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Doxapram Hydrochloride
Read all of this leaflet carefully before you start using this medicine.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their
symptoms are the same as yours.
If any of the side effects become serious, or if you notice any side effects not listed in this leaflet,
please tell your doctor or pharmacist.
In this leaflet:
1. What Dopram Infusion is and what it is used for
2. Before you are given Dopram Infusion
3. How Dopram Infusion is given to you
4. Possible side effects
5. How to store Dopram Infusion
6. Further information
Dopram Infusion is used to help you breathe after you have been given an anaesthetic, when your
breathing may not be as good as it should be. Also some pain-killers used in anaesthesia have the side
effect of decreasing your breathing and Dopram Infusion can prevent this problem. Your doctor can
also use Dopram Infusion to speed up your recovery after an anaesthetic and also from associated
Dopram Infusion works by increasing the amount of air that goes in and out of your lungs and
increases your rate of breathing.
Dopram Infusion is therefore useful in conditions where breathing properly may be difficult.
You should not be given Dopram Infusion if:
• you know that you are allergic to any of the ingredients of Dopram Infusion (See section 6 of this
• you have very high blood pressure
• you are suffering from sudden, severe wheezing.
• you have heart disease
• you suffer from epilepsy or a similar condition involving fits or convulsions
• you have what is called cerebral oedema, where there is build up of fluid in the brain
• you have suffered from a stroke
• you suffer from the condition known as hyperthyroidism/ thyrotoxicosis. (when you have
an overactive thyroid gland and your body produces too much of the hormone thyroxine)
• the airways in your lungs or the muscles in the chest wall that you use to breathe are
severely blocked in any way
• you have an injury to the head
• you suffer from a blood clot in the lung (pulmonary embolism).
Make sure your doctor knows if you suffer from any of the above.

Before you are given Dopram Infusion, your doctor will take special care if any of the
following situations apply to you.
Make sure your doctor is aware of these situations if it is not already obvious:
• If you are wheezing or have problems with your breathing, your doctor will probably give you
another drug or oxygen to control this while you are taking Dopram Infusion
• If you suffer from any liver problems
• You have been under anaesthetic, the type of anaesthetic used will affect the way your doctor gives
you Dopram Infusion. Your doctor will monitor you closely after having an anaesthetic, as the effects
of other drugs used during an operation must be considered when Dopram Infusion is being given
• If you have a tumour of the adrenal glands called a phaeochromocytoma
• If you have high blood pressure.
Tell your doctor if any of these apply to you.
Taking other medicines
Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines.
This includes medicines obtained without a prescription. This is extremely important because some
medicines can strengthen or weaken the effects of others.
In particular, tell your doctor if you are taking any of the following as it may alter their effect:
• Drugs that stimulate certain nerves known as sympathomimetics. These are often used in the
treatment of asthma, eg salbutamol and terbutaline
• A Monoamine oxidase inhibitor (MAOI) which is a drug used to treat depression (eg. phenelzine,
• Certain anaesthetics such as halothane, cyclopropane and enflurane
• A drug called aminophylline/theophylline which may be used in the treatment of asthma
• Curare type muscle relaxant drugs (which decrease the muscle tone).
Pregnancy and breast feeding
If you are pregnant, think you may be pregnant, are planning to become pregnant or are
breast feeding you should tell your doctor. This may affect their decision about whether to give you
Dopram Infusion or not.
Ask your doctor or pharmacist for advice before taking any medicine.
Important information about some of the ingredients of Dopram Infusion:
Contains 0.05g(50mg) glucose per ml. This should be taken into account in patients with diabetes
mellitus when doses more than 100ml are administered.
Your doctor will give you Dopram Infusion through a drip into one of your veins. The amount you are
given will depend on your condition and on how well you are responding to the medicine.
Adults and the elderly:
Normally you will be given between 1.0 and 4 mg of Dopram Infusion per minute, up to periods of an
hour or more.
Dopram Infusion is not recommended for use in children.
If you are given more Dopram Infusion than you should.
If your doctor accidentally gives you too much of this medicine you may feel the following, your
heartbeat becomes irregular, you develop some shortness of breath and your muscle movements
become more difficult. Tell your doctor immediately if you feel any of these symptoms.
If you have any further questions on the use of this product ask your doctor or pharmacist.

Like all medicines Dopram Infusion can sometimes cause side-effects, although not everybody gets
All medicines can cause allergic reactions although serious allergic reactions are very rare. Any
sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching
(especially affecting your whole body) should be reported to a doctor immediately.
If you develop sudden and severe increase in blood pressure or difficulty in breathing your doctor will
stop Dopram Infusion.
The following side effects have also been reported:
• feeling feverish, flushed and possibly sweating
• headache
• coughing
• dizziness
• shortness of breath
• feeling hyperactive
• tightening of the chest and throat
• feeling confused
• increased blood pressure
• having hallucinations (see, hear, smell,
• quicker or slower heartbeat than usual
taste, or feel something that is not there)
• feeling sick and perhaps being sick
• warmth at the base of the tummy
• vomiting
• salivation
• irregular heart beat
• muscle twitches
• weakness in the limbs, slurred speech or visual disturbance, • inability to pass urine or sudden
which may be caused by reduced blood supply to the brain
passing of urine
• chest pain or chest tightness
• increase in muscle tone
• fits
• sustained/continuous muscle contractions
• reflex of toe in response to foot stroke
• increase reflexes in brain function
• premature contraction of heart
Children, Infants and premature newborns:
Although Dopram Infusion is not recommended for use in children, its use in children is known to
cause the following side effects:
• Prolonged use of Dopram Infusion in premature infants may cause slow development of some parts
of the brain.
• Dopram Infusion use in premature infants may cause heart related problems including irregular or
slow heartbeats.
• Bleeding in stools, painful swelling of the stomach, death of tissue in portions of the bowel, multiple
perforations of the wall of the stomach.
• Early teeth eruption.
If any of the side effects persist or become more serious, or if you notice any side effects not listed in
this leaflet, please tell your doctor or pharmacist.
Your doctor, pharmacist or nurse will know how to store Dopram Infusion properly.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the infusion bag. The expiry date
refers to the last day of that month.
Do not store above 25°C.
For single use only. Discard any unused contents.

The active substance is Doxapram hydrochloride. There is 2mg of Doxapram hydrochloride in 1ml of
the infusion solution.
The other ingredient is 5% glucose and water for injections.
What Dopram Infusion looks like and contents of pack
The name of your medicine is Dopram Infusion and is supplied in flexible plastic bags inside a
protective plastic overpouch.
Each Infusion bag contains 500 ml of a clear colourless sterile solution for infusion.
Marketing authorisation holder
MercuryPharm Ltd
4045, Kingswood Road,
City West Business Park,
Co Dublin, Ireland.
Baxter Healthcare Limited, Caxton Way, Thetford, Norfolk, IP24 3SE United Kingdom.
This leaflet was last revised in: August 2012.
Mercurypharm is licensed to use the registered trademark Dopram.

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Further information

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