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DIFFERIN GEL

Active substance(s): ADAPALENE

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THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

® GEL
DIFFERIN®

(Adapalene)
Patient Information Leaflet
Your medicine is known by the above name but will be referred to as Differin throughout this leaflet.





1. What Differin is and what it is used for
The active substance in Differin is adapalene, which has an anti-inflammatory effect reducing
soreness and irritation.
It is used on the face, chest or back for acne, where the skin has lots of blackheads, spots and
pimples.
Differin is only absorbed into the body in very small amounts and has little effect, except on the
surface of the skin.

DATE:

WARNING!

Warnings and precautions
• Do not use this medicine on areas where you have cuts or scrapes or if you have a skin condition
called eczema.
• Avoid contact with the eyes, mouth or nostrils, and avoid other very sensitive areas of the body. If
accidental contact does occur, immediately wash with warm water.
• Avoid exposure to strong sunlight and artificial UV light.
• If you experience sensitivity or irritation when applying this medicine, stop using it and tell your
doctor. You may be asked to use the gel less often, or to stop using it for a short time.
Talk to your doctor or pharmacist if you are not sure.
Other medicines and Differin
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
• Other acne products (containing benzoyl peroxide, erythromycin or clindamycin) may be used with
Differin but they must be applied in the morning and Differin at night.
• Cosmetics may be used but they must not cause blackheads or dry the skin.
Pregnancy and breast-feeding
• Differin should not be used during pregnancy. If you fall pregnant while using Differin, the treatment
must be discontinued and you should inform your doctor as soon as possible for a further follow-up.
• Differin can be used during breast-feeding. To avoid contact exposure of the infant, application of
Differin to the chest should be avoided.

DATE:

Q.A.
APPROVED:

CUSTOMER
APPROVED:

2. What you need to know before you use Differin
Do not use Differin:
• If you are allergic to adapalene or any of the other ingredients of this medicine (listed in section 6).

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your
doctor or pharmacist for advice before using this medicine.

UK PIL DATED AUGUST 2013
REPORTING OF SIDE EFFECTS

17/12/13
TVT CHECKED
6464/2239
CODE:

DT

DATE OF PROOF:

Differin Gel

ARTWORKER:

3. How to use Differin
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you
are not sure.

PRODUCT:

CUSTOMER: Waymade

PRE-PRESS NO.:

05-0440

Differin contains:
- propylene glycol (E1520) which may cause skin irritation
- methyl parahydroxybenzoate (E218) which may cause allergic reactions (possibly delayed).

• Differin is only intended for use in adults and adolescents aged 12 years and over.
• This medicine is for EXTERNAL USE ONLY.
• Differin is applied at night before going to bed, unless your doctor has told you otherwise.
• Thoroughly wash the areas to be treated with water. Make sure the skin is clean and dry before
using this medicine.
• Put on a thin film of the gel with your fingertips to the affected areas and rub in gently.
• Don’t forget to wash your hands afterwards.
• How long you will have to use this medicine will depend on how quickly your acne improves.
After you have used this medicine for three months, it is important that you see your doctor. He or
she can then check the improvement of your acne.
If you use more Differin than you should or accidentally swallow the gel
• If you put too much Differin on your skin, you will not get rid of your acne any quicker, but your skin
may become irritated and red. Some peeling or discomfort could also occur.
• In the rare event that you accidentally swallow any of this medicine, seek medical advice.
If you forget to use Differin
Don’t worry if you forget to apply your Differin at the right time. When you remember, start using this
medicine again, in the same way as before.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Colour
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Black

WARNING!

ARIAL REGULAR FONT SIZE 8
ARIAL BOLD
FONT SIZE 8
BRIDGED TO
CRESTOR 6464/2069 2070

«PAdBì

Read all of this leaflet carefully before you start using this medicine because it contains important
information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their
signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not
listed in this leaflet. See section 4.
What is in this leaflet:
1. What Differin is and what it is used for
2. What you need to know before you use Differin
3. How to use Differin
4. Possible side effects
5. How to store Differin
6. Contents of the pack and other information

PROOF HISTORY:
v.1 - waymade - 17/12/13

Leaflet Flat Size = 148 x 317

27mm

WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

000-0000A

THE COLOURS SHOWN ON THIS PROOF ARE FOR GENERAL REPRESENTATION PURPOSES ONLY. THEY ARE NOT ACCURATE AND MUST NOT BE
USED AS A COLOUR MATCH FOR THE FINISHED JOB. PLEASE REFER TO THE PANTONE COLOUR GUIDES FOR ACCURATE COLOUR REFERENCES.

4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.

Not known: frequency cannot be estimated from the available data
- pain or swelling of the skin
- irritation, redness, itching or swelling of the eyelids
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not
listed in this leaflet.
You can also report side effects directly via www.mhra.gov.uk/yellowcard. By reporting side effects you can
help provide more information on the safety of this medicine.

WARNING!

6. Contents of the pack and other information
What Differin contains
Your medicine is called Differin gel. Differin gel contains 0.1%w/w of the active ingredient, Adapalene in a
white, opaque, smooth topical gel.
Differin gel also contains the following inactive ingredients; carbomer, propylene glycol, poloxamer 182,
disodium edetate, methylparahydroxybenzoate, phenoxyethanol, sodium hydroxide and purified water.
Differin gel is available as a pack containing 60 grams of gel.

DATE:

CUSTOMER
APPROVED:



5. How to store Differin
Differin gel should not be stored above 25°C. Do not freeze.
Do not use after the expiry date printed on the carton or plastic tube.
KEEP ALL MEDICINES OUT OF THE SIGHT AND REACH OF CHILDREN.
If your doctor tells you to stop using the gel, please take it back to the pharmacist for safe disposal.
Only keep the gel if your doctor tells you to.
If the gel becomes discoloured or shows any other signs of deterioration, you should consult your
pharmacist who will advise you what to do.

POM

PL No: 6464/2239

This product is manufactured by Laboratoires Galderma, 74540 Alby-sur-Cheran, France and is procured
within the EU and repackaged by the Product Licence holder:
Waymade plc, Miles Gray Road, Basildon, Essex SS14 3FR

17/12/13
DATE OF PROOF:

6464/2239
CODE:

UK PIL DATED AUGUST 2013
REPORTING OF SIDE EFFECTS

TVT CHECKED

DT
ARTWORKER:
Differin Gel
PRODUCT:

05-0440
PRE-PRESS NO.:

DATE:

Differin® is a registered trademark of GALDERMA S.A.

CUSTOMER: Waymade

Q.A.
APPROVED:

Leaflet revision and issue date (Ref.) 16.12.2013

Colour
Swatch

Black

WARNING!






WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. THE ARTWORK RECEIVED HAS BEEN SIGNIFICANTLY
ADJUSTED, REVISED OR RESET BY US FROM DISK OR HARD COPY. WHILST WE TAKE EXTREME CARE AT ALL TIMES TO ENSURE ACCURACY, THE FINAL RESPONSIBILITY
MUST BE TAKEN BY OUR CUSTOMER. IF YOU SIGN THIS PROOF YOU ARE SIGNIFYING FULL APPROVAL OF DESIGN AND TEXT.

ARIAL REGULAR FONT SIZE 8
ARIAL BOLD
FONT SIZE 8
BRIDGED TO
CRESTOR 6464/2069 2070

«PAdBì

Uncommon: may affect up to 1 in 100 people
- local skin reaction (contact dermatitis)
- skin discomfort
- sunburn
- itching of the skin (pruritus)
- peeling skin (exfoliation)
- flare up of acne

PROOF HISTORY:
v.1 - waymade - 17/12/13

Leaflet Flat Size = 148 x 317

27mm

Differin Gel may cause the following side effects at the site of application.
Common: may affect up to 1 in 10 people
- dry skin
- irritation of the skin
- burning sensation of the skin
- redness of the skin (erythema)

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Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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