
or pharmacist. This includes any possible side
effects not listed in this leaflet. See section 4.
What is in this leaflet:
1. What Doxycycline is and what it is used for
2. What you need to know before you take
3. How to take Doxycycline
4. Possible side effects
5. How to store Doxycycline
6. Contents of the pack and other information.


2. What you need to know before you
take Doxycycline
Do not take Doxycycline
• if you are allergic to doxycycline, a similar
medicine or any of the other ingredients of this
medicine (listed in section 6).
• if you are pregnant or breast-feeding
• if you are a child under 12 years old, as
tetracyclines can affect growing bones and teeth
and can also cause staining and a reduction in the
amount of enamel in the teeth.
Warnings and precautions
Talk to your doctor or pharmacist before
taking Doxycycline
• if you have liver disease or are taking medicine


Your blood tests may show:
• reduction in red blood cells which can make the
skin pale or yellow and cause weakness
or breathlessness
• reduction in white blood cells which can cause
more infections e.g. colds than usual
• an increase in the number of white blood cells
• reduction in blood platelets which increase risk
of bleeding or bruising
• a rise in blood urea
• a rise in liver function tests
• an increase in the number of white blood cells
Reporting of side effects
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side

a prescription, herbal medicines or any of
the following:
• anticoagulants to thin the blood e.g. warfarin
• antacids, used for indigestion
• sucralfate used to treat stomach or gut ulcers
• zinc sulphate
• preparations containing iron
• barbiturates e.g. phenobarbital
• antiepileptics e.g. carbamazepine, phenytoin
• medicine containing iron
• penicillin antibiotic
• ciclosporin.

medicine should not be taken immediately
before bedtime or if lying down.
Patients being treated for certain diseases may
need monthly blood tests to check the infection
is clearing up.
Adults and older people
The recommended dose is two capsules (200 mg) on
the first day (either as a single dose or one capsule
followed by a further 100 mg capsule 12 hours later),
followed by one 100 mg capsule daily thereafter.
To treat more serious infections your doctor may
prescribe two capsules (200 mg) to be taken daily.
The following doses may be given to treat
specific infections:
Sexually transmitted diseases: the recommended

fever, blisters or ulcers)or Toxic epidermal
necrolysis (reddening, peeling and swelling that
resembles burns),
• severe headaches with changes in eyesight and
blurred or double vision, or loss of vision,
• rarely, liver problems which can cause yellowing
of skin and whites of eyes, dark urine, pale stools,
• inflammation of the pancreas which causes
severe pain in the abdomen and back,
• severe diarrhoea with blood in the stools,
• pericarditis (inflammation of the membrane
around the heart),
• haemolytic anaemia (low number of red blood
cells). Signs include tiredness, headaches, being
short of breath when exercising, dizziness with
yellowing of the skin and/or eyes,

which can affect the liver
• if you suffer from a rare disorder called porphyria
• if you suffer from myasthenia gravis (a disease
causing muscle weakness)
• if you have SLE (systemic lupus erythematosus)
Avoid strong sunlight or ultra violet light as
Doxycycline can make the skin more sensitive. If
your skin becomes red and patchy, tell your doctor
as he may need to stop treatment.
If you are having tests, such as liver function tests
or a urine test, tell your doctor you are taking
Other medicines and Doxycycline
Please tell your doctor if you are taking any other
medicines including medicines obtained without

effects directly via the Yellow Card Scheme at By reporting side
effects you can help provide more information on
the safety of this medicine.

Stop taking Doxycycline and tell your doctor if
your skin becomes sensitive to sunlight or UV light.
Doxycycline can cause staining of the teeth during
tooth development (e.g. during pregnancy and if
given to children under 12 years). Stop taking this
medicine and tell your doctor straight away if this
happens to you. It is more likely in patients on
long-term treatment.
If you have SLE (lupus), Doxycycline may make the
symptoms worse. Stop taking this medicine and
tell your doctor if this happens to you.
Other side effects include:
• muscle and joint pain,
• feeling or being sick, diarrhoea, loss of appetite,
swelling or soreness of the tongue or mouth,

taking this medicine.
Driving and using machines
Do not drive or use machines if you suffer from
visual disturbances such as blurred vision while
taking Doxycycline.

your visit and for 4 weeks after leaving the area.
To prevent scrub typhus: the recommended dose
is a single dose of 200 mg
To prevent traveller's diarrhoea: the
recommended dose is 200 mg as a single dose on
the day of travel (or 100 mg followed by a second
dose of 100 mg 12 hours later), then 100 mg daily
throughout the stay (up to 3 weeks).
To prevent leptospirosis: the recommended dose
is 200 mg once a week throughout the stay in the
area and 200 mg on completion of the trip.
Use in children
Doxycycline must not be given to children under
12 years of age.

If you take more Doxycycline than you should
If you take more Doxycycline than you should
contact your doctor or hospital emergency
department immediately.
If you forget to take Doxycycline
If you forget to take a dose of Doxycycline take it
as soon as you remember unless it is nearly time
for your next dose. Never take two doses at the
same time.
If you stop taking Doxycycline
Do not stop taking Doxycycline without talking
to your doctor first. It is important to finish the
course of antibiotic as instructed by your doctor.
If you have any further questions on the use of this
product, ask your doctor or pharmacist.


5. How to store Doxycycline
Keep out of the sight and reach of children.
Do not take Doxycycline after the expiry date which
is stated on the label or carton after 'EXP'. The expiry
date refers to the last day of that month.
Store in the original package in order to protect
from light and moisture. Store below 25°C. Do
not throw away any medicines via wastewater
or household waste. Ask your pharmacist how to
throw away medicines you no longer use. These
measures will help to protect the environment.


If you are going to have an operation and need an
anaesthetic, tell the anaesthetist or dentist you are
taking Doxycycline.
Doxycycline with alcohol
Do not drink alcohol during treatment.
Pregnancy and breast-feeding
Do not take Doxycycline if you are pregnant,
think you may be pregnant, or plan to become
pregnant, as it can affect the development of your
unborn baby.
Do not breast-feed if you are taking Doxycycline
as doxycycline can pass into breast milk.
If you are pregnant or breast-feeding, think you
may be pregnant or are planning to have a baby,
ask your doctor or pharmacist for advice before


ulcers, stomach pain, wind, feeling flushed,
• Doxycycline can also cause pain and difficulty
swallowing – this is less likely to happen if the
capsules are taken with plenty of fluid whilst sat
upright (see 'section 3'),
• Soreness, itchiness and a fungal infection
(candida) in the genital or anal area,
• Bulging fontanelle (soft spot on head) of babies,
• Headache,
• ringing in the ears,
• discolouration of the thyroid tissue when given
for long periods of time (this medicine does not
affect thyroid function),
• loosening of the nail from the nail bed after
exposure to the sun.




4. Possible side effects
Like all medicines, this medicine can cause side
effects, although not everybody gets them.
If any of the following happen, stop taking
Doxycycline and tell your doctor immediately or go
to your nearest hospital emergency department:
• allergic reactions such as severe skin rashes, red
itchy swollen skin, blistering of the skin swollen
ankles, joint pain, fever, swelling of the lips,
tongue, face throat, tightening of the chest and
difficulty breathing, chest pain, shock, low blood
pressure, a racing heart beat,
• Severe skin reactions such as erythema
multiforme (circular, irregular red patches),
Stevens-Johnson syndrome (rash with flushing,

dose is 100 mg twice daily. Depending on the type of
infection being treated, your treatment may continue
for between 7 to 10 days.
Primary and secondary syphilis: the recommended
dose is 200 mg twice a day for 2 weeks.
Louse and tick-borne fevers: the recommended
dose is a single dose of 100 mg or 200 mg
To treat malaria: (when chloroquine is not
effective): the recommended dose is 200 mg daily
for at least 7 days. Your doctor will also prescribe
another medicine as well, possibly quinine, to help
treat the disease.
To prevent malaria: the recommended dose is
100 mg daily starting 1 or 2 days before travelling to
the malarial area. Treatment should continue during




Description Doxycycline 100 mg 90,60,30,28,56,84,25,250,50,21,20,8,7,5,14,100,10
Component Type Label Leaflet
Affiliate Item Code 836398
Superceded Affiliate Item Code 350656
TrackWise PR No. 836398
MA No. 04569/0035
Packing Site/Printer NA
Supplier Code LL0448AF

Pharma Code TBC
Vendor Job No. 275232
Trackwise Proof No. 1
Glams Proof No. 1
Client Market United Kingdom
Keyline/Drawing No. NA
Barcode Info 5016695560090

Date: 01 Mar 2016
No. of colours

Time: 16:56


Page Count







Equate CMYK
Main Font Myriad Pro
Dimensions 52 x 101 mm

Body Text Size 7.7 pt
Min Text Size used 7 pt


v1/May 2015


3. How to take Doxycycline
Always take Doxycycline exactly as your doctor
has told you. You should check with your doctor or
pharmacist if you are not sure.
You must complete the course of treatment as
directed by your doctor, even if you feel better.
• Swallow the capsules with plenty of fluid
• Take the capsules with milk or food to reduce
the likelihood of stomach upset.
• Take whilst sitting or standing upright: this


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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.